JP6896839B2 - 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる - Google Patents

腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる Download PDF

Info

Publication number
JP6896839B2
JP6896839B2 JP2019502289A JP2019502289A JP6896839B2 JP 6896839 B2 JP6896839 B2 JP 6896839B2 JP 2019502289 A JP2019502289 A JP 2019502289A JP 2019502289 A JP2019502289 A JP 2019502289A JP 6896839 B2 JP6896839 B2 JP 6896839B2
Authority
JP
Japan
Prior art keywords
frequency
amplitude
electric field
time interval
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019502289A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019510606A5 (https=
JP2019510606A (ja
Inventor
ローザ・シュナイダーマン
モシェ・ギラディ
Original Assignee
ノボキュア ゲーエムベーハー
ノボキュア ゲーエムベーハー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノボキュア ゲーエムベーハー, ノボキュア ゲーエムベーハー filed Critical ノボキュア ゲーエムベーハー
Publication of JP2019510606A publication Critical patent/JP2019510606A/ja
Publication of JP2019510606A5 publication Critical patent/JP2019510606A5/ja
Priority to JP2021095883A priority Critical patent/JP7171827B2/ja
Application granted granted Critical
Publication of JP6896839B2 publication Critical patent/JP6896839B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Program-control systems
    • G05B19/02—Program-control systems electric
    • G05B19/04—Program control other than numerical control, i.e. in sequence controllers or logic controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019502289A 2016-04-04 2017-04-04 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる Active JP6896839B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021095883A JP7171827B2 (ja) 2016-04-04 2021-06-08 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317985P 2016-04-04 2016-04-04
US62/317,985 2016-04-04
PCT/IB2017/051898 WO2017175116A1 (en) 2016-04-04 2017-04-04 Reducing motility of cancer cells using tumor treating fields (ttfields)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021095883A Division JP7171827B2 (ja) 2016-04-04 2021-06-08 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる

Publications (3)

Publication Number Publication Date
JP2019510606A JP2019510606A (ja) 2019-04-18
JP2019510606A5 JP2019510606A5 (https=) 2020-05-07
JP6896839B2 true JP6896839B2 (ja) 2021-06-30

Family

ID=58530601

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019502289A Active JP6896839B2 (ja) 2016-04-04 2017-04-04 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる
JP2021095883A Active JP7171827B2 (ja) 2016-04-04 2021-06-08 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021095883A Active JP7171827B2 (ja) 2016-04-04 2021-06-08 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる

Country Status (12)

