TWI648257B - 牛樟芝化合物、製備方法及其用途 - Google Patents

牛樟芝化合物、製備方法及其用途 Download PDF

Info

Publication number
TWI648257B
TWI648257B TW104144385A TW104144385A TWI648257B TW I648257 B TWI648257 B TW I648257B TW 104144385 A TW104144385 A TW 104144385A TW 104144385 A TW104144385 A TW 104144385A TW I648257 B TWI648257 B TW I648257B
Authority
TW
Taiwan
Prior art keywords
cancer
compound
hexane
pharmaceutical composition
ethyl acetate
Prior art date
Application number
TW104144385A
Other languages
English (en)
Chinese (zh)
Other versions
TW201623208A (zh
Inventor
劉瓊琳
蔡濰澤
謝凱欣
Original Assignee
合一生技股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 合一生技股份有限公司 filed Critical 合一生技股份有限公司
Publication of TW201623208A publication Critical patent/TW201623208A/zh
Application granted granted Critical
Publication of TWI648257B publication Critical patent/TWI648257B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12Acetic acid esters
    • C07C69/21Acetic acid esters of hydroxy compounds with more than three hydroxy groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78Separation; Purification; Stabilisation; Use of additives
    • C07C45/79Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/48Separation; Purification; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/48Separation; Purification; Stabilisation; Use of additives
    • C07C67/56Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW104144385A 2014-12-30 2015-12-30 牛樟芝化合物、製備方法及其用途 TWI648257B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098177P 2014-12-30 2014-12-30
US62/098,177 2014-12-30

Publications (2)

Publication Number Publication Date
TW201623208A TW201623208A (zh) 2016-07-01
TWI648257B true TWI648257B (zh) 2019-01-21

Family

ID=56163420

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104144385A TWI648257B (zh) 2014-12-30 2015-12-30 牛樟芝化合物、製備方法及其用途

Country Status (9)

Country Link
US (1) US9884801B2 (enExample)
EP (1) EP3240772B1 (enExample)
JP (1) JP6896630B2 (enExample)
CN (1) CN105732381B (enExample)
ES (1) ES2869904T3 (enExample)
MY (1) MY173104A (enExample)
PL (1) PL3240772T3 (enExample)
TW (1) TWI648257B (enExample)
WO (1) WO2016107582A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106063800B (zh) * 2016-08-01 2020-02-18 上海交通大学 牛樟芝在抗前列腺增生药物中的应用
ES2941463T3 (es) 2016-11-18 2023-05-23 Golden Biotechnology Corp Composiciones para el tratamiento de la dermatitis atópica
CN108409571A (zh) * 2018-03-23 2018-08-17 中国药科大学 从金刚纂中提取的用于治疗癌症的化合物
WO2020176436A1 (en) * 2019-02-25 2020-09-03 Arjil Biotech Holding Company Limited Method and composition for inhibiting virus infection
CN113831221B (zh) * 2021-09-18 2023-04-07 云南民族大学 一种倍半萜类化合物及其制备方法与应用
CN114487252B (zh) * 2021-12-28 2024-03-26 陕西嘉禾生物科技股份有限公司 一种用于区别牛樟芝和牛樟木的薄层色谱鉴别方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342137B1 (en) * 2007-01-08 2008-03-11 Golden Biotechnology Corporation Cyclohexenone compounds from Antrodia camphorata and application thereof
CN101417934A (zh) * 2007-10-24 2009-04-29 国鼎生物科技股份有限公司 分离自牛樟芝萃取物的新化合物
TW201249426A (en) * 2011-06-10 2012-12-16 Golden Biotechnology Corp Methods and compositions for treating brain cancer
CN103570531A (zh) * 2012-07-25 2014-02-12 丽丰实业股份有限公司 樟芝菌丝体的化合物及其用途
TW201436789A (zh) * 2013-03-20 2014-10-01 曾卉菱 分離自牛樟芝的化合物、萃取物及其用途
CN104177240A (zh) * 2013-05-28 2014-12-03 曾卉菱 分离自牛樟芝的化合物、萃取物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6247838B1 (en) 1998-11-24 2001-06-19 The Boc Group, Inc. Method for producing a liquid mixture having a predetermined concentration of a specified component
US7531627B2 (en) 2003-12-19 2009-05-12 Po-Jung Chien Protein ACA1 of Antrodia camphorata
US7109232B2 (en) 2004-03-08 2006-09-19 Simpson Biotech Co., Ltd. Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity
EP1634877B1 (en) 2004-08-17 2011-06-22 Simpson Biotech Co., Ltd. Mixture and compounds from mycelia of antrodia camphorata and use thereof
US7601854B2 (en) 2006-10-25 2009-10-13 Kang Jian Biotech Corp., Ltd. Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
TW200918498A (en) * 2007-10-19 2009-05-01 Golden Biotechnology Corp Novel compound isolated from Antrodia camphorate extracts
TW201000112A (en) 2008-06-18 2010-01-01 Mackay Memorial Hospital Use of dehydrosulphurenic acid for inhibiting the growth of cancer cells
US8309611B2 (en) * 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
JP5908002B2 (ja) * 2013-03-20 2016-04-26 卉菱 曽 ベニクスノキタケに含まれる化合物及びその用途
CN104211627A (zh) * 2013-05-29 2014-12-17 曾卉菱 牛樟芝化合物、萃取物及其用途
US9249117B2 (en) * 2014-05-20 2016-02-02 Hui Ling Tseng Use of compounds from Antrodia camphorata in manufacturing medicaments for treating kidney diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342137B1 (en) * 2007-01-08 2008-03-11 Golden Biotechnology Corporation Cyclohexenone compounds from Antrodia camphorata and application thereof
CN101417934A (zh) * 2007-10-24 2009-04-29 国鼎生物科技股份有限公司 分离自牛樟芝萃取物的新化合物
TW201249426A (en) * 2011-06-10 2012-12-16 Golden Biotechnology Corp Methods and compositions for treating brain cancer
CN103570531A (zh) * 2012-07-25 2014-02-12 丽丰实业股份有限公司 樟芝菌丝体的化合物及其用途
TW201436789A (zh) * 2013-03-20 2014-10-01 曾卉菱 分離自牛樟芝的化合物、萃取物及其用途
CN104177240A (zh) * 2013-05-28 2014-12-03 曾卉菱 分离自牛樟芝的化合物、萃取物及其用途

