JP7055636B2 - ＡＬＫ７：ＡｃｔＲＩＩＢヘテロ多量体およびその使用 - Google Patents

ＡＬＫ７：ＡｃｔＲＩＩＢヘテロ多量体およびその使用 Download PDF

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JP7055636B2
JP7055636B2 JP2017552155A JP2017552155A JP7055636B2 JP 7055636 B2 JP7055636 B2 JP 7055636B2 JP 2017552155 A JP2017552155 A JP 2017552155A JP 2017552155 A JP2017552155 A JP 2017552155A JP 7055636 B2 JP7055636 B2 JP 7055636B2
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actriib
alk7
heteromultimer
polypeptide
seq
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JP2018517399A5 (https=
JP2018517399A (ja
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ジョン クノップフ，
ラビンドラ クマール，
アシャ グリンバーグ，
ダイアン エス． サコ，
ロバート スコット ピアーソル，
ロズリーヌ カストンギー，
ガン リー，
ヨッシ ダゴン，
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アクセルロン ファーマ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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JP2017552155A 2015-04-06 2016-04-06 ＡＬＫ７：ＡｃｔＲＩＩＢヘテロ多量体およびその使用 Expired - Fee Related JP7055636B2 (ja)

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US201562143579P 2015-04-06 2015-04-06
US62/143,579 2015-04-06
PCT/US2016/026277 WO2016164503A1 (en) 2015-04-06 2016-04-06 Alk7:actriib heteromultimers and uses thereof

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JP2017552491A Expired - Fee Related JP7037363B2 (ja) 2015-04-06 2016-04-06 Ｔｇｆベータスーパーファミリーｉ型およびｉｉ型受容体ヘテロ多量体およびその使用
JP2021069060A Active JP7246618B2 (ja) 2015-04-06 2021-04-15 ＡＬＫ７：ＡｃｔＲＩＩＢヘテロ多量体およびその使用

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JP2021069060A Active JP7246618B2 (ja) 2015-04-06 2021-04-15 ＡＬＫ７：ＡｃｔＲＩＩＢヘテロ多量体およびその使用

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US (7) US10227392B2 (https=)
EP (5) EP3889171B1 (https=)
JP (3) JP7055636B2 (https=)
KR (2) KR20180002661A (https=)
CN (4) CN107847561B (https=)
AU (4) AU2016246708B2 (https=)
BR (1) BR112017021510A2 (https=)
CA (2) CA2981833A1 (https=)
DK (1) DK3280728T3 (https=)
EA (2) EA202190016A1 (https=)
ES (2) ES2863564T3 (https=)
HK (2) HK1252957A1 (https=)
MA (4) MA41920B1 (https=)
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