Country Link
US (2) US10821283B2 (https=)
EP (3) EP3439733B1 (https=)
JP (2) JP6896839B2 (https=)
KR (1) KR102430229B1 (https=)
CN (2) CN109475735B (https=)
CA (1) CA3019474A1 (https=)
DK (1) DK3439733T3 (https=)
ES (1) ES2779990T3 (https=)
HU (1) HUE048646T2 (https=)
PL (1) PL3439733T3 (https=)
PT (1) PT3439733T (https=)
WO (1) WO2017175116A1 (https=)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) * 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
EP3474760B1 (en) 2016-06-27 2023-01-11 Galvanize Therapeutics, Inc. Generator and a catheter with an electrode for treating a lung passageway
JP6980706B2 (ja) 2016-06-30 2021-12-15 ノボキュア ゲーエムベーハー 身体への腫瘍治療電場の長手方向伝達用のアレイ
EP3571503B1 (en) 2017-01-19 2026-04-15 Novocure GmbH System for viewing cell cultures under a microscope whilst applying ttfields
US11338135B2 (en) 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
US12403306B2 (en) * 2017-10-23 2025-09-02 Cardiac Pacemakers, Inc. Electric field shaping leads for treatment of cancer
US20190117969A1 (en) * 2017-10-23 2019-04-25 Cardiac Pacemakers, Inc. Medical devices for treatment of cancer with electric fields
EP3710102A4 (en) * 2017-11-17 2021-08-04 AbbVie Inc. METHOD OF TREATMENT OF GLIOBLASTOMA
DK3731771T3 (da) 2017-12-26 2023-08-28 Galvanize Therapeutics Inc V462033dk00
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
JP7139448B2 (ja) 2018-04-09 2022-09-20 ノボキュア ゲーエムベーハー ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療
PL3775956T3 (pl) 2018-04-10 2022-10-10 Novocure Gmbh Szacunki przewodności ac o niskiej częstotliwości (< 1 mhz) pozyskane z dwóch obrazów mri o różnych czasach repetycji
CN114082099A (zh) * 2018-07-03 2022-02-25 埃德温·阊 使用交变电场提高细胞膜通透性
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
CA3103070C (en) * 2018-07-10 2024-01-09 Novocure Gmbh Inhibiting viral infection using alternating electric fields
BR112020025269A2 (pt) 2018-07-18 2021-03-09 Novocure Gmbh Uso de densidade de perda de energia e medidas relacionadas para quantificar a dose dos campos de tratamento de tumor (ttfields)
JP6974671B2 (ja) * 2018-08-23 2021-12-01 ノボキュア ゲーエムベーハー 血液脳関門の透過性を向上させるための交流電界の使用
WO2020047285A1 (en) 2018-08-29 2020-03-05 Regents Of The University Of Minnesota Devices and methods for treatment of tumors using electromagnetic signal
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
WO2020049482A1 (en) * 2018-09-07 2020-03-12 Yaniv Alon Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
CN112930209B (zh) 2018-10-15 2024-10-15 诺沃库勒有限责任公司 生成遍及大脑具有高均匀性的肿瘤治疗场(ttfields)的装置和方法
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達
WO2020102312A1 (en) 2018-11-13 2020-05-22 The Methodist Hospital Method and apparatus for oncomagnetic treatement
WO2020104921A1 (en) 2018-11-19 2020-05-28 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
CN113164745B (zh) 2018-11-29 2024-04-26 诺沃库勒有限责任公司 用于递送TTField（肿瘤治疗场）的增强灵活性换能器阵列
JP7246486B2 (ja) 2019-01-08 2023-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価
CN113573774B (zh) * 2019-02-26 2026-03-06 诺沃库勒有限责任公司 基于靶向癌细胞的电特性确定TTfield治疗的频率
JP2022522936A (ja) 2019-02-27 2022-04-21 ノボキュア ゲーエムベーハー 埋込可能な変換器アレイを使用した腫瘍治療電場（ｔｔｆｉｅｌｄｓ）の送達
EP3988099B1 (en) 2019-03-29 2023-06-07 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
CN111803792A (zh) * 2019-04-12 2020-10-23 上海必修福企业管理有限公司 空间电场的发生装置
