JP6943859B2 - 駆虫性デプシペプチド化合物 - Google Patents
駆虫性デプシペプチド化合物 Download PDFInfo
- Publication number
- JP6943859B2 JP6943859B2 JP2018534122A JP2018534122A JP6943859B2 JP 6943859 B2 JP6943859 B2 JP 6943859B2 JP 2018534122 A JP2018534122 A JP 2018534122A JP 2018534122 A JP2018534122 A JP 2018534122A JP 6943859 B2 JP6943859 B2 JP 6943859B2
- Authority
- JP
- Japan
- Prior art keywords
- independently
- alkyl
- substituted
- alkoxy
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- NNQYLWZZECRXLT-OAHLLOKOSA-N O[C@H](Cc(cc1)ccc1Br)C(OCc1ccccc1)=O Chemical compound O[C@H](Cc(cc1)ccc1Br)C(OCc1ccccc1)=O NNQYLWZZECRXLT-OAHLLOKOSA-N 0.000 description 2
- NKJIYYDCYKUWNB-UHFFFAOYSA-N Brc(cc1)cnc1N1CCOCC1 Chemical compound Brc(cc1)cnc1N1CCOCC1 NKJIYYDCYKUWNB-UHFFFAOYSA-N 0.000 description 1
- 0 C*[C@@](CC(C)C)C(O[C@](C)C(OCc1ccccc1)=O)=O Chemical compound C*[C@@](CC(C)C)C(O[C@](C)C(OCc1ccccc1)=O)=O 0.000 description 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N C1NCCOC1 Chemical compound C1NCCOC1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
- YDLHWKNKFAPLAJ-QMMMGPOBSA-N CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O)=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O)=O)=O YDLHWKNKFAPLAJ-QMMMGPOBSA-N 0.000 description 1
- AXASDQQMFBCTSO-VQTJNVASSA-N CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(O)=O)=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(O)=O)=O)=O AXASDQQMFBCTSO-VQTJNVASSA-N 0.000 description 1
- DSXAVEWTGBOPRC-RRPNLBNLSA-N CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(OCc1ccccc1)=O)=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(OCc1ccccc1)=O)=O)=O DSXAVEWTGBOPRC-RRPNLBNLSA-N 0.000 description 1
- UGLPCXPIGBLEJV-YEOOOGFDSA-N CC(C)(C)OC(N(C)[C@@H](CC(C)([O]1[C@H](Cc(cc2)cc(F)c2C2=CCOCC2)C(OCc2ccccc2)=O)F)C1=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC(C)([O]1[C@H](Cc(cc2)cc(F)c2C2=CCOCC2)C(OCc2ccccc2)=O)F)C1=O)=O UGLPCXPIGBLEJV-YEOOOGFDSA-N 0.000 description 1
- YLAGHBFGSYSQND-VIFPVBQESA-N CC(C)(C)OC(N(C)[C@@H](CC1CC1)C(O)=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC1CC1)C(O)=O)=O YLAGHBFGSYSQND-VIFPVBQESA-N 0.000 description 1
- UZKQORCTKMSVSF-LEWJYISDSA-N CC(C)(C)OC(N(C)[C@@H](CC1CC1)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(O)=O)=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC1CC1)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(O)=O)=O)=O UZKQORCTKMSVSF-LEWJYISDSA-N 0.000 description 1
- FZLQFOZNGDFTIP-WUFINQPMSA-N CC(C)(C)OC(N(C)[C@@H](CC1CC1)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(OCc1ccccc1)=O)=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC1CC1)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(OCc1ccccc1)=O)=O)=O FZLQFOZNGDFTIP-WUFINQPMSA-N 0.000 description 1
- GKRRTFCDSZGFSZ-QMMMGPOBSA-N CC(C)(C)OC(N[C@@H](CC1CC1)C(O)=O)=O Chemical compound CC(C)(C)OC(N[C@@H](CC1CC1)C(O)=O)=O GKRRTFCDSZGFSZ-QMMMGPOBSA-N 0.000 description 1
- ICFGYUOQRWVQLG-AEFFLSMTSA-N CC(C)C[C@@H](C(O[C@H](C)C(OCc1ccccc1)=O)=O)N(C)C(OC(C)(C)C)=O Chemical compound CC(C)C[C@@H](C(O[C@H](C)C(OCc1ccccc1)=O)=O)N(C)C(OC(C)(C)C)=O ICFGYUOQRWVQLG-AEFFLSMTSA-N 0.000 description 1
