JP6974168B2 - Pufa生成のための材料及び方法並びにpufa含有組成物 - Google Patents

Pufa生成のための材料及び方法並びにpufa含有組成物 Download PDF

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JP6974168B2
JP6974168B2 JP2017525878A JP2017525878A JP6974168B2 JP 6974168 B2 JP6974168 B2 JP 6974168B2 JP 2017525878 A JP2017525878 A JP 2017525878A JP 2017525878 A JP2017525878 A JP 2017525878A JP 6974168 B2 JP6974168 B2 JP 6974168B2
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desaturase
plant
content
seed
dna
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JP2018500885A (ja
Inventor
アンドレ,カール
エー. ハーテル,ハイコー
ゼンガー,トラルフ
バウアー,イェルク
ライン,ディートリッヒ
クンツェ,イレーネ
マーティ,ローレント
マケルヴァー,ジョン
イルマズ,ジェニー リンドバーグ
ブレマー,スティーブン
ブラゼール,スティーブン
ヴリンテン,パトリシア
スティムン,ステン
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ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー
バイオリジナル フード アンド サイエンス コーポレーション
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Application filed by ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー, バイオリジナル フード アンド サイエンス コーポレーション filed Critical ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/158Fatty acids; Fats; Products containing oils or fats
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D7/00Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/02Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12Fatty acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • C12Y114/19003Linoleoyl-CoA desaturase (1.14.19.3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
    • C12Y114/19006DELTA12-fatty-acid desaturase (1.14.19.6), i.e. oleoyl-CoA DELTA12 desaturase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y602/00Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01Acid-Thiol Ligases (6.2.1)
    • C12Y602/01003Long-chain-fatty-acid-CoA ligase (6.2.1.3)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Animal Husbandry (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2017525878A 2014-11-14 2015-11-13 Pufa生成のための材料及び方法並びにpufa含有組成物 Expired - Fee Related JP6974168B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021134471A JP2021184744A (ja) 2014-11-14 2021-08-20 Pufa生成のための材料及び方法並びにpufa含有組成物
JP2023030778A JP2023081920A (ja) 2014-11-14 2023-03-01 Pufa生成のための材料及び方法並びにpufa含有組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462079622P 2014-11-14 2014-11-14
US62/079,622 2014-11-14
US201562234373P 2015-09-29 2015-09-29
US62/234,373 2015-09-29
PCT/EP2015/076631 WO2016075326A2 (en) 2014-11-14 2015-11-13 Materials and methods for pufa production, and pufa-containing compositions

Related Child Applications (1)

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JP2021134471A Division JP2021184744A (ja) 2014-11-14 2021-08-20 Pufa生成のための材料及び方法並びにpufa含有組成物

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JP2018500885A JP2018500885A (ja) 2018-01-18
JP6974168B2 true JP6974168B2 (ja) 2021-12-01

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Family Applications (7)

Application Number Title Priority Date Filing Date
JP2017525878A Expired - Fee Related JP6974168B2 (ja) 2014-11-14 2015-11-13 Pufa生成のための材料及び方法並びにpufa含有組成物
JP2017525981A Active JP7067926B2 (ja) 2014-11-14 2015-11-13 種子油においてトコフェロール含量を増加させるための材料および方法
JP2017525951A Active JP7423177B2 (ja) 2014-11-14 2015-11-13 Pufaを含有する植物性脂質の改質
JP2021134471A Pending JP2021184744A (ja) 2014-11-14 2021-08-20 Pufa生成のための材料及び方法並びにpufa含有組成物
JP2022042097A Withdrawn JP2022088464A (ja) 2014-11-14 2022-03-17 種子油においてトコフェロール含量を増加させるための材料および方法
JP2022067353A Pending JP2022106787A (ja) 2014-11-14 2022-04-15 Pufaを含有する植物性脂質の改質
JP2023030778A Pending JP2023081920A (ja) 2014-11-14 2023-03-01 Pufa生成のための材料及び方法並びにpufa含有組成物

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2017525981A Active JP7067926B2 (ja) 2014-11-14 2015-11-13 種子油においてトコフェロール含量を増加させるための材料および方法
JP2017525951A Active JP7423177B2 (ja) 2014-11-14 2015-11-13 Pufaを含有する植物性脂質の改質
JP2021134471A Pending JP2021184744A (ja) 2014-11-14 2021-08-20 Pufa生成のための材料及び方法並びにpufa含有組成物
JP2022042097A Withdrawn JP2022088464A (ja) 2014-11-14 2022-03-17 種子油においてトコフェロール含量を増加させるための材料および方法
JP2022067353A Pending JP2022106787A (ja) 2014-11-14 2022-04-15 Pufaを含有する植物性脂質の改質
JP2023030778A Pending JP2023081920A (ja) 2014-11-14 2023-03-01 Pufa生成のための材料及び方法並びにpufa含有組成物

Country Status (14)

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US (12) US11484560B2 (enExample)
EP (4) EP3218496A1 (enExample)
JP (7) JP6974168B2 (enExample)
KR (2) KR20170099884A (enExample)
CN (6) CN115094081A (enExample)
AU (12) AU2015344993C9 (enExample)
CA (5) CA2967132A1 (enExample)
CL (4) CL2017001223A1 (enExample)
EC (3) ECSP17036764A (enExample)
MX (4) MX388387B (enExample)
MY (1) MY184649A (enExample)
PH (4) PH12017500880A1 (enExample)
SG (1) SG11201703858YA (enExample)
WO (6) WO2016075326A2 (enExample)

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CN112969792A (zh) * 2018-09-07 2021-06-15 巴斯夫植物科学有限公司 用于在植物中产生高水平pufa的改进方法
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KR102721484B1 (ko) * 2022-02-17 2024-10-24 대한민국 유전자변형 유채를 검정하기 위한 양성대조군 플라스미드 및 이를 이용한 유전자변형 유채의 검정방법
KR102721490B1 (ko) * 2022-02-17 2024-10-24 대한민국 유전자변형 면화를 검정하기 위한 양성대조군 플라스미드 및 이를 이용한 유전자변형 면화의 검정방법
WO2024005187A1 (ja) 2022-07-01 2024-01-04 田辺三菱製薬株式会社 組成物、およびエダラボンの応答可能性の評価方法
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