JP6875996B2 - 神経刺激性ステロイド、組成物、およびその使用 - Google Patents

神経刺激性ステロイド、組成物、およびその使用 Download PDF

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Publication number
JP6875996B2
JP6875996B2 JP2017543767A JP2017543767A JP6875996B2 JP 6875996 B2 JP6875996 B2 JP 6875996B2 JP 2017543767 A JP2017543767 A JP 2017543767A JP 2017543767 A JP2017543767 A JP 2017543767A JP 6875996 B2 JP6875996 B2 JP 6875996B2
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alkyl
pharmaceutically acceptable
acceptable salt
compound
disorders
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JP2018505898A (ja
JP2018505898A5 (enExample
Inventor
アルバート ジーン ロビチャウド，
アルバート ジーン ロビチャウド，
フランセスコ ジー． サリトゥロ，
フランセスコ ジー． サリトゥロ，
ボイド エル． ハリソン，
ボイド エル． ハリソン，
ボテーラ， ガブリエル マルティネス
ボテーラ， ガブリエル マルティネス
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Sage Therapeutics, LLC
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Sage Therapeutics, LLC
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Priority to JP2021042532A priority Critical patent/JP7161558B2/ja
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Priority to JP2022111940A priority patent/JP2022137194A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017543767A 2015-02-20 2016-02-19 神経刺激性ステロイド、組成物、およびその使用 Active JP6875996B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021042532A JP7161558B2 (ja) 2015-02-20 2021-03-16 神経刺激性ステロイド、組成物、およびその使用
JP2022111940A JP2022137194A (ja) 2015-02-20 2022-07-12 神経刺激性ステロイド、組成物、およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562118884P 2015-02-20 2015-02-20
US62/118,884 2015-02-20
PCT/US2016/018748 WO2016134301A2 (en) 2015-02-20 2016-02-19 Neuroactive steroids, compositions, and uses thereof

Related Child Applications (1)

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JP2021042532A Division JP7161558B2 (ja) 2015-02-20 2021-03-16 神経刺激性ステロイド、組成物、およびその使用

Publications (3)

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JP2018505898A JP2018505898A (ja) 2018-03-01
JP2018505898A5 JP2018505898A5 (enExample) 2019-03-22
JP6875996B2 true JP6875996B2 (ja) 2021-05-26

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JP2021042532A Active JP7161558B2 (ja) 2015-02-20 2021-03-16 神経刺激性ステロイド、組成物、およびその使用
JP2022111940A Pending JP2022137194A (ja) 2015-02-20 2022-07-12 神経刺激性ステロイド、組成物、およびその使用

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JP2022111940A Pending JP2022137194A (ja) 2015-02-20 2022-07-12 神経刺激性ステロイド、組成物、およびその使用

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US (4) US10329320B2 (enExample)
EP (2) EP3258939B1 (enExample)
JP (3) JP6875996B2 (enExample)
DK (1) DK3258939T3 (enExample)
ES (1) ES2935476T3 (enExample)
WO (1) WO2016134301A2 (enExample)

Cited By (1)

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JP2021098747A (ja) * 2015-02-20 2021-07-01 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用

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US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
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