AU2016380868B2 - Anthelmintic depsipeptide compounds - Google Patents
Anthelmintic depsipeptide compounds Download PDFInfo
- Publication number
- AU2016380868B2 AU2016380868B2 AU2016380868A AU2016380868A AU2016380868B2 AU 2016380868 B2 AU2016380868 B2 AU 2016380868B2 AU 2016380868 A AU2016380868 A AU 2016380868A AU 2016380868 A AU2016380868 A AU 2016380868A AU 2016380868 B2 AU2016380868 B2 AU 2016380868B2
- Authority
- AU
- Australia
- Prior art keywords
- independently
- substituted
- alkyl
- halogen
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *c1ccc(C2CCCCC2)c(F)c1 Chemical compound *c1ccc(C2CCCCC2)c(F)c1 0.000 description 6
- NKJIYYDCYKUWNB-UHFFFAOYSA-N Brc(cc1)cnc1N1CCOCC1 Chemical compound Brc(cc1)cnc1N1CCOCC1 NKJIYYDCYKUWNB-UHFFFAOYSA-N 0.000 description 1
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- YDLHWKNKFAPLAJ-QMMMGPOBSA-N CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O)=O)=O Chemical compound CC(C)(C)OC(N(C)[C@@H](CC(C)(C)F)C(O)=O)=O YDLHWKNKFAPLAJ-QMMMGPOBSA-N 0.000 description 1
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- OOARETDJDBXCHZ-MZVOZVGYSA-N C[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O Chemical compound C[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(N(C)[C@@H](CC(C)(C)F)C(O[C@H](Cc(cc1)ccc1N1CCOCC1)C(N(C)[C@@H](CC1CC1)C(O[C@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O OOARETDJDBXCHZ-MZVOZVGYSA-N 0.000 description 1
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- JKWHLDTZYUJNJD-KZNIJNHCSA-N C[C@H](C(O)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O Chemical compound C[C@H](C(O)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O JKWHLDTZYUJNJD-KZNIJNHCSA-N 0.000 description 1
- JCPKJNMYUQPNKH-WATUZKQISA-N C[C@H](C(OC)=O)OC(C(C1)(C1C1CC1)N(C)C(C(C1)(C1c(cc1)ccc1N1CCOCC1)OC([C@H](CC1CC1)N(C)C(OC(C)(C)C)=O)=O)=O)=O Chemical compound C[C@H](C(OC)=O)OC(C(C1)(C1C1CC1)N(C)C(C(C1)(C1c(cc1)ccc1N1CCOCC1)OC([C@H](CC1CC1)N(C)C(OC(C)(C)C)=O)=O)=O)=O JCPKJNMYUQPNKH-WATUZKQISA-N 0.000 description 1
- JQCNATSXTYQWQI-UZSZOTKDSA-N C[C@H](C(OCc1ccccc1)=O)OC(C(C1)(C1C1CC1)N(C)C([C@@H](Cc(cc1)ccc1N1CCOCC1)OC([C@H](CC1CC1)N(C)C(OC(C)(C)C)=O)=O)=O)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC(C(C1)(C1C1CC1)N(C)C([C@@H](Cc(cc1)ccc1N1CCOCC1)OC([C@H](CC1CC1)N(C)C(OC(C)(C)C)=O)=O)=O)=O JQCNATSXTYQWQI-UZSZOTKDSA-N 0.000 description 1
- GASSUHXGJJTYPK-JJVQHPENSA-N C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc(cc1)ccc1N1CCOCC1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc(cc1)ccc1N1CCOCC1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O GASSUHXGJJTYPK-JJVQHPENSA-N 0.000 description 1
- XKSKGWHVYTUDJO-SDINPPEVSA-N C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)N(C)C(OC(C)(C)C)=O)=O)=O)=O XKSKGWHVYTUDJO-SDINPPEVSA-N 0.000 description 1
- XURXWRNJWFQGRL-JMHOIKKCSA-N C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)NC)=O)=O)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)N(C)C([C@@H](Cc1ccc(C2CCOCC2)cc1)OC([C@H](CC(C)(C)F)NC)=O)=O)=O XURXWRNJWFQGRL-JMHOIKKCSA-N 0.000 description 1
- ANEULEDCQHRMBA-DOMZBBRYSA-N C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)NC)=O Chemical compound C[C@H](C(OCc1ccccc1)=O)OC([C@H](CC1CC1)NC)=O ANEULEDCQHRMBA-DOMZBBRYSA-N 0.000 description 1
- BUONKDJXGIAJFU-DUXPYHPUSA-N OC(/C=C/c(cc1)cnc1N1CCOCC1)=O Chemical compound OC(/C=C/c(cc1)cnc1N1CCOCC1)=O BUONKDJXGIAJFU-DUXPYHPUSA-N 0.000 description 1