US11291837B2 (en) 2019-04-17 2022-04-05 Novocure Gmbh Uploading data from an isolated system without compromising isolation
CN118203401A (zh) 2019-04-18 2024-06-18 盖能适治疗股份有限公司 用于治疗异常组织的装置、系统和方法
CN113727753B (zh) 2019-04-22 2024-09-13 波士顿科学国际有限公司 用于癌症治疗的电刺激装置
WO2020219337A1 (en) * 2019-04-22 2020-10-29 Boston Scientific Scimed, Inc. Systems for administering electrical stimulation to treat cancer
US12109412B2 (en) 2019-04-22 2024-10-08 Boston Scientific Scimed, Inc. Combination electrical and chemotherapeutic treatment of cancer
US11712561B2 (en) 2019-04-23 2023-08-01 Boston Scientific Scimed, Inc. Electrical stimulation with thermal treatment or thermal monitoring
US11607542B2 (en) 2019-04-23 2023-03-21 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
WO2020219519A1 (en) 2019-04-23 2020-10-29 Boston Scientific Scimed, Inc. Electrodes for electrical stimulation to treat cancer
EP3998973A4 (en) 2019-07-16 2023-07-26 Galvanize Therapeutics, Inc. TREATMENT OF THE REPRODUCTIVE TRACT WITH PULSED ELECTRIC FIELDS
JP7472264B2 (ja) 2019-07-31 2024-04-22 ノボキュア ゲーエムベーハー 頭蓋骨インプラントに埋め込まれた電極による腫瘍治療電場（ｔｔフィールド）の印加
US12343336B2 (en) 2019-08-05 2025-07-01 Novocure Gmbh Increasing cancer cells' sensitivity to tumor treating fields (TTFields) by inhibiting IL11 activity
JP2022545794A (ja) * 2019-08-30 2022-10-31 ノボキュア ゲーエムベーハー 頸部への腫瘍治療電界（ＴＴＦｉｅｌｄｓ）の印加
US12458709B2 (en) * 2019-12-11 2025-11-04 Novocure Gmbh Compositions and methods for imaging a cell
US20210199640A1 (en) * 2019-12-26 2021-07-01 The Board of Trustees of the Leland Stanford Junior Unviersity Methods of Normalizing Aberrant Glycolytic Metabolism in Cancer Cells
US20230147250A1 (en) * 2019-12-31 2023-05-11 Novocure Gmbh Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy
MX2022006136A (es) 2019-12-31 2022-06-17 Novocure Gmbh Matrices para suministrar campos de tratamiento de tumores (ttfields) con elementos de electrodos y sensores de temperatura accesibles individualmente.
US12121739B2 (en) 2019-12-31 2024-10-22 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
JP7670721B6 (ja) 2019-12-31 2025-06-06 ノボキュア ゲーエムベーハー 振幅調整およびチャネルの切り替え中のスパイクを防止する高電圧、高効率正弦波発生器
CN115515674A (zh) 2020-02-24 2022-12-23 波士顿科学国际有限公司 用于治疗胰腺癌的系统和方法
WO2021198864A1 (en) 2020-03-30 2021-10-07 Novocure Gmbh Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases
KR102644003B1 (ko) 2020-04-01 2024-03-07 한국전자통신연구원 암 치료 장치
MX2022010015A (es) * 2020-04-24 2022-09-05 Novocure Gmbh Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica.
JP7785693B2 (ja) * 2020-05-08 2025-12-15 ノボキュア ゲーエムベーハー 多能性幹細胞に交流電場を印加する組成物及び方法
KR102464313B1 (ko) * 2020-05-18 2022-11-08 주식회사 필드큐어 전기장 암 치료 시스템을 위한 품질 보증 장치 및 방법
WO2021257967A1 (en) 2020-06-19 2021-12-23 The Methodist Hospital Dba Houston Methodist Hospital Method and apparatus for oncomagnetic treatment
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
CA3178883A1 (en) * 2020-06-30 2022-01-06 Novocure Gmbh Flexible transducer arrays with a polymer insulating layer for applying tumor treating fields (ttfields)
EP4213933A1 (en) * 2020-09-18 2023-07-26 Novocure Gmbh Methods and compositions for treating coronavirus
WO2022064339A1 (en) 2020-09-25 2022-03-31 Novocure Gmbh Varying the metallization area on individual electrode elements in a tumor treating fields (ttfields) system to maximize current without overheating
JP7145280B2 (ja) * 2020-10-13 2022-09-30 Ｔｖｓ Ｒｅｇｚａ株式会社 送受信方法
