JP6983075B2 - 極性の組換え延長部を有するインスリン - Google Patents
極性の組換え延長部を有するインスリン Download PDFInfo
- Publication number
- JP6983075B2 JP6983075B2 JP2017562721A JP2017562721A JP6983075B2 JP 6983075 B2 JP6983075 B2 JP 6983075B2 JP 2017562721 A JP2017562721 A JP 2017562721A JP 2017562721 A JP2017562721 A JP 2017562721A JP 6983075 B2 JP6983075 B2 JP 6983075B2
- Authority
- JP
- Japan
- Prior art keywords
- human insulin
- insulin
- desb30 human
- desb30
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021070977A JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15170337.8 | 2015-06-02 | ||
| EP15170337 | 2015-06-02 | ||
| EP15176207.7 | 2015-07-10 | ||
| EP15176207 | 2015-07-10 | ||
| PCT/EP2016/062514 WO2016193380A1 (en) | 2015-06-02 | 2016-06-02 | Insulins with polar recombinant extensions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021070977A Division JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527288A JP2018527288A (ja) | 2018-09-20 |
| JP2018527288A5 JP2018527288A5 (enExample) | 2019-05-09 |
| JP6983075B2 true JP6983075B2 (ja) | 2021-12-17 |
Family
ID=56098249
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562721A Expired - Fee Related JP6983075B2 (ja) | 2015-06-02 | 2016-06-02 | 極性の組換え延長部を有するインスリン |
| JP2021070977A Withdrawn JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021070977A Withdrawn JP2021119156A (ja) | 2015-06-02 | 2021-04-20 | 極性の組換え延長部を有するインスリン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11208452B2 (enExample) |
| EP (1) | EP3303380B1 (enExample) |
| JP (2) | JP6983075B2 (enExample) |
| CN (1) | CN107743494B (enExample) |
| ES (1) | ES2784603T3 (enExample) |
| WO (1) | WO2016193380A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016193380A1 (en) | 2015-06-02 | 2016-12-08 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
| MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
| CN110612112B (zh) | 2016-12-09 | 2024-03-29 | 阿卡斯通生物科学公司 | 胰岛素-fc融合物及使用方法 |
| WO2018185131A2 (en) | 2017-04-05 | 2018-10-11 | Novo Nordisk A/S | Oligomer extended insulin-fc conjugates |
| ES2929416T3 (es) * | 2018-06-21 | 2022-11-29 | Novo Nordisk As | Nuevos compuestos para el tratamiento de la obesidad |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| DK4186920T5 (da) | 2018-06-29 | 2024-07-22 | Akston Biosciences Corp | Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse |
| EP3863680A1 (en) | 2018-10-10 | 2021-08-18 | Novo Nordisk A/S | Oligomer extended insulin-fc conjugates and their medical use |
| KR102865175B1 (ko) | 2019-12-19 | 2025-09-30 | 악스톤 바이오사이언시스 코퍼레이션 | 초-장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| CN116925237A (zh) | 2019-12-31 | 2023-10-24 | 北京质肽生物医药科技有限公司 | Glp-1和gdf15的融合蛋白以及其缀合物 |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| BR112022020486A2 (pt) | 2020-04-10 | 2023-01-17 | Akston Biosciences Corp | Imunoterapia específica de antígeno para proteínas de fusão de covid-19 e métodos de uso |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| EP3915571A1 (en) * | 2020-05-29 | 2021-12-01 | Adocia | Pharmaceutical composition in the form of an injectable aqueous solution including at least a rapid acting insulin analog and a glucagon suppressor with prandial action |
| JP2023545684A (ja) * | 2020-09-30 | 2023-10-31 | ベイジン キューエル バイオファーマシューティカル カンパニー,リミテッド | ポリペプチドコンジュゲートおよび使用の方法 |
| WO2023004406A2 (en) | 2021-07-23 | 2023-01-26 | Akston Biosciences Corporation | Insulin-fc fusion proteins and methods of use to treat cancer |
| CA3252113A1 (en) | 2022-03-30 | 2023-10-05 | Beijing Ql Biopharmaceutical Co Ltd | Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use |
| CN116284433B (zh) * | 2022-07-04 | 2023-09-12 | 北京惠之衡生物科技有限公司 | 一种胰岛素和glp-1的缀合物及其应用 |
