JP6983455B2 - 高純度ｒｎａ組成物及びその調製のための方法 - Google Patents

高純度ｒｎａ組成物及びその調製のための方法 Download PDF

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JP6983455B2
JP6983455B2 JP2019535224A JP2019535224A JP6983455B2 JP 6983455 B2 JP6983455 B2 JP 6983455B2 JP 2019535224 A JP2019535224 A JP 2019535224A JP 2019535224 A JP2019535224 A JP 2019535224A JP 6983455 B2 JP6983455 B2 JP 6983455B2
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スティーヴン・ホグ
ウィリアム・アイッサ
エドワード・ジェイ・ミラッコ
ジェニファー・ネルソン
エイミー・イー・ラビドー
ガボール・ブトラ
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モデルナティーエックス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry

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  • Urology & Nephrology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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JP2019535224A 2016-09-14 2017-09-14 高純度ｒｎａ組成物及びその調製のための方法 Active JP6983455B2 (ja)

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JP2021155734A JP7566710B2 (ja) 2016-09-14 2021-09-24 高純度ｒｎａ組成物及びその調製のための方法
JP2024173493A JP2025032068A (ja) 2016-09-14 2024-10-02 高純度ｒｎａ組成物及びその調製のための方法

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US201662394711P 2016-09-14 2016-09-14
US62/394,711 2016-09-14
PCT/US2017/051674 WO2018053209A1 (en) 2016-09-14 2017-09-14 High purity rna compositions and methods for preparation thereof

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JP2021155734A Active JP7566710B2 (ja) 2016-09-14 2021-09-24 高純度ｒｎａ組成物及びその調製のための方法
JP2024173493A Pending JP2025032068A (ja) 2016-09-14 2024-10-02 高純度ｒｎａ組成物及びその調製のための方法

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EP (2) EP3512944B1 (OSRAM)
JP (3) JP6983455B2 (OSRAM)
CN (2) CN109937253B (OSRAM)
AU (2) AU2017326423B2 (OSRAM)
CA (1) CA3036831A1 (OSRAM)
ES (1) ES2928475T3 (OSRAM)
MA (1) MA46240A (OSRAM)
MX (1) MX2019002904A (OSRAM)
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US11202793B2 (en) 2021-12-21
US20250275999A1 (en) 2025-09-04
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CA3036831A1 (en) 2018-03-22
US20220096522A1 (en) 2022-03-31
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