KR102270315B1 - 재조합 결합 단백질 및 그의 용도 - Google Patents

재조합 결합 단백질 및 그의 용도 Download PDF

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KR102270315B1
KR102270315B1 KR1020197009396A KR20197009396A KR102270315B1 KR 102270315 B1 KR102270315 B1 KR 102270315B1 KR 1020197009396 A KR1020197009396 A KR 1020197009396A KR 20197009396 A KR20197009396 A KR 20197009396A KR 102270315 B1 KR102270315 B1 KR 102270315B1
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gly
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protein
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KR20190050802A (ko
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클라라 메츠
울리케 피들러
이그나시오 도라도
헤이크 마리아 스트로벨
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몰리큘라 파트너스 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197009396A 2016-09-22 2017-09-20 재조합 결합 단백질 및 그의 용도 Expired - Fee Related KR102270315B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16190221.8 2016-09-22
EP16190221 2016-09-22
PCT/EP2017/073768 WO2018054971A1 (en) 2016-09-22 2017-09-20 Recombinant binding proteins and their use

Publications (2)

Publication Number Publication Date
KR20190050802A KR20190050802A (ko) 2019-05-13
KR102270315B1 true KR102270315B1 (ko) 2021-06-29

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Country Status (20)

Country Link
US (2) US10717772B2 (https=)
EP (1) EP3515933B9 (https=)
JP (1) JP6976335B2 (https=)
KR (1) KR102270315B1 (https=)
CN (1) CN109790206A (https=)
AR (1) AR109680A1 (https=)
AU (1) AU2017331329B2 (https=)
BR (1) BR112019005587A2 (https=)
CA (1) CA3036301C (https=)
CL (1) CL2019000729A1 (https=)
CO (1) CO2019002609A2 (https=)
ES (1) ES2953516T3 (https=)
IL (1) IL265489B (https=)
MX (1) MX377424B (https=)
MY (1) MY196882A (https=)
NZ (1) NZ751689A (https=)
PH (1) PH12019500596B1 (https=)
SA (1) SA519401369B1 (https=)
WO (1) WO2018054971A1 (https=)
ZA (1) ZA201901592B (https=)

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CN114222757A (zh) * 2019-06-04 2022-03-22 分子伴侣公司 重组4-1bb结合蛋白及其用途
CA3138805A1 (en) 2019-06-04 2020-12-10 Johannes Schilling Designed ankyrin repeat domain with improved stability
IL293698A (en) 2019-12-11 2022-08-01 Molecular Partners Ag Recombinant peptide-mhc complex binding proteins, their production and use
JP2023525518A (ja) 2020-05-06 2023-06-16 モレキュラー パートナーズ アクチェンゲゼルシャフト 新規アンキリンリピート結合タンパク質とその用途
US20240279309A1 (en) * 2020-05-14 2024-08-22 Molecular Partners Ag Recombinant cd40 binding proteins and their use
US20240279290A1 (en) 2020-05-14 2024-08-22 Molecular Partners Ag Multispecific proteins
AU2021403833A1 (en) 2020-12-16 2023-07-27 Molecular Partners Ag Novel slow-release prodrugs
EP4305063A1 (en) 2021-03-09 2024-01-17 Molecular Partners AG Protease cleavable prodrugs
US20240317852A1 (en) 2021-03-09 2024-09-26 Molecular Partners Ag Novel darpin based cd33 engagers
CA3211368A1 (en) 2021-03-09 2022-09-15 Molecular Partners Ag Novel darpin based cd123 engagers
BR112023018293A2 (pt) 2021-03-09 2023-10-31 Molecular Partners Ag Acopladores de célula t multiespecíficos à base de darpin
WO2023110983A1 (en) 2021-12-14 2023-06-22 Molecular Partners Ag Designed repeat domains with dual binding specificity and their use
WO2024028278A1 (en) 2022-08-01 2024-02-08 Molecular Partners Ag Charge modified designed repeat domains and their use
WO2024038307A1 (en) 2022-08-19 2024-02-22 Novartis Ag Dosing regimens for sars-cov-2 binding molecules
TW202448926A (zh) 2023-02-17 2024-12-16 比利時商艾伯霖克斯公司 結合新生兒fc受體之多肽
EP4673159A1 (en) 2023-02-27 2026-01-07 Molecular Partners AG Darpins for use in reducing renal accumulation of drugs
EP4724460A1 (en) 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd16a binding proteins and their use
EP4724486A1 (en) 2023-06-06 2026-04-15 Molecular Partners AG Recombinant cd2 binding proteins and their use
WO2025146487A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Multispecific binding proteins
WO2025146491A1 (en) 2024-01-05 2025-07-10 Molecular Partners Ag Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent
WO2025163144A1 (en) 2024-01-31 2025-08-07 Molecular Partners Ag Recombinant mesothelin binding proteins and their use
WO2025181039A1 (en) 2024-03-01 2025-09-04 Molecular Partners Ag Therapeutic combinations comprising a multi-specific t cell engager
WO2026013280A1 (en) * 2024-07-11 2026-01-15 Johann Wolfgang Goethe-Universität Frankfurt am Main Designed ankyrin repeat proteins binding p53, and uses thereof