| CN115850385B (zh) * | 2022-07-04 | 2023-08-11 | 北京惠之衡生物科技有限公司 | 一种促表达肽及其应用 |
| WO2024051787A1 (zh) * | 2022-09-09 | 2024-03-14 | 北京惠之衡生物科技有限公司 | 一种长效酰化胰岛素衍生物及其应用 |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE257197C (enExample) | ||||
| DE286509C (enExample) | ||||
| US3914252A (en) | 1971-03-15 | 1975-10-21 | Continental Oil Co | Preparation of N-iodocompounds |
| DD257197A1 (de) | 1987-01-28 | 1988-06-08 | Univ Dresden Tech | Verfahren zur herstellung von immobilisierten, in ihrer biologischen aktivitaet stabilisierten und in ihren pharmakologischen eigenschaften modifizierten insulinpraeparationen |
| DK105489D0 (da) | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DD286509A5 (de) | 1989-06-30 | 1991-01-31 | Veb Berlin-Chemie,De | Verfahren zur herstellung von aktivitaetsstabilisierten, wirkungsverlaengerten rektal applizierbaren insulinpraeparationen |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| ZA954983B (en) | 1994-06-17 | 1996-02-14 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| DE851925T1 (de) | 1995-09-21 | 2003-08-14 | Genentech Inc., San Francisco | Varianten des menschlichen wachstumshormons |
| WO1998022577A1 (en) | 1996-11-15 | 1998-05-28 | Maria Grazia Masucci | Fusion proteins having increased half-lives |
| ES2258797T3 (es) | 1996-12-20 | 2006-09-01 | Novo Nordisk A/S | Proteinas con extension n-terminal expresadas en la levadura. |
| EP1012184B1 (en) | 1997-07-14 | 2007-10-10 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
| JP4944324B2 (ja) | 1999-07-13 | 2012-05-30 | ボルダー バイオテクノロジー, インコーポレイテッド | 免疫グロブリン融合タンパク質 |
| US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| WO2001045746A2 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20060183197A1 (en) | 2001-01-11 | 2006-08-17 | Andersen Kim V | Variant growth hormone molecules conjugated with macromolecules compounds |
| AU2002219021A1 (en) | 2001-01-11 | 2002-07-24 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
| PE20020908A1 (es) | 2001-03-21 | 2002-10-26 | Cell Therapeutics Inc | Produccion recombinante de polimeros polianionicos y uso de de los mismos |
| JP2005518786A (ja) | 2001-11-12 | 2005-06-30 | ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド | ヒトにおける成長ホルモン変異とその用途 |
| GB2389115B (en) | 2001-12-14 | 2005-03-16 | Asterion Ltd | Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone |
| CA2499816C (en) | 2002-09-27 | 2013-07-30 | Xencor, Inc. | Optimized fc variants and methods for their generation |
| US20040180054A1 (en) | 2003-03-13 | 2004-09-16 | Hanmi Pharm. Co., Ltd. | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| BRPI0406606A (pt) | 2003-11-13 | 2005-12-06 | Hanmi Pharm Ind Co Ltd | Composição farmacêutica compreendendo uma região fc de imunoglobulina como um veìculo |
| KR100594607B1 (ko) | 2004-11-03 | 2006-06-30 | 재단법인서울대학교산학협력재단 | 신규한 경구투여용 재조합 인간 성장호르몬 분비미생물제제 및 그 제조방법 |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| CN101111516B (zh) * | 2005-01-25 | 2013-02-27 | 细胞治疗学公司 | 体内半衰期改变的生物活性蛋白质偶联物 |
| JP5735194B2 (ja) * | 2005-01-25 | 2015-06-17 | セル セラピューティクス インコーポレーテッド | 改善された生体内半減期を有する生物学的に活性なタンパク質 |
| WO2006079641A2 (en) | 2005-01-27 | 2006-08-03 | Novo Nordisk A/S | Insulin derivatives conjugated with structurally well defined branched polymers |
| WO2006087354A2 (en) | 2005-02-16 | 2006-08-24 | Novo Nordisk A/S | Insulinotropic agents conjugated with structurally well defined branched polymers |
| KR100754667B1 (ko) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물 |
| JP5255435B2 (ja) | 2005-04-26 | 2013-08-07 | メディミューン,エルエルシー | ヒンジドメイン操作による抗体エフェクター機能の調節 |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US8492129B2 (en) | 2005-12-12 | 2013-07-23 | Innova Biosciences, Ltd. | Production of conjugates |
| EP1971355B1 (en) | 2005-12-20 | 2020-03-11 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| EP1996937A4 (en) | 2006-03-06 | 2009-04-08 | Amunix Inc | GENETIC PACKS AND USES THEREOF |
| JP5256199B2 (ja) * | 2006-08-07 | 2013-08-07 | テヴァ バイオファーマシューティカルズ ユーエスエー,インコーポレーティッド | アルブミン−インスリン融合タンパク質 |
| US8093068B2 (en) | 2006-10-26 | 2012-01-10 | Centocor, Inc. | Methods for use in human-adapting monoclonal antibodies |
| WO2008049711A1 (en) * | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
| WO2008147456A2 (en) | 2006-11-20 | 2008-12-04 | Massachusetts Institute Of Technology | Drug delivery systems using fc fragments |
| WO2008092117A2 (en) | 2007-01-25 | 2008-07-31 | Xencor, Inc. | Immunoglobulins with modifications in the fcr binding region |
| KR20080095141A (ko) | 2007-04-23 | 2008-10-28 | 포항공과대학교 산학협력단 | 인간 알부민 링커를 통하여 면역글로불린의 Fc에 결합된생리학적 활성 폴리펩티드의 융합 폴리펩티드, 및 이의제조방법 |
| EP3176264B1 (en) | 2007-05-30 | 2018-09-26 | Postech Academy-Industry- Foundation | Immunoglobulin fusion proteins |
| WO2008145142A1 (en) | 2007-05-31 | 2008-12-04 | Genmab A/S | Stable igg4 antibodies |
| WO2009015345A1 (en) | 2007-07-25 | 2009-01-29 | Amgen Inc. | Pharmaceutical compositions comprising fc fusion proteins |
| BRPI0815416A2 (pt) * | 2007-08-15 | 2014-10-21 | Amunix Inc | Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos |
| EP2203180B1 (en) | 2007-10-22 | 2012-11-21 | Merck Serono S.A. | Single ifn-beta fused to a mutated igg fc fragment |
| KR101784231B1 (ko) | 2008-06-20 | 2017-11-08 | 노파르티스 아게 | 응집이 감소된 면역글로불린 |
| US20110119848A1 (en) | 2008-07-02 | 2011-05-26 | Koninklijke Philips Electronics N.V. | V-spring configuration and end attachment assemblies therefor for use in a personal care appliance |
| KR101200659B1 (ko) | 2008-07-23 | 2012-11-12 | 한미사이언스 주식회사 | 세 말단 반응기를 갖는 비펩타이드성 중합체를 이용한 생리활성 폴리펩타이드 약물 결합체 |
| WO2010091122A1 (en) * | 2009-02-03 | 2010-08-12 | Amunix, Inc. | Extended recombinant polypeptides and compositions comprising same |
| GB0914110D0 (en) | 2009-08-12 | 2009-09-16 | Medical Res Council | Peptide libraries |
| BR112012007374A2 (pt) | 2009-09-30 | 2019-09-24 | Glaxo Group Ltd | composição, formulação oral, injetável, inalável ou nebulizável, e, ácido nucleico isolado ou recombinante |
| BR112012010252A2 (pt) | 2009-10-29 | 2016-12-06 | Janssen Biotech Inc | variantes de glicosilação de anticorpo |
| US8637637B2 (en) | 2010-01-12 | 2014-01-28 | Bill Nai-Chau Sun | Fc fusion proteins of human growth hormone |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| DK2571510T3 (en) | 2010-05-21 | 2018-11-19 | Xl Protein Gmbh | BIOSYNTHETIC PROLIN / ALANIN-RANDOM COIL POLYPEPTIDES AND THEIR APPLICATIONS |
| KR101337797B1 (ko) | 2010-07-14 | 2013-12-06 | 한미사이언스 주식회사 | 지속형 인간 성장 호르몬 결합체 액상 제제 |
| EP2694528A1 (en) | 2011-04-05 | 2014-02-12 | Martin-Protean, LLC | Isolation of cysteine containing peptides |
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| CN107496932A (zh) | 2012-02-27 | 2017-12-22 | 阿穆尼克斯运营公司 | Xten缀合组合物和制造其的方法 |
| WO2013170272A2 (en) | 2012-05-11 | 2013-11-14 | Alexander Krantz | Site-specific labeling and targeted delivery of proteins for the treatment of cancer |
| US20160115216A1 (en) | 2013-06-07 | 2016-04-28 | Novo Nordisk A/S | Method for Making Mature Insulin Polypeptides |
| CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
| ES2909014T3 (es) | 2013-11-26 | 2022-05-04 | Brigham & Womens Hospital Inc | Composiciones y métodos para modular una respuesta inmunitaria |
| BR112016020368A2 (pt) | 2014-03-05 | 2018-01-23 | Ucb Biopharma Sprl | proteínas fc multiméricas |
