JP6739335B2 - ゲノムエンジニアリング - Google Patents

ゲノムエンジニアリング Download PDF

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JP6739335B2
JP6739335B2 JP2016530062A JP2016530062A JP6739335B2 JP 6739335 B2 JP6739335 B2 JP 6739335B2 JP 2016530062 A JP2016530062 A JP 2016530062A JP 2016530062 A JP2016530062 A JP 2016530062A JP 6739335 B2 JP6739335 B2 JP 6739335B2
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dna
cell
nucleic acid
cells
enzyme
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JP2016528894A5 (https=
JP2016528894A (ja
Inventor
ジョージ エム． チャーチ、
ジョージ エム． チャーチ、
ルハン ヤン、
ルハン ヤン、
マーク グエル カーゴル、
マーク グエル カーゴル、
ジョイス リチ ヤン、
ジョイス リチ ヤン、
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Harvard University
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Harvard University
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
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    • C12N2510/00—Genetically modified cells
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible

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  • Bioinformatics & Cheminformatics (AREA)
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  • Cell Biology (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
JP2016530062A 2013-07-26 2014-07-25 ゲノムエンジニアリング Active JP6739335B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361858866P 2013-07-26 2013-07-26
US61/858,866 2013-07-26
PCT/US2014/048140 WO2015013583A2 (en) 2013-07-26 2014-07-25 Genome engineering

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020028641A Division JP6993063B2 (ja) 2013-07-26 2020-02-21 ゲノムエンジニアリング

Publications (3)

Publication Number Publication Date
JP2016528894A JP2016528894A (ja) 2016-09-23
JP2016528894A5 JP2016528894A5 (https=) 2017-07-20
JP6739335B2 true JP6739335B2 (ja) 2020-08-12

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JP2016530062A Active JP6739335B2 (ja) 2013-07-26 2014-07-25 ゲノムエンジニアリング
JP2020028641A Active JP6993063B2 (ja) 2013-07-26 2020-02-21 ゲノムエンジニアリング
JP2021198648A Active JP7419328B2 (ja) 2013-07-26 2021-12-07 ゲノムエンジニアリング
JP2024002064A Pending JP2024029218A (ja) 2013-07-26 2024-01-10 ゲノムエンジニアリング
JP2025269882A Pending JP2026053496A (ja) 2013-07-26 2025-12-19 ゲノムエンジニアリング

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JP2020028641A Active JP6993063B2 (ja) 2013-07-26 2020-02-21 ゲノムエンジニアリング
JP2021198648A Active JP7419328B2 (ja) 2013-07-26 2021-12-07 ゲノムエンジニアリング
JP2024002064A Pending JP2024029218A (ja) 2013-07-26 2024-01-10 ゲノムエンジニアリング
JP2025269882A Pending JP2026053496A (ja) 2013-07-26 2025-12-19 ゲノムエンジニアリング

Country Status (13)

Country Link
US (5) US10563225B2 (https=)
EP (4) EP4234703A3 (https=)
JP (5) JP6739335B2 (https=)
KR (2) KR20230096134A (https=)
CN (3) CN105473773B (https=)
AU (4) AU2014293015B2 (https=)
BR (1) BR112016001721B1 (https=)
CA (1) CA2918540A1 (https=)
ES (1) ES2715666T3 (https=)
IL (2) IL243560B (https=)
RU (2) RU2764757C2 (https=)
SG (3) SG10201913000PA (https=)
WO (1) WO2015013583A2 (https=)

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