JP7034951B2 - 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する - Google Patents

操作されたウイルスベクターは炎症および免疫応答の誘導を低減する Download PDF

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JP7034951B2
JP7034951B2 JP2018563666A JP2018563666A JP7034951B2 JP 7034951 B2 JP7034951 B2 JP 7034951B2 JP 2018563666 A JP2018563666 A JP 2018563666A JP 2018563666 A JP2018563666 A JP 2018563666A JP 7034951 B2 JP7034951 B2 JP 7034951B2
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aav
nucleic acid
egfp
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JP2019517266A (ja
JP2019517266A5 (OSRAM
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カイ チャン，イン
エム． チャーチ，ジョージ
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Harvard University
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JP2018563666A 2016-06-08 2017-06-08 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する Active JP7034951B2 (ja)

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US201662347302P 2016-06-08 2016-06-08
US62/347,302 2016-06-08
PCT/US2017/036525 WO2017214378A1 (en) 2016-06-08 2017-06-08 Engineered viral vector reduces induction of inflammatory and immune responses

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JP2022031422A Active JP7394898B2 (ja) 2016-06-08 2022-03-02 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する

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EP (1) EP3468605A4 (OSRAM)
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CN (2) CN109451729B (OSRAM)
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KR20190017872A (ko) 2016-06-08 2019-02-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 염증 및 면역 반응 유도를 감소시키는 조작된 바이러스 벡터
KR20200085812A (ko) 2017-11-08 2020-07-15 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 바이러스 벡터-유도된 염증 반응을 억제하기 위한 조성물 및 방법
US10736957B2 (en) 2017-12-19 2020-08-11 President And Fellows Of Harvard College Enhanced immunogenicity of mRNA with co-encoded adjuvant sequences
SG11202107922QA (en) * 2019-01-24 2021-08-30 Generation Bio Co Closed-ended dna (cedna) and use in methods of reducing gene or nucleic acid therapy related immune response
JP2022521755A (ja) * 2019-02-22 2022-04-12 ライフ テクノロジーズ コーポレーション アデノ随伴ウイルスの産生のための浮遊システム
US20220259599A1 (en) * 2019-05-15 2022-08-18 President And Fellows Of Harvard College Compositions and methods for inhibiting nucleic acid vector-induced inflammatory responses
EP4114928A4 (en) * 2020-03-05 2024-10-16 Flagship Pioneering Innovations VI, LLC Host defense suppressing methods and compositions for modulating a genome
WO2022187679A1 (en) * 2021-03-04 2022-09-09 Kriya Therapeutics, Inc. Viral vector constructs incorporating dna for inhibiting toll like receptors and methods of using the same
WO2025087987A1 (en) * 2023-10-23 2025-05-01 Sartorius Stedim Cellca Gmbh Plasmids for improved aav titers and empty full ratios

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002505580A (ja) 1997-06-06 2002-02-19 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Ｄｎａ免疫刺激配列活性の阻害剤
JP2013544816A (ja) 2010-11-19 2013-12-19 イデラ ファーマシューティカルズ インコーポレイテッド トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
WO2014105870A1 (en) 2012-12-27 2014-07-03 Sierra Sciences, Inc. Enhancing health in mammals using telomerase reverse transcriptase gene therapy
JP2015532095A (ja) 2012-09-28 2015-11-09 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 希突起神経膠細胞を標的とするアデノ随伴ウイルスベクター
JP2015536659A (ja) 2012-11-29 2015-12-24 Ｓｂｉバイオテック株式会社 阻害性オリゴヌクレオチド及びその使用

