JP7069138B2 - 抗Ｃ１ｓ抗体およびその使用方法 - Google Patents

抗Ｃ１ｓ抗体およびその使用方法 Download PDF

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JP7069138B2
JP7069138B2 JP2019519690A JP2019519690A JP7069138B2 JP 7069138 B2 JP7069138 B2 JP 7069138B2 JP 2019519690 A JP2019519690 A JP 2019519690A JP 2019519690 A JP2019519690 A JP 2019519690A JP 7069138 B2 JP7069138 B2 JP 7069138B2
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antibody
seq
region
amino acid
antibodies
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JP2020502996A5 (OSRAM
JP2020502996A (ja
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サンディップ・パニッカー
グラハム・パリー
ナンシー・イー・スタグリアーノ
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バイオベラティブ・ユーエスエイ・インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2019519690A 2016-10-12 2017-10-12 抗Ｃ１ｓ抗体およびその使用方法 Active JP7069138B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022073972A JP7420864B2 (ja) 2016-10-12 2022-04-28 抗Ｃ１ｓ抗体およびその使用方法
JP2024002216A JP2024038319A (ja) 2016-10-12 2024-01-11 抗Ｃ１ｓ抗体およびその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662407390P 2016-10-12 2016-10-12
US62/407,390 2016-10-12
PCT/US2017/056349 WO2018071676A1 (en) 2016-10-12 2017-10-12 Anti-c1s antibodies and methods of use thereof

Related Child Applications (1)

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JP2022073972A Division JP7420864B2 (ja) 2016-10-12 2022-04-28 抗Ｃ１ｓ抗体およびその使用方法

Publications (3)

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JP2020502996A JP2020502996A (ja) 2020-01-30
JP2020502996A5 JP2020502996A5 (OSRAM) 2020-11-12
JP7069138B2 true JP7069138B2 (ja) 2022-05-17

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JP2019519690A Active JP7069138B2 (ja) 2016-10-12 2017-10-12 抗Ｃ１ｓ抗体およびその使用方法
JP2022073972A Active JP7420864B2 (ja) 2016-10-12 2022-04-28 抗Ｃ１ｓ抗体およびその使用方法
JP2024002216A Withdrawn JP2024038319A (ja) 2016-10-12 2024-01-11 抗Ｃ１ｓ抗体およびその使用方法

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JP2024002216A Withdrawn JP2024038319A (ja) 2016-10-12 2024-01-11 抗Ｃ１ｓ抗体およびその使用方法

Country Status (32)

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US (2) US20200048332A1 (OSRAM)
EP (2) EP4652926A2 (OSRAM)
JP (3) JP7069138B2 (OSRAM)
KR (3) KR102638884B1 (OSRAM)
CN (2) CN116554320A (OSRAM)
AR (1) AR110677A1 (OSRAM)
AU (3) AU2017341766A1 (OSRAM)
BR (1) BR112019007309A2 (OSRAM)
CA (1) CA3040253A1 (OSRAM)
CL (1) CL2019000975A1 (OSRAM)
CO (1) CO2019004741A2 (OSRAM)
CR (1) CR20190223A (OSRAM)
DK (1) DK3525583T3 (OSRAM)
DO (1) DOP2019000085A (OSRAM)
EA (1) EA201990884A1 (OSRAM)
EC (1) ECSP19033211A (OSRAM)
ES (1) ES3049257T3 (OSRAM)
FI (1) FI3525583T3 (OSRAM)
HR (1) HRP20251304T1 (OSRAM)
IL (2) IL308156A (OSRAM)
LT (1) LT3525583T (OSRAM)
MX (2) MX2019004259A (OSRAM)
MY (1) MY198182A (OSRAM)
PE (1) PE20191031A1 (OSRAM)
PH (1) PH12019500789A1 (OSRAM)
PT (1) PT3525583T (OSRAM)
RS (1) RS67326B1 (OSRAM)
SG (1) SG11201903012RA (OSRAM)
TN (1) TN2019000109A1 (OSRAM)
TW (3) TWI846007B (OSRAM)
WO (1) WO2018071676A1 (OSRAM)
ZA (1) ZA201902247B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024038319A (ja) * 2016-10-12 2024-03-19 バイオベラティブ・ユーエスエイ・インコーポレイテッド 抗Ｃ１ｓ抗体およびその使用方法

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EP3280440B1 (en) 2015-04-06 2022-11-16 Bioverativ USA Inc. Humanized anti-c1s antibodies and methods of use thereof
CN111556895B (zh) 2017-11-14 2024-09-13 中外制药株式会社 抗-c1s抗体及使用方法
US12473353B2 (en) 2019-05-15 2025-11-18 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule, a pharmaceutical composition, and a method
MX2022013135A (es) * 2020-04-20 2022-11-10 Genzyme Corp Anticuerpos anti-factor bb del complemento humanizados y usos de los mismos.
US20230235037A1 (en) * 2020-04-22 2023-07-27 Chemomab Ltd. Method of treatment using anti-ccl24 antibody
WO2021231211A1 (en) * 2020-05-11 2021-11-18 Genentech, Inc. Complement component c1s inhibitors for treating a neurological disease, and related compositions, systems and methods of using same
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WO2022246154A2 (en) 2021-05-20 2022-11-24 Dianthus Therapeutics, Inc. Antibodies that bind to c1s and uses thereof
US11958899B2 (en) 2021-07-13 2024-04-16 Mabwell Therapeutics Inc. Anti-C1s antibodies and uses thereof
CN119698296A (zh) 2022-06-15 2025-03-25 美国比奥维拉迪维股份有限公司 抗补体c1s抗体配制品
IL317947A (en) 2022-06-24 2025-02-01 Bioverativ Usa Inc Complementary disease treatment methods
WO2024112734A1 (en) 2022-11-21 2024-05-30 Dianthus Therapeutics Opco, Inc. Antibodies that bind to c1s and uses thereof
US20240401082A1 (en) 2023-03-16 2024-12-05 Genzyme Corporation Treatment of Dry Age-Related Macular Degeneration

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