KR102519139B1 (ko) 2020-11-25 2023-04-25 주식회사 필드큐어 회전하는 교류 전기장을 이용한 전기장 인가 장치 및 방법
EP4282465B1 (en) * 2020-12-21 2025-07-23 Novocure GmbH Optimization of composite electrode
CN112553075A (zh) * 2020-12-28 2021-03-26 湖南安泰康成生物科技有限公司 一种用敏感频率电场抑制肿瘤细胞快速生长的方法及装置
US12161876B2 (en) * 2020-12-30 2024-12-10 Novocure Gmbh Amplitude modulation for tumor treating fields
WO2022147153A1 (en) * 2020-12-30 2022-07-07 Novocure Gmbh Amplitude modulation for tumor treating fields
IT202100000119A1 (it) * 2021-01-05 2022-07-05 Telea Electronic Eng Srl Dispositivo e farmaco antitumorale per il trattamento di cellule neoplastiche
WO2022167939A1 (en) * 2021-02-03 2022-08-11 Novocure Gmbh Varying parameters of tumor treating fields (ttfields) treatment to overcome treatment resistance
EP4043071A1 (en) * 2021-02-12 2022-08-17 Scientia Biotech S.L. Non-invasive cancer treatment
US12397151B2 (en) 2021-02-17 2025-08-26 Novocure Gmbh Arrays for delivering tumor treating fields (TTFields) with sets of electrode elements having individually adjustable active areas
JP2024509964A (ja) 2021-03-12 2024-03-05 ノボキュア ゲーエムベーハー 交流電界を用いてマクロファージの表現型をスキューイングすることによる、疾患を処置する方法
JP2024510812A (ja) * 2021-03-23 2024-03-11 ノボキュア ゲーエムベーハー 被験者の身体に腫瘍治療電場を送達するための変換器装置
JP2024513854A (ja) 2021-03-31 2024-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）システムの電極を使用したインピーダンス断層撮影法
TWI905187B (zh) * 2021-05-11 2025-11-21 瑞士商諾萬可有限公司 用於治療子宮外孕的交變電場
WO2022271769A1 (en) * 2021-06-22 2022-12-29 Lifebridge Innovations, Pbc Apparatus and method for improving electric field therapy to reduce solid tumors
EP4363039A2 (en) * 2021-06-30 2024-05-08 Novocure GmbH Methods of treating cancer with alternating electric fields, checkpoint inhibitors, and combination chemotherapy
KR20240027008A (ko) 2021-06-30 2024-02-29 노보큐어 게엠베하 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용
US12599765B2 (en) 2021-12-14 2026-04-14 Novocure Gmbh Shifting of transducer array to reduce skin irritation
WO2023126842A1 (en) 2021-12-29 2023-07-06 Novocure Gmbh Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes
JP2024545019A (ja) 2021-12-30 2024-12-05 ノボキュア ゲーエムベーハー 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択
CA3255022A1 (en) * 2022-03-30 2023-10-05 Novocure Gmbh USE OF INTERLACED COOLING PERIODS TO INCREASE THE MAXIMUM INTENSITY OF TUMOR TREATMENT FIELDS
IL314392A (en) 2022-03-30 2024-09-01 Novocure Gmbh Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together
US20230310854A1 (en) * 2022-03-31 2023-10-05 Novocure Gmbh Alternating electric field waveform for electrosensation reduction
WO2023193012A2 (en) 2022-04-01 2023-10-05 The Board Of Regents Of The University Of Texas System Methods and apparatus for applying tumor treating fields combined with personalized ultra-fractionated stereotactic adaptive radiotherapy
KR102853607B1 (ko) * 2022-10-25 2025-09-03 주식회사 필드큐어 전기장 전달 시스템 및 방법
WO2024090939A1 (ko) * 2022-10-25 2024-05-02 주식회사 필드큐어 전기장 전달 시스템 및 방법
US12268863B2 (en) 2023-02-06 2025-04-08 Novocure Gmbh Shiftable transducer array with anisotropic material layer
GB2631521A (en) * 2023-07-05 2025-01-08 Qv Bioelectronics Ltd Electric field therapy
CN121925295A (zh) 2023-09-29 2026-04-24 诺沃库勒有限责任公司 使用振幅和频率的交错变化来改善用交变电场进行治疗期间的电感觉
WO2026062559A1 (en) * 2024-09-20 2026-03-26 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields (ttfields) and interferon gamma

