JP6983075B2 - 極性の組換え延長部を有するインスリン - Google Patents
極性の組換え延長部を有するインスリン Download PDFInfo
- Publication number
- JP6983075B2 JP6983075B2 JP2017562721A JP2017562721A JP6983075B2 JP 6983075 B2 JP6983075 B2 JP 6983075B2 JP 2017562721 A JP2017562721 A JP 2017562721A JP 2017562721 A JP2017562721 A JP 2017562721A JP 6983075 B2 JP6983075 B2 JP 6983075B2
- Authority
- JP
- Japan
- Prior art keywords
- human insulin
- insulin
- desb30 human
- desb30
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021070977A JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15170337.8 | 2015-06-02 | ||
| EP15170337 | 2015-06-02 | ||
| EP15176207 | 2015-07-10 | ||
| EP15176207.7 | 2015-07-10 | ||
| PCT/EP2016/062514 WO2016193380A1 (en) | 2015-06-02 | 2016-06-02 | Insulins with polar recombinant extensions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021070977A Division JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527288A JP2018527288A (ja) | 2018-09-20 |
| JP2018527288A5 JP2018527288A5 (enExample) | 2019-05-09 |
| JP6983075B2 true JP6983075B2 (ja) | 2021-12-17 |
Family
ID=56098249
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562721A Expired - Fee Related JP6983075B2 (ja) | 2015-06-02 | 2016-06-02 | 極性の組換え延長部を有するインスリン |
| JP2021070977A Withdrawn JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021070977A Withdrawn JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11208452B2 (enExample) |
| EP (1) | EP3303380B1 (enExample) |
| JP (2) | JP6983075B2 (enExample) |
| CN (1) | CN107743494B (enExample) |
| ES (1) | ES2784603T3 (enExample) |
| WO (1) | WO2016193380A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107743494B (zh) | 2015-06-02 | 2022-04-29 | 诺和诺德股份有限公司 | 具有极性重组延伸体的胰岛素 |
| EP3355931B1 (en) | 2015-10-01 | 2024-06-26 | Novo Nordisk A/S | Protein conjugates |
| WO2018107117A1 (en) | 2016-12-09 | 2018-06-14 | Akston Biosciences Corporation | Insulin-fc fusions and methods of use |
| MA49339A (fr) * | 2017-04-05 | 2020-02-12 | Novo Nordisk As | Conjugués insuline-fc à extension oligomère |
| EP3810186B1 (en) * | 2018-06-21 | 2022-09-28 | Novo Nordisk A/S | Novel compounds for treatment of obesity |
| CN113038964B (zh) | 2018-06-29 | 2025-05-27 | 德克拉有限公司 | 超长效胰岛素-fc融合蛋白及使用方法 |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| JP2022502467A (ja) | 2018-10-10 | 2022-01-11 | ノヴォ ノルディスク アー/エス | オリゴマー伸長インスリン−fcコンジュゲートおよびそれらの医学的使用 |
| HUE064376T2 (hu) | 2019-12-19 | 2024-03-28 | Akston Biosciences Corp | Ultra-hosszú hatású inzulin-FC fúziós fehérjék és felhasználási eljárások |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| CN116925237A (zh) * | 2019-12-31 | 2023-10-24 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| KR102898622B1 (ko) | 2020-04-10 | 2025-12-12 | 악스톤 바이오사이언시스 코퍼레이션 | Covid-19 융합 단백질에 대한 항원 특이적 면역요법 및 사용 방법 |
| DE102020110543A1 (de) | 2020-04-17 | 2021-10-21 | Bayerische Motoren Werke Aktiengesellschaft | Energiespeichereinrichtung, Kraftfahrzeug und Kühlplattenanordnung |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| EP3915571A1 (en) * | 2020-05-29 | 2021-12-01 | Adocia | Pharmaceutical composition in the form of an injectable aqueous solution including at least a rapid acting insulin analog and a glucagon suppressor with prandial action |
| EP4222176A4 (en) * | 2020-09-30 | 2024-02-28 | Beijing QL Biopharmaceutical Co., Ltd. | POLYPEPTIDE CONJUGATES AND METHODS OF USE |
| WO2023004406A2 (en) | 2021-07-23 | 2023-01-26 | Akston Biosciences Corporation | Insulin-fc fusion proteins and methods of use to treat cancer |
| KR20240163717A (ko) | 2022-03-30 | 2024-11-19 | 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 | 폴리펩티드 접합체의 액체 약학 조성물 및 그의 사용 방법 |
| CN115716877B (zh) * | 2022-07-04 | 2023-09-01 | 北京惠之衡生物科技有限公司 | 一种表达glp-1和胰岛素缀合物多肽的重组工程菌 |