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5643890A (en) 1995-01-31 1997-07-01 The Board Of Regents Of The University Of Nebraska Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
US6551795B1 (en) * 1998-02-18 2003-04-22 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
JP2002541264A (ja) 1999-04-08 2002-12-03 ユーエイビー・リサーチ・ファウンデーション 冨ｇオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法
PL354997A1 (en) 1999-09-25 2004-03-22 University Of Iowa Research Foundation Immunostimulatory nucleic acids
MXPA00011713A (es) * 2000-11-28 2002-05-31 Tgt Lab S A De C V Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe
US7060690B2 (en) 2001-01-22 2006-06-13 Genta Incorporated Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof
WO2003027313A2 (en) 2001-09-24 2003-04-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
ES2543710T3 (es) 2002-04-04 2015-08-21 Zoetis Belgium S.A. Oligorribonucleótidos inmunoestimulantes que contienen G y U
US7357928B2 (en) 2002-04-08 2008-04-15 University Of Louisville Research Foundation, Inc. Method for the diagnosis and prognosis of malignant diseases
US20040009949A1 (en) 2002-06-05 2004-01-15 Coley Pharmaceutical Group, Inc. Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids
EP1575504A4 (en) 2002-08-01 2009-11-04 Us Gov Health & Human Serv METHOD FOR THE TREATMENT OF INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF THE CPG OLIGONUCLEOTIDES
US8043622B2 (en) 2002-10-08 2011-10-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides
US7790867B2 (en) 2002-12-05 2010-09-07 Rosetta Genomics Inc. Vaccinia virus-related nucleic acids and microRNA
US20050013812A1 (en) 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
US20050239733A1 (en) 2003-10-31 2005-10-27 Coley Pharmaceutical Gmbh Sequence requirements for inhibitory oligonucleotides
WO2005072097A2 (en) 2003-12-16 2005-08-11 University Of Massachusetts Toll-like receptor 9 modulators
MXPA06012915A (es) 2004-05-06 2007-03-01 Gov Health & Human Serv Metodos y composiciones para el tratamiento de uveitis.
IL179285A (en) 2004-05-14 2011-04-28 Rosetta Genomics Ltd Micrornas and uses thereof
WO2005116250A2 (en) 2004-05-26 2005-12-08 Rosetta Genomics Ltd. Viral and viral associated mirnas and uses thereof
KR101268877B1 (ko) 2004-09-01 2013-05-31 다이나박스 테크놀로지 코퍼레이션 선천성 면역반응 및 자가면역의 억제를 위한 방법 및조성물
JP2008000001A (ja) 2004-09-30 2008-01-10 Osaka Univ 免疫刺激オリゴヌクレオチドおよびその医薬用途
US20060193869A1 (en) 2004-12-17 2006-08-31 Franck Barrat Methods and compositions for induction or promotion of immune tolerance
US20070077231A1 (en) * 2005-09-30 2007-04-05 Contag Christopher H Immune effector cells pre-infected with oncolytic virus
EP2341059A1 (en) 2005-10-12 2011-07-06 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
JP2009522372A (ja) 2006-01-09 2009-06-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ワクチンおよび腫瘍免疫療法のためのｔｎｆｒｓｆ、ｔｌｒ、ｎｌｒ、ｒｈｒ、プリン受容体、およびサイトカイン受容体アゴニストの組み合わせ免疫刺激剤
US8298818B2 (en) * 2006-04-28 2012-10-30 University Of Florida Research Foundation, Inc. Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
EP2034833A2 (en) 2006-06-13 2009-03-18 Bayhill Therapeutics, Inc. Polynucleotide therapy
US8377898B2 (en) 2006-10-12 2013-02-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US20110033448A1 (en) 2006-12-15 2011-02-10 Michel Gilliet Inhibitors of LL-37 Mediated Immune Reactivity to Self Nucleic Acids
AU2008220449A1 (en) 2007-03-01 2008-09-04 Rosetta Genomics Ltd. Methods for distingushing between lung squamous carcinoma and other non smallcell lung cancers
