DK3909972T3 - Pd1-cd28-fusionsproteiner og disses anvendelse i medicin - Google Patents

Pd1-cd28-fusionsproteiner og disses anvendelse i medicin Download PDF

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Publication number
DK3909972T3
DK3909972T3 DK21155542.0T DK21155542T DK3909972T3 DK 3909972 T3 DK3909972 T3 DK 3909972T3 DK 21155542 T DK21155542 T DK 21155542T DK 3909972 T3 DK3909972 T3 DK 3909972T3
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Denmark
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medicine
fusion proteins
fusion
proteins
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DK21155542.0T
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English (en)
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DK3909972T5 (da
Inventor
Stefan Endres
Sebastian Kobold
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Sebastian Kobold
Endres Stefan Prof Dr
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK21155542.0T 2015-06-19 2016-06-20 Pd1-cd28-fusionsproteiner og disses anvendelse i medicin DK3909972T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15172913 2015-06-19
EP16736802.6A EP3310805B1 (en) 2015-06-19 2016-06-20 Pd-1-cd28 fusion proteins and their use in medicine

Publications (2)

Publication Number Publication Date
DK3909972T3 true DK3909972T3 (da) 2024-04-29
DK3909972T5 DK3909972T5 (da) 2024-08-05

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK21155542.0T DK3909972T5 (da) 2015-06-19 2016-06-20 Pd1-cd28-fusionsproteiner og disses anvendelse i medicin
DK16736802.6T DK3310805T3 (da) 2015-06-19 2016-06-20 Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin

Family Applications After (1)

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DK16736802.6T DK3310805T3 (da) 2015-06-19 2016-06-20 Pd-1-cd28-fusionsproteiner og anvendelse deraf i medicin

Country Status (13)

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US (2) US11192935B2 (da)
EP (3) EP3909972B1 (da)
JP (3) JP7085988B2 (da)
CN (3) CN108026151B (da)
AU (1) AU2016277883B2 (da)
CA (1) CA2989949A1 (da)
DK (2) DK3909972T5 (da)
ES (2) ES2976647T3 (da)
FI (1) FI3909972T3 (da)
HU (1) HUE054201T2 (da)
PL (1) PL3310805T3 (da)
PT (1) PT3310805T (da)
WO (1) WO2016203048A1 (da)

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EP3770168A1 (en) 2015-05-18 2021-01-27 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
HUE054201T2 (hu) * 2015-06-19 2021-08-30 Endres Stefan Prof Dr PD-1-CD28 fúziós fehérjék és gyógyászatban való alkalmazásuk
AU2016285859A1 (en) * 2015-06-29 2018-02-15 The Johns Hopkins University Immune checkpoint chimeric antigen receptors therapy
CN105331585A (zh) * 2015-11-13 2016-02-17 科济生物医药(上海)有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
EP4286522A3 (en) * 2016-03-23 2024-02-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Fusion proteins of pd-1 and 4-1bb
CN107523545A (zh) * 2016-06-20 2017-12-29 上海细胞治疗研究院 一种高效稳定表达抗体的杀伤性细胞及其用途
WO2018002358A1 (en) * 2016-06-30 2018-01-04 F. Hoffmann-La Roche Ag Improved adoptive t-cell therapy
WO2018026953A1 (en) 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
JP7217970B2 (ja) 2016-10-07 2023-02-06 ティーシーアール2 セラピューティクス インク. 融合タンパク質を用いてt細胞受容体をリプログラミングするための組成物及び方法
JP7291396B2 (ja) 2016-11-22 2023-06-15 ティーシーアール2 セラピューティクス インク. 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法
JP2020513754A (ja) * 2016-12-21 2020-05-21 ティーシーアール2 セラピューティクス インク. がん治療用に操作されたt細胞
ES2912408T3 (es) * 2017-01-26 2022-05-25 Novartis Ag Composiciones de CD28 y métodos para terapia con receptores quiméricos para antígenos
JP2020511136A (ja) 2017-03-17 2020-04-16 フレッド ハッチンソン キャンサー リサーチ センター 免疫調節性融合タンパク質およびその使用
CN112119157A (zh) * 2018-03-06 2020-12-22 宾夕法尼亚大学董事会 前列腺特异性膜抗原car及其使用方法
CN108727504B (zh) * 2018-04-16 2021-08-27 泉州向日葵生物科技有限公司 一种ifn与抗pd-l1抗体的融合蛋白及其应用
CN111606999B (zh) * 2019-02-26 2022-09-06 南京惟亚德生物医药有限公司 兼具激活免疫共刺激信号通路和阻断免疫检查点的复制型溶瘤腺病毒及其应用
BR112022000976A2 (pt) * 2019-07-19 2022-04-05 Memorial Hospital For Cancer And Allied Diseases Polipeptídeo de fusão para imunoterapia
CN113832111A (zh) * 2020-06-23 2021-12-24 南京大学 一种类外泌体技术用于制备新型溶瘤病毒的方法
CN113832114A (zh) * 2020-06-23 2021-12-24 南京大学 一种新型溶瘤腺病毒EM/VSV-G Ad5-P及其在制备抗肿瘤药物中的应用
CN115197314A (zh) * 2021-04-11 2022-10-18 中国科学院分子细胞科学卓越创新中心 一种pd1变体及其用途
US20240252613A1 (en) * 2021-05-20 2024-08-01 Achelois Biopharma, Inc. Immune checkpoint multivalent particles compositions and methods of use
WO2023235479A1 (en) * 2022-06-02 2023-12-07 TCR2 Therapeutics Inc. Compositions and methods for treating cancer
WO2024107577A2 (en) * 2022-11-14 2024-05-23 Achelois Biopharma, Inc. Immune checkpoint multivalent particles compositions and methods of use

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Also Published As

Publication number Publication date
AU2016277883A8 (en) 2018-01-25
CN108026151A (zh) 2018-05-11
AU2016277883A1 (en) 2018-01-18
US20190010207A1 (en) 2019-01-10
JP7460675B2 (ja) 2024-04-02
EP3909972B1 (en) 2024-02-14
EP4349854A2 (en) 2024-04-10
ES2976647T3 (es) 2024-08-06
JP2018518990A (ja) 2018-07-19
JP7085988B2 (ja) 2022-06-17
EP3310805A1 (en) 2018-04-25
CN115925971A (zh) 2023-04-07
EP3310805B1 (en) 2021-02-17
WO2016203048A1 (en) 2016-12-22
US11192935B2 (en) 2021-12-07
CN108026151B (zh) 2022-07-15
CA2989949A1 (en) 2016-12-22
CN115927474A (zh) 2023-04-07
ES2870174T3 (es) 2021-10-26
HUE054201T2 (hu) 2021-08-30
US20220169699A1 (en) 2022-06-02
JP2024073636A (ja) 2024-05-29
AU2016277883B2 (en) 2020-09-17
EP3909972A1 (en) 2021-11-17
PT3310805T (pt) 2021-05-19
JP2022084787A (ja) 2022-06-07
PL3310805T3 (pl) 2021-08-23
EP4349854A3 (en) 2024-07-10
FI3909972T3 (fi) 2024-05-03
DK3310805T3 (da) 2021-05-03
DK3909972T5 (da) 2024-08-05

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