- FXIJZOQWQFFENP-HIFRSBDPSA-N CC(C)C[C@@H](C(O[C@H](C)C(OCc1ccccc1)=O)=O)NC Chemical compound CC(C)C[C@@H](C(O[C@H](C)C(OCc1ccccc1)=O)=O)NC FXIJZOQWQFFENP-HIFRSBDPSA-N 0.000 description 1
- NLPREOAVJYMBKZ-CDMHEIPLSA-N CCC(C(C)F)[C@@H](C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(O)=O)=O)N(C)C(OC(C)(C)C)=O Chemical compound CCC(C(C)F)[C@@H](C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(O)=O)=O)N(C)C(OC(C)(C)C)=O NLPREOAVJYMBKZ-CDMHEIPLSA-N 0.000 description 1
- KYNLNERYAWYHOI-GXDHUFHOSA-N COC(/C(/O)=C\c(cc1)ccc1C1=CCOCC1)=O Chemical compound COC(/C(/O)=C\c(cc1)ccc1C1=CCOCC1)=O KYNLNERYAWYHOI-GXDHUFHOSA-N 0.000 description 1
- BYWCHBPJXQVZNN-UKOABYEESA-N C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1C1=CCOCC1)C(OCc1ccccc1)=O)=O)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O Chemical compound C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1C1=CCOCC1)C(OCc1ccccc1)=O)=O)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O BYWCHBPJXQVZNN-UKOABYEESA-N 0.000 description 1
- KLVWTTRCDRCFRQ-SWSTZQHCSA-N C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc1ccc(C2CCOCC2)cc1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(O)=O)=O)=O)=O)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)NC)=O)=O)=O Chemical compound C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc1ccc(C2CCOCC2)cc1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(O)=O)=O)=O)=O)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)NC)=O)=O)=O KLVWTTRCDRCFRQ-SWSTZQHCSA-N 0.000 description 1
- OOABBKNCZRUFJL-ZHUXWESOSA-N C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc1ccc(C2CCOCC2)cc1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(OCc1ccccc1)=O)=O)=O)=O)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)NC)=O)=O)=O Chemical compound C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc1ccc(C2CCOCC2)cc1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(OCc1ccccc1)=O)=O)=O)=O)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)NC)=O)=O)=O OOABBKNCZRUFJL-ZHUXWESOSA-N 0.000 description 1
- SUVITXLJQHJCCC-QGUKFAFCSA-N C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc1ccc(C2CCOCC2)cc1)C(O)=O)=O)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O Chemical compound C[C@H](C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc1ccc(C2CCOCC2)cc1)C(O)=O)=O)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O SUVITXLJQHJCCC-QGUKFAFCSA-N 0.000 description 1
- CFOGRAVBUPWOJP-MRVPVSSYSA-N C[C@H](C(O)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O Chemical compound C[C@H](C(O)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O CFOGRAVBUPWOJP-MRVPVSSYSA-N 0.000 description 1
- GRKWVQLSYHAEQL-CQSZACIVSA-N C[C@H](C(OCc1ccccc1)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC(C1(CC1)N(C)C(OC(C)(C)C)=O)=O GRKWVQLSYHAEQL-CQSZACIVSA-N 0.000 description 1
- GASSUHXGJJTYPK-JJVQHPENSA-N C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc(cc1)ccc1N1CCOCC1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc(cc1)ccc1N1CCOCC1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O GASSUHXGJJTYPK-JJVQHPENSA-N 0.000 description 1
