JP6797803B2 - ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 - Google Patents

ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 Download PDF

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JP6797803B2
JP6797803B2 JP2017534929A JP2017534929A JP6797803B2 JP 6797803 B2 JP6797803 B2 JP 6797803B2 JP 2017534929 A JP2017534929 A JP 2017534929A JP 2017534929 A JP2017534929 A JP 2017534929A JP 6797803 B2 JP6797803 B2 JP 6797803B2
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JP2018502114A (ja
JP2018502114A5 (cg-RX-API-DMAC7.html
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カング リン
カング リン
ズハング キアオクイ
ズハング キアオクイ
ハリス ジェフリー
ハリス ジェフリー
ジャンコビク ウラジミール
ジャンコビク ウラジミール
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Celgene Corp
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JP2017534929A 2014-12-31 2015-12-30 ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 Expired - Fee Related JP6797803B2 (ja)

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US201462098547P 2014-12-31 2014-12-31
US62/098,547 2014-12-31
US201562139952P 2015-03-30 2015-03-30
US62/139,952 2015-03-30
PCT/US2015/068069 WO2016109668A1 (en) 2014-12-31 2015-12-30 Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

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WO2014100615A1 (en) 2012-12-20 2014-06-26 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
HK1220205A1 (zh) 2013-03-15 2017-04-28 Celgene Corporation 修饰的t淋巴细胞
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
HRP20230265T1 (hr) * 2014-08-22 2023-04-14 Celgene Corporation Postupci liječenja multiplog mijeloma imunomodulatornim spojevima u kombinaciji s protutijelima
JP6893873B2 (ja) 2014-12-01 2021-06-23 スンマ ヘルスＳｕｍｍａ Ｈｅａｌｔｈ 新規の再生治療剤としてのｃａｍｋｋ１
WO2016118832A1 (en) 2015-01-22 2016-07-28 University Of Massachusetts Cancer immunotherapy
RS60792B1 (sr) 2015-05-29 2020-10-30 Agenus Inc Anti-ctla-4 antitela i postupci za njihovu primenu
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
EP3439675A4 (en) 2016-04-08 2019-12-18 Purdue Research Foundation METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY
EP3484478B1 (en) * 2016-07-15 2025-11-05 Viracta Subsidiary, Inc. Histone deacetylase inhibitors for use in immunotherapy
TWI843168B (zh) 2016-10-11 2024-05-21 美商艾吉納斯公司 抗ｌａｇ－３抗體及其使用方法
EP3532638A4 (en) * 2016-10-31 2020-07-29 University of Massachusetts TARGETING MICROARN-101-3 P IN CARCINOTHERAPY
MD3551660T2 (ro) 2016-12-07 2024-03-31 Agenus Inc Anticorpi anti-CTLA-4 și procedee de utilizare a acestora
EP3551225A1 (en) 2016-12-07 2019-10-16 Agenus Inc. Antibodies and methods of use thereof
BR112019011450A2 (pt) 2016-12-09 2019-10-15 Onkimmune Ltd células naturais killer modificadas e uso das mesmas
WO2018121679A1 (zh) * 2016-12-30 2018-07-05 四川大学 表达cxcr4的嵌合抗原受体修饰的淋巴细胞及制备方法和用途
CN110582288B (zh) 2017-02-28 2024-09-20 恩多塞特公司 用于car t细胞疗法的组合物和方法
RU2019128544A (ru) 2017-03-27 2021-04-28 Нэшнл Юниверсити Оф Сингапур Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров
CN117384929A (zh) 2017-03-27 2024-01-12 新加坡国立大学 一种编码由细胞表达的嵌合受体的多核苷酸
WO2018177971A1 (en) * 2017-03-27 2018-10-04 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to obtain lymphoid progenitors
AU2018273963B2 (en) * 2017-05-25 2023-07-20 University Of Central Florida Research Foundation, Inc. Novel oncolytic viruses for sensitizing tumor cells to killing by natural killer cells
TWI676483B (zh) * 2017-08-06 2019-11-11 強普生技股份有限公司 醫藥套組及其用途
US20200246393A1 (en) * 2017-09-28 2020-08-06 Celularity, Inc. Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
IL273757B2 (en) * 2017-10-02 2025-01-01 Gamida Cell Ltd Growing and using NK cell populations
US11760806B2 (en) * 2017-11-03 2023-09-19 Sorrento Therapeutics, Inc. CD-38 directed chimeric antigen receptor constructs
KR20200098590A (ko) * 2017-12-12 2020-08-20 마크로제닉스, 인크. 이중특이적 cd16-결합 분자 및 질환 치료에서의 그것의 용도
CN108060137B (zh) * 2017-12-26 2021-07-02 博生吉医药科技(苏州)有限公司 Il7和il21修饰的nk92细胞、制备方法及其应用
WO2019127215A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
KR102338992B1 (ko) 2018-01-05 2021-12-14 지엔티 바이오테크 & 메디컬즈 코포레이션 종양 미세환경 및 면역요법의 조절을 위한 약제학적 조합물 및 방법
CN112055595B (zh) 2018-01-22 2024-12-17 恩多塞特公司 Car t细胞的使用方法
US11814623B2 (en) 2018-01-30 2023-11-14 University Of Massachusetts Methods of treating a wound using epigenetic regulation
MY199514A (en) 2018-02-01 2023-11-02 Nkmax Co Ltd Method of producing natural killer cells and composition for treating cancer
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CN111918661A (zh) 2018-02-21 2020-11-10 得克萨斯大学体系董事会 用于活化和扩增自然杀伤细胞的方法及其用途
JP7568224B2 (ja) 2018-02-23 2024-10-16 エンドサイト・インコーポレイテッド Ｃａｒ ｔ細胞療法のための配列決定法
EP3768281B1 (en) * 2018-03-19 2023-07-05 The Regents Of The University Of Michigan Compositions and methods for t-cell and cytokine activation
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
JP2021521193A (ja) 2018-04-18 2021-08-26 スンマ ヘルスＳｕｍｍａ Ｈｅａｌｔｈ 虚血および心筋症の処置のための組成物および方法
WO2019200586A1 (en) * 2018-04-19 2019-10-24 The Chinese University Of Hong Kong Modified nk cells and uses thereof
GB201807050D0 (en) * 2018-04-30 2018-06-13 Cellprotect Nordic Pharmaceuticals Ab Medical uses
KR102373502B1 (ko) 2018-05-14 2022-03-11 주식회사 금호에이치티 골수유래억제세포 관련 질환의 예방 및 치료 용도
KR102069704B1 (ko) * 2018-05-16 2020-01-23 고려대학교 산학협력단 Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법
US12304962B2 (en) * 2018-05-30 2025-05-20 Glycostem Therapeutics B.V. CAR NK cells
WO2019240934A1 (en) 2018-06-12 2019-12-19 Promab Biotechnologies, Inc. Plap-car-effector cells
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
EP3846829A4 (en) * 2018-09-05 2022-09-14 Arizona Board of Regents on behalf of Arizona State University ONCOLYTIC VIRUS PLATFORM FOR THE TREATMENT OF HEMATOLOGICAL CANCER
CA3114707A1 (en) * 2018-10-19 2020-04-23 Regents Of The University Of Minnesota Nk engager molecules and methods of use thereof
SG11202104524YA (en) 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
KR20210111244A (ko) * 2018-11-30 2021-09-10 셀룰래리티 인코포레이티드 태반-유래 동종이계 car-t 세포 및 이의 용도
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY
CA3133419A1 (en) * 2019-03-21 2020-09-24 Gamida Cell Ltd. Expansion and use of expanded nk cell fractions suitable for transplantation in combination therapy