WO2009006141A2 (en) 2007-07-05 2009-01-08 Bausch & Lomb Incorporated Authority to read as follows: compositions and methods for treating or controlling infections of the eye a sequelae thereof
US7879812B2 (en) 2007-08-06 2011-02-01 University Of Iowa Research Foundation Immunomodulatory oligonucleotides and methods of use therefor
MX2010001785A (es) 2007-08-15 2010-03-10 Idera Pharmaceuticals Inc Moduladores de receptores tipo larga distancia.
JP5749492B2 (ja) 2007-10-26 2015-07-15 ダイナバックス テクノロジーズ コーポレイション 免疫応答と自己免疫を阻害する方法及び組成物
WO2009089401A2 (en) 2008-01-10 2009-07-16 Bausch & Lomb Incorporated Compositions comprising toll-like receptor or coreceptor antagonists and methods for treating or controlling ocular allergy using same
WO2009089399A2 (en) 2008-01-10 2009-07-16 Bausch & Lomb Incorporated Compositions comprising toll-like receptor or coreceptor antagonists and methods for ocular neuroprotection
WO2009143292A2 (en) 2008-05-21 2009-11-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating pneumoconiosis with oligodeoxynucleotides
JP5415724B2 (ja) * 2008-08-05 2014-02-12 長春華普生物技術有限公司 一種のオリゴヌクレオチド及びその応用
US8030289B2 (en) 2008-08-06 2011-10-04 Changchun Huapu Biotechnology Co., Ltd. Oligonucleotide and use thereof
WO2010034779A2 (en) * 2008-09-24 2010-04-01 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Composition and method for treatment of preterm labor
GB0906130D0 (en) 2008-10-03 2009-05-20 Procrata Biosystems Ltd Transcription factor decoys
EP2349271A2 (en) 2008-10-06 2011-08-03 Idera Pharmaceuticals, Inc. Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
US8053422B2 (en) 2008-12-04 2011-11-08 The United States Of America As Represented By The Department Of Health And Human Services Anti-cancer oligodeoxynucleotides
WO2010108035A1 (en) * 2009-03-18 2010-09-23 Isis Pharmaceuticals, Inc. Compounds and methods for modulating toxic and proinflammatory effects
US8728458B2 (en) 2009-04-30 2014-05-20 The Regents Of The University Of California Combination anti-HIV vectors, targeting vectors, and methods of use
ES2624767T3 (es) 2009-06-01 2017-07-17 Idera Pharmaceuticals, Inc Potenciación de tratamientos de enfermedades autoinmunitarias e inflamatorias mediante oligonucleótidos inmunorreguladores (IRO) antagonistas de TLR7 y TLR9
US20110070241A1 (en) 2009-06-30 2011-03-24 Duke University Methods for modulating immune responses to aav gene therapy vectors
WO2011005942A2 (en) 2009-07-08 2011-01-13 Idera Pharmaceuticals, Inc. Oligonucleotide-based compounds as inhibitors of toll-like receptors
CN101712957B (zh) * 2009-11-25 2011-11-23 中国人民解放军第三军医大学第一附属医院 Toll样受体9阻断剂及应用
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US9272053B2 (en) 2010-04-23 2016-03-01 University Of Massachusetts AAV-based treatment of cholesterol-related disorders
WO2011159328A1 (en) 2010-06-16 2011-12-22 Dynavax Technologies Corporation Methods of treatment using tlr7 and/or tlr9 inhibitors
BR112012032240A2 (pt) 2010-06-16 2019-09-24 Dynavax Technologies Corporation método de tratamento utilizando inibidores tlr7 e/ou tlr9
GB201014026D0 (en) 2010-08-20 2010-10-06 Ucl Business Plc Treatment
WO2012051491A1 (en) * 2010-10-14 2012-04-19 The United States Of America, As Represented By The Secretary National Institutes Of Health Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
US20140378531A1 (en) 2012-02-01 2014-12-25 New York University Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
