JP7085988B2 - Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用 - Google Patents

Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用 Download PDF

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JP7085988B2
JP7085988B2 JP2018517487A JP2018517487A JP7085988B2 JP 7085988 B2 JP7085988 B2 JP 7085988B2 JP 2018517487 A JP2018517487 A JP 2018517487A JP 2018517487 A JP2018517487 A JP 2018517487A JP 7085988 B2 JP7085988 B2 JP 7085988B2
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cells
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fusion protein
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セバスチャン コボルド
ステファン エンドレス
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2018517487A 2015-06-19 2016-06-20 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用 Active JP7085988B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022044885A JP7460675B2 (ja) 2015-06-19 2022-03-22 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用
JP2024044396A JP2024073636A (ja) 2015-06-19 2024-03-21 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15172913 2015-06-19
EP15172913.4 2015-06-19
PCT/EP2016/064195 WO2016203048A1 (en) 2015-06-19 2016-06-20 Pd-1-cd28 fusion proteins and their use in medicine

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JP2022044885A Division JP7460675B2 (ja) 2015-06-19 2022-03-22 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

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JP2018518990A JP2018518990A (ja) 2018-07-19
JP2018518990A5 JP2018518990A5 (https=) 2019-06-06
JP7085988B2 true JP7085988B2 (ja) 2022-06-17

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JP2022044885A Active JP7460675B2 (ja) 2015-06-19 2022-03-22 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用
JP2024044396A Pending JP2024073636A (ja) 2015-06-19 2024-03-21 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

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JP2024044396A Pending JP2024073636A (ja) 2015-06-19 2024-03-21 Ｐｄ－１－ｃｄ２８融合タンパク質および医療におけるその使用

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US (2) US11192935B2 (https=)
EP (3) EP3909972B1 (https=)
JP (3) JP7085988B2 (https=)
CN (3) CN108026151B (https=)
AU (1) AU2016277883B2 (https=)
CA (1) CA2989949A1 (https=)
DK (2) DK3909972T5 (https=)
ES (2) ES2870174T3 (https=)
FI (1) FI3909972T3 (https=)
HU (1) HUE054201T2 (https=)
PL (1) PL3310805T3 (https=)
PT (1) PT3310805T (https=)
WO (1) WO2016203048A1 (https=)

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CN105331585A (zh) * 2015-11-13 2016-02-17 科济生物医药（上海）有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
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JP2020513754A (ja) * 2016-12-21 2020-05-21 ティーシーアール２ セラピューティクス インク． がん治療用に操作されたｔ細胞
ES2912408T3 (es) * 2017-01-26 2022-05-25 Novartis Ag Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos
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CN111606999B (zh) * 2019-02-26 2022-09-06 南京惟亚德生物医药有限公司 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用
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AU2020315796A1 (en) * 2019-07-19 2022-02-24 Memorial Hospital For Cancer And Allied Diseases Fusion polypeptide for immunotherapy
CN113832111A (zh) * 2020-06-23 2021-12-24 南京大学 一种类外泌体技术用于制备新型溶瘤病毒的方法
CN113832114A (zh) * 2020-06-23 2021-12-24 南京大学 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用
IL305795A (en) * 2021-03-10 2023-11-01 B G Negev Technologies & Applications Ltd At Ben Gurion Univ Reporter cells expressing chimeric proteins for use in determining the presence and or activity of immune barrier molecules
CN115197314B (zh) * 2021-04-11 2025-08-19 中国科学院分子细胞科学卓越创新中心 一种pd1变体及其用途
JP2024519945A (ja) * 2021-05-20 2024-05-21 アチェロイス バイオファーマ，インク． 免疫チェックポイント多価粒子の組成物、および使用方法
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CN121057753A (zh) * 2022-11-14 2025-12-02 阿奇洛伊斯生物制药公司 免疫检查点多价颗粒组合物和使用方法
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EP3909972B1 (en) 2024-02-14
CA2989949A1 (en) 2016-12-22
AU2016277883A1 (en) 2018-01-18
PL3310805T3 (pl) 2021-08-23
JP2022084787A (ja) 2022-06-07
US20220169699A1 (en) 2022-06-02
ES2870174T3 (es) 2021-10-26
CN115927474A (zh) 2023-04-07
FI3909972T3 (fi) 2024-05-03
EP3310805B1 (en) 2021-02-17
WO2016203048A1 (en) 2016-12-22
CN108026151B (zh) 2022-07-15
EP4349854A3 (en) 2024-07-10
JP2018518990A (ja) 2018-07-19
AU2016277883B2 (en) 2020-09-17
US12570718B2 (en) 2026-03-10
EP4349854A2 (en) 2024-04-10
ES2976647T3 (es) 2024-08-06
EP3909972A1 (en) 2021-11-17
DK3909972T5 (da) 2024-08-05
JP2024073636A (ja) 2024-05-29
CN108026151A (zh) 2018-05-11
JP7460675B2 (ja) 2024-04-02
HUE054201T2 (hu) 2021-08-30
AU2016277883A8 (en) 2018-01-25
EP3310805A1 (en) 2018-04-25
PT3310805T (pt) 2021-05-19
US11192935B2 (en) 2021-12-07
DK3909972T3 (da) 2024-04-29
CN115925971A (zh) 2023-04-07
US20190010207A1 (en) 2019-01-10
DK3310805T3 (da) 2021-05-03

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