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
CN1416466A (zh) 2000-02-17 2003-05-07 约朗姆·帕尔蒂 破坏正在分裂的细胞的方法和装置
US7805201B2 (en) 2000-02-17 2010-09-28 Standen Ltd. Treating a tumor or the like with an electric field
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7016725B2 (en) * 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US6546290B1 (en) 2000-04-12 2003-04-08 Roamitron Holding S.A. Method and apparatus for electromedical therapy
US6904322B2 (en) 2002-02-15 2005-06-07 Kalaco Scientific, Inc. Transcranial electrostimulation apparatus and method
DE602005020504D1 (de) 2004-12-07 2010-05-20 Standen Ltd Vivo über einen längeren zeitraum
CA2594231C (en) * 2004-12-27 2016-04-19 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US20060173493A1 (en) 2005-01-28 2006-08-03 Cyberonics, Inc. Multi-phasic signal for stimulation by an implantable device
CN101321555B (zh) * 2005-10-03 2020-12-08 诺沃库勒有限责任公司 优化电场特征以增加电场在增殖细胞上的效果
US8019414B2 (en) * 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
DK2167194T3 (en) 2007-03-06 2017-06-19 Novocure Ltd TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY
EP2183024B1 (en) 2007-08-14 2019-05-15 Novocure Ltd. Treating parasites with electric fields
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US20190117963A1 (en) 2014-07-25 2019-04-25 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US9833617B2 (en) 2014-07-25 2017-12-05 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
JP6980706B2 (ja) 2016-06-30 2021-12-15 ノボキュア ゲーエムベーハー 身体への腫瘍治療電場の長手方向伝達用のアレイ
US20180008708A1 (en) 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
ES2959582T3 (es) 2016-08-18 2024-02-27 Novocure Gmbh Medición de temperatura en diversos conjuntos para aplicar campos de tratamiento de tumores
WO2018109691A2 (en) 2016-12-13 2018-06-21 Zeev Bomzon Treating patients with ttfields with the electrode positions optimized using deformable templates
EP3571503B1 (en) 2017-01-19 2026-04-15 Novocure GmbH System for viewing cell cultures under a microscope whilst applying ttfields
JP7139448B2 (ja) 2018-04-09 2022-09-20 ノボキュア ゲーエムベーハー ＴＴＦｉｅｌｄｓ及びオーロラキナーゼ阻害剤による腫瘍の治療
PL3775956T3 (pl) 2018-04-10 2022-10-10 Novocure Gmbh Szacunki przewodności ac o niskiej częstotliwości (< 1 mhz) pozyskane z dwóch obrazów mri o różnych czasach repetycji
CN114082099A (zh) 2018-07-03 2022-02-25 埃德温·阊 使用交变电场提高细胞膜通透性
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
BR112020025269A2 (pt) 2018-07-18 2021-03-09 Novocure Gmbh Uso de densidade de perda de energia e medidas relacionadas para quantificar a dose dos campos de tratamento de tumor (ttfields)
JP6974671B2 (ja) 2018-08-23 2021-12-01 ノボキュア ゲーエムベーハー 血液脳関門の透過性を向上させるための交流電界の使用
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
WO2020049482A1 (en) 2018-09-07 2020-03-12 Yaniv Alon Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
US20200108031A1 (en) 2018-10-05 2020-04-09 Novocure Gmbh Treating Tumors Using TTFields Combined with ABT-751
WO2020086753A1 (en) 2018-10-23 2020-04-30 The Board Of Trustees Of The Leland Stanford Junior University Prevention and treatment of teratoma formation in stem cell-based thereapies using alternating electric fields
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達
US20200146586A1 (en) 2018-11-14 2020-05-14 Novocure Gmbh Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images
WO2020104921A1 (en) 2018-11-19 2020-05-28 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
CN113164745B (zh) 2018-11-29 2024-04-26 诺沃库勒有限责任公司 用于递送TTField（肿瘤治疗场）的增强灵活性换能器阵列
JP7246486B2 (ja) 2019-01-08 2023-03-27 ノボキュア ゲーエムベーハー 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価
JP7216829B2 (ja) 2019-02-22 2023-02-01 ノボキュア ゲーエムベーハー Ｘｅｌｏｘ又はｆｏｌｆｏｘと組み合わせたｔｔフィールドを用いる胃癌の治療
CN113573774B (zh) 2019-02-26 2026-03-06 诺沃库勒有限责任公司 基于靶向癌细胞的电特性确定TTfield治疗的频率
JP2022522936A (ja) 2019-02-27 2022-04-21 ノボキュア ゲーエムベーハー 埋込可能な変換器アレイを使用した腫瘍治療電場（ｔｔｆｉｅｌｄｓ）の送達
EP3988099B1 (en) 2019-03-29 2023-06-07 Novocure GmbH Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
US11291837B2 (en) 2019-04-17 2022-04-05 Novocure Gmbh Uploading data from an isolated system without compromising isolation