- ANEULEDCQHRMBA-DOMZBBRYSA-N C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)NC)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)NC)=O ANEULEDCQHRMBA-DOMZBBRYSA-N 0.000 description 1
- PEAOEIWYQVXZMB-UHFFFAOYSA-N Clc(cc1)ncc1Br Chemical compound Clc(cc1)ncc1Br PEAOEIWYQVXZMB-UHFFFAOYSA-N 0.000 description 1
- KNQZVZHVJCIMTL-QMMMGPOBSA-N N[C@@H](Cc(cc1)cc(F)c1Br)C(O)=O Chemical compound N[C@@H](Cc(cc1)cc(F)c1Br)C(O)=O KNQZVZHVJCIMTL-QMMMGPOBSA-N 0.000 description 1
- QSKUTCRCDOEBKA-QMMMGPOBSA-N O[C@@H](Cc(cc1F)ccc1Br)C(O)=O Chemical compound O[C@@H](Cc(cc1F)ccc1Br)C(O)=O QSKUTCRCDOEBKA-QMMMGPOBSA-N 0.000 description 1
- AXBZSLGGZHZOFZ-FQEVSTJZSA-N O[C@@H](Cc1ccc(C2=CCOCC2)c(F)c1)C(OCc1ccccc1)=O Chemical compound O[C@@H](Cc1ccc(C2=CCOCC2)c(F)c1)C(OCc1ccccc1)=O AXBZSLGGZHZOFZ-FQEVSTJZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562272040P | 2015-12-28 | 2015-12-28 | |
| US62/272,040 | 2015-12-28 | ||
| PCT/US2016/066497 WO2017116702A1 (en) | 2015-12-28 | 2016-12-14 | Anthelmintic depsipeptide compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504050A JP2019504050A (ja) | 2019-02-14 |
| JP2019504050A5 JP2019504050A5 (enExample) | 2020-01-30 |
| JP6943859B2 true JP6943859B2 (ja) | 2021-10-06 |
Family
ID=57868331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018534122A Expired - Fee Related JP6943859B2 (ja) | 2015-12-28 | 2016-12-14 | 駆虫性デプシペプチド化合物 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10344056B2 (enExample) |
| EP (1) | EP3397638B1 (enExample) |
| JP (1) | JP6943859B2 (enExample) |
| KR (2) | KR20220003663A (enExample) |
| CN (1) | CN108699052B (enExample) |
| AR (1) | AR107249A1 (enExample) |
| AU (2) | AU2016380868B2 (enExample) |
| BR (1) | BR112018013369A2 (enExample) |
| CA (1) | CA3009867C (enExample) |
| CL (1) | CL2018001744A1 (enExample) |
| CO (1) | CO2018006527A2 (enExample) |
| HK (1) | HK1255391A1 (enExample) |
| HU (1) | HUE065907T2 (enExample) |
| IL (1) | IL260262B2 (enExample) |
| MX (1) | MX2018007948A (enExample) |
| MY (1) | MY194716A (enExample) |
| NZ (1) | NZ743913A (enExample) |
| PH (1) | PH12018501367B1 (enExample) |
| RU (2) | RU2020107484A (enExample) |
| SG (1) | SG11201805368YA (enExample) |
| TW (1) | TWI787165B (enExample) |
| UY (1) | UY37050A (enExample) |
| WO (1) | WO2017116702A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62130B1 (sr) * | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| EP3397638B1 (en) | 2015-12-28 | 2023-08-23 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| EP3579696B1 (en) | 2017-02-08 | 2023-06-28 | Boehringer Ingelheim Animal Health USA Inc. | In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm |
| EP3480195A1 (en) | 2017-11-07 | 2019-05-08 | Bayer Animal Health GmbH | Method for the synthesis of cyclic depsipeptides |
| PL3676265T3 (pl) | 2017-11-07 | 2025-12-15 | Elanco Animal Health Gmbh | Sposób syntezy cyklicznych depsypeptydów |
| RU2747149C9 (ru) * | 2017-11-29 | 2021-06-29 | ЗОЕТИС СЕРВИСИЗ ЭлЭлСи | Анти-эндопаразитарные депсипептиды |
| US11583545B2 (en) | 2018-02-08 | 2023-02-21 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| US20220071183A1 (en) | 2019-01-10 | 2022-03-10 | Zoetis Services Llc | Anthelmintic laboratory animal model for heartworm |
