JP6573830B2 - 一酸化窒素送達中のドーズの希釈を最小にするためのカニューレ - Google Patents
一酸化窒素送達中のドーズの希釈を最小にするためのカニューレ Download PDFInfo
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- JP6573830B2 JP6573830B2 JP2015545524A JP2015545524A JP6573830B2 JP 6573830 B2 JP6573830 B2 JP 6573830B2 JP 2015545524 A JP2015545524 A JP 2015545524A JP 2015545524 A JP2015545524 A JP 2015545524A JP 6573830 B2 JP6573830 B2 JP 6573830B2
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- nasal cannula
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Description
・送達装置103内の通過時間中(例えば、エラストマーOリングなどの気体境界部を通じた送達装置の内部気体中への酸素の拡散などに起因する)、
・NOガスの鼻カニューレ101の通過中(例えば、カニューレ壁、鼻当て、コネクタ、レジューサ、結合ジョイントなどにわたる拡散による)、