CN108699052B - 驱虫缩酚酸肽化合物 - Google Patents

驱虫缩酚酸肽化合物 Download PDF

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Publication number
CN108699052B
CN108699052B CN201680082548.2A CN201680082548A CN108699052B CN 108699052 B CN108699052 B CN 108699052B CN 201680082548 A CN201680082548 A CN 201680082548A CN 108699052 B CN108699052 B CN 108699052B
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CN
China
Prior art keywords
independently
substituted
alkyl
haloalkyl
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201680082548.2A
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English (en)
Chinese (zh)
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CN108699052A (zh
Inventor
L·勒伊德法洛斯
G·帕考斯基
A·龙
C·孟
H·I·李
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Boehringer Ingelheim Animal Health USA Inc
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Merial Inc
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201680082548.2A 2015-12-28 2016-12-14 驱虫缩酚酸肽化合物 Expired - Fee Related CN108699052B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562272040P 2015-12-28 2015-12-28
US62/272,040 2015-12-28
PCT/US2016/066497 WO2017116702A1 (en) 2015-12-28 2016-12-14 Anthelmintic depsipeptide compounds

Publications (2)

Publication Number Publication Date
CN108699052A CN108699052A (zh) 2018-10-23
CN108699052B true CN108699052B (zh) 2022-04-29

Family

ID=57868331

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680082548.2A Expired - Fee Related CN108699052B (zh) 2015-12-28 2016-12-14 驱虫缩酚酸肽化合物

Country Status (23)

Country Link
US (3) US10344056B2 (enExample)
EP (1) EP3397638B1 (enExample)
JP (1) JP6943859B2 (enExample)
KR (2) KR20220003663A (enExample)
CN (1) CN108699052B (enExample)
AR (1) AR107249A1 (enExample)
AU (2) AU2016380868B2 (enExample)
BR (1) BR112018013369A2 (enExample)
CA (1) CA3009867C (enExample)
CL (1) CL2018001744A1 (enExample)
CO (1) CO2018006527A2 (enExample)
HK (1) HK1255391A1 (enExample)
HU (1) HUE065907T2 (enExample)
IL (1) IL260262B2 (enExample)
MX (1) MX2018007948A (enExample)
MY (1) MY194716A (enExample)
NZ (1) NZ743913A (enExample)
PH (1) PH12018501367B1 (enExample)
RU (2) RU2020107484A (enExample)
SG (1) SG11201805368YA (enExample)
TW (1) TWI787165B (enExample)
UY (1) UY37050A (enExample)
WO (1) WO2017116702A1 (enExample)

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RS62130B1 (sr) * 2015-05-20 2021-08-31 Boehringer Ingelheim Animal Health Usa Inc Antihelmintička depsipeptidna jedinjenja
EP3397638B1 (en) 2015-12-28 2023-08-23 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
BR112019009977A2 (pt) 2016-11-16 2019-08-27 Boehringer Ingelheim Animal Health Usa Inc compostos depsipeptídicos anti-helmínticos
EP3579696B1 (en) 2017-02-08 2023-06-28 Boehringer Ingelheim Animal Health USA Inc. In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm
EP3480195A1 (en) 2017-11-07 2019-05-08 Bayer Animal Health GmbH Method for the synthesis of cyclic depsipeptides
PL3676265T3 (pl) 2017-11-07 2025-12-15 Elanco Animal Health Gmbh Sposób syntezy cyklicznych depsypeptydów
RU2747149C9 (ru) * 2017-11-29 2021-06-29 ЗОЕТИС СЕРВИСИЗ ЭлЭлСи Анти-эндопаразитарные депсипептиды
US11583545B2 (en) 2018-02-08 2023-02-21 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
US20220071183A1 (en) 2019-01-10 2022-03-10 Zoetis Services Llc Anthelmintic laboratory animal model for heartworm
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
WO2021178834A1 (en) * 2020-03-06 2021-09-10 LifeMax Laboratories, Inc. Topical pharmaceutical formulations of a cyclic depsipeptide
BR112022024156A2 (pt) 2020-05-29 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Compostos heterocílicos antelmínticos
EP4262789A1 (en) 2020-12-21 2023-10-25 Boehringer Ingelheim Vetmedica GmbH Parasiticidal collar comprising isoxazoline compounds
US12258193B2 (en) 2022-02-17 2025-03-25 Boehringer Ingelheim Vetmedica Gmbh Method and system for providing a fluid product mailer
WO2025057117A1 (en) * 2023-09-15 2025-03-20 Animol Discovery, Inc. Antiparasitic cyclic depsipeptides
WO2025202940A2 (en) * 2024-03-27 2025-10-02 Animol Discovery, Inc. Antiparasitic cyclic depsipeptides

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CN1121429A (zh) * 1994-01-11 1996-05-01 拜尔公司 杀体内寄生虫组合物
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Also Published As

Publication number Publication date
RU2018127195A (ru) 2020-01-30
EP3397638A1 (en) 2018-11-07
IL260262A (en) 2018-07-31
RU2018127195A3 (enExample) 2020-01-30
US20170233438A1 (en) 2017-08-17
NZ743913A (en) 2019-04-26
TWI787165B (zh) 2022-12-21
US20190248840A1 (en) 2019-08-15
JP6943859B2 (ja) 2021-10-06
CO2018006527A2 (es) 2018-07-10
MY194716A (en) 2022-12-15
TW201726670A (zh) 2017-08-01
AU2016380868B2 (en) 2019-11-28
JP2019504050A (ja) 2019-02-14
CA3009867A1 (en) 2017-07-06
AR107249A1 (es) 2018-04-11
KR20220003663A (ko) 2022-01-10
UY37050A (es) 2017-07-31
KR102427124B1 (ko) 2022-07-28
HUE065907T2 (hu) 2024-06-28
CN108699052A (zh) 2018-10-23
CL2018001744A1 (es) 2018-08-17
EP3397638B1 (en) 2023-08-23
SG11201805368YA (en) 2018-07-30
US12018048B2 (en) 2024-06-25
HK1255391A1 (zh) 2019-08-16
RU2020107484A (ru) 2020-03-19
AU2016380868A1 (en) 2018-07-19
MX2018007948A (es) 2018-08-01
KR20180100349A (ko) 2018-09-10
CA3009867C (en) 2022-05-31
IL260262B2 (en) 2023-06-01
AU2020200854A1 (en) 2020-02-27
US10344056B2 (en) 2019-07-09
US11230571B2 (en) 2022-01-25
RU2715556C2 (ru) 2020-03-02
BR112018013369A2 (pt) 2019-02-19
US20220098241A1 (en) 2022-03-31
WO2017116702A1 (en) 2017-07-06
AU2020200854B2 (en) 2021-08-05
PH12018501367B1 (en) 2022-10-21
PH12018501367A1 (en) 2019-02-27

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