- KJUIRRYTDUIEDH-HXUWFJFHSA-N O[C@H](Cc1cc(F)c(C2CCOCC2)cc1)C(OCc1ccccc1)=O Chemical compound O[C@H](Cc1cc(F)c(C2CCOCC2)cc1)C(OCc1ccccc1)=O KJUIRRYTDUIEDH-HXUWFJFHSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2020200854A AU2020200854B2 (en) | 2015-12-28 | 2020-02-06 | Anthelmintic depsipeptide compounds |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562272040P | 2015-12-28 | 2015-12-28 | |
| US62/272,040 | 2015-12-28 | ||
| PCT/US2016/066497 WO2017116702A1 (en) | 2015-12-28 | 2016-12-14 | Anthelmintic depsipeptide compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020200854A Division AU2020200854B2 (en) | 2015-12-28 | 2020-02-06 | Anthelmintic depsipeptide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2016380868A1 AU2016380868A1 (en) | 2018-07-19 |
| AU2016380868B2 true AU2016380868B2 (en) | 2019-11-28 |
Family
ID=57868331
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016380868A Ceased AU2016380868B2 (en) | 2015-12-28 | 2016-12-14 | Anthelmintic depsipeptide compounds |
| AU2020200854A Ceased AU2020200854B2 (en) | 2015-12-28 | 2020-02-06 | Anthelmintic depsipeptide compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020200854A Ceased AU2020200854B2 (en) | 2015-12-28 | 2020-02-06 | Anthelmintic depsipeptide compounds |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10344056B2 (enExample) |
| EP (1) | EP3397638B1 (enExample) |
| JP (1) | JP6943859B2 (enExample) |
| KR (2) | KR20220003663A (enExample) |
| CN (1) | CN108699052B (enExample) |
| AR (1) | AR107249A1 (enExample) |
| AU (2) | AU2016380868B2 (enExample) |
| BR (1) | BR112018013369A2 (enExample) |
| CA (1) | CA3009867C (enExample) |
| CL (1) | CL2018001744A1 (enExample) |
| CO (1) | CO2018006527A2 (enExample) |
| HK (1) | HK1255391A1 (enExample) |
| HU (1) | HUE065907T2 (enExample) |
| IL (1) | IL260262B2 (enExample) |
| MX (1) | MX2018007948A (enExample) |
| MY (1) | MY194716A (enExample) |
| NZ (1) | NZ743913A (enExample) |
| PH (1) | PH12018501367B1 (enExample) |
| RU (2) | RU2020107484A (enExample) |
| SG (1) | SG11201805368YA (enExample) |
| TW (1) | TWI787165B (enExample) |
| UY (1) | UY37050A (enExample) |
| WO (1) | WO2017116702A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62130B1 (sr) * | 2015-05-20 | 2021-08-31 | Boehringer Ingelheim Animal Health Usa Inc | Antihelmintička depsipeptidna jedinjenja |
| EP3397638B1 (en) | 2015-12-28 | 2023-08-23 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| BR112019009977A2 (pt) | 2016-11-16 | 2019-08-27 | Boehringer Ingelheim Animal Health Usa Inc | compostos depsipeptídicos anti-helmínticos |
| EP3579696B1 (en) | 2017-02-08 | 2023-06-28 | Boehringer Ingelheim Animal Health USA Inc. | In vivo model for parasitic worm infection and methods for evaluating antiparasitic compounds, including compounds active against canine heartworm |
| EP3480195A1 (en) | 2017-11-07 | 2019-05-08 | Bayer Animal Health GmbH | Method for the synthesis of cyclic depsipeptides |
| PL3676265T3 (pl) | 2017-11-07 | 2025-12-15 | Elanco Animal Health Gmbh | Sposób syntezy cyklicznych depsypeptydów |
| RU2747149C9 (ru) * | 2017-11-29 | 2021-06-29 | ЗОЕТИС СЕРВИСИЗ ЭлЭлСи | Анти-эндопаразитарные депсипептиды |
| US11583545B2 (en) | 2018-02-08 | 2023-02-21 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
| US20220071183A1 (en) | 2019-01-10 | 2022-03-10 | Zoetis Services Llc | Anthelmintic laboratory animal model for heartworm |
| KR20220002890A (ko) | 2019-03-19 | 2022-01-07 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물 |
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