BR112017004069A2 - levedura recombinante produzindo ácido 3-hidroxipropiônico e método para produzir ácido 3-hidroxipropiônico usando o mesmo - Google Patents

levedura recombinante produzindo ácido 3-hidroxipropiônico e método para produzir ácido 3-hidroxipropiônico usando o mesmo

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Publication number
BR112017004069A2
BR112017004069A2 BR112017004069A BR112017004069A BR112017004069A2 BR 112017004069 A2 BR112017004069 A2 BR 112017004069A2 BR 112017004069 A BR112017004069 A BR 112017004069A BR 112017004069 A BR112017004069 A BR 112017004069A BR 112017004069 A2 BR112017004069 A2 BR 112017004069A2
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BR
Brazil
Prior art keywords
producing
hydroxypropionic acid
gene
same
recombinant yeast
Prior art date
Application number
BR112017004069A
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English (en)
Other versions
BR112017004069B1 (pt
Inventor
Conley Andrew
Yeon Park Jae
Min Park Joong
Ruohonen Laura
Ilmén Marja
Oja Merja
Koivistoinen Outi
Jouhten Paula
Min Lee Sang
Chan Park Woo
Bin Seo Young
Original Assignee
Sk Innovation Co Ltd
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Publication date
Application filed by Sk Innovation Co Ltd filed Critical Sk Innovation Co Ltd
Publication of BR112017004069A2 publication Critical patent/BR112017004069A2/pt
Publication of BR112017004069B1 publication Critical patent/BR112017004069B1/pt

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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N1/14—Fungi; Culture media therefor
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    • C12N15/09—Recombinant DNA-technology
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12Y101/0103—3-Hydroxybutyrate dehydrogenase (1.1.1.30)
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    • C12Y101/01031—3-Hydroxyisobutyrate dehydrogenase (1.1.1.31)
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    • C12Y101/01059—3-Hydroxypropionate dehydrogenase (1.1.1.59)
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01298—3-Hydroxypropionate dehydrogenase (NADP+) (1.1.1.298)
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    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
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    • C12Y102/01075—Malonyl CoA reductase (malonate semialdehyde-forming)(1.2.1.75)
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    • C12Y208/04—Transferases transferring sulfur-containing groups (2.8) transferring alkylthio groups (2.8.4)
    • C12Y208/04001—Coenzyme-B sulfoethylthiotransferase (2.8.4.1)
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    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
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  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

são providas uma levedura recombinante produzindo ácido 3-hidroxipropiônico (3-hp) e um método para produzir 3-hp usando o mesmo, mais particularmente, uma levedura recombinante produzindo 3-hp, compreendendo um gene aadh exógeno; um gene acc endógeno ou gene exógeno; um gene mcr exógeno; e um gene hpdh exógeno, produzindo 3-hp através da via biossintética [piruvato ¿ acetaldeído ¿ acetil-coa ¿ malonil-coa ¿ malonato semialdeído ¿ 3-hp], e um método para produzir 3-hp usando o mesmo.
BR112017004069-7A 2014-08-29 2015-08-28 Levedura recombinante produzindo ácido 3-hidroxipropiônico e método para produzir ácido 3-hidroxipropiônico usando o mesmo BR112017004069B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20140114505 2014-08-29
KR10-2014-0114505 2014-08-29
PCT/KR2015/009061 WO2016032279A1 (en) 2014-08-29 2015-08-28 Recombinant Yeast Producing 3-Hydroxypropionic Acid and Method for Producing 3-Hydroxypropionic Acid Using the Same

Publications (2)

Publication Number Publication Date
BR112017004069A2 true BR112017004069A2 (pt) 2018-01-23
BR112017004069B1 BR112017004069B1 (pt) 2024-02-06

Family

ID=55400077

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017004069-7A BR112017004069B1 (pt) 2014-08-29 2015-08-28 Levedura recombinante produzindo ácido 3-hidroxipropiônico e método para produzir ácido 3-hidroxipropiônico usando o mesmo

Country Status (7)

Country Link
US (1) US10704064B2 (pt)
JP (1) JP6786477B2 (pt)
KR (1) KR102281806B1 (pt)
CN (1) CN107002019B (pt)
BR (1) BR112017004069B1 (pt)
DE (1) DE112015003962T5 (pt)
WO (1) WO2016032279A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108728471B (zh) * 2017-04-14 2020-01-31 中国科学院微生物研究所 产3-羟基丙酸的重组菌及其制备方法与应用
CN108118004B (zh) * 2017-12-15 2021-06-25 北京工商大学 一株喜仙人掌毕赤酵母在水果采后病害防治中的应用
WO2019152754A1 (en) * 2018-02-01 2019-08-08 Invista North America S.A.R.L. Methods and materials for the biosynthesis of beta hydroxy acids and derivatives and compounds related thereto
KR102140596B1 (ko) * 2018-04-17 2020-08-04 에스케이이노베이션 주식회사 유기산 내성 효모 유래 신규 프로모터 및 이를 이용한 목적유전자의 발현방법
KR102140597B1 (ko) 2018-04-17 2020-08-03 에스케이이노베이션 주식회사 에탄올 생산 경로가 억제된 내산성 효모 및 이를 이용한 젖산의 제조방법
KR20200040017A (ko) * 2018-10-08 2020-04-17 에스케이이노베이션 주식회사 알코올 생성이 억제된 재조합 내산성 효모 및 이를 이용한 젖산의 제조방법
KR20210041903A (ko) 2019-10-08 2021-04-16 에스케이이노베이션 주식회사 락테이트 대사 및 알코올 생성이 억제된 재조합 내산성 효모 및 이를 이용한 젖산의 제조방법
KR20210128742A (ko) * 2020-04-17 2021-10-27 에스케이이노베이션 주식회사 글리세롤 생성이 억제된 재조합 내산성 효모 및 이를 이용한 젖산의 제조방법
KR20210158676A (ko) 2020-06-24 2021-12-31 에스케이이노베이션 주식회사 젖산 생산능이 증가된 재조합 내산성 효모
CN114480232B (zh) * 2020-10-26 2024-02-02 北京化工大学 生产丙二酸的工程菌及其构建方法和应用
US20220333117A1 (en) * 2021-04-13 2022-10-20 Debut Biotechnology, Inc. Flavonoid and anthocyanin bioproduction using microorganism hosts
CN113563410A (zh) * 2021-07-06 2021-10-29 南京瑞源生物技术有限公司 一种蛋白提取试剂配方

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4532116B2 (ja) 2002-01-18 2010-08-25 ノボザイムズ エー／エス アラニン２，３−アミノムターゼ
JP5013448B2 (ja) * 2006-08-02 2012-08-29 帝人株式会社 出芽酵母の乳酸耐性又は生産性を向上させる多重遺伝子破壊の組み合わせ
US20100248233A1 (en) * 2007-07-23 2010-09-30 Dsm Ip Assets B.V. Acetyl-coa producing enzymes in yeast
MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
CA2818499A1 (en) * 2010-11-22 2012-06-07 Novozymes, Inc. Compositions and methods for 3-hydroxypropionic acid production
KR101860442B1 (ko) * 2011-06-27 2018-05-24 삼성전자주식회사 3-하이드록시프로피온산의 생산을 위한 유전자 조작

Also Published As

Publication number Publication date
DE112015003962T5 (de) 2017-08-03
US10704064B2 (en) 2020-07-07
CN107002019A (zh) 2017-08-01
US20170240932A1 (en) 2017-08-24
JP2017525372A (ja) 2017-09-07
KR20170025315A (ko) 2017-03-08
WO2016032279A9 (en) 2016-04-28
BR112017004069B1 (pt) 2024-02-06
CN107002019B (zh) 2021-11-23
JP6786477B2 (ja) 2020-11-18
KR102281806B1 (ko) 2021-07-27
WO2016032279A1 (en) 2016-03-03

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