PL3439733T3 - Zmniejszanie ruchliwości komórek nowotworowych z użyciem leczących nowotwory pól (ttfields) - Google Patents
Zmniejszanie ruchliwości komórek nowotworowych z użyciem leczących nowotwory pól (ttfields)Info
- Publication number
- PL3439733T3 PL3439733T3 PL17716642T PL17716642T PL3439733T3 PL 3439733 T3 PL3439733 T3 PL 3439733T3 PL 17716642 T PL17716642 T PL 17716642T PL 17716642 T PL17716642 T PL 17716642T PL 3439733 T3 PL3439733 T3 PL 3439733T3
- Authority
- PL
- Poland
- Prior art keywords
- ttfields
- cancer cells
- tumor treating
- treating fields
- reducing motility
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Program-control systems
- G05B19/02—Program-control systems electric
- G05B19/04—Program control other than numerical control, i.e. in sequence controllers or logic controllers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317985P | 2016-04-04 | 2016-04-04 | |
| EP17716642.8A EP3439733B1 (en) | 2016-04-04 | 2017-04-04 | Reducing motility of cancer cells using tumor treating fields (ttfields) |
| PCT/IB2017/051898 WO2017175116A1 (en) | 2016-04-04 | 2017-04-04 | Reducing motility of cancer cells using tumor treating fields (ttfields) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3439733T3 true PL3439733T3 (pl) | 2020-07-27 |
Family
ID=58530601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17716642T PL3439733T3 (pl) | 2016-04-04 | 2017-04-04 | Zmniejszanie ruchliwości komórek nowotworowych z użyciem leczących nowotwory pól (ttfields) |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10821283B2 (pl) |
| EP (3) | EP4234005A3 (pl) |
| JP (2) | JP6896839B2 (pl) |
| KR (1) | KR102430229B1 (pl) |
| CN (2) | CN116549848A (pl) |
| CA (1) | CA3019474A1 (pl) |
| DK (1) | DK3439733T3 (pl) |
| ES (1) | ES2779990T3 (pl) |
| HU (1) | HUE048646T2 (pl) |
| PL (1) | PL3439733T3 (pl) |
| PT (1) | PT3439733T (pl) |
| WO (1) | WO2017175116A1 (pl) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) * | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| CN109788979B (zh) | 2016-06-27 | 2022-04-19 | 盖能适治疗股份有限公司 | 发生器和具有电极的导管以及用于治疗肺通道的方法 |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| US20180001075A1 (en) | 2016-06-30 | 2018-01-04 | Novocure Limited | Arrays for Longitudinal Delivery of TTFields to a Body |
| WO2018134733A1 (en) | 2017-01-19 | 2018-07-26 | Moshe Giladi | System for viewing cell cultures under a microscope whilst applying ttfields |
| US12403306B2 (en) | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US20190117969A1 (en) * | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Medical devices for treatment of cancer with electric fields |
| CN112543661A (zh) * | 2017-11-17 | 2021-03-23 | 艾伯维公司 | 治疗胶质母细胞瘤的方法 |
| CN118383863A (zh) | 2017-12-26 | 2024-07-26 | 盖能适治疗股份有限公司 | 用于各种应用的能量输送的优化 |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| EP3773726B1 (en) | 2018-04-09 | 2024-06-05 | Novocure GmbH | Treating tumors with ttfields and an aurora kinase inhibitor |
| EP3775956B1 (en) | 2018-04-10 | 2022-03-23 | Novocure GmbH | Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times |
| ES3047748T3 (en) * | 2018-07-03 | 2025-12-04 | Univ Leland Stanford Junior | Using alternating electric fields to increase cell membrane permeability |
| KR102794415B1 (ko) * | 2018-07-10 | 2025-04-09 | 노보큐어 게엠베하 | 교류 전기장을 사용한 바이러스 감염 억제 |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| MX2020013431A (es) | 2018-07-18 | 2021-05-27 | Novocure Gmbh | Uso de densidad de perdida de potencia y mediciones relacionadas para cuantificar la dosis de campos de tratamiento de tumores (ttfield). |
| EP3878389B1 (en) * | 2018-08-23 | 2025-08-06 | Novocure GmbH | Using alternating electric fields to increase permeability of the blood brain barrier |
| WO2020047285A1 (en) | 2018-08-29 | 2020-03-05 | Regents Of The University Of Minnesota | Devices and methods for treatment of tumors using electromagnetic signal |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| WO2020049482A1 (en) * | 2018-09-07 | 2020-03-12 | Yaniv Alon | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| EP3984590B1 (en) | 2018-10-15 | 2022-12-07 | Novocure GmbH | Generating tumor treating fields (ttfields) with high uniformity throughout the brain |
