JP6621463B2 - 血糖値を低下させ、体重管理をするための健康食品組成物 - Google Patents

血糖値を低下させ、体重管理をするための健康食品組成物 Download PDF

Info

Publication number
JP6621463B2
JP6621463B2 JP2017504290A JP2017504290A JP6621463B2 JP 6621463 B2 JP6621463 B2 JP 6621463B2 JP 2017504290 A JP2017504290 A JP 2017504290A JP 2017504290 A JP2017504290 A JP 2017504290A JP 6621463 B2 JP6621463 B2 JP 6621463B2
Authority
JP
Japan
Prior art keywords
extract
health food
food composition
blood glucose
white
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2017504290A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017515499A (ja
JP2017515499A5 (enExample
Inventor
オルロフスキー，マルク
クロツキエフスキ，マルチン
ビリング−マルチャック，カタジナ
Original Assignee
マルマル インベストメント エスピー．ゼット オー．オー．
マルマル インベストメント エスピー．ゼット オー．オー．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マルマル インベストメント エスピー．ゼット オー．オー．, マルマル インベストメント エスピー．ゼット オー．オー． filed Critical マルマル インベストメント エスピー．ゼット オー．オー．
Publication of JP2017515499A publication Critical patent/JP2017515499A/ja
Publication of JP2017515499A5 publication Critical patent/JP2017515499A5/ja
Application granted granted Critical
Publication of JP6621463B2 publication Critical patent/JP6621463B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/742—Coffea, e.g. coffee
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L23/00—Soups; Sauces; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10—Cereal-derived products
    • A23L7/109—Types of pasta, e.g. macaroni or noodles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2017504290A 2014-04-13 2015-04-12 血糖値を低下させ、体重管理をするための健康食品組成物 Expired - Fee Related JP6621463B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461978900P 2014-04-13 2014-04-13
US61/978,900 2014-04-13
PCT/IB2015/052650 WO2015159195A1 (en) 2014-04-13 2015-04-12 Dietary compositions for reducing blood glucose levels and for weight management

Publications (3)

Publication Number Publication Date
JP2017515499A JP2017515499A (ja) 2017-06-15
JP2017515499A5 JP2017515499A5 (enExample) 2018-05-31
JP6621463B2 true JP6621463B2 (ja) 2019-12-18

Family

ID=53276199

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017504290A Expired - Fee Related JP6621463B2 (ja) 2014-04-13 2015-04-12 血糖値を低下させ、体重管理をするための健康食品組成物

Country Status (8)

Country Link
US (1) US11071767B2 (enExample)
EP (1) EP3145332B1 (enExample)
JP (1) JP6621463B2 (enExample)
CN (1) CN106456692A (enExample)
AU (1) AU2015248506B2 (enExample)
CA (1) CA2945269A1 (enExample)
IL (1) IL248271A0 (enExample)
WO (1) WO2015159195A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111345422A (zh) * 2018-12-21 2020-06-30 中粮营养健康研究院有限公司 一种具有协同降糖作用的固体饮料及其制作和食用方法
CN110693028A (zh) * 2019-10-25 2020-01-17 陕西中鸿科瑞再生医学研究院有限公司 一种降糖减脂组合物
WO2021086271A1 (en) * 2019-10-31 2021-05-06 Mark One Innovation Center Company Limited A composition containing mulberry extract and production method thereof
BR112022019002A2 (pt) 2020-04-24 2022-11-01 Nestle Sa Uso de extrato de amora para controlar a resposta glicêmica pós-prandial
BR112022019018A2 (pt) 2020-04-24 2022-11-01 Nestle Sa Composição que compreende fibra e amora
KR102561661B1 (ko) * 2021-11-30 2023-08-02 주식회사 언리얼모닝 발효가 가능한 저당질 고단백의 베이킹 프리믹스 조성물 및 이를 이용한 저칼로리 당질 제한의 다이어트용 빵의 제조방법
CN114343099B (zh) * 2022-01-11 2024-03-26 山东中大药业有限公司 一种l-阿拉伯糖膳食纤维固体饮料及其制备方法
US20250213635A1 (en) 2022-03-02 2025-07-03 Societe Des Produits Nestle S.A. Use of a composition for managing postprandial glucose response and associated disorders