AR091569A1 (es) 2012-06-28 2015-02-11 Intervet Int Bv Receptores de tipo toll
CN102925485B (zh) 2012-11-09 2014-07-09 中国农业科学院兰州兽医研究所 双表达的aav重组病毒的制备方法
EP2943251B1 (en) 2013-01-08 2018-10-10 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
US20140271550A1 (en) 2013-03-14 2014-09-18 The Trustees Of The University Of Pennsylvania Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses
US20170035864A1 (en) 2013-12-09 2017-02-09 Bullet Biotechnology, Inc. SPECIFIC VIRUS-LIKE PARTICLE-CpG OLIGONUCLEOTIDE VACCINES AND USES THEREOF
CA2974651A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
US12139542B2 (en) 2014-05-27 2024-11-12 Trustees Of Boston University Inhibitors of aortic carboxypeptidase-like protein (ACLP)
EP2982756A1 (en) 2014-08-04 2016-02-10 Berlin Cures Holding AG Aptamers for use against autoantibody-associated diseases
US20170333565A1 (en) 2014-10-31 2017-11-23 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tlr9 targeted cytotoxic agents
WO2016130832A1 (en) 2015-02-13 2016-08-18 Idera Pharmaceuticals, Inc. Toll-like receptor 9 antagonist and methods of use thereof
US11156599B2 (en) 2015-03-19 2021-10-26 The Johns Hopkins University Assay for telomere length regulators
US10775367B2 (en) 2015-04-15 2020-09-15 Ji Hoon Lee Aptasensor and method of detecting target material
WO2016183370A1 (en) 2015-05-13 2016-11-17 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Synthetic immunosuppressive oligodeoxynucleotides reduce ischemic tissue damage
DK3329004T3 (da) 2015-07-29 2020-04-20 Ifom Fondazione St Firc Di Oncologia Molecolare Terapeutiske oligonukleotider
EP3377095B1 (en) 2015-11-18 2020-01-01 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for treating rhabdomyolysis
EP3394263B1 (en) 2015-12-25 2025-02-26 SBI Biotech Co., Ltd. Tlr inhibitory oligonucleotides and their use
CN105597079A (zh) * 2016-01-11 2016-05-25 中国人民解放军第三军医大学第一附属医院 用于治疗银屑病的药物
US10124062B2 (en) 2016-02-26 2018-11-13 The United States Of America As Represented By The Department Of Veterans Affairs Methods of treating, inhibiting and/or preventing an auditory impairment
KR20190017872A (ko) 2016-06-08 2019-02-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 염증 및 면역 반응 유도를 감소시키는 조작된 바이러스 벡터
US10947545B2 (en) 2016-11-23 2021-03-16 Berlin Cures GmbH Aptamers for use in inhibition and/or suppression of TLR9 activation
KR20200085812A (ko) 2017-11-08 2020-07-15 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 바이러스 벡터-유도된 염증 반응을 억제하기 위한 조성물 및 방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002505580A (ja) 1997-06-06 2002-02-19 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア Ｄｎａ免疫刺激配列活性の阻害剤
JP2013544816A (ja) 2010-11-19 2013-12-19 イデラ ファーマシューティカルズ インコーポレイテッド トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
JP2015532095A (ja) 2012-09-28 2015-11-09 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 希突起神経膠細胞を標的とするアデノ随伴ウイルスベクター
JP2015536659A (ja) 2012-11-29 2015-12-24 Ｓｂｉバイオテック株式会社 阻害性オリゴヌクレオチド及びその使用
WO2014105870A1 (en) 2012-12-27 2014-07-03 Sierra Sciences, Inc. Enhancing health in mammals using telomerase reverse transcriptase gene therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Gursel I. et al.，The Journal of Immunology，2003年，Vol. 171，p. 1393-1400
Li Y. et al.，Vaccine，2011年，Vol. 29，p. 2193-2198
Martino A. T. et al.，Blood，2011年，Vol. 117, No. 24，p. 6459-6468

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