ES2779990T3 - Reducción de la motilidad de células cancerosas utilizando campos de tratamiento de tumores (TTFIELDS) - Google Patents
Reducción de la motilidad de células cancerosas utilizando campos de tratamiento de tumores (TTFIELDS) Download PDFInfo
- Publication number
- ES2779990T3 ES2779990T3 ES17716642T ES17716642T ES2779990T3 ES 2779990 T3 ES2779990 T3 ES 2779990T3 ES 17716642 T ES17716642 T ES 17716642T ES 17716642 T ES17716642 T ES 17716642T ES 2779990 T3 ES2779990 T3 ES 2779990T3
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Classifications
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Program-control systems
- G05B19/02—Program-control systems electric
- G05B19/04—Program control other than numerical control, i.e. in sequence controllers or logic controllers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317985P | 2016-04-04 | 2016-04-04 | |
| PCT/IB2017/051898 WO2017175116A1 (en) | 2016-04-04 | 2017-04-04 | Reducing motility of cancer cells using tumor treating fields (ttfields) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2779990T3 true ES2779990T3 (es) | 2020-08-21 |
Family
ID=58530601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17716642T Active ES2779990T3 (es) | 2016-04-04 | 2017-04-04 | Reducción de la motilidad de células cancerosas utilizando campos de tratamiento de tumores (TTFIELDS) |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10821283B2 (https=) |
| EP (3) | EP4234005A3 (https=) |
| JP (2) | JP6896839B2 (https=) |
| KR (1) | KR102430229B1 (https=) |
| CN (2) | CN116549848A (https=) |
| CA (1) | CA3019474A1 (https=) |
| DK (1) | DK3439733T3 (https=) |
| ES (1) | ES2779990T3 (https=) |
| HU (1) | HUE048646T2 (https=) |
| PL (1) | PL3439733T3 (https=) |
| PT (1) | PT3439733T (https=) |
| WO (1) | WO2017175116A1 (https=) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) * | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| JP7287888B2 (ja) | 2016-06-27 | 2023-06-06 | ギャラリー，インコーポレイテッド | ジェネレータ、電極付きのカテーテル、及び肺通路の治療方法 |
| US20180001075A1 (en) | 2016-06-30 | 2018-01-04 | Novocure Limited | Arrays for Longitudinal Delivery of TTFields to a Body |
| EP3571503B1 (en) | 2017-01-19 | 2026-04-15 | Novocure GmbH | System for viewing cell cultures under a microscope whilst applying ttfields |
| US20190117969A1 (en) * | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Medical devices for treatment of cancer with electric fields |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US12403306B2 (en) * | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US20200368525A1 (en) * | 2017-11-17 | 2020-11-26 | Abbvie Inc. | Methods of Treating Glioblastoma |
| DK4218641T3 (da) | 2017-12-26 | 2025-08-18 | Galvanize Therapeutics Inc | Optimering af energilevering til forskellige anvendelser |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| US11298422B2 (en) | 2018-04-09 | 2022-04-12 | Novocure Gmbh | Treating tumors with TTFields and an aurora kinase inhibitor |
| WO2019197999A1 (en) | 2018-04-10 | 2019-10-17 | Zeev Bomzon | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| KR102870236B1 (ko) * | 2018-07-03 | 2025-10-14 | 에드윈 창 | 세포막 투과성을 향상시키기 위한 교류 전기장 사용 |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| BR112020025692A2 (pt) * | 2018-07-10 | 2021-03-16 | Novocure Gmbh | Inibição de infecção viral usando campos elétricos alternados |
| EP3967361A1 (en) | 2018-07-18 | 2022-03-16 | Novocure GmbH | Using power loss density and related measures to quantify the dose of tumor treating fields |
| DK3804648T3 (da) * | 2018-08-23 | 2022-04-11 | Novocure Gmbh | Anvendelse af elektriske vekseltrømsfelter til forøgelse af permeabilitet af blodhjernebarrieren |
| WO2020047285A1 (en) * | 2018-08-29 | 2020-03-05 | Regents Of The University Of Minnesota | Devices and methods for treatment of tumors using electromagnetic signal |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP3846894B8 (en) | 2018-09-07 | 2025-06-18 | Novocure GmbH | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| PL3984590T3 (pl) | 2018-10-15 | 2023-05-02 | Novocure Gmbh | Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu |
| CN112955208B (zh) | 2018-10-25 | 2024-11-22 | 诺沃库勒有限责任公司 | 向受试者的脊柱解剖结构递送交变电场(例如，ttfields)的方法 |
| EP3880299B1 (en) | 2018-11-13 | 2025-09-24 | The Methodist Hospital | Device for oncomagnetic treatment |
| CN113015553B (zh) * | 2018-11-19 | 2025-01-14 | 诺沃库勒有限责任公司 | 用于递送具有选择性可寻址子元件的肿瘤治疗场（TTField）的阵列 |
| BR112021004336A2 (pt) | 2018-11-29 | 2021-08-17 | Novocure Gmbh | matrizes de transdutor com flexibilidade melhorada para entregar ttfields (campos de tratamento de tumor) |
| EP3968279B1 (en) | 2019-01-08 | 2025-01-01 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| US11554262B2 (en) | 2019-02-26 | 2023-01-17 | Novocure Gmbh | Determining a frequency for TTFields treatment based on an electrical characteristic of targeted cancer cells |
| EP4491214B1 (en) | 2019-02-27 | 2026-01-21 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| JP7419391B2 (ja) | 2019-03-29 | 2024-01-22 | ノボキュア ゲーエムベーハー | ＰＴＧＥＲ３阻害剤によりＴＴＦｉｅｌｄｓ－耐性がん細胞におけるＴＴＦｉｅｌｄｓに対する感受性を回復させるための方法 |
| WO2020207488A1 (zh) * | 2019-04-12 | 2020-10-15 | 上海必修福企业管理有限公司 | 空间电场的发生装置 |
| ES2940749T3 (es) | 2019-04-17 | 2023-05-11 | Novocure Gmbh | Carga de datos desde un sistema aislado sin comprometer el aislamiento |
| JP7551648B2 (ja) | 2019-04-18 | 2024-09-17 | ガルヴァナイズ セラピューティクス，インコーポレイテッド | 異常組織を治療するための器械、及びシステム、 |
| CN113766949B (zh) * | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| EP4480526A3 (en) * | 2019-04-22 | 2025-03-12 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| EP3958954B1 (en) | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Electrical stimulation devices for cancer treatment |
| US11850422B2 (en) | 2019-04-23 | 2023-12-26 | Boston Scientific Scimed, Inc. | Electrodes for electrical stimulation to treat cancer |
| CN113766950A (zh) * | 2019-04-23 | 2021-12-07 | 波士顿科学国际有限公司 | 带有热治疗或热监测的电刺激 |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| AU2020314830B2 (en) | 2019-07-16 | 2026-01-22 | Galvanize Therapeutics, Inc. | Treatment of the reproductive tract with pulsed electric fields |
| CN121314073A (zh) | 2019-07-31 | 2026-01-13 | 诺沃库勒有限责任公司 | 经由埋入颅骨植入物中的电极施加肿瘤治疗场（TTField） |
| WO2021024170A1 (en) | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| CN114364433A (zh) | 2019-08-30 | 2022-04-15 | 诺沃库勒有限责任公司 | 向颈部输送肿瘤治疗场（TTFields） |
| JP2023505575A (ja) * | 2019-12-11 | 2023-02-09 | ノボキュア ゲーエムベーハー | 細胞を画像化する組成物及び方法 |
| EP4081257A1 (en) * | 2019-12-26 | 2022-11-02 | The Board of Trustees of the Leland Stanford Junior University | Methods of normalizing aberrant glycolytic metabolism in cancer cells |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| CN121314067A (zh) | 2019-12-31 | 2026-01-13 | 诺沃库勒有限责任公司 | 防止幅度调整和信道切换期间的尖峰的高电压、高效率正弦波生成器 |
| WO2021136960A1 (en) * | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy |
| CN121695416A (zh) | 2019-12-31 | 2026-03-20 | 诺沃库勒有限责任公司 | 具有可单独访问的电极元件和温度传感器的用于传递肿瘤治疗场（tt场）的阵列 |
| US11883655B2 (en) | 2020-02-24 | 2024-01-30 | Boston Scientific Scimed, Inc. | Systems and methods for treatment of pancreatic cancer |
| US20210299440A1 (en) | 2020-03-30 | 2021-09-30 | Novocure Gmbh | Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases |
| KR102644003B1 (ko) | 2020-04-01 | 2024-03-07 | 한국전자통신연구원 | 암 치료 장치 |
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| WO2022003419A1 (en) * | 2020-06-30 | 2022-01-06 | Novocure Gmbh | Flexible transducer arrays with a polymer insulating layer for applying tumor treating fields (ttfields) |
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| EP4223364B1 (en) | 2020-09-25 | 2024-04-24 | Novocure GmbH | Varying the metallization area on individual electrode elements in a tumor treating fields system to maximize current without overheating |
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| EP4282465B1 (en) * | 2020-12-21 | 2025-07-23 | Novocure GmbH | Optimization of composite electrode |