Also Published As

Publication number Publication date
US20170281934A1 (en) 2017-10-05
JP7171827B2 (ja) 2022-11-15
EP3439733A1 (en) 2019-02-13
CN116549848A (zh) 2023-08-08
EP3693054C0 (en) 2023-06-28
PL3439733T3 (pl) 2020-07-27
WO2017175116A1 (en) 2017-10-12
US20210008367A1 (en) 2021-01-14
DK3439733T3 (da) 2020-03-23
EP3693054A3 (en) 2020-10-28
CA3019474A1 (en) 2017-10-12
EP3439733B1 (en) 2019-12-25
EP4234005A3 (en) 2024-01-10
JP2021126552A (ja) 2021-09-02
ES2779990T3 (es) 2020-08-21
EP4234005A2 (en) 2023-08-30
HUE048646T2 (hu) 2020-08-28
JP2019510606A (ja) 2019-04-18
EP3693054A2 (en) 2020-08-12
US11191956B2 (en) 2021-12-07
US10821283B2 (en) 2020-11-03
CN109475735B (zh) 2023-05-23
EP3693054B1 (en) 2023-06-28
KR20180133431A (ko) 2018-12-14
PT3439733T (pt) 2020-03-25
CN109475735A (zh) 2019-03-15
KR102430229B1 (ko) 2022-08-05

Similar Documents

Publication Publication Date Title
JP6896839B2 (ja) 腫瘍治療電場（ＴＴＦｉｅｌｄｓ）を使用してがん細胞の運動性を低下させる
Henry et al. Inhibition of miR-155 limits neuroinflammation and improves functional recovery after experimental traumatic brain injury in mice
CN112469465B (zh) 使用交变电场抑制病毒感染的方法或装置
US20170348525A1 (en) Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms
JP2024095840A (ja) Ｔ細胞の増殖を低減する交流電場を使用する自己免疫性疾患の治療
Sommer et al. Opposite optimal current flow directions for induction of neuroplasticity and excitation threshold in the human motor cortex
Yan et al. XIST accelerates neuropathic pain progression through regulation of miR‐150 and ZEB1 in CCI rat models
JP2004505604A5 (https=)
Ling et al. Non-coding RNAs: emerging therapeutic targets in spinal cord ischemia–reperfusion injury
Zhang et al. Low-frequency low energy ultrasound combined with microbubbles induces distinct apoptosis of A7r5 cells
HK40098373A (en) Reducing motility of cancer cells using tumor treating fields (ttfields)
JP2021518398A (ja) 痙縮および関連障害のための治療戦略としてのニューロンのｎｋｃｃ１の調節
HK40023684A (en) Reducing motility of cancer cells using tumor treating fields (ttfields)
HK40023684B (en) Reducing motility of cancer cells using tumor treating fields (ttfields)
HK1260435A1 (en) Reducing motility of cancer cells using tumor treating fields (ttfields)
HK1260435B (en) Reducing motility of cancer cells using tumor treating fields (ttfields)
Tanaka et al. Preventive effects of kilohertz frequency electrical stimulation on sepsis-induced muscle atrophy
Jenrow et al. Electromagnetic techniques in neural therapy
CN121444171A (zh) 电场疗法
Kerslake Targeting the senescence-associated secretory phenotype in cancer therapy
Kinzel et al. P11. 18 Tumor treating fields (TTFields) treatment of spinal cord metastases
Dong et al. Effects of Neurotrophin-3 Plasmids on Myocyte Apoptosis and Ca2+-ATPase Content in the Muscle After Nerve Injury in Rats
Peruzzi et al. Therapeutic targeting based on gene-expression profiling in vestibular schwannomas
Säisänen et al. rTMS Therapy on M1 Modifies the Motor Map in Chronic Neuropathic Facial Pain-A Pilot Study.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200327

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200327

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20201124

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210303

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210415

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210510

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210609

R150 Certificate of patent or registration of utility model

Ref document number: 6896839

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250