| CN115947822B (zh) * | 2022-07-04 | 2023-08-18 | 北京惠之衡生物科技有限公司 | 一种长效酰化胰岛素衍生物及其药物组合物和应用 |
| WO2024051787A1 (zh) * | 2022-09-09 | 2024-03-14 | 北京惠之衡生物科技有限公司 | 一种长效酰化胰岛素衍生物及其应用 |
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| DD257197A1 (de) | 1987-01-28 | 1988-06-08 | Univ Dresden Tech | Verfahren zur herstellung von immobilisierten, in ihrer biologischen aktivitaet stabilisierten und in ihren pharmakologischen eigenschaften modifizierten insulinpraeparationen |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DD286509A5 (de) | 1989-06-30 | 1991-01-31 | Veb Berlin-Chemie,De | Verfahren zur herstellung von aktivitaetsstabilisierten, wirkungsverlaengerten rektal applizierbaren insulinpraeparationen |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
| IL114160A (en) | 1994-06-17 | 2006-12-31 | Novo Nordisk As | Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast |
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| AU5065198A (en) | 1996-11-15 | 1998-06-10 | Maria Grazia Masucci | Fusion proteins having increased half-lives |
| ES2258797T3 (es) | 1996-12-20 | 2006-09-01 | Novo Nordisk A/S | Proteinas con extension n-terminal expresadas en la levadura. |
| CN1269805A (zh) | 1997-07-14 | 2000-10-11 | 博尔德生物技术公司 | 生长激素和相关蛋白的衍生物 |
| ATE407697T1 (de) | 1999-07-13 | 2008-09-15 | Bolder Biotechnology Inc | Erythropoietin immunglobulin fusionsproteine |
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| US20050233417A1 (en) | 2001-11-12 | 2005-10-20 | Cooper David N | Growth hormone variations in humans and their uses |
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| US20160115216A1 (en) | 2013-06-07 | 2016-04-28 | Novo Nordisk A/S | Method for Making Mature Insulin Polypeptides |
| AU2014318579A1 (en) | 2013-09-13 | 2016-04-14 | The California Institute For Biomedical Research | Modified therapeutic agents and compositions thereof |
| JP6620094B2 (ja) | 2013-11-26 | 2019-12-11 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | 免疫応答を調節するための組成物および方法 |
| RU2016139006A (ru) | 2014-03-05 | 2018-04-05 | Юсб Биофарма Спрл | Мультимерные fc-белки |
| CN106687482B (zh) | 2014-09-17 | 2022-01-25 | 诺和诺德股份有限公司 | 能够结合组织因子途径抑制剂(1-161)上的两个表位的抗体 |
| JP2018508504A (ja) | 2015-02-17 | 2018-03-29 | ハンミ ファーマシューティカル カンパニー リミテッド | 持続型インスリンまたはインスリンアナログ結合体 |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| CN107743494B (zh) | 2015-06-02 | 2022-04-29 | 诺和诺德股份有限公司 | 具有极性重组延伸体的胰岛素 |
| HUE057906T2 (hu) | 2015-08-14 | 2022-07-28 | Remegen Biosciences Inc | Kovalens kötõcsoportok ellenanyag-hatóanyag konjugátumokban és eljárások elõállításukra és alkalmazásukra |
| EP3355931B1 (en) | 2015-10-01 | 2024-06-26 | Novo Nordisk A/S | Protein conjugates |
| MA49339A (fr) | 2017-04-05 | 2020-02-12 | Novo Nordisk As | Conjugués insuline-fc à extension oligomère |
-
2016
- 2016-06-02 CN CN201680031703.8A patent/CN107743494B/zh not_active Expired - Fee Related
- 2016-06-02 EP EP16726866.3A patent/EP3303380B1/en active Active
- 2016-06-02 JP JP2017562721A patent/JP6983075B2/ja not_active Expired - Fee Related
- 2016-06-02 ES ES16726866T patent/ES2784603T3/es active Active
- 2016-06-02 US US15/577,990 patent/US11208452B2/en not_active Expired - Fee Related
- 2016-06-02 WO PCT/EP2016/062514 patent/WO2016193380A1/en not_active Ceased
-
2021
- 2021-04-20 JP JP2021070977A patent/JP2021119156A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN107743494A (zh) | 2018-02-27 |
| CN107743494B (zh) | 2022-04-29 |
| EP3303380B1 (en) | 2020-01-15 |
| EP3303380A1 (en) | 2018-04-11 |
| WO2016193380A1 (en) | 2016-12-08 |
| US11208452B2 (en) | 2021-12-28 |
| JP2021119156A (ja) | 2021-08-12 |
| JP2018527288A (ja) | 2018-09-20 |
| ES2784603T3 (es) | 2020-09-29 |
| US20180291076A1 (en) | 2018-10-11 |
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