| JP7148722B2 (ja) | 2018-10-25 | 2022-10-05 | ゼーヴ・ボンゾン | 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達 |
| EP3880299B1 (en) | 2018-11-13 | 2025-09-24 | The Methodist Hospital | Device for oncomagnetic treatment |
| IL280843B2 (en) | 2018-11-19 | 2025-10-01 | Novocure Gmbh | Arrays for providing fields treat growth with selectively addressable sub-elements |
| SG11202101810SA (en) | 2018-11-29 | 2021-03-30 | Novocure Gmbh | Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields) |
| EP3961565A1 (en) | 2019-01-08 | 2022-03-02 | Novocure GmbH | Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields) |
| IL284284B2 (en) | 2019-02-26 | 2026-03-01 | Novocure Gmbh | Frequency determination for tumor-treating field therapy is based on the electrical characteristic of targeted cancer cells. |
| EP3954314B1 (en) * | 2019-02-27 | 2025-01-08 | Novocure GmbH | Delivering tumor treating fields (ttfields) using implantable transducer arrays |
| CN113613651B (zh) | 2019-03-29 | 2025-08-12 | 诺沃库勒有限责任公司 | 用PTGER3抑制剂恢复TTField抗性癌细胞中对TTField的敏感性的方法 |
| CN111803792A (zh) * | 2019-04-12 | 2020-10-23 | 上海必修福企业管理有限公司 | 空间电场的发生装置 |
| US11291837B2 (en) | 2019-04-17 | 2022-04-05 | Novocure Gmbh | Uploading data from an isolated system without compromising isolation |
| AU2020257266A1 (en) | 2019-04-18 | 2021-11-11 | Galvanize Therapeutics, Inc. | Devices, systems and methods for the treatment of abnormal tissue |
| CN113766949B (zh) * | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| US11691006B2 (en) | 2019-04-22 | 2023-07-04 | Boston Scientific Scimed, Inc. | Electrical stimulation devices for cancer treatment |
| EP4480526A3 (en) * | 2019-04-22 | 2025-03-12 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| JP2022529374A (ja) | 2019-04-23 | 2022-06-21 | ボストン サイエンティフィック サイムド，インコーポレイテッド | がん治療のための電気刺激用電極 |
| EP3958960B1 (en) | 2019-04-23 | 2025-06-18 | Boston Scientific Scimed, Inc. | Electrical stimulation with thermal treatment or thermal monitoring |
| US11607542B2 (en) | 2019-04-23 | 2023-03-21 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| WO2021011733A1 (en) | 2019-07-16 | 2021-01-21 | Galary, Inc. | Treatment of the reproductive tract with pulsed electric fields |
| US11654279B2 (en) | 2019-07-31 | 2023-05-23 | Novocure Gmbh | Applying tumor treating fields (TTFields) via electrodes embedded into skull implants |
| WO2021024170A1 (en) | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
| US11890467B2 (en) | 2019-08-30 | 2024-02-06 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the neck |
| WO2021116748A2 (en) * | 2019-12-11 | 2021-06-17 | Novocure Gmbh | Compositions and methods for imaging a cell |
| JP7687698B2 (ja) * | 2019-12-26 | 2025-06-03 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 癌細胞における異常な解糖的代謝を正常化する方法 |
| US20230147250A1 (en) * | 2019-12-31 | 2023-05-11 | Novocure Gmbh | Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy |
| ES2950234T3 (es) | 2019-12-31 | 2023-10-06 | Novocure Gmbh | Matrices para administrar campos de tratamiento de tumores (camposTT) con elementos de electrodos y sensores de temperatura accesibles individualmente |
| EP4091665B1 (en) | 2019-12-31 | 2024-10-30 | Novocure GmbH | High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
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| KR102644003B1 (ko) | 2020-04-01 | 2024-03-07 | 한국전자통신연구원 | 암 치료 장치 |
| BR112022021484A2 (pt) | 2020-04-24 | 2022-12-13 | Novocure Gmbh | Uso de campos elétricos alternados para aumentar a permeabilidade da barreira hematoencefálica |
| WO2021224687A1 (en) * | 2020-05-08 | 2021-11-11 | Novocure Gmbh | Compositions and methods of applying alternating electric fields to pluripotent stem cells |
| KR102464313B1 (ko) | 2020-05-18 | 2022-11-08 | 주식회사 필드큐어 | 전기장 암 치료 시스템을 위한 품질 보증 장치 및 방법 |
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| TW202541865A (zh) * | 2020-06-30 | 2025-11-01 | 瑞士商諾沃庫勒有限責任公司 | 用於施加腫瘤治療電場（tt電場）之具有聚合物絕緣層的彈性轉換器陣列 |
| EP4213933A1 (en) * | 2020-09-18 | 2023-07-26 | Novocure Gmbh | Methods and compositions for treating coronavirus |
| JP7777118B2 (ja) | 2020-09-25 | 2025-11-27 | ノボキュア ゲーエムベーハー | 過熱することなく電流を最大化するために腫瘍治療電場（ＴＴＦｉｅｌｄ）における個々の電極要素における金属化範囲を変化させること |
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| KR102519139B1 (ko) | 2020-11-25 | 2023-04-25 | 주식회사 필드큐어 | 회전하는 교류 전기장을 이용한 전기장 인가 장치 및 방법 |
| US11883652B2 (en) | 2020-12-21 | 2024-01-30 | Novocure Gmbh | Optimization of composite electrode |
| CN112553075A (zh) * | 2020-12-28 | 2021-03-26 | 湖南安泰康成生物科技有限公司 | 一种用敏感频率电场抑制肿瘤细胞快速生长的方法及装置 |
| JP2024501886A (ja) * | 2020-12-30 | 2024-01-16 | ノボキュア ゲーエムベーハー | 腫瘍治療電界のための振幅変調 |
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| IT202100000119A1 (it) | 2021-01-05 | 2022-07-05 | Telea Electronic Eng Srl | Dispositivo e farmaco antitumorale per il trattamento di cellule neoplastiche |
| WO2022167939A1 (en) * | 2021-02-03 | 2022-08-11 | Novocure Gmbh | Varying parameters of tumor treating fields (ttfields) treatment to overcome treatment resistance |
| EP4043071A1 (en) * | 2021-02-12 | 2022-08-17 | Scientia Biotech S.L. | Non-invasive cancer treatment |
| EP4240470A1 (en) | 2021-02-17 | 2023-09-13 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas |
| US12440680B2 (en) | 2021-03-12 | 2025-10-14 | Novocure Gmbh | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| JP2024510812A (ja) * | 2021-03-23 | 2024-03-11 | ノボキュア ゲーエムベーハー | 被験者の身体に腫瘍治療電場を送達するための変換器装置 |
| EP4284489B1 (en) | 2021-03-31 | 2025-07-16 | Novocure Gmbh | Impedance tomography using electrodes of a tumor treating fields (ttfields) system |
| TWI905187B (zh) * | 2021-05-11 | 2025-11-21 | 瑞士商諾萬可有限公司 | 用於治療子宮外孕的交變電場 |
| EP4359065A4 (en) * | 2021-06-22 | 2025-03-19 | LifeBridge Innovations, PBC | Device and method for improving electrical field therapy for reducing solid tumors |
| KR20240027008A (ko) | 2021-06-30 | 2024-02-29 | 노보큐어 게엠베하 | 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용 |
| US20230001221A1 (en) * | 2021-06-30 | 2023-01-05 | Novocure Gmbh | Methods of Treating Cancer with Alternating Electric Fields, Checkpoint Inhibitors, and Combination Chemotherapy |
| US12599765B2 (en) | 2021-12-14 | 2026-04-14 | Novocure Gmbh | Shifting of transducer array to reduce skin irritation |
| WO2023126842A1 (en) | 2021-12-29 | 2023-07-06 | Novocure Gmbh | Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes |
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| US12478793B2 (en) | 2022-03-30 | 2025-11-25 | Novocure Gmbh | Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together |
| EP4460361B1 (en) | 2022-03-30 | 2025-03-19 | Novocure GmbH | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| US20230310854A1 (en) * | 2022-03-31 | 2023-10-05 | Novocure Gmbh | Alternating electric field waveform for electrosensation reduction |
| CN119173302A (zh) | 2022-04-01 | 2024-12-20 | 得克萨斯大学体系董事会 | 用于应用与个性化超分割立体定向适应性放射疗法相组合的肿瘤治疗电场的方法和仪器 |
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-
2017
- 2017-04-03 US US15/478,066 patent/US10821283B2/en active Active
- 2017-04-04 EP EP23181273.6A patent/EP4234005A3/en active Pending
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- 2017-04-04 PT PT177166428T patent/PT3439733T/pt unknown
- 2017-04-04 CA CA3019474A patent/CA3019474A1/en active Pending
- 2017-04-04 HU HUE17716642A patent/HUE048646T2/hu unknown
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- 2017-04-04 ES ES17716642T patent/ES2779990T3/es active Active
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| CN109475735B (zh) | 2023-05-23 |
| EP3439733A1 (en) | 2019-02-13 |
| EP4234005A2 (en) | 2023-08-30 |
| US20170281934A1 (en) | 2017-10-05 |
| JP6896839B2 (ja) | 2021-06-30 |
| US11191956B2 (en) | 2021-12-07 |
| CN116549848A (zh) | 2023-08-08 |
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| EP3693054A3 (en) | 2020-10-28 |
| JP2021126552A (ja) | 2021-09-02 |
| JP7171827B2 (ja) | 2022-11-15 |
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| EP4234005A3 (en) | 2024-01-10 |
| US10821283B2 (en) | 2020-11-03 |
| WO2017175116A1 (en) | 2017-10-12 |
| CA3019474A1 (en) | 2017-10-12 |
| KR20180133431A (ko) | 2018-12-14 |
| PT3439733T (pt) | 2020-03-25 |
| KR102430229B1 (ko) | 2022-08-05 |
| EP3693054C0 (en) | 2023-06-28 |
| ES2779990T3 (es) | 2020-08-21 |
| JP2019510606A (ja) | 2019-04-18 |
| EP3693054A2 (en) | 2020-08-12 |
| EP3439733B1 (en) | 2019-12-25 |
| HUE048646T2 (hu) | 2020-08-28 |
| CN109475735A (zh) | 2019-03-15 |
| EP3693054B1 (en) | 2023-06-28 |
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