KR20200012833A - 통증 치료용 11,13-개질된 색시톡신 - Google Patents

통증 치료용 11,13-개질된 색시톡신 Download PDF

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Publication number
KR20200012833A
KR20200012833A KR1020197031530A KR20197031530A KR20200012833A KR 20200012833 A KR20200012833 A KR 20200012833A KR 1020197031530 A KR1020197031530 A KR 1020197031530A KR 20197031530 A KR20197031530 A KR 20197031530A KR 20200012833 A KR20200012833 A KR 20200012833A
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South Korea
Prior art keywords
alkyl
compound
halo
formula
optionally substituted
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Ceased
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KR1020197031530A
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English (en)
Korean (ko)
Inventor
존 멀케이
하산 파조헤쉬
조지 밀자니크
안톤 델위그
제이콥 베클리
그랜트 마사아키 시부야
보이스 저스틴 두
Original Assignee
사이트원 테라퓨틱스, 인코포레이티드
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티
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Application filed by 사이트원 테라퓨틱스, 인코포레이티드, 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티, 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 filed Critical 사이트원 테라퓨틱스, 인코포레이티드
Publication of KR20200012833A publication Critical patent/KR20200012833A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020197031530A 2017-03-29 2018-03-29 통증 치료용 11,13-개질된 색시톡신 Ceased KR20200012833A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762478523P 2017-03-29 2017-03-29
US62/478,523 2017-03-29
PCT/US2018/025301 WO2018183781A1 (en) 2017-03-29 2018-03-29 11,13-modified saxitoxins for the treatment of pain

Publications (1)

Publication Number Publication Date
KR20200012833A true KR20200012833A (ko) 2020-02-05

Family

ID=62063184

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197031530A Ceased KR20200012833A (ko) 2017-03-29 2018-03-29 통증 치료용 11,13-개질된 색시톡신

Country Status (11)

Country Link
US (2) US11236097B2 (enExample)
EP (1) EP3601291A1 (enExample)
JP (1) JP7090100B2 (enExample)
KR (1) KR20200012833A (enExample)
CN (1) CN110831945B (enExample)
AU (1) AU2018243463C1 (enExample)
BR (1) BR112019020111A2 (enExample)
CA (1) CA3058214A1 (enExample)
IL (1) IL269599B2 (enExample)
MX (1) MX2019011530A (enExample)
WO (1) WO2018183781A1 (enExample)

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JP2020515611A (ja) * 2017-03-29 2020-05-28 サイトワン セラピューティクス， インコーポレイテッド 疼痛の処置のための１１，１３−修飾サキシトキシン
US12162886B2 (en) 2018-10-03 2024-12-10 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
CN110128292A (zh) * 2019-06-12 2019-08-16 成都美域高制药有限公司 一种Ozanimod中间体4-氰基茚酮的合成方法
HUE069128T2 (hu) 2019-12-06 2025-02-28 Vertex Pharma Szubsztituált tetrahidrofurán vegyületek mint nátriumcsatornák modulátorai
CN117794918A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 经取代的四氢呋喃类似物作为钠通道调节剂
US20240285596A1 (en) 2021-06-04 2024-08-29 Vertex Pharmaceuticals Incorporated Solid dosage forms and dosing regimens comprising (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide
AU2022284886A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
US20240294512A1 (en) 2021-06-04 2024-09-05 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
US20240368135A1 (en) 2021-06-04 2024-11-07 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
US20240400544A1 (en) 2021-06-04 2024-12-05 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
JP2025513454A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
AU2023255558A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
CN119522214A (zh) 2022-04-22 2025-02-25 沃泰克斯药物股份有限公司 用于治疗疼痛的杂芳基化合物
TW202404969A (zh) 2022-04-22 2024-02-01 美商維泰克斯製藥公司 用於治療疼痛之雜芳基化合物
KR20250120351A (ko) 2022-12-06 2025-08-08 버텍스 파마슈티칼스 인코포레이티드 나트륨 채널의 치환된 테트라하이드로푸란 조절제의 합성을 위한 방법
WO2025090516A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing compounds for treating pain and solid forms thereof
TW202523313A (zh) 2023-10-23 2025-06-16 美商維泰克斯製藥公司 用於治療疼痛之雜芳基化合物
WO2025090480A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090511A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing modulators of sodium channels and solid forms of the same for treating pain
US20250186419A1 (en) 2023-12-07 2025-06-12 Vertex Pharmaceuticals Incorporated Dosing regimens for treating pain

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Also Published As

Publication number Publication date
CN110831945A (zh) 2020-02-21
JP2020515610A (ja) 2020-05-28
IL269599A (en) 2019-11-28
IL269599B1 (en) 2023-03-01
CA3058214A1 (en) 2018-10-04
AU2018243463A8 (en) 2019-11-07
MX2019011530A (es) 2020-01-27
US11834456B2 (en) 2023-12-05
RU2019134300A (ru) 2021-04-29
CN110831945B (zh) 2023-08-08
WO2018183781A1 (en) 2018-10-04
US11236097B2 (en) 2022-02-01
RU2019134300A3 (enExample) 2021-05-25
AU2018243463B2 (en) 2022-05-19
US20220259218A1 (en) 2022-08-18
IL269599B2 (en) 2023-07-01
BR112019020111A2 (pt) 2020-05-05
AU2018243463A1 (en) 2019-10-31
JP7090100B2 (ja) 2022-06-23
EP3601291A1 (en) 2020-02-05
AU2018243463C1 (en) 2022-12-01
US20200102318A1 (en) 2020-04-02

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