JP6896630B2 - 牛樟芝化合物、その製造方法及び用途 - Google Patents

牛樟芝化合物、その製造方法及び用途 Download PDF

Info

Publication number
JP6896630B2
JP6896630B2 JP2017535086A JP2017535086A JP6896630B2 JP 6896630 B2 JP6896630 B2 JP 6896630B2 JP 2017535086 A JP2017535086 A JP 2017535086A JP 2017535086 A JP2017535086 A JP 2017535086A JP 6896630 B2 JP6896630 B2 JP 6896630B2
Authority
JP
Japan
Prior art keywords
hexane
ethyl acetate
fractions
silica gel
mobile phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017535086A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018507175A5 (enExample
JP2018507175A (ja
Inventor
チゥン−リン リウ
チゥン−リン リウ
ウェイ−シェ ツァイ
ウェイ−シェ ツァイ
カイ−シン シエ
カイ−シン シエ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oneness Biotech Co Ltd
Original Assignee
Oneness Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oneness Biotech Co Ltd filed Critical Oneness Biotech Co Ltd
Publication of JP2018507175A publication Critical patent/JP2018507175A/ja
Publication of JP2018507175A5 publication Critical patent/JP2018507175A5/ja
Application granted granted Critical
Publication of JP6896630B2 publication Critical patent/JP6896630B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/21—Acetic acid esters of hydroxy compounds with more than three hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017535086A 2014-12-30 2015-12-30 牛樟芝化合物、その製造方法及び用途 Active JP6896630B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098177P 2014-12-30 2014-12-30
US62/098,177 2014-12-30
PCT/CN2015/099894 WO2016107582A1 (en) 2014-12-30 2015-12-30 Compounds from antrodia camphorata, method for preparing the same and use thereof

Publications (3)

Publication Number Publication Date
JP2018507175A JP2018507175A (ja) 2018-03-15
JP2018507175A5 JP2018507175A5 (enExample) 2021-03-18
JP6896630B2 true JP6896630B2 (ja) 2021-06-30

Family

ID=56163420

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017535086A Active JP6896630B2 (ja) 2014-12-30 2015-12-30 牛樟芝化合物、その製造方法及び用途

Country Status (9)

Country Link
US (1) US9884801B2 (enExample)
EP (1) EP3240772B1 (enExample)
JP (1) JP6896630B2 (enExample)
CN (1) CN105732381B (enExample)
ES (1) ES2869904T3 (enExample)
MY (1) MY173104A (enExample)
PL (1) PL3240772T3 (enExample)
TW (1) TWI648257B (enExample)
WO (1) WO2016107582A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106063800B (zh) * 2016-08-01 2020-02-18 上海交通大学 牛樟芝在抗前列腺增生药物中的应用
ES2941463T3 (es) 2016-11-18 2023-05-23 Golden Biotechnology Corp Composiciones para el tratamiento de la dermatitis atópica
CN108409571A (zh) * 2018-03-23 2018-08-17 中国药科大学 从金刚纂中提取的用于治疗癌症的化合物
WO2020176436A1 (en) * 2019-02-25 2020-09-03 Arjil Biotech Holding Company Limited Method and composition for inhibiting virus infection
CN113831221B (zh) * 2021-09-18 2023-04-07 云南民族大学 一种倍半萜类化合物及其制备方法与应用
CN114487252B (zh) * 2021-12-28 2024-03-26 陕西嘉禾生物科技股份有限公司 一种用于区别牛樟芝和牛樟木的薄层色谱鉴别方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6247838B1 (en) 1998-11-24 2001-06-19 The Boc Group, Inc. Method for producing a liquid mixture having a predetermined concentration of a specified component
US7531627B2 (en) 2003-12-19 2009-05-12 Po-Jung Chien Protein ACA1 of Antrodia camphorata
US7109232B2 (en) 2004-03-08 2006-09-19 Simpson Biotech Co., Ltd. Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity
EP1634877B1 (en) 2004-08-17 2011-06-22 Simpson Biotech Co., Ltd. Mixture and compounds from mycelia of antrodia camphorata and use thereof
US7601854B2 (en) 2006-10-25 2009-10-13 Kang Jian Biotech Corp., Ltd. Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
TW200829234A (en) * 2007-01-08 2008-07-16 Golden Biotechnology Corp Antrodia camphorata isophorone extract
TW200918498A (en) * 2007-10-19 2009-05-01 Golden Biotechnology Corp Novel compound isolated from Antrodia camphorate extracts
CN101417934B (zh) * 2007-10-24 2012-04-18 国鼎生物科技股份有限公司 分离自牛樟芝萃取物的化合物
TW201000112A (en) 2008-06-18 2010-01-01 Mackay Memorial Hospital Use of dehydrosulphurenic acid for inhibiting the growth of cancer cells
US8309611B2 (en) * 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
CN103796647A (zh) * 2011-06-10 2014-05-14 国鼎生物科技股份有限公司 用于治疗脑癌的方法和组合物
CN103570531A (zh) * 2012-07-25 2014-02-12 丽丰实业股份有限公司 樟芝菌丝体的化合物及其用途
JP5908002B2 (ja) * 2013-03-20 2016-04-26 卉菱 曽 ベニクスノキタケに含まれる化合物及びその用途
TWI583376B (zh) * 2013-03-20 2017-05-21 曾卉菱 Compounds isolated from Antelroxicus and their use
CN104177240B (zh) * 2013-05-28 2016-10-19 曾卉菱 分离自牛樟芝的化合物、萃取物及其用途
CN104211627A (zh) * 2013-05-29 2014-12-17 曾卉菱 牛樟芝化合物、萃取物及其用途
US9249117B2 (en) * 2014-05-20 2016-02-02 Hui Ling Tseng Use of compounds from Antrodia camphorata in manufacturing medicaments for treating kidney diseases