| KR20220002890A (ko) | 2019-03-19 | 2022-01-07 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물 |
| WO2021178834A1 (en) * | 2020-03-06 | 2021-09-10 | LifeMax Laboratories, Inc. | Topical pharmaceutical formulations of a cyclic depsipeptide |
| BR112022024156A2 (pt) | 2020-05-29 | 2023-02-14 | Boehringer Ingelheim Animal Health Usa Inc | Compostos heterocílicos antelmínticos |
| EP4262789A1 (en) | 2020-12-21 | 2023-10-25 | Boehringer Ingelheim Vetmedica GmbH | Parasiticidal collar comprising isoxazoline compounds |
| US12258193B2 (en) | 2022-02-17 | 2025-03-25 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
| WO2025057117A1 (en) * | 2023-09-15 | 2025-03-20 | Animol Discovery, Inc. | Antiparasitic cyclic depsipeptides |
| WO2025202940A2 (en) * | 2024-03-27 | 2025-10-02 | Animol Discovery, Inc. | Antiparasitic cyclic depsipeptides |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO176766C (no) | 1989-02-07 | 1995-05-24 | Meiji Seika Kaisha | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet |
| DK0634408T3 (da) | 1992-03-17 | 2002-04-22 | Fujisawa Pharmaceutical Co | Depsipeptidderivater, fremstilling og anvendelse deraf |
| CN1073560C (zh) | 1993-02-19 | 2001-10-24 | 明治制果株式会社 | 环缩酚酸肽pf1022衍生物 |
| DE4317457A1 (de) * | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| DE4317432A1 (de) | 1993-05-26 | 1994-12-01 | Bayer Ag | Octacyclodepsipeptide mit endoparasitizider Wirkung |
| EP0718293B1 (en) | 1993-09-06 | 2002-03-13 | Fujisawa Pharmaceutical Co., Ltd. | Cyclodepsipeptide compound |
| SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Astra Ab | Short-acting dihydropyridines |
| DE4400464A1 (de) | 1994-01-11 | 1995-07-13 | Bayer Ag | Endoparasitizide Mittel |
| DE4437198A1 (de) | 1994-10-18 | 1996-04-25 | Bayer Ag | Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden |
| DE19520275A1 (de) | 1995-06-02 | 1996-12-05 | Bayer Ag | Endoparasitizide Mittel |
| DE69634961T2 (de) * | 1995-09-22 | 2006-04-20 | Bayer Ag | Neue zyklische depsipeptid pf1022 derivate |
| DE69721055T2 (de) | 1996-10-07 | 2004-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Verfahren zur herstellung von depsipeptiden und zwischenprodukten davon |
| DE19713626A1 (de) | 1997-04-02 | 1998-10-08 | Bayer Ag | Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung |
| US6355615B1 (en) | 1997-06-04 | 2002-03-12 | Bayer Aktiengesellschaft | Desoxycyclodepsipeptides and their use for combatting endoparasites |
| DE19811559A1 (de) | 1998-03-17 | 1999-09-23 | Bayer Ag | Cyclooctadepsipeptide |
| DE19828043A1 (de) | 1998-06-24 | 1999-12-30 | Bayer Ag | Ektoparasitizide Mittel |
| DE19921887A1 (de) | 1999-05-12 | 2000-11-16 | Bayer Ag | Endoparasitizide Mittel |
| DE19962147A1 (de) | 1999-12-22 | 2001-06-28 | Bayer Ag | Schädlingsbekämpfungsmittel / PF 1022-221 |
| DE19962145A1 (de) | 1999-12-22 | 2001-06-28 | Bayer Ag | Schädlingsbekämpfungsmittel/Depsipeptide |
| DE10008128A1 (de) | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
| DE10031044A1 (de) | 2000-06-26 | 2002-01-03 | Bayer Ag | Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere |
| DE10104362A1 (de) | 2001-02-01 | 2002-08-08 | Bayer Ag | Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit |
| UY26592A1 (es) | 2001-02-20 | 2001-09-28 | Bayer Ag | Agentes endoparasiticidas |
| US6893652B2 (en) * | 2001-08-27 | 2005-05-17 | Wyeth | Endoparasiticidal gel composition |
| US20040236191A1 (en) | 2003-05-19 | 2004-11-25 | Poliska Steven A. | System and method for identifying and labeling livestock products, and managing data associated with those products |
| DE10358525A1 (de) | 2003-12-13 | 2005-07-07 | Bayer Healthcare Ag | Endoparasitizide Mittel zur topischen Applikation |
| ES2351972T3 (es) | 2004-02-27 | 2011-02-14 | Ic Services | Procedimiento y set para la identificación de animales. |
| DE102004055316A1 (de) | 2004-11-16 | 2006-05-18 | Bayer Healthcare Ag | Verhinderung vertikaler Endoparasiten-Infektionen |
| US20060202835A1 (en) | 2005-02-25 | 2006-09-14 | Osborne Industries, Inc. | Dual frequency identification device |
| DE102008022520A1 (de) | 2008-05-07 | 2009-11-12 | Bayer Animal Health Gmbh | Feste Arzneimittelformulierung mit verzögerter Freisetzung |
| DE102008030764A1 (de) | 2008-06-28 | 2009-12-31 | Bayer Animal Health Gmbh | Kombination von Amidin-Derivaten mit cyclischen Depsipeptiden |
| DE102008031284A1 (de) | 2008-07-02 | 2010-01-07 | Bayer Schering Pharma Aktiengesellschaft | Neue Bekämpfungsmöglichkeit der Giardiose |
| DE102008031283A1 (de) | 2008-07-02 | 2010-01-07 | Bayer Schering Pharma Aktiengesellschaft | Neue Bekämpfungsmöglichkeit von durch Trichomonadida hervorgerufenen Krankheiten |
| WO2010072323A1 (de) | 2008-12-16 | 2010-07-01 | Bayer Animal Health Gmbh | Verfahren zur herstellung milchsäure- und phenylmilchsäurehaltiger optisch aktiver, cyclischer depsipeptide mit 24 ringatomen mit hilfe von pilzstämmen der art rosellinia sowie weiteren gattungen xylariaceen |
| KR101002530B1 (ko) | 2009-02-18 | 2010-12-17 | 삼성에스디아이 주식회사 | 알에프아이디 통신 장치 |
| WO2011069995A1 (en) | 2009-12-11 | 2011-06-16 | Bayer Animal Health Gmbh | Novel 24-membered cyclooctadepsipeptides from fungal strains and their use as anthelmintics or endoparasiticides |
| WO2012028556A1 (en) | 2010-08-31 | 2012-03-08 | Bayer Animal Health Gmbh | Macrocyclic lactones and their use and their combinations with other active substances |
| WO2012065031A2 (en) | 2010-11-11 | 2012-05-18 | Mlp Technology Inc. | Animal data management |
| US9848290B2 (en) | 2011-03-10 | 2017-12-19 | Aruba Networks, Inc. | Location based computerized system and method thereof |
| KR101978620B1 (ko) | 2011-12-21 | 2019-08-28 | 바이엘 파마 악티엔게젤샤프트 | 무정형 에모뎁시드를 함유하는 제제 |
| CA2876387A1 (en) | 2012-06-13 | 2013-12-19 | Meiji Seika Pharma Co., Ltd. | Novel cyclic depsipeptide derivatives and harmful organism control agents comprising the same |
| US20140306005A1 (en) | 2013-04-14 | 2014-10-16 | Forever Yours, Inc. | Method for Data Transport and Recovery of Dependent Creatures |
| RS62130B1 (sr) | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| EP3397638B1 (en) | 2015-12-28 | 2023-08-23 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
-
2016
