JP6595984B2 - 腎機能に関連付けられるバイオマーカーおよびそれを使用する方法 - Google Patents

腎機能に関連付けられるバイオマーカーおよびそれを使用する方法 Download PDF

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JP6595984B2
JP6595984B2 JP2016514016A JP2016514016A JP6595984B2 JP 6595984 B2 JP6595984 B2 JP 6595984B2 JP 2016514016 A JP2016514016 A JP 2016514016A JP 2016514016 A JP2016514016 A JP 2016514016A JP 6595984 B2 JP6595984 B2 JP 6595984B2
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biomarkers
renal function
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JP2016520192A5 (enExample
JP2016520192A (ja
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ペリション、リージス
コブ、ジェフリー、エドモンド
ブラウン、メレディス、ブイ．
ケネディー、アダム
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メタボロン，インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/64—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016514016A 2013-05-14 2014-05-13 腎機能に関連付けられるバイオマーカーおよびそれを使用する方法 Active JP6595984B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361822965P 2013-05-14 2013-05-14
US61/822,965 2013-05-14
PCT/US2014/037762 WO2014186311A1 (en) 2013-05-14 2014-05-13 Biomarkers related to kidney function and methods using the same

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JP2016520192A JP2016520192A (ja) 2016-07-11
JP2016520192A5 JP2016520192A5 (enExample) 2017-06-22
JP6595984B2 true JP6595984B2 (ja) 2019-10-23

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US (2) US10539575B2 (enExample)
EP (3) EP3410115A1 (enExample)
JP (1) JP6595984B2 (enExample)
CN (2) CN105209909B (enExample)
AU (1) AU2014265669B2 (enExample)
BR (1) BR112015028253A2 (enExample)
CA (2) CA3184836A1 (enExample)
ES (2) ES2871823T3 (enExample)
MX (2) MX391220B (enExample)
WO (1) WO2014186311A1 (enExample)

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MX388989B (es) * 2015-01-09 2025-03-11 Global Genomics Group Llc Biomarcadores basados en sangre para diagnosticar enfermedad de arteria coronaria ateroesclerótica.
WO2016115496A1 (en) * 2015-01-15 2016-07-21 Joslin Diabetes Center Metabolite biomarkers predictive of renal disease in diabetic patients
US11266730B2 (en) 2015-09-29 2022-03-08 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for BCG therapy
US20170234874A1 (en) * 2015-10-07 2017-08-17 Clearbridge Biophotonics Pte Ltd. Integrated visual morphology and cell protein expression using resonance-light scattering
US12057228B1 (en) * 2015-12-30 2024-08-06 Cerner Innovation, Inc. Predicting newly incident chronic kidney disease
EP3491004B1 (en) 2016-07-28 2021-09-01 Metabolon, Inc. Diagnostic methods, therapeutic agents and uses thereof
JP7097380B2 (ja) * 2016-11-25 2022-07-07 ベケッド、フレデリク 代謝性障害
WO2018118630A1 (en) 2016-12-19 2018-06-28 Metabolon, Inc. Mass spectrometry assay method for detection and quantitation of kidney function metabolites
CN108956790A (zh) * 2017-05-18 2018-12-07 中国人民解放军第二军医大学第二附属医院 一组氨基酸标志物在急性肾损伤诊断试剂盒中的应用
CN107132266A (zh) * 2017-06-21 2017-09-05 佛山科学技术学院 一种基于随机森林的水质分类方法及系统
US11026625B2 (en) 2017-08-08 2021-06-08 Fresenius Medical Care Holdings, Inc. Systems and methods for treating and estimating progression of chronic kidney disease
CN107326093B (zh) * 2017-09-04 2020-01-21 东南大学 基于Taqman探针的慢性肾脏病相关基因检测荧光定量PCR一步法试剂盒及其应用
US11680042B2 (en) * 2017-09-28 2023-06-20 Metabolon, Inc. Compounds, reagents, and uses thereof
WO2019144081A1 (en) * 2018-01-19 2019-07-25 Mars, Incorporated Biomarkers and classification algorithms for chronic kidney disease in cats
EP3821254A1 (en) * 2018-07-14 2021-05-19 Mars Incorporated Biomarkers and test models for chronic kidney disease
JP7205940B2 (ja) * 2019-02-20 2023-01-17 株式会社パートナーファーム 固相反応チップ及びこれを用いた測定方法
CN114269722B (zh) * 2019-07-26 2024-11-22 贝尔维奇生物医学研究所(伊迪贝尔) 麦角硫因、s-甲基-麦角硫因及其用途
CN112305089B (zh) * 2019-07-26 2022-04-29 长沙都正生物科技股份有限公司 一种慢性肾病诊断生物标记物及其应用
CN111487338B (zh) * 2020-04-16 2022-06-10 中南大学湘雅二医院 一种与肾功能相关的无创生物标记物及其应用
CN114026427B (zh) * 2020-05-19 2023-11-17 深圳市中医院 诊断肾病的标志物以及诊断方法
CN114910587B (zh) * 2022-05-12 2024-03-19 军科正源(上海)生物医药科技有限公司 一种尿液检测用高效液相-串联质谱分析方法

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Publication number Publication date
EP2997366B1 (en) 2018-10-10
CA2911204C (en) 2023-03-28
EP2997366A4 (en) 2017-04-12
CA2911204A1 (en) 2014-11-20
CN110196335A (zh) 2019-09-03
EP2997366A1 (en) 2016-03-23
CN105209909A (zh) 2015-12-30
US20200103417A1 (en) 2020-04-02
MX2015015561A (es) 2016-02-05
EP3410115A1 (en) 2018-12-05
BR112015028253A2 (pt) 2017-07-25
ES2702123T3 (es) 2019-02-27
CA3184836A1 (en) 2014-11-20
HK1218331A1 (zh) 2017-02-10
MX2019005748A (es) 2019-08-12
WO2014186311A1 (en) 2014-11-20
AU2014265669B2 (en) 2020-05-14
US20160116486A1 (en) 2016-04-28
HK1222905A1 (en) 2017-07-14
MX391220B (es) 2025-03-21
US10539575B2 (en) 2020-01-21
MX365061B (es) 2019-05-22
CN105209909B (zh) 2019-06-07
ES2871823T3 (es) 2021-11-02
EP3546940B1 (en) 2021-02-17
EP3546940A1 (en) 2019-10-02
JP2016520192A (ja) 2016-07-11
AU2014265669A1 (en) 2015-12-24

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