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11335285A (ja) 1998-05-25 1999-12-07 Toyotama Koryo Kk 整腸・便秘改善剤およびこれを含有する飲食物並びに動物用飼料
JP2000219632A (ja) 1999-01-28 2000-08-08 Toyotama Koryo Kk カロリー軽減剤
JP3659631B2 (ja) 2000-11-02 2005-06-15 ユニチカ株式会社 ダイエット食品及び糖尿病用食品並びにそれらの製造方法
US6458392B1 (en) 2000-07-12 2002-10-01 Kao Corporation Preventive, alleviative or remedy for hypertension
US20030003212A1 (en) * 2001-06-13 2003-01-02 Givaudan Sa Taste modifiers
WO2006016701A1 (ja) 2004-08-13 2006-02-16 Kodaka, Isamu 糖尿病予防・改善剤及び糖尿病の予防・改善用機能性食品
WO2006119038A1 (en) * 2005-04-29 2006-11-09 Naturegen, Inc. Compositions and methods for controlling glucose uptake
DK1893224T3 (en) 2005-06-10 2018-08-06 Thylabisco Ab APPLICATION OF PLANT CELL MEMBRANE TO TREAT OBESITAS
MY147363A (en) 2005-09-20 2012-11-30 Nestec Sa Water dispersible composition and method for preparing same
PT1923067T (pt) 2006-11-20 2016-07-14 S I I T S R L -Servizio Int Imballaggi Termosaldanti Composições contendo um extrato de phaseolus vulgaris e um extrato de alpinia officinarum para a prevenção e tratamento da obesidade e da diabetes do tipo ii
WO2008115723A1 (en) 2007-03-19 2008-09-25 Atm Metabolics Lllp Composition for treating diabetes and metabolic disorders with quercetin, myrcetin and chlorogenic acid
CA2730753A1 (en) 2008-07-14 2010-01-21 Thylabisco Ab Large-scale process for the preparation of thylakoids
US9066973B2 (en) 2009-09-02 2015-06-30 Nuvocare Health Sciences Inc. Weight loss composition and method
CN103491947A (zh) 2011-02-25 2014-01-01 西拉比索公司 一种用于延迟分子摄取的含有类囊体的组合物
US20130177506A1 (en) 2011-10-27 2013-07-11 Parker E. Atkins Bio-Available Chlorogenic Acid Preparations for Supplemental Human Consumption and Use
CN102524769B (zh) 2011-11-04 2013-06-19 博仲盛景医药技术（北京）有限公司 一种桑叶提取物、其制备方法及其用途
CN103998051A (zh) * 2011-12-01 2014-08-20 雀巢产品技术援助有限公司 桑属浆果及其避免血糖峰值的用途
KR20130078144A (ko) 2011-12-30 2013-07-10 주식회사 빙그레 캡슐커피
CN103961395A (zh) * 2014-05-21 2014-08-06 吕健军 一种植物提取物组合物及其用于调控血糖的方法

Also Published As

Publication number Publication date
JP2017515499A (ja) 2017-06-15
US11071767B2 (en) 2021-07-27
US20170028011A1 (en) 2017-02-02
AU2015248506A1 (en) 2016-11-17
IL248271A0 (en) 2016-11-30
EP3145332A1 (en) 2017-03-29
CN106456692A (zh) 2017-02-22
CA2945269A1 (en) 2015-10-22
WO2015159195A1 (en) 2015-10-22
EP3145332B1 (en) 2019-09-18
AU2015248506B2 (en) 2020-09-03

Similar Documents

Publication Publication Date Title
JP6621463B2 (ja) 血糖値を低下させ、体重管理をするための健康食品組成物
US11213543B2 (en) Human gastrointestinal microbiome modulating composition and methods of use
ES2230573T3 (es) Agente anti-obesidad cuyo principio activo es la procianidina.
US10076553B2 (en) Dietary product intended for the prevention of cardiometabolic risk
CN106456693A (zh) 糖尿病预防或改善剂
ZA200600812B (en) Composition for treating and/or preventing dysfunctions associated with type 2 diabetes mellitus and insulin resistance
JP2004105157A (ja) 糖類分解酵素阻害飲食組成物
JP5094150B2 (ja) 血糖値上昇抑制剤
EP3536326A1 (en) Dietary fiber compositions for curative or prophylactic treatment of obesity and other conditions
JP2005170836A (ja) 海藻抽出物およびそれを含むリパーゼ阻害剤
KR20210052731A (ko) 블랙베리 추출물을 포함하는 지방간, 당뇨병 또는 비만의 예방 또는 개선용 조성물
WO2010048705A1 (en) Composition for the maintenance of blood sugar levels comprising cinnamon and ginseng
KR100891881B1 (ko) 3,4,5-트리히드록시벤즈알데히드를 유효성분으로 포함하는고지혈증 및 ｍｍｐ 과다활성으로 인한 혈관질환 예방 및치료용 조성물
JP2000342228A (ja) ヤーコン・桑葉配合茶
JP2014051436A (ja) α−アミラーゼ阻害剤
KR101492213B1 (ko) 폴리코사놀을 유효성분으로 하는 히스타민 수용체 길항제 조성물
HK1233966A1 (en) Dietary compositions for reducing blood glucose levels and for weight management
KR102096345B1 (ko) 아출 추출물을 유효성분으로 함유하는 혈관염의 예방, 개선 또는 치료용 조성물
JP2005022994A (ja) 血糖上昇抑制用組成物
JP3476835B2 (ja) ヤーコン・ウーロン配合食品
WO2005082390A1 (ja) 脂肪蓄積抑制剤
JP7724290B2 (ja) 小胞体ストレス減少用組成物
KR101147913B1 (ko) 혈당 조절용 조성물
KR102361526B1 (ko) 난각막을 유효성분으로 함유하는 고요산혈증 또는 고요산혈증 관련 대사 장애의 예방, 개선 또는 치료용 조성물
JP2009275026A (ja) 膵臓リパーゼ活性阻害作用を有する組成物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170307

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180412

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190226

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190222

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190522

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190723

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20191029

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20191119

R150 Certificate of patent or registration of utility model

Ref document number: 6621463

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees