JP7090100B2 - 疼痛の処置のための１１，１３－修飾サキシトキシン： - Google Patents

疼痛の処置のための１１，１３－修飾サキシトキシン： Download PDF

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Publication number
JP7090100B2
JP7090100B2 JP2019553572A JP2019553572A JP7090100B2 JP 7090100 B2 JP7090100 B2 JP 7090100B2 JP 2019553572 A JP2019553572 A JP 2019553572A JP 2019553572 A JP2019553572 A JP 2019553572A JP 7090100 B2 JP7090100 B2 JP 7090100B2
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alkyl
halo
compound
salts
pain
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JP2020515610A (ja
JP2020515610A5 (enExample
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ジョン マルケイヒー，
ハッサン パジョヘシュ，
ジョージ ミルジャニッチ，
アントン デルウィグ，
ジェイコブ ベックリー，
グラント マサアキ シブヤ，
ボイス， ジャスティン デュ
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019553572A 2017-03-29 2018-03-29 疼痛の処置のための１１，１３－修飾サキシトキシン： Active JP7090100B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762478523P 2017-03-29 2017-03-29
US62/478,523 2017-03-29
PCT/US2018/025301 WO2018183781A1 (en) 2017-03-29 2018-03-29 11,13-modified saxitoxins for the treatment of pain

Publications (3)

Publication Number Publication Date
JP2020515610A JP2020515610A (ja) 2020-05-28
JP2020515610A5 JP2020515610A5 (enExample) 2021-05-20
JP7090100B2 true JP7090100B2 (ja) 2022-06-23

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JP2019553572A Active JP7090100B2 (ja) 2017-03-29 2018-03-29 疼痛の処置のための１１，１３－修飾サキシトキシン：

Country Status (11)

Country Link
US (2) US11236097B2 (enExample)
EP (1) EP3601291B1 (enExample)
JP (1) JP7090100B2 (enExample)
KR (1) KR20200012833A (enExample)
CN (1) CN110831945B (enExample)
AU (1) AU2018243463C1 (enExample)
BR (1) BR112019020111A2 (enExample)
CA (1) CA3058214A1 (enExample)
IL (1) IL269599B2 (enExample)
MX (1) MX2019011530A (enExample)
WO (1) WO2018183781A1 (enExample)

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JP2020515611A (ja) * 2017-03-29 2020-05-28 サイトワン セラピューティクス， インコーポレイテッド 疼痛の処置のための１１，１３−修飾サキシトキシン
CA3058214A1 (en) 2017-03-29 2018-10-04 The Board Of Trustees Of The Leland Stanford Junior University 11,13-modified saxitoxins for the treatment of pain
EP3860714B1 (en) 2018-10-03 2023-09-06 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
CN110128292A (zh) * 2019-06-12 2019-08-16 成都美域高制药有限公司 一种Ozanimod中间体4-氰基茚酮的合成方法
PH12022551379A1 (en) 2019-12-06 2023-05-03 Vertex Pharma Substituted tetrahydrofurans as modulators of sodium channels
SMT202600064T1 (it) 2021-06-04 2026-03-09 Vertex Pharma Forme farmaceutiche solide e regimi di dosaggio comprendenti (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-metossi-fenil)-4,5-dimetil-5-(trifluorometil) tetraidrofuran-2-carbonil]ammino]piridin-2-carbossammide
WO2022256842A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
US20240368135A1 (en) 2021-06-04 2024-11-07 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
CA3221939A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
CN117794918A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 经取代的四氢呋喃类似物作为钠通道调节剂
IL316422A (en) 2022-04-22 2024-12-01 Vertex Pharma Heteroaryl compounds for pain treatment
AU2023257313A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
AU2023255558A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
KR20250120351A (ko) 2022-12-06 2025-08-08 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 치환된 테트라하이드로푸란 조절제의 합성을 위한 방법
TW202535867A (zh) 2023-10-23 2025-09-16 美商維泰克斯製藥公司 用於治療疼痛之鈉通道調節劑及其固體形式的製備方法
KR20260116140A (ko) 2023-10-23 2026-07-28 버텍스 파마슈티칼스 인코포레이티드 통증 치료를 위한 헤테로아릴 화합물
KR20260116141A (ko) 2023-10-23 2026-07-28 버텍스 파마슈티칼스 인코포레이티드 통증 치료용 화합물 및 이의 고체 형태의 제조방법
KR20260118418A (ko) 2023-10-23 2026-07-30 버텍스 파마슈티칼스 인코포레이티드 통증 치료를 위한 헤테로아릴 화합물
AU2024393245A1 (en) 2023-12-07 2026-06-18 Vertex Pharmaceuticals Incorporated Dosing regimens and formulations of suzetrigine for use in the treatment of acute and chronic pain
TW202606663A (zh) 2024-06-28 2026-02-16 美商維泰克斯製藥公司 用於治療疼痛之雜芳基化合物
LU605402B1 (en) 2024-07-11 2026-07-14 Sea4Us Biotecnologia E Recursos Marinhos Sa Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain

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US11834456B2 (en) 2023-12-05
RU2019134300A3 (enExample) 2021-05-25
AU2018243463B2 (en) 2022-05-19
JP2020515610A (ja) 2020-05-28
CN110831945A (zh) 2020-02-21
EP3601291A1 (en) 2020-02-05
US11236097B2 (en) 2022-02-01
IL269599B2 (en) 2023-07-01
US20220259218A1 (en) 2022-08-18
IL269599A (en) 2019-11-28
CN110831945B (zh) 2023-08-08
AU2018243463C1 (en) 2022-12-01
RU2019134300A (ru) 2021-04-29
AU2018243463A8 (en) 2019-11-07
CA3058214A1 (en) 2018-10-04
MX2019011530A (es) 2020-01-27
US20200102318A1 (en) 2020-04-02
AU2018243463A1 (en) 2019-10-31
IL269599B1 (en) 2023-03-01
WO2018183781A1 (en) 2018-10-04
EP3601291B1 (en) 2026-05-20
KR20200012833A (ko) 2020-02-05
BR112019020111A2 (pt) 2020-05-05

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