JP6976335B2 - 組み換え結合タンパク質及びその使用 - Google Patents

組み換え結合タンパク質及びその使用 Download PDF

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JP6976335B2
JP6976335B2 JP2019536693A JP2019536693A JP6976335B2 JP 6976335 B2 JP6976335 B2 JP 6976335B2 JP 2019536693 A JP2019536693 A JP 2019536693A JP 2019536693 A JP2019536693 A JP 2019536693A JP 6976335 B2 JP6976335 B2 JP 6976335B2
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protein
seq
her2
binding protein
ankyrin repeat
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JP2019531093A5 (https=
JP2019531093A (ja
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クララ メッツ
ウルリケ フィードラー
イグナシオ ドラド
ハイケ マリア シュトローベル
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モレキュラー パートナーズ アクチェンゲゼルシャフト
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019536693A 2016-09-22 2017-09-20 組み換え結合タンパク質及びその使用 Expired - Fee Related JP6976335B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16190221.8 2016-09-22
EP16190221 2016-09-22
PCT/EP2017/073768 WO2018054971A1 (en) 2016-09-22 2017-09-20 Recombinant binding proteins and their use

Publications (3)

Publication Number Publication Date
JP2019531093A JP2019531093A (ja) 2019-10-31
JP2019531093A5 JP2019531093A5 (https=) 2020-05-21
JP6976335B2 true JP6976335B2 (ja) 2021-12-08

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JP2019536693A Expired - Fee Related JP6976335B2 (ja) 2016-09-22 2017-09-20 組み換え結合タンパク質及びその使用

Country Status (20)

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US (2) US10717772B2 (https=)
EP (1) EP3515933B9 (https=)
JP (1) JP6976335B2 (https=)
KR (1) KR102270315B1 (https=)
CN (1) CN109790206A (https=)
AR (1) AR109680A1 (https=)
AU (1) AU2017331329B2 (https=)
BR (1) BR112019005587A2 (https=)
CA (1) CA3036301C (https=)
CL (1) CL2019000729A1 (https=)
CO (1) CO2019002609A2 (https=)
ES (1) ES2953516T3 (https=)
IL (1) IL265489B (https=)
MX (1) MX377424B (https=)
MY (1) MY196882A (https=)
NZ (1) NZ751689A (https=)
PH (1) PH12019500596B1 (https=)
SA (1) SA519401369B1 (https=)
WO (1) WO2018054971A1 (https=)
ZA (1) ZA201901592B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020245746A1 (en) * 2019-06-04 2020-12-10 Molecular Partners Ag Multispecific proteins
JP7611173B2 (ja) * 2019-06-04 2025-01-09 モレキュラー パートナーズ アクチェンゲゼルシャフト 組換えｆａｐ結合タンパク質及びそれらの使用
CN114222757A (zh) * 2019-06-04 2022-03-22 分子伴侣公司 重组4-1bb结合蛋白及其用途
CA3138805A1 (en) 2019-06-04 2020-12-10 Johannes Schilling Designed ankyrin repeat domain with improved stability
IL293698A (en) 2019-12-11 2022-08-01 Molecular Partners Ag Recombinant peptide-mhc complex binding proteins, their production and use
JP2023525518A (ja) 2020-05-06 2023-06-16 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規アンキリンリピート結合タンパク質とその用途
US20240279309A1 (en) * 2020-05-14 2024-08-22 Molecular Partners Ag Recombinant cd40 binding proteins and their use
US20240279290A1 (en) 2020-05-14 2024-08-22 Molecular Partners Ag Multispecific proteins
AU2021403833A1 (en) 2020-12-16 2023-07-27 Molecular Partners Ag Novel slow-release prodrugs
EP4305063A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Protease cleavable prodrugs
US20240317852A1 (en) 2021-03-09 2024-09-26 Molecular Partners Ag Novel darpin based cd33 engagers
CA3211368A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd123 engagers
BR112023018293A2 (pt) 2021-03-09 2023-10-31 Molecular Partners Ag Acopladores de célula t multiespecíficos à base de darpin
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
TW202448926A (zh) 2023-02-17 2024-12-16 比利時商艾伯霖克斯公司 結合新生兒fc受體之多肽
EP4673159A1 (en) 2023-02-27 2026-01-07 Molecular Partners AG Darpins for use in reducing renal accumulation of drugs
EP4724460A1 (en) 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd16a binding proteins and their use
EP4724486A1 (en) 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd2 binding proteins and their use
WO2025146487A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Multispecific binding proteins
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025163144A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recombinant mesothelin binding proteins and their use
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager
WO2026013280A1 (en) * 2024-07-11 2026-01-15 Johann Wolfgang Goethe-Universität Frankfurt am Main Designed ankyrin repeat proteins binding p53, and uses thereof

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
JP4319908B2 (ja) * 2001-08-24 2009-08-26 ユニバーシティ オブ ビクトリア イノベーション アンド ディベロップメント コーポレーション プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法
JP2008519590A (ja) 2004-11-12 2008-06-12 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 組換えニューカッスル病ウィルス
BRPI0613593A2 (pt) 2005-07-08 2011-01-18 Univ Zuerich método de teste "phage display" filamentoso, vetor de fago ou de fagomìdeo e biblioteca de vetores de fago ou fagomìdeo
US9365629B2 (en) 2007-09-24 2016-06-14 University Of Zurich Designed armadillo repeat proteins
EP2650311A3 (en) 2007-11-27 2014-06-04 Ablynx N.V. Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
BRPI0921469B1 (pt) 2008-11-03 2022-01-18 Molecular Partners Ag Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica
AR081361A1 (es) 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
PL2643349T3 (pl) 2010-11-26 2020-03-31 Molecular Partners Ag Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy
EA201391607A1 (ru) 2011-04-29 2014-04-30 Янссен Байотек, Инк. Связывающие il4/il13 белки с повторами и их применение
WO2014001442A1 (en) 2012-06-28 2014-01-03 Molecular Partners Ag Designed ankyrin repeat proteins binding to platelet-derived growth factor
WO2014060365A1 (en) * 2012-10-15 2014-04-24 Universität Zürich Prorektorat Mnw Bispecific her2 ligands for cancer therapy
EP2738180A1 (en) * 2012-11-30 2014-06-04 Molecular Partners AG Binding proteins comprising at least two binding domains against HER2.
CN105209483B (zh) 2013-05-31 2021-07-27 分子组合公司 与肝细胞生长因子结合的设计锚蛋白重复蛋白
KR102427117B1 (ko) * 2015-04-02 2022-07-29 몰리큘라 파트너스 아게 혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인

Also Published As

Publication number Publication date
WO2018054971A1 (en) 2018-03-29
CN109790206A (zh) 2019-05-21
PH12019500596B1 (en) 2024-02-21
ZA201901592B (en) 2021-04-28
US10717772B2 (en) 2020-07-21
EP3515933B1 (en) 2023-06-07
RU2019111628A (ru) 2020-10-19
IL265489B (en) 2021-07-29
JP2019531093A (ja) 2019-10-31
MY196882A (en) 2023-05-08
MX2019003298A (es) 2019-09-26
PH12019500596A1 (en) 2019-07-29
KR20190050802A (ko) 2019-05-13
CA3036301C (en) 2021-04-20
AU2017331329A1 (en) 2019-04-04
AR109680A1 (es) 2019-01-09
EP3515933B9 (en) 2023-08-16
ES2953516T3 (es) 2023-11-14
US20180155402A1 (en) 2018-06-07
CA3036301A1 (en) 2018-03-29
IL265489A (en) 2019-05-30
US20210130420A1 (en) 2021-05-06
EP3515933C0 (en) 2023-06-07
CO2019002609A2 (es) 2019-05-31
EP3515933A1 (en) 2019-07-31
AU2017331329B2 (en) 2020-10-29
SA519401369B1 (ar) 2022-12-22
CL2019000729A1 (es) 2019-06-14
MX377424B (es) 2025-03-10
BR112019005587A2 (pt) 2019-06-11
NZ751689A (en) 2021-07-30
KR102270315B1 (ko) 2021-06-29
RU2019111628A3 (https=) 2020-10-30

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