Also Published As

Publication number Publication date
TW201623208A (zh) 2016-07-01
JP6896630B2 (ja) 2021-06-30
EP3240772A1 (en) 2017-11-08
ES2869904T3 (es) 2021-10-26
US9884801B2 (en) 2018-02-06
US20160185703A1 (en) 2016-06-30
EP3240772B1 (en) 2021-03-03
CN105732381A (zh) 2016-07-06
JP2018507175A (ja) 2018-03-15
MY173104A (en) 2019-12-26
EP3240772A4 (en) 2018-08-29
CN105732381B (zh) 2021-07-20
PL3240772T3 (pl) 2021-06-28
WO2016107582A1 (en) 2016-07-07

Similar Documents

Publication Publication Date Title
CN101392015B (zh) 山茶种子中的三萜皂苷及其制备方法和医药用途
TWI648257B (zh) 牛樟芝化合物、製備方法及其用途
JP2012522022A (ja) 新規サルビアノール酸化合物l、その調製方法及び使用
CN104622865B (zh) 巨大戟二萜类化合物在制备抗肿瘤药物中的应用
CN102516344B (zh) 一种具有抗肿瘤活性的化合物及其制备方法和应用
JP6302102B2 (ja) ベニコウジカビ(monascus purpureus)から単離された化合物、その調製方法及び使用
CN103599145B (zh) 铁筷子提取物及其中有效成分的分离方法和所得化合物
CN106176716B (zh) 瑞香烷型二萜化合物pimelotide C的新用途
CN110437247B (zh) 一种具有保肝护肝作用的混源萜类化合物及其用途
TW201335177A (zh) 甾醇類衍生物及其製備方法與應用
CN110903268B (zh) 沃卡帕烷型二萜衍生物及其制备方法和应用
CN103833823B (zh) 二萜二聚体类化合物及其药物组合物和制备方法与应用
CN107746403A (zh) 系列开环松香烷型二萜类化合物及其药物组合物与其在制药中的应用
CN108948040B (zh) 一种烟管头草中提取的吉玛烷型倍半萜化合物及其应用
CN114533719A (zh) 松香烷型二萜类化合物在制备抗炎药物中的应用
CN110812479A (zh) 没食子酸和egfr靶点抗体组合物及其在肺癌上应用
CN117586214B (zh) 乌药烷型倍半萜二聚体及其制备方法和用途
CN110934877A (zh) 过氧麦角甾醇和egfr靶点抗体组合物及其在头颈部鳞状细胞癌上应用
CN104788528B (zh) 霞草齐墩果烷型五环三萜化合物,含有该化合物的药物组合物及其应用
JPH0386824A (ja) ジテルペン系化合物及びこれを有効成分とする抗炎症剤
CN109180632A (zh) 一种从雷公藤中分离出的新化合物及其制备方法和医药用途
CN110204477B (zh) 一种具有抗氧化作用的二萜生物碱及其在制备药物中的应用
CN105440047B (zh) 口山酮化合物及其制备方法、药物组合物和用途
CN100582110C (zh) 环己酮类饱和三环(桥环)化合物及其制备方法与用途
CN110959851A (zh) 圆孢蘑菇没食子酸在功能食品中的应用