TWI648257B - 牛樟芝化合物、製備方法及其用途 - Google Patents

牛樟芝化合物、製備方法及其用途 Download PDF

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Publication number
TWI648257B
TWI648257B TW104144385A TW104144385A TWI648257B TW I648257 B TWI648257 B TW I648257B TW 104144385 A TW104144385 A TW 104144385A TW 104144385 A TW104144385 A TW 104144385A TW I648257 B TWI648257 B TW I648257B
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Taiwan
Prior art keywords
cancer
compound
hexane
pharmaceutical composition
ethyl acetate
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TW104144385A
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English (en)
Chinese (zh)
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TW201623208A (zh
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劉瓊琳
蔡濰澤
謝凱欣
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合一生技股份有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/21—Acetic acid esters of hydroxy compounds with more than three hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
TW104144385A 2014-12-30 2015-12-30 牛樟芝化合物、製備方法及其用途 TWI648257B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098177P 2014-12-30 2014-12-30
US62/098,177 2014-12-30

Publications (2)

Publication Number Publication Date
TW201623208A TW201623208A (zh) 2016-07-01
TWI648257B true TWI648257B (zh) 2019-01-21

Family

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Family Applications (1)

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TW104144385A TWI648257B (zh) 2014-12-30 2015-12-30 牛樟芝化合物、製備方法及其用途

Country Status (9)

Country Link
US (1) US9884801B2 (enExample)
EP (1) EP3240772B1 (enExample)
JP (1) JP6896630B2 (enExample)
CN (1) CN105732381B (enExample)
ES (1) ES2869904T3 (enExample)
MY (1) MY173104A (enExample)
PL (1) PL3240772T3 (enExample)
TW (1) TWI648257B (enExample)
WO (1) WO2016107582A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106063800B (zh) * 2016-08-01 2020-02-18 上海交通大学 牛樟芝在抗前列腺增生药物中的应用
EP3541777B1 (en) * 2016-11-18 2023-01-11 Golden Biotechnology Corporation Compositions for treating atopic dermatitis
CN108409571A (zh) * 2018-03-23 2018-08-17 中国药科大学 从金刚纂中提取的用于治疗癌症的化合物
CN113795258B (zh) * 2019-02-25 2024-04-16 吉亚生技控股股份有限公司 抑制病毒感染的方法及组合物
CN112851510B (zh) * 2021-01-27 2022-07-19 Ａｇｃ株式会社 他氟前列素的纯化方法
CN113831221B (zh) * 2021-09-18 2023-04-07 云南民族大学 一种倍半萜类化合物及其制备方法与应用
CN114487252B (zh) * 2021-12-28 2024-03-26 陕西嘉禾生物科技股份有限公司 一种用于区别牛樟芝和牛樟木的薄层色谱鉴别方法

Citations (6)

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Publication number Priority date Publication date Assignee Title
US7342137B1 (en) * 2007-01-08 2008-03-11 Golden Biotechnology Corporation Cyclohexenone compounds from Antrodia camphorata and application thereof
CN101417934A (zh) * 2007-10-24 2009-04-29 国鼎生物科技股份有限公司 分离自牛樟芝萃取物的新化合物
TW201249426A (en) * 2011-06-10 2012-12-16 Golden Biotechnology Corp Methods and compositions for treating brain cancer
CN103570531A (zh) * 2012-07-25 2014-02-12 丽丰实业股份有限公司 樟芝菌丝体的化合物及其用途
TW201436789A (zh) * 2013-03-20 2014-10-01 曾卉菱 分離自牛樟芝的化合物、萃取物及其用途
CN104177240A (zh) * 2013-05-28 2014-12-03 曾卉菱 分离自牛樟芝的化合物、萃取物及其用途

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US6247838B1 (en) 1998-11-24 2001-06-19 The Boc Group, Inc. Method for producing a liquid mixture having a predetermined concentration of a specified component
US7531627B2 (en) 2003-12-19 2009-05-12 Po-Jung Chien Protein ACA1 of Antrodia camphorata
US7109232B2 (en) 2004-03-08 2006-09-19 Simpson Biotech Co., Ltd. Compounds from Antrodia camphorata having anti-inflammatory and anti-tumor activity
ATE513823T1 (de) 2004-08-17 2011-07-15 Simpson Biotech Co Ltd Mischung und verbindungen von mycelien von antrodia camphorata und deren verwendung
US7601854B2 (en) 2006-10-25 2009-10-13 Kang Jian Biotech Corp., Ltd. Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
TW200918498A (en) 2007-10-19 2009-05-01 Golden Biotechnology Corp Novel compound isolated from Antrodia camphorate extracts
TW201000112A (en) 2008-06-18 2010-01-01 Mackay Memorial Hospital Use of dehydrosulphurenic acid for inhibiting the growth of cancer cells
US8309611B2 (en) * 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
JP5908002B2 (ja) * 2013-03-20 2016-04-26 卉菱 曽 ベニクスノキタケに含まれる化合物及びその用途
CN104211627A (zh) * 2013-05-29 2014-12-17 曾卉菱 牛樟芝化合物、萃取物及其用途
US9249117B2 (en) * 2014-05-20 2016-02-02 Hui Ling Tseng Use of compounds from Antrodia camphorata in manufacturing medicaments for treating kidney diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342137B1 (en) * 2007-01-08 2008-03-11 Golden Biotechnology Corporation Cyclohexenone compounds from Antrodia camphorata and application thereof
CN101417934A (zh) * 2007-10-24 2009-04-29 国鼎生物科技股份有限公司 分离自牛樟芝萃取物的新化合物
TW201249426A (en) * 2011-06-10 2012-12-16 Golden Biotechnology Corp Methods and compositions for treating brain cancer
CN103570531A (zh) * 2012-07-25 2014-02-12 丽丰实业股份有限公司 樟芝菌丝体的化合物及其用途
TW201436789A (zh) * 2013-03-20 2014-10-01 曾卉菱 分離自牛樟芝的化合物、萃取物及其用途
CN104177240A (zh) * 2013-05-28 2014-12-03 曾卉菱 分离自牛樟芝的化合物、萃取物及其用途

Also Published As

Publication number Publication date
EP3240772A1 (en) 2017-11-08
JP2018507175A (ja) 2018-03-15
CN105732381B (zh) 2021-07-20
JP6896630B2 (ja) 2021-06-30
PL3240772T3 (pl) 2021-06-28
TW201623208A (zh) 2016-07-01
MY173104A (en) 2019-12-26
WO2016107582A1 (en) 2016-07-07
EP3240772B1 (en) 2021-03-03
US9884801B2 (en) 2018-02-06
EP3240772A4 (en) 2018-08-29
US20160185703A1 (en) 2016-06-30
ES2869904T3 (es) 2021-10-26
CN105732381A (zh) 2016-07-06

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