JP6585158B2 - ヤヌスキナーゼの阻害に有用なピロロ［２，３−ｄ］ピリミジン誘導体 - Google Patents

ヤヌスキナーゼの阻害に有用なピロロ［２，３−ｄ］ピリミジン誘導体 Download PDF

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JP6585158B2
JP6585158B2 JP2017507009A JP2017507009A JP6585158B2 JP 6585158 B2 JP6585158 B2 JP 6585158B2 JP 2017507009 A JP2017507009 A JP 2017507009A JP 2017507009 A JP2017507009 A JP 2017507009A JP 6585158 B2 JP6585158 B2 JP 6585158B2
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methyl
pyrrolo
cyclobutyl
cis
pyrimidin
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JP2017524007A (ja
JP2017524007A5 (pt-PT
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ジェイ．コフマン カレン
ジェイ．コフマン カレン
エム．デュール ジェームズ
エム．デュール ジェームズ
カイラ ニール
カイラ ニール
ディ． パリーク ミヒール
ディ． パリーク ミヒール
アール．リース マシュー
アール．リース マシュー
サマド タレク
サマド タレク
スャボラ シモーネ
スャボラ シモーネ
ビー．タトル ジャミソン
ビー．タトル ジャミソン
エル． ヴァズケズ マイケル
エル． ヴァズケズ マイケル
ロバート ヴァーホスト パトリック
ロバート ヴァーホスト パトリック
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ファイザー・インク
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D491/04—Ortho-condensed systems
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
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  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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JP2017507009A 2014-08-12 2015-07-31 ヤヌスキナーゼの阻害に有用なピロロ［２，３−ｄ］ピリミジン誘導体 Expired - Fee Related JP6585158B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462036276P 2014-08-12 2014-08-12
US62/036,276 2014-08-12
US201562189347P 2015-07-07 2015-07-07
US62/189,347 2015-07-07
PCT/IB2015/055823 WO2016024185A1 (en) 2014-08-12 2015-07-31 Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase

Publications (3)

Publication Number Publication Date
JP2017524007A JP2017524007A (ja) 2017-08-24
JP2017524007A5 JP2017524007A5 (pt-PT) 2018-07-19
JP6585158B2 true JP6585158B2 (ja) 2019-10-02

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JP2017507009A Expired - Fee Related JP6585158B2 (ja) 2014-08-12 2015-07-31 ヤヌスキナーゼの阻害に有用なピロロ［２，３−ｄ］ピリミジン誘導体

Country Status (8)

Country Link
US (1) US10966980B2 (pt-PT)
EP (1) EP3180344B1 (pt-PT)
JP (1) JP6585158B2 (pt-PT)
CA (1) CA2899888A1 (pt-PT)
ES (1) ES2750655T3 (pt-PT)
TW (1) TW201619159A (pt-PT)
UY (1) UY36265A (pt-PT)
WO (1) WO2016024185A1 (pt-PT)

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MA38347A1 (fr) 2013-02-22 2017-10-31 Pfizer Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak)
WO2016024185A1 (en) 2014-08-12 2016-02-18 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
MX2018013413A (es) * 2016-05-26 2019-06-06 Zeno Royalties & Milestones Llc Compuestos inhibidores de egfr.
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
WO2018053190A1 (en) 2016-09-14 2018-03-22 Gilead Sciences, Inc. Syk inhibitors
EP3543241B8 (en) * 2016-11-23 2022-10-12 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Preparation method for and intermediate of pyrrolo six-membered heteroaromatic ring derivative
WO2018195471A1 (en) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Syk inhibitors in combination with hypomethylating agents
US20220040197A1 (en) * 2017-12-21 2022-02-10 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising a dementia
WO2019182924A1 (en) * 2018-03-21 2019-09-26 Xibin Liao Jak inhibitors
AU2019299666B2 (en) * 2018-07-06 2024-07-11 Pfizer Inc. Manufacturing process and intermediates for a pyrrolo(2,3- d)pyrimidine compound and use thereof
KR20210072125A (ko) * 2018-11-05 2021-06-16 아비스타 파마 솔루션즈, 아이엔씨. 화합물
AU2020256166A1 (en) 2019-04-02 2021-10-14 Aligos Therapeutics, Inc. Compounds targeting PRMT5
WO2020232470A1 (en) 2019-05-13 2020-11-19 Boragen, Inc. Chemical compounds
CN110483338A (zh) * 2019-08-14 2019-11-22 苏州汉德创宏生化科技有限公司 一种大环类抑制剂中间体环庚烷基磺酰氯的合成方法
US20230219963A1 (en) * 2020-05-28 2023-07-13 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives
CN112697912B (zh) * 2020-12-14 2021-09-21 上海博悦生物科技有限公司 一种检测枸橼酸托法替布中间体及其相关杂质的方法

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