JP6954890B2 - ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 - Google Patents
ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 Download PDFInfo
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- JP6954890B2 JP6954890B2 JP2018501179A JP2018501179A JP6954890B2 JP 6954890 B2 JP6954890 B2 JP 6954890B2 JP 2018501179 A JP2018501179 A JP 2018501179A JP 2018501179 A JP2018501179 A JP 2018501179A JP 6954890 B2 JP6954890 B2 JP 6954890B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/31—Chimeric antigen receptors [CAR]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
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- A—HUMAN NECESSITIES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
- A61K2239/29—Multispecific CARs
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020209010A JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562191918P | 2015-07-13 | 2015-07-13 | |
| US62/191,918 | 2015-07-13 | ||
| US201562247469P | 2015-10-28 | 2015-10-28 | |
| US62/247,469 | 2015-10-28 | ||
| US201662315438P | 2016-03-30 | 2016-03-30 | |
| US62/315,438 | 2016-03-30 | ||
| PCT/US2016/042024 WO2017011519A1 (en) | 2015-07-13 | 2016-07-13 | Delivery methods and compositions for nuclease-mediated genome engineering |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020209010A Division JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018525979A JP2018525979A (ja) | 2018-09-13 |
| JP2018525979A5 JP2018525979A5 (enExample) | 2019-08-22 |
| JP6954890B2 true JP6954890B2 (ja) | 2021-10-27 |
Family
ID=57758305
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018501179A Active JP6954890B2 (ja) | 2015-07-13 | 2016-07-13 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
| JP2020209010A Active JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020209010A Active JP7348160B2 (ja) | 2015-07-13 | 2020-12-17 | ヌクレアーゼ媒介ゲノム遺伝子操作のための送達方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10450585B2 (enExample) |
| EP (1) | EP3322297B1 (enExample) |
| JP (2) | JP6954890B2 (enExample) |
| CN (1) | CN108024544B (enExample) |
| AU (1) | AU2016291778B2 (enExample) |
| CA (1) | CA2991301A1 (enExample) |
| WO (1) | WO2017011519A1 (enExample) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
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| EP3322297A4 (en) | 2019-04-17 |
| EP3322297B1 (en) | 2024-12-04 |
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| CA2991301A1 (en) | 2017-01-19 |
| EP3322297A1 (en) | 2018-05-23 |
| US20200102577A1 (en) | 2020-04-02 |
| US20170016027A1 (en) | 2017-01-19 |
| JP7348160B2 (ja) | 2023-09-20 |
| CN108024544A (zh) | 2018-05-11 |
| EP3322297C0 (en) | 2024-12-04 |
| JP2018525979A (ja) | 2018-09-13 |
| CN108024544B (zh) | 2022-04-29 |
| JP2021045166A (ja) | 2021-03-25 |
| WO2017011519A1 (en) | 2017-01-19 |
| US10450585B2 (en) | 2019-10-22 |
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