AU2016291778B2 - Delivery methods and compositions for nuclease-mediated genome engineering - Google Patents
Delivery methods and compositions for nuclease-mediated genome engineering Download PDFInfo
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- AU2016291778B2 AU2016291778B2 AU2016291778A AU2016291778A AU2016291778B2 AU 2016291778 B2 AU2016291778 B2 AU 2016291778B2 AU 2016291778 A AU2016291778 A AU 2016291778A AU 2016291778 A AU2016291778 A AU 2016291778A AU 2016291778 B2 AU2016291778 B2 AU 2016291778B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A61K40/00—Cellular immunotherapy
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- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/41—Vertebrate antigens
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- A61K40/4203—Receptors for growth factors
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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- A61K40/42—Cancer antigens
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- A61K40/4203—Receptors for growth factors
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4203—Receptors for growth factors
- A61K40/4209—Hepatocyte growth factor receptor [HGFR] or c-met]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
- A61K2239/29—Multispecific CARs
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562191918P | 2015-07-13 | 2015-07-13 | |
| US62/191,918 | 2015-07-13 | ||
| US201562247469P | 2015-10-28 | 2015-10-28 | |
| US62/247,469 | 2015-10-28 | ||
| US201662315438P | 2016-03-30 | 2016-03-30 | |
| US62/315,438 | 2016-03-30 | ||
| PCT/US2016/042024 WO2017011519A1 (en) | 2015-07-13 | 2016-07-13 | Delivery methods and compositions for nuclease-mediated genome engineering |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2016291778A1 AU2016291778A1 (en) | 2018-01-25 |
| AU2016291778B2 true AU2016291778B2 (en) | 2021-05-06 |
Family
ID=57758305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016291778A Active AU2016291778B2 (en) | 2015-07-13 | 2016-07-13 | Delivery methods and compositions for nuclease-mediated genome engineering |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10450585B2 (enExample) |
| EP (1) | EP3322297B1 (enExample) |
| JP (2) | JP6954890B2 (enExample) |
| CN (1) | CN108024544B (enExample) |
| AU (1) | AU2016291778B2 (enExample) |
| CA (1) | CA2991301A1 (enExample) |
| WO (1) | WO2017011519A1 (enExample) |
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| AU2016333898B2 (en) * | 2015-10-05 | 2020-11-12 | Precision Biosciences, Inc. | Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene |
| PH12018500927B1 (en) | 2015-10-28 | 2024-07-03 | Sangamo Therapeutics Inc | Liver-specific constructs, factor viii expression cassettes and methods of use thereof |
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2016
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| US20140296326A1 (en) * | 2010-09-10 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Epidermal growth factor receptor (egfr) and methods of use in adenoviral-associated virus type 6 (aav6) transduction |
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| US20200102577A1 (en) | 2020-04-02 |
| US20170016027A1 (en) | 2017-01-19 |
| CN108024544A (zh) | 2018-05-11 |
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| CA2991301A1 (en) | 2017-01-19 |
| EP3322297A4 (en) | 2019-04-17 |
| EP3322297A1 (en) | 2018-05-23 |
| JP2021045166A (ja) | 2021-03-25 |
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| AU2016291778A1 (en) | 2018-01-25 |
| JP6954890B2 (ja) | 2021-10-27 |
| EP3322297B1 (en) | 2024-12-04 |
| EP3322297C0 (en) | 2024-12-04 |
| JP7348160B2 (ja) | 2023-09-20 |
| CN108024544B (zh) | 2022-04-29 |
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