Also Published As

Publication number Publication date
TW201623208A (zh) 2016-07-01
EP3240772A1 (en) 2017-11-08
ES2869904T3 (es) 2021-10-26
US9884801B2 (en) 2018-02-06
US20160185703A1 (en) 2016-06-30
EP3240772B1 (en) 2021-03-03
CN105732381A (zh) 2016-07-06
JP2018507175A (ja) 2018-03-15
MY173104A (en) 2019-12-26
EP3240772A4 (en) 2018-08-29
CN105732381B (zh) 2021-07-20
PL3240772T3 (pl) 2021-06-28
WO2016107582A1 (en) 2016-07-07
TWI648257B (zh) 2019-01-21

Similar Documents

Publication Publication Date Title
JP6896630B2 (ja) 牛樟芝化合物、その製造方法及び用途
JP5755633B2 (ja) 新規サルビアノール酸化合物ｌ、その調製方法及び使用
JP6549544B2 (ja) ガンおよび他の疾患を治療するための新規化合物
JP6302102B2 (ja) ベニコウジカビ（ｍｏｎａｓｃｕｓ ｐｕｒｐｕｒｅｕｓ）から単離された化合物、その調製方法及び使用
JP2018507175A5 (enExample)
CN1308000C (zh) 用于治疗实体瘤的含有白头翁根浸膏作为活性成分的药物
TWI580689B (zh) 甾醇類衍生物及其製備方法與應用
CN110437247B (zh) 一种具有保肝护肝作用的混源萜类化合物及其用途
CN107746403A (zh) 系列开环松香烷型二萜类化合物及其药物组合物与其在制药中的应用
CN103570531A (zh) 樟芝菌丝体的化合物及其用途
CN114533719A (zh) 松香烷型二萜类化合物在制备抗炎药物中的应用
CN110934877A (zh) 过氧麦角甾醇和egfr靶点抗体组合物及其在头颈部鳞状细胞癌上应用
CN119707883B (zh) 二氢沉香呋喃型倍半萜类化合物、含有该类化合物的提取物及应用
CN110812479A (zh) 没食子酸和egfr靶点抗体组合物及其在肺癌上应用
US20090022827A1 (en) Agent and method for eliminating malignance of cancer cells without harmful effect to normal cells
CN108864130A (zh) Enmein衍生物及其制备方法和应用
JP4500951B1 (ja) Ｄｎａ合成酵素阻害剤
KR101873607B1 (ko) 암 및 다른 질환들을 치료하기 위한 화합물
CN103800308A (zh) 环菠萝蜜烷型降三萜在制备抗肿瘤药物中的用途
JP2004331501A (ja) 新規化合物またはその誘導体を含有する抗炎症剤
KR20060086781A (ko) 진세노사이드 유도체 및 그의 용도
JPH0892118A (ja) 狼毒に含まれる抗癌および抗ウィルス性成分の採取法および使用法
CN110959851A (zh) 圆孢蘑菇没食子酸在功能食品中的应用
JPH08311056A (ja) 狼毒に含まれる抗ウィルス性を有する成分
CN105440047A (zh) 口山酮化合物及其制备方法、药物组合物和用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170921

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170921

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171130

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180621

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180703

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20181003

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190212

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20190611

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20190611

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20190611

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20190704

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20190709

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20190913

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20190924

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20200225

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20200414

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20200609

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20200908

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20201027

C13 Notice of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: C13

Effective date: 20201104

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20210201

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20210413

C23 Notice of termination of proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C23

Effective date: 20210420

C03 Trial/appeal decision taken

Free format text: JAPANESE INTERMEDIATE CODE: C03

Effective date: 20210525

C30A Notification sent

Free format text: JAPANESE INTERMEDIATE CODE: C3012

Effective date: 20210525

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210609

R150 Certificate of patent or registration of utility model

Ref document number: 6896630

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250