- 2016-12-14 EP EP16829348.8A patent/EP3397638B1/en active Active
- 2016-12-14 CA CA3009867A patent/CA3009867C/en active Active
- 2016-12-14 KR KR1020217043332A patent/KR20220003663A/ko not_active Abandoned
- 2016-12-14 RU RU2020107484A patent/RU2020107484A/ru unknown
- 2016-12-14 JP JP2018534122A patent/JP6943859B2/ja not_active Expired - Fee Related
- 2016-12-14 CN CN201680082548.2A patent/CN108699052B/zh not_active Expired - Fee Related
- 2016-12-14 WO PCT/US2016/066497 patent/WO2017116702A1/en not_active Ceased
- 2016-12-14 AU AU2016380868A patent/AU2016380868B2/en not_active Ceased
- 2016-12-14 NZ NZ743913A patent/NZ743913A/en not_active IP Right Cessation
- 2016-12-14 HU HUE16829348A patent/HUE065907T2/hu unknown
- 2016-12-14 BR BR112018013369-8A patent/BR112018013369A2/pt not_active Application Discontinuation
- 2016-12-14 MY MYPI2018001112A patent/MY194716A/en unknown
- 2016-12-14 HK HK18114530.8A patent/HK1255391A1/zh unknown
- 2016-12-14 PH PH1/2018/501367A patent/PH12018501367B1/en unknown
- 2016-12-14 MX MX2018007948A patent/MX2018007948A/es unknown
- 2016-12-14 KR KR1020187021726A patent/KR102427124B1/ko not_active Expired - Fee Related
- 2016-12-14 SG SG11201805368YA patent/SG11201805368YA/en unknown
- 2016-12-14 US US15/378,219 patent/US10344056B2/en active Active
- 2016-12-14 RU RU2018127195A patent/RU2715556C2/ru active
- 2016-12-26 UY UY0001037050A patent/UY37050A/es not_active Application Discontinuation
- 2016-12-28 TW TW105143547A patent/TWI787165B/zh not_active IP Right Cessation
- 2016-12-28 AR ARP160104061A patent/AR107249A1/es not_active Application Discontinuation
-
2018
- 2018-06-25 CO CONC2018/0006527A patent/CO2018006527A2/es unknown
- 2018-06-25 CL CL2018001744A patent/CL2018001744A1/es unknown
- 2018-06-25 IL IL260262A patent/IL260262B2/en unknown
-
2019
- 2019-04-23 US US16/392,412 patent/US11230571B2/en active Active
-
2020
- 2020-02-06 AU AU2020200854A patent/AU2020200854B2/en not_active Ceased
-
2021
- 2021-12-08 US US17/643,251 patent/US12018048B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI787165B (zh) | 驅蟲酯肽化合物 | |
| JP7045191B2 (ja) | 駆虫性デプシペプチド化合物 | |
| CN113825543B (zh) | 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物 | |
| CN112996788B (zh) | 驱蠕虫的杂环化合物 | |
| JP2020504710A (ja) | 駆虫性デプシペプチド化合物 | |
| RU2798093C2 (ru) | Противогельминтные гетероциклические соединения | |
| BR112021000257B1 (pt) | Compostos heterocíclicos anti-helmínticos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191216 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191216 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20200107 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20201126 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201130 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210301 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210428 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210531 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210810 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210909 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6943859 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |