MX2022010015A - Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica. - Google Patents

Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica.

Info

Publication number
MX2022010015A
MX2022010015A MX2022010015A MX2022010015A MX2022010015A MX 2022010015 A MX2022010015 A MX 2022010015A MX 2022010015 A MX2022010015 A MX 2022010015A MX 2022010015 A MX2022010015 A MX 2022010015A MX 2022010015 A MX2022010015 A MX 2022010015A
Authority
MX
Mexico
Prior art keywords
electric fields
alternating electric
bbb
frequencies
brain barrier
Prior art date
Application number
MX2022010015A
Other languages
English (en)
Inventor
Tali VOLOSHIN-SELA
Hadas Sara Hershkovich
Carsten Hagemann
Mario Lohr
Almuth F Kessler
Malgorzata Burek
Carola Forster
Catherine BRAMI
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of MX2022010015A publication Critical patent/MX2022010015A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0504—Subcutaneous electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrotherapy Devices (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Muchos fármacos y otras moléculas no pueden atravesar ordinariamente la barrera hematoencefálica (BBB). Sin embargo, cuando campos eléctricos alternos en ciertas frecuencias óptimas (por ejemplo, 100 kHz) se aplican al cerebro, la BBB se vuelve permeable a estas moléculas. Cuando se descontinuó los campos eléctricos alternos, la BBB eventualmente se recupera a su estado impermeable original. Subsecuentemente, la nueva aplicación de campos eléctricos alternos en las frecuencias óptimas reabrirá la BBB. Ordinariamente, muchas frecuencias (por ejemplo, 200 kHz) de campos eléctricos alternos son ya sea ineficaces o menos eficaces al inducir permeabilidad que las frecuencias óptimas. Pero una vez que se ha abierto la BBB al aplicar campos eléctricos alternos a las frecuencias óptimas, campos eléctricos alternos a las frecuencias no óptimas pueden mantener la permeabilidad de una BBB previamente abierta.
MX2022010015A 2020-04-24 2021-04-21 Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica. MX2022010015A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063015099P 2020-04-24 2020-04-24
US202063071748P 2020-08-28 2020-08-28
PCT/IB2021/053305 WO2021214693A1 (en) 2020-04-24 2021-04-21 Using alternating electric fields to increase permeability of the blood brain barrier

Publications (1)

Publication Number Publication Date
MX2022010015A true MX2022010015A (es) 2022-09-05

Family

ID=75787146

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010015A MX2022010015A (es) 2020-04-24 2021-04-21 Uso de campos electricos alternos para aumentar la permeabilidad de la barrera hematoencefalica.

Country Status (12)

Country Link
US (1) US20210330950A1 (es)
EP (1) EP4138988A1 (es)
JP (1) JP2023522817A (es)
KR (1) KR20230002800A (es)
CN (1) CN115916325A (es)
AU (1) AU2021261745A1 (es)
BR (1) BR112022021484A2 (es)
CA (1) CA3171313A1 (es)
IL (1) IL295251A (es)
MX (1) MX2022010015A (es)
TW (1) TW202206140A (es)
WO (1) WO2021214693A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018002879A1 (en) 2016-06-30 2018-01-04 Zeev Bomzon Arrays for longitudinal delivery of ttfields to a body
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
EP3840823B1 (en) 2018-10-15 2023-07-12 Novocure GmbH Generating tumor treating fields (ttfields) with high uniformity throughout the brain
CN113164745B (zh) 2018-11-29 2024-04-26 诺沃库勒有限责任公司 用于递送TTField（肿瘤治疗场）的增强灵活性换能器阵列
WO2020144582A1 (en) 2019-01-08 2020-07-16 Novocure Gmbh Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
EP3924039B1 (en) 2019-04-17 2023-11-22 Novocure GmbH Uploading data from an isolated system without compromising isolation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7599746B2 (en) * 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
EP1740268A2 (en) 2004-04-23 2007-01-10 Standen Ltd. Treating a tumor or the like with electric fields at different frequencies
US10245098B2 (en) * 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US10821283B2 (en) * 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
US11931569B2 (en) * 2018-03-12 2024-03-19 Tel Hashomer Medical Research, Infrastructure & Services Ltd. Method for changing blood brain barrier permeability
CN113908431A (zh) * 2018-08-23 2022-01-11 诺沃库勒有限责任公司 使用交变电场来提高血脑屏障的通透性

Also Published As

Publication number Publication date
JP2023522817A (ja) 2023-06-01
WO2021214693A1 (en) 2021-10-28
CN115916325A (zh) 2023-04-04
EP4138988A1 (en) 2023-03-01
US20210330950A1 (en) 2021-10-28
IL295251A (en) 2022-10-01
KR20230002800A (ko) 2023-01-05
CA3171313A1 (en) 2021-10-28
BR112022021484A2 (pt) 2022-12-13
AU2021261745A1 (en) 2022-08-25
TW202206140A (zh) 2022-02-16

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