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US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
JP4319908B2 (ja) * 2001-08-24 2009-08-26 ユニバーシティ オブ ビクトリア イノベーション アンド ディベロップメント コーポレーション プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法
JP2008519590A (ja) 2004-11-12 2008-06-12 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 組換えニューカッスル病ウィルス
BRPI0613593A2 (pt) 2005-07-08 2011-01-18 Univ Zuerich método de teste "phage display" filamentoso, vetor de fago ou de fagomìdeo e biblioteca de vetores de fago ou fagomìdeo
US9365629B2 (en) 2007-09-24 2016-06-14 University Of Zurich Designed armadillo repeat proteins
EP2650311A3 (en) 2007-11-27 2014-06-04 Ablynx N.V. Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
BRPI0921469B1 (pt) 2008-11-03 2022-01-18 Molecular Partners Ag Proteínas de ligação que inibem a interação com o receptor de vegf-a, composição farmacêutica
AR081361A1 (es) 2010-04-30 2012-08-29 Molecular Partners Ag Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a
PL2643349T3 (pl) 2010-11-26 2020-03-31 Molecular Partners Ag Zaprojektowane białka z powtórzeniami wiążące się z albuminą surowicy
EA201391607A1 (ru) 2011-04-29 2014-04-30 Янссен Байотек, Инк. Связывающие il4/il13 белки с повторами и их применение
WO2014001442A1 (en) 2012-06-28 2014-01-03 Molecular Partners Ag Designed ankyrin repeat proteins binding to platelet-derived growth factor
WO2014060365A1 (en) * 2012-10-15 2014-04-24 Universität Zürich Prorektorat Mnw Bispecific her2 ligands for cancer therapy
CN105209483B (zh) 2013-05-31 2021-07-27 分子组合公司 与肝细胞生长因子结合的设计锚蛋白重复蛋白
KR102427117B1 (ko) * 2015-04-02 2022-07-29 몰리큘라 파트너스 아게 혈청 알부민에 대한 결합 특이성을 갖는 설계된 안키린 반복 도메인

Patent Citations (1)

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JP2015537044A (ja) 2012-11-30 2015-12-24 モレキュラー パートナーズ アクチェンゲゼルシャフト 少なくとも２つの抗ｈｅｒ２反復ドメインを含む結合タンパク質

Also Published As

Publication number Publication date
WO2018054971A1 (en) 2018-03-29
CN109790206A (zh) 2019-05-21
PH12019500596B1 (en) 2024-02-21
ZA201901592B (en) 2021-04-28
US10717772B2 (en) 2020-07-21
EP3515933B1 (en) 2023-06-07
RU2019111628A (ru) 2020-10-19
IL265489B (en) 2021-07-29
JP2019531093A (ja) 2019-10-31
MY196882A (en) 2023-05-08
MX2019003298A (es) 2019-09-26
PH12019500596A1 (en) 2019-07-29
KR20190050802A (ko) 2019-05-13
CA3036301C (en) 2021-04-20
AU2017331329A1 (en) 2019-04-04
AR109680A1 (es) 2019-01-09
EP3515933B9 (en) 2023-08-16
ES2953516T3 (es) 2023-11-14
US20180155402A1 (en) 2018-06-07
CA3036301A1 (en) 2018-03-29
IL265489A (en) 2019-05-30
US20210130420A1 (en) 2021-05-06
EP3515933C0 (en) 2023-06-07
CO2019002609A2 (es) 2019-05-31
EP3515933A1 (en) 2019-07-31
AU2017331329B2 (en) 2020-10-29
JP6976335B2 (ja) 2021-12-08
SA519401369B1 (ar) 2022-12-22
CL2019000729A1 (es) 2019-06-14
MX377424B (es) 2025-03-10
BR112019005587A2 (pt) 2019-06-11
NZ751689A (en) 2021-07-30
RU2019111628A3 (https=) 2020-10-30

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