TW202110873A (zh) 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法
US20220273716A1 (en) * 2019-07-25 2022-09-01 Celularity Inc. Populations of natural killer cells comprising a cd38 chimeric antigen receptor
US20220340927A1 (en) * 2019-09-01 2022-10-27 Exuma Biotech Corp. Methods and compositions for the modification and delivery of lymphocytes
EP4041256A4 (en) * 2019-10-10 2023-11-08 Arizona Board of Regents on behalf of Arizona State University Oncolytic viruses that express multi-specific immune cell engagers
US20230017590A1 (en) * 2019-11-27 2023-01-19 Deverra Therapeutics Inc. Compositions and methods for culturing hematopoietic stem and progenitor cells
CN115943214A (zh) * 2019-11-28 2023-04-07 格雷克斯迪姆医疗私人有限公司 用于获得car-nk细胞的方法
EP4114400A4 (en) * 2020-03-05 2023-10-18 Exuma Biotech Corp. Methods and compositions for the delivery of modified lymphocyte aggregates
WO2021188836A1 (en) * 2020-03-18 2021-09-23 Barron Annelise E Upregulation of cathelicidin gene expression as an adjuvant to other treatments for diseases
CN116249770A (zh) * 2020-09-22 2023-06-09 环球生物科技再生医疗集团有限公司 表达car的自然杀伤细胞与双特异性抗原结合分子作为癌症治疗剂的方法和组合物
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
CN113398264B (zh) * 2021-08-06 2022-04-29 朱有建 Nk细胞及其组合物在治疗癌症中的用途
KR20240054424A (ko) * 2021-08-10 2024-04-25 가미다-셀 리미티드 항-her2 car nk 세포, 이의 생산 방법 및 용도
CN113577267B (zh) * 2021-09-06 2022-04-08 江西北正干细胞生物科技有限公司 Nk细胞和抗体的药物组合物及其在治疗癌症中的用途
AU2022342919A1 (en) * 2021-09-08 2024-03-14 Gaia Biomedicine Inc. Method for treating cells
EP4180049A1 (en) * 2021-11-16 2023-05-17 Ostravska univerzita Therapeutic composition for cancer treatment
CN114058584B (zh) * 2022-01-07 2022-07-01 山东省齐鲁干细胞工程有限公司 一种临床用自然杀伤细胞的制备方法
CN115927169B (zh) * 2022-10-11 2023-08-11 再造再生医学科技(杭州)有限公司 用于扩增cd34+造血干细胞的培养液和体外扩增cd34+造血干细胞的方法
CN119082021B (zh) * 2024-09-30 2025-03-28 广东壹加再生医学研究院有限公司 一种增强型nk细胞及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
CA2370330C (en) 1999-04-16 2009-01-20 Wm. Marsh Rice University Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
JP2002045174A (ja) 2000-07-31 2002-02-12 Inst Of Physical & Chemical Res ナチュラルキラー細胞増殖法
KR100915482B1 (ko) 2000-12-06 2009-09-03 하리리 로버트 제이 태반 줄기 세포의 회수 방법
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
JP6850528B2 (ja) * 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
CN103483452B (zh) * 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
CN114134113A (zh) * 2012-08-13 2022-03-04 人类起源公司 自然杀伤细胞及其用途
EP3811954A1 (en) * 2013-02-26 2021-04-28 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
WO2014164554A1 (en) * 2013-03-10 2014-10-09 Baylor College Of Medicine Chemotherapy-resistant immune cells
ES2769574T3 (es) * 2013-03-15 2020-06-26 Michael C Milone Reconocimiento de células citotóxicas con receptores quiméricos para inmunoterapia adoptiva
KR102098985B1 (ko) * 2013-05-03 2020-04-09 오하이오 스테이트 이노베이션 파운데이션 Cs1-특이적 키메라 항원 수용체 가공된 면역 작동체 세포
WO2014186469A2 (en) * 2013-05-14 2014-11-20 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells

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