JP6997620B2 - B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 - Google Patents
B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 Download PDFInfo
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- JP6997620B2 JP6997620B2 JP2017529746A JP2017529746A JP6997620B2 JP 6997620 B2 JP6997620 B2 JP 6997620B2 JP 2017529746 A JP2017529746 A JP 2017529746A JP 2017529746 A JP2017529746 A JP 2017529746A JP 6997620 B2 JP6997620 B2 JP 6997620B2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4214—Receptors for cytokines
- A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2840/00—Vectors comprising a special translation-regulating system
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- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Genetics & Genomics (AREA)
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- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Biotechnology (AREA)
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- Developmental Biology & Embryology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462088309P | 2014-12-05 | 2014-12-05 | |
| US62/088,309 | 2014-12-05 | ||
| PCT/US2015/064112 WO2016090320A1 (en) | 2014-12-05 | 2015-12-04 | Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075434A Division JP2020114254A (ja) | 2014-12-05 | 2020-04-21 | B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537925A JP2017537925A (ja) | 2017-12-21 |
| JP2017537925A5 JP2017537925A5 (en:Method) | 2019-01-17 |
| JP6997620B2 true JP6997620B2 (ja) | 2022-02-04 |
Family
ID=56092569
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529746A Active JP6997620B2 (ja) | 2014-12-05 | 2015-12-04 | B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
| JP2020075434A Withdrawn JP2020114254A (ja) | 2014-12-05 | 2020-04-21 | B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
| JP2022077378A Pending JP2022105192A (ja) | 2014-12-05 | 2022-05-10 | B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020075434A Withdrawn JP2020114254A (ja) | 2014-12-05 | 2020-04-21 | B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
| JP2022077378A Pending JP2022105192A (ja) | 2014-12-05 | 2022-05-10 | B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US10918665B2 (en:Method) |
| EP (2) | EP3227432B1 (en:Method) |
| JP (3) | JP6997620B2 (en:Method) |
| KR (2) | KR102698738B1 (en:Method) |
| CN (3) | CN107208047B (en:Method) |
| AU (2) | AU2015357526B2 (en:Method) |
| CA (1) | CA2969870A1 (en:Method) |
| DK (1) | DK3227432T3 (en:Method) |
| ES (1) | ES2966099T3 (en:Method) |
| FI (1) | FI3227432T3 (en:Method) |
| IL (2) | IL295298A (en:Method) |
| MX (2) | MX2017007244A (en:Method) |
| MY (1) | MY191537A (en:Method) |
| NZ (1) | NZ732563A (en:Method) |
| PH (1) | PH12017501040B1 (en:Method) |
| PL (1) | PL3227432T3 (en:Method) |
| PT (1) | PT3227432T (en:Method) |
| RU (1) | RU2761632C2 (en:Method) |
| SA (1) | SA517381666B1 (en:Method) |
| SG (2) | SG10201900931XA (en:Method) |
| WO (1) | WO2016090320A1 (en:Method) |
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| WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| EP2888349B1 (en) | 2012-08-24 | 2022-02-09 | Yale University | System, device and method for high-throughput multi-plexed detection |
| EP2954330A4 (en) | 2013-02-08 | 2016-08-31 | Inst Myeloma & Bone Cancer Res | IMPROVED DIAGNOSTIC, PROGNOSTIC AND MONITORING PROCEDURES FOR MULTIPLE MYELOMA, CHRONIC LYMPHATIC LEUKEMIA AND NON-HODGKIN B CELL LYMPHOMA |
| CN106659757B (zh) | 2014-04-24 | 2022-01-28 | 利兰斯坦福初级大学董事会 | 白介素2的超级激动剂、部分激动剂和拮抗剂 |
| MX2017001011A (es) | 2014-07-21 | 2018-05-28 | Novartis Ag | Tratamiento de cancer de usando un receptor quimerico de antigeno anti-bcma. |
| EP3227684B1 (en) | 2014-12-03 | 2019-10-02 | Isoplexis Corporation | Analysis and screening of cell secretion profiles |
| CN109072199B (zh) * | 2014-12-05 | 2022-10-28 | 纪念斯隆-凯特琳癌症中心 | 靶向Fc受体样5的嵌合抗原受体及其用途 |
| CA2969870A1 (en) | 2014-12-05 | 2016-06-09 | Memorial Sloan-Kettering Cancer Center | Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof |
| AU2015357533B2 (en) | 2014-12-05 | 2021-10-07 | Eureka Therapeutics, Inc. | Antibodies targeting B-cell maturation antigen and methods of use |
| US11353448B2 (en) | 2015-02-13 | 2022-06-07 | California Institute Of Technology | Methods and compositions for quantifying metabolites and proteins from single cells |
| PE20171653A1 (es) | 2015-04-13 | 2017-11-13 | Pfizer | Receptores del antigeno quimerico dirigidos al antigeno de maduracion de celulas b |
| EP3466967A1 (en) | 2015-05-18 | 2019-04-10 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| EP3402515B8 (en) | 2016-01-12 | 2021-12-08 | Oncotracker, Inc. | Improved methods for monitoring immune status of a subject |
| PE20190120A1 (es) | 2016-04-01 | 2019-01-17 | Kite Pharma Inc | Moleculas de union a bcma y metodos de uso de las mismas |
| US11242376B2 (en) | 2016-08-02 | 2022-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| US20200166518A1 (en) | 2016-09-12 | 2020-05-28 | IsoPlexis Corporation | System and methods for multiplexed analysis of cellular and other immunotherapeutics |
| GB2564823B8 (en) | 2016-10-07 | 2022-06-29 | Tcr2 Therapeutics Inc | Compositions and methods for TCR reprogramming using fusion proteins |
| EP3538891B1 (en) | 2016-11-11 | 2022-01-05 | Isoplexis Corporation | Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells |
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| EP3545284A4 (en) | 2016-11-22 | 2020-07-01 | Isoplexis Corporation | SYSTEMS, DEVICES AND METHODS FOR CAPTURING CELLS AND MANUFACTURING METHODS THEREOF |
| AU2017384900B2 (en) | 2016-12-28 | 2020-12-10 | GC Cell Corporation | Chimeric antigen receptor and natural killer cells expressing same |
| JP2020506700A (ja) | 2017-01-31 | 2020-03-05 | ノバルティス アーゲー | 多重特異性を有するキメラt細胞受容体タンパク質を用いた癌の治療 |
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| JP2020517287A (ja) | 2017-04-26 | 2020-06-18 | ユーリカ セラピューティックス, インコーポレイテッド | キメラ抗体/t細胞受容体構築物及びその使用 |
| EP3615068A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| EP3615055A1 (en) | 2017-04-28 | 2020-03-04 | Novartis AG | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| EP3618842B1 (en) | 2017-05-01 | 2023-10-18 | Juno Therapeutics, Inc. | Combination of a cell therapy and an immunomodulatory compound |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
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| AU2018287317B2 (en) * | 2017-06-19 | 2024-06-20 | Medicenna Therapeutics Inc. | Uses and methods for IL-2 superagonists, agonists, and fusions thereof |
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| JP7233425B2 (ja) | 2017-11-06 | 2023-03-06 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法とガンマセクレターゼ阻害剤との組み合わせ |
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| JP7447006B2 (ja) | 2017-11-01 | 2024-03-11 | ジュノー セラピューティクス インコーポレイテッド | B細胞成熟抗原(bcma)に特異的なキメラ抗原受容体 |
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| WO2013154760A1 (en) | 2012-04-11 | 2013-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptors targeting b-cell maturation antigen |
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