| ES2905085T3 (es) | 2014-09-17 | 2022-04-07 | Novo Nordisk As | Anticuerpos que pueden unirse a dos epítopos en el inhibidor de la vía del factor tisular (1-161) |
| JP2018508504A (ja) | 2015-02-17 | 2018-03-29 | ハンミ ファーマシューティカル カンパニー リミテッド | 持続型インスリンまたはインスリンアナログ結合体 |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| WO2016193380A1 (en) | 2015-06-02 | 2016-12-08 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
| CN107921030B (zh) | 2015-08-14 | 2024-07-02 | 荣昌生物制药(烟台)股份有限公司 | 抗体-药物偶联物的共价连接子及其制备方法与应用 |
| MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
| WO2018185131A2 (en) | 2017-04-05 | 2018-10-11 | Novo Nordisk A/S | Oligomer extended insulin-fc conjugates |
-
2016
- 2016-06-02 WO PCT/EP2016/062514 patent/WO2016193380A1/en not_active Ceased
- 2016-06-02 US US15/577,990 patent/US11208452B2/en active Active
- 2016-06-02 JP JP2017562721A patent/JP6983075B2/ja not_active Expired - Fee Related
- 2016-06-02 EP EP16726866.3A patent/EP3303380B1/en active Active
- 2016-06-02 ES ES16726866T patent/ES2784603T3/es active Active
- 2016-06-02 CN CN201680031703.8A patent/CN107743494B/zh not_active Expired - Fee Related
-
2021
- 2021-04-20 JP JP2021070977A patent/JP2021119156A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2784603T3 (es) | 2020-09-29 |
| JP2018527288A (ja) | 2018-09-20 |
| CN107743494B (zh) | 2022-04-29 |
| WO2016193380A1 (en) | 2016-12-08 |
| US20180291076A1 (en) | 2018-10-11 |
| US11208452B2 (en) | 2021-12-28 |
| EP3303380B1 (en) | 2020-01-15 |
| JP2021119156A (ja) | 2021-08-12 |
| EP3303380A1 (en) | 2018-04-11 |
| CN107743494A (zh) | 2018-02-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6983075B2 (ja) | 極性の組換え延長部を有するインスリン | |
| RU2684456C2 (ru) | Новые производные инсулина и их применение в медицине | |
| JP2021177779A (ja) | 新規インスリン誘導体及びその医学的使用 | |
| CN102083855A (zh) | 活性延长的新胰岛素类似物 | |
| US20090069216A1 (en) | Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof | |
| KR20090071561A (ko) | 프로테아제 내성 인슐린 유사체 | |
| JPH11502110A (ja) | インスリン誘導体 | |
| JP2007537142A (ja) | アルブミン様物質に結合した新規のglp−1類似物 | |
| EP3642338A1 (en) | Fusion protein with half-life extending polypeptide | |
| US20200283493A1 (en) | Novel Insulin Derivatives and the Medical Uses Hereof | |
| JP6995284B2 (ja) | 新規インスリン類似体およびそれらの使用 | |
| US7078485B2 (en) | N-terminal modified recombinant human endostatin and its production | |
| JP6013330B2 (ja) | 追加のジスルフィド結合を含有するヒトインスリン | |
| JP2018531899A (ja) | 新規インスリン誘導体及びその医学的使用 | |
| EP1654283A1 (en) | Improved method of purifying tfpi and tfpi analogs | |
| JP2022533066A (ja) | ポリペプチド誘導体およびその調製方法 | |
| Liang et al. | Purification and Activity Evaluation of a Novel Thrombopoietin Mimetic Peptide | |
| JP2006508695A (ja) | 単量体インスリン |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190325 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190325 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200117 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200210 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200430 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200709 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20201221 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210420 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20210420 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20210427 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20210510 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210628 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210927 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20211101 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20211122 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6983075 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |