JP6771464B2 - Ｃｂｐおよび／またはｅｐ３００インヒビターとしての、４，５，６，７−テトラヒドロ−１ｈ−ピラゾロ［４，３−ｃ］ピリジン−３−アミン化合物 - Google Patents
Ｃｂｐおよび／またはｅｐ３００インヒビターとしての、４，５，６，７−テトラヒドロ−１ｈ−ピラゾロ［４，３−ｃ］ピリジン−３−アミン化合物 Download PDFInfo
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- JP6771464B2 JP6771464B2 JP2017528520A JP2017528520A JP6771464B2 JP 6771464 B2 JP6771464 B2 JP 6771464B2 JP 2017528520 A JP2017528520 A JP 2017528520A JP 2017528520 A JP2017528520 A JP 2017528520A JP 6771464 B2 JP6771464 B2 JP 6771464B2
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Classifications
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| CN2014092380 | 2014-11-27 | ||
| CNPCT/CN2014/092380 | 2014-11-27 | ||
| CNPCT/CN2015/092965 | 2015-10-27 | ||
| CN2015092965 | 2015-10-27 | ||
| PCT/US2015/062794 WO2016086200A1 (en) | 2014-11-27 | 2015-11-25 | 4,5,6,7-tetrahydro-1 h-pyrazolo[4,3-c]pyridin-3-amine compounds as cbp and/or ep300 inhibitors |
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| JP2017537100A JP2017537100A (ja) | 2017-12-14 |
| JP2017537100A5 JP2017537100A5 (enExample) | 2019-01-10 |
| JP6771464B2 true JP6771464B2 (ja) | 2020-10-21 |
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| US (2) | US9763922B2 (enExample) |
| EP (2) | EP3224258B1 (enExample) |
| JP (1) | JP6771464B2 (enExample) |
| CN (1) | CN107531690B (enExample) |
| WO (1) | WO2016086200A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019516759A (ja) * | 2016-05-24 | 2019-06-20 | ジェネンテック， インコーポレイテッド | がんの処置のためのピラゾロピリジン誘導体 |
| JP2024517496A (ja) * | 2021-05-14 | 2024-04-22 | 武漢朗来科技発展有限公司 | Ｒｏｃｋ阻害剤の酸付加塩及び塩の結晶形、組成物並びに薬物用途 |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016077375A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| MA40940A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| MA40943A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| RU2745999C1 (ru) * | 2014-12-05 | 2021-04-05 | Х. Ли Моффитт Кэнсер Сентер Энд Рисёч Инститьют, Инк. | Ингибитор бромодомена в качестве адъюванта в противоопухолевой иммунотерапии |
| CN107531692B (zh) | 2015-01-29 | 2020-12-25 | 基因泰克公司 | 治疗化合物及其用途 |
| AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| JP7160688B2 (ja) * | 2016-05-24 | 2022-10-25 | ジェネンテック， インコーポレイテッド | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
| CA3031525A1 (en) | 2016-07-25 | 2018-02-01 | Epizyme, Inc. | Crebbp related cancer therapy |
| GB201617630D0 (en) * | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201617627D0 (en) * | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| TW201906838A (zh) | 2017-06-21 | 2019-02-16 | 日商第一三共股份有限公司 | Ｅｐ３００／ｃｒｅｂｂｐ抑制劑 |
| TWI846350B (zh) * | 2017-09-15 | 2024-06-21 | 美商佛瑪治療公司 | 作為ＣＢＰ／ｐ３００抑制劑之四氫－咪唑並喹啉化合物 |
| EA202091114A1 (ru) | 2017-11-02 | 2020-07-24 | Айкурис Гмбх Унд Ко. Кг | Новые высокоактивные пиразолопиперидин-замещенные индол-2-карбоксамиды, активные против вируса гепатита в (hbv) |
| AU2019245403B2 (en) * | 2018-03-29 | 2025-02-06 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| US10899769B2 (en) | 2018-04-06 | 2021-01-26 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| GB201806320D0 (en) * | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019516759A (ja) * | 2016-05-24 | 2019-06-20 | ジェネンテック， インコーポレイテッド | がんの処置のためのピラゾロピリジン誘導体 |
| JP7014736B2 (ja) | 2016-05-24 | 2022-02-01 | ジェネンテック， インコーポレイテッド | がんの処置のためのピラゾロピリジン誘導体 |
| JP2024517496A (ja) * | 2021-05-14 | 2024-04-22 | 武漢朗来科技発展有限公司 | Ｒｏｃｋ阻害剤の酸付加塩及び塩の結晶形、組成物並びに薬物用途 |
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| CN107531690A (zh) | 2018-01-02 |
| US20170333406A1 (en) | 2017-11-23 |
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| US20160158207A1 (en) | 2016-06-09 |
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| US9763922B2 (en) | 2017-09-19 |
| EP3224258A1 (en) | 2017-10-04 |
| WO2016086200A1 (en) | 2016-06-02 |
| CN107531690B (zh) | 2020-11-06 |
| EP3224258B1 (en) | 2019-08-14 |
| WO2016086200A9 (en) | 2016-06-23 |
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