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| JP2024501886A (ja) * | 2020-12-30 | 2024-01-16 | ノボキュア ゲーエムベーハー | 腫瘍治療電界のための振幅変調 |
| CN117098577A (zh) * | 2020-12-30 | 2023-11-21 | 诺沃库勒有限责任公司 | 用于肿瘤治疗场的调幅 |
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| WO2022167939A1 (en) * | 2021-02-03 | 2022-08-11 | Novocure Gmbh | Varying parameters of tumor treating fields (ttfields) treatment to overcome treatment resistance |
| EP4043071A1 (en) * | 2021-02-12 | 2022-08-17 | Scientia Biotech S.L. | Non-invasive cancer treatment |
| US12397151B2 (en) | 2021-02-17 | 2025-08-26 | Novocure Gmbh | Arrays for delivering tumor treating fields (TTFields) with sets of electrode elements having individually adjustable active areas |
| US12440680B2 (en) | 2021-03-12 | 2025-10-14 | Novocure Gmbh | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| JP2024510812A (ja) * | 2021-03-23 | 2024-03-11 | ノボキュア ゲーエムベーハー | 被験者の身体に腫瘍治療電場を送達するための変換器装置 |
| EP4284489B1 (en) | 2021-03-31 | 2025-07-16 | Novocure Gmbh | Impedance tomography using electrodes of a tumor treating fields (ttfields) system |
| TWI905187B (zh) * | 2021-05-11 | 2025-11-21 | 瑞士商諾萬可有限公司 | 用於治療子宮外孕的交變電場 |
| EP4359065A4 (en) * | 2021-06-22 | 2025-03-19 | LifeBridge Innovations, PBC | Device and method for improving electrical field therapy for reducing solid tumors |
| WO2023275749A1 (en) | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Using capacitors to regulate current in transducer arrays for applying tumor treating fields (ttfields) |
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| MX2024006036A (es) | 2021-12-14 | 2024-06-05 | Novocure Gmbh | Desplazamiento de matriz de transductores para reducir la irritacion cutanea. |
| TW202333820A (zh) | 2021-12-29 | 2023-09-01 | 瑞士商諾沃庫勒有限責任公司 | 在使用交流電場治療受試者時藉由使用較大陰極和較小陽極來降低電知覺 |
| JP2024545019A (ja) | 2021-12-30 | 2024-12-05 | ノボキュア ゲーエムベーハー | 腫瘍治療フィールド（ｔｔｆｉｅｌｄ）を使用した治療のためのパラメータ値の選択 |
| EP4460361B1 (en) | 2022-03-30 | 2025-03-19 | Novocure GmbH | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| JP7710117B2 (ja) * | 2022-03-30 | 2025-07-17 | ノボキュア ゲーエムベーハー | トランスデューサアレイをペアリングすることによる交流電場を用いた被験者の治療および電気感覚の軽減 |
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-
2017
- 2017-04-03 US US15/478,066 patent/US10821283B2/en active Active
- 2017-04-04 CN CN202310518476.3A patent/CN116549848A/zh active Pending
- 2017-04-04 JP JP2019502289A patent/JP6896839B2/ja active Active
- 2017-04-04 PL PL17716642T patent/PL3439733T3/pl unknown
- 2017-04-04 WO PCT/IB2017/051898 patent/WO2017175116A1/en not_active Ceased
- 2017-04-04 EP EP23181273.6A patent/EP4234005A3/en active Pending
- 2017-04-04 EP EP19219639.2A patent/EP3693054B1/en active Active
- 2017-04-04 HU HUE17716642A patent/HUE048646T2/hu unknown
- 2017-04-04 DK DK17716642.8T patent/DK3439733T3/da active
- 2017-04-04 EP EP17716642.8A patent/EP3439733B1/en active Active
- 2017-04-04 CA CA3019474A patent/CA3019474A1/en active Pending
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|---|---|
| KR20180133431A (ko) | 2018-12-14 |
| CN109475735A (zh) | 2019-03-15 |
| PL3439733T3 (pl) | 2020-07-27 |
| US20210008367A1 (en) | 2021-01-14 |
| EP3693054C0 (en) | 2023-06-28 |
| EP4234005A2 (en) | 2023-08-30 |
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| HUE048646T2 (hu) | 2020-08-28 |
| JP6896839B2 (ja) | 2021-06-30 |
| EP3439733B1 (en) | 2019-12-25 |
| EP3439733A1 (en) | 2019-02-13 |
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| EP3693054B1 (en) | 2023-06-28 |
| PT3439733T (pt) | 2020-03-25 |
| US20170281934A1 (en) | 2017-10-05 |
| JP2019510606A (ja) | 2019-04-18 |
| JP7171827B2 (ja) | 2022-11-15 |
| US11191956B2 (en) | 2021-12-07 |
| US10821283B2 (en) | 2020-11-03 |
| CA3019474A1 (en) | 2017-10-12 |
| DK3439733T3 (da) | 2020-03-23 |
| CN116549848A (zh) | 2023-08-08 |
| JP2021126552A (ja) | 2021-09-02 |
| KR102430229B1 (ko) | 2022-08-05 |
| CN109475735B (zh) | 2023-05-23 |
| EP4234005A3 (en) | 2024-01-10 |
| EP3693054A2 (en) | 2020-08-12 |
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