JP6786477B2 - ３−ｈｐを生産することができる組換え酵母およびこれを利用した３−ｈｐの製造方法 - Google Patents

３−ｈｐを生産することができる組換え酵母およびこれを利用した３−ｈｐの製造方法 Download PDF

Info

Publication number
JP6786477B2
JP6786477B2 JP2017510862A JP2017510862A JP6786477B2 JP 6786477 B2 JP6786477 B2 JP 6786477B2 JP 2017510862 A JP2017510862 A JP 2017510862A JP 2017510862 A JP2017510862 A JP 2017510862A JP 6786477 B2 JP6786477 B2 JP 6786477B2
Authority
JP
Japan
Prior art keywords
coa
yeast
acetyl
glucose
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017510862A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017525372A (ja
JP2017525372A5 (enExample
Inventor
ジョン ミン パク
ジョン ミン パク
ジェ ヨン パク
ジェ ヨン パク
ウー チャン パク
ウー チャン パク
サン ミン イ
サン ミン イ
ヨン ビン ソ
ヨン ビン ソ
メルヤ オヤ
メルヤ オヤ
オウティ コイヴィストイネン
オウティ コイヴィストイネン
アンドリュー コンレイ
アンドリュー コンレイ
マルヤ イルメン
マルヤ イルメン
ローラ ルオホネン
ローラ ルオホネン
パウラ ヨウフテン
パウラ ヨウフテン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SK Innovation Co Ltd
Original Assignee
SK Innovation Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SK Innovation Co Ltd filed Critical SK Innovation Co Ltd
Publication of JP2017525372A publication Critical patent/JP2017525372A/ja
Publication of JP2017525372A5 publication Critical patent/JP2017525372A5/ja
Application granted granted Critical
Publication of JP6786477B2 publication Critical patent/JP6786477B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0103—3-Hydroxybutyrate dehydrogenase (1.1.1.30)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01031—3-Hydroxyisobutyrate dehydrogenase (1.1.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01059—3-Hydroxypropionate dehydrogenase (1.1.1.59)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01061—4-Hydroxybutyrate dehydrogenase (1.1.1.61)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01298—3-Hydroxypropionate dehydrogenase (NADP+) (1.1.1.298)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
    • C12Y208/04—Transferases transferring sulfur-containing groups (2.8) transferring alkylthio groups (2.8.4)
    • C12Y208/04001—Coenzyme-B sulfoethylthiotransferase (2.8.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017510862A 2014-08-29 2015-08-28 ３−ｈｐを生産することができる組換え酵母およびこれを利用した３−ｈｐの製造方法 Active JP6786477B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20140114505 2014-08-29
KR10-2014-0114505 2014-08-29
PCT/KR2015/009061 WO2016032279A1 (en) 2014-08-29 2015-08-28 Recombinant Yeast Producing 3-Hydroxypropionic Acid and Method for Producing 3-Hydroxypropionic Acid Using the Same

Publications (3)

Publication Number Publication Date
JP2017525372A JP2017525372A (ja) 2017-09-07
JP2017525372A5 JP2017525372A5 (enExample) 2019-05-23
JP6786477B2 true JP6786477B2 (ja) 2020-11-18

Family

ID=55400077

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017510862A Active JP6786477B2 (ja) 2014-08-29 2015-08-28 ３−ｈｐを生産することができる組換え酵母およびこれを利用した３−ｈｐの製造方法

Country Status (7)

Country Link
US (1) US10704064B2 (enExample)
JP (1) JP6786477B2 (enExample)
KR (1) KR102281806B1 (enExample)
CN (1) CN107002019B (enExample)
BR (1) BR112017004069B1 (enExample)
DE (1) DE112015003962B4 (enExample)
WO (1) WO2016032279A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108728471B (zh) * 2017-04-14 2020-01-31 中国科学院微生物研究所 产3-羟基丙酸的重组菌及其制备方法与应用
CN108118004B (zh) * 2017-12-15 2021-06-25 北京工商大学 一株喜仙人掌毕赤酵母在水果采后病害防治中的应用
WO2019152754A1 (en) * 2018-02-01 2019-08-08 Invista North America S.A.R.L. Methods and materials for the biosynthesis of beta hydroxy acids and derivatives and compounds related thereto
KR102140596B1 (ko) 2018-04-17 2020-08-04 에스케이이노베이션 주식회사 유기산 내성 효모 유래 신규 프로모터 및 이를 이용한 목적유전자의 발현방법
KR102140597B1 (ko) * 2018-04-17 2020-08-03 에스케이이노베이션 주식회사 에탄올 생산 경로가 억제된 내산성 효모 및 이를 이용한 젖산의 제조방법
KR102736070B1 (ko) 2018-10-08 2024-12-02 에스케이이노베이션 주식회사 알코올 생성이 억제된 재조합 내산성 효모 및 이를 이용한 젖산의 제조방법
US20220235385A1 (en) * 2019-04-24 2022-07-28 Genomatica, Inc. Engineered microorganisms and methods for improved aldehyde dehydrogenase activity
KR20210041903A (ko) 2019-10-08 2021-04-16 에스케이이노베이션 주식회사 락테이트 대사 및 알코올 생성이 억제된 재조합 내산성 효모 및 이를 이용한 젖산의 제조방법
KR20210128742A (ko) * 2020-04-17 2021-10-27 에스케이이노베이션 주식회사 글리세롤 생성이 억제된 재조합 내산성 효모 및 이를 이용한 젖산의 제조방법
KR20210158676A (ko) 2020-06-24 2021-12-31 에스케이이노베이션 주식회사 젖산 생산능이 증가된 재조합 내산성 효모
CN114480232B (zh) * 2020-10-26 2024-02-02 北京化工大学 生产丙二酸的工程菌及其构建方法和应用
BR112023021282A2 (pt) * 2021-04-13 2023-12-26 Debut Biotechnology Inc Bioprodução de flavonoides e antocianinas usando hospedeiro de microrganismos
CN113563410A (zh) * 2021-07-06 2021-10-29 南京瑞源生物技术有限公司 一种蛋白提取试剂配方

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60327804D1 (de) 2002-01-18 2009-07-09 Novozymes As Alanin-2,3-aminomutase
JP5013448B2 (ja) 2006-08-02 2012-08-29 帝人株式会社 出芽酵母の乳酸耐性又は生産性を向上させる多重遺伝子破壊の組み合わせ
WO2009013157A1 (en) 2007-07-23 2009-01-29 Dsm Ip Assets B.V. Butanol production in a eukaryotic cell
WO2011038364A1 (en) 2009-09-27 2011-03-31 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
MX2013005654A (es) 2010-11-22 2013-07-17 Novozymes Inc Composiciones y metodos para la produccion de acido 3-hidroxipropionico.
KR101860442B1 (ko) * 2011-06-27 2018-05-24 삼성전자주식회사 3-하이드록시프로피온산의 생산을 위한 유전자 조작

Also Published As

Publication number Publication date
BR112017004069A2 (pt) 2018-01-23
DE112015003962B4 (de) 2024-12-19
CN107002019B (zh) 2021-11-23
WO2016032279A1 (en) 2016-03-03
CN107002019A (zh) 2017-08-01
KR102281806B1 (ko) 2021-07-27
JP2017525372A (ja) 2017-09-07
BR112017004069B1 (pt) 2024-02-06
US20170240932A1 (en) 2017-08-24
DE112015003962T5 (de) 2017-08-03
KR20170025315A (ko) 2017-03-08
WO2016032279A9 (en) 2016-04-28
US10704064B2 (en) 2020-07-07

Similar Documents

Publication Publication Date Title
JP6786477B2 (ja) ３−ｈｐを生産することができる組換え酵母およびこれを利用した３−ｈｐの製造方法
JP5551448B2 (ja) １，４−ブタンジオールおよびその前駆体の生合成のための組成物および方法
KR101149566B1 (ko) Ｎａｄｐｈ를 소비하는 생합성 경로에 최적화시킨 미생물 균주
CN107384846B (zh) 生产1,4-丁二醇的微生物和相关方法
CN112877272B (zh) 一种n-乙酰氨基葡萄糖的大肠杆菌工程菌及发酵生产方法
Emmerling et al. Glucose Catabolism ofEscherichia coliStrains with Increased Activity and Altered Regulation of Key Glycolytic Enzymes
Hua et al. Metabolic analysis of adaptive evolution for in silico‐designed lactate‐producing strains
JP2010521182A5 (enExample)
JP2016533162A (ja) 再生可能資源から化合物を生成するための高収量経路
US10385322B2 (en) Mutant glutamate dehydrogenase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
JP2011515083A (ja) グリオキサラーゼｉｉｉ活性を有するポリペプチド、それをコードするポリヌクレオチドおよびその使用
US9957497B2 (en) Hydrocarbon synthase gene and use thereof
JP2014506466A (ja) イソ酪酸を製造するための細胞及び方法
JP2022515078A (ja) マロン酸セミアルデヒドからの３－ＨＰおよびアセチル－ＣｏＡ誘導体の共産生経路
AU2020262490A1 (en) Production of chemicals from renewable sources
Schorsch et al. High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii
JP2023528727A (ja) 動的代謝制御を利用したキシロースからキシリトールを産生するための方法及び組成物
CN110869488A (zh) 增强型代谢物生产酵母
CN106318917B (zh) 天冬氨酸-β-半醛脱氢酶突变体及其应用
JP6917239B2 (ja) タンパク質およびその製造方法、タンパク質組成物ならびにそれを用いたｎｍｎの測定方法および測定組成物
US20160230198A1 (en) Methylmalonic acid compositions, biological methods for making same, and microorganisms for making same
CN114026246B (en) Production of chemicals from renewable sources
Fang et al. Enzyme mining and D-tagatose synthesis using a dual-enzyme redox system
Zamfir Metabolic Engineering of Saccharomyces cerevisiae: From p-Coumaric Acid to Rosmarinic Acid
Lertsriwong Metabolic engineering of saccharomyces cerevisiae for 3-hydroxypropionic acid production

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170406

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180306

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180605

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20181204

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20190327

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20190410

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20190524

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200703

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201028

R150 Certificate of patent or registration of utility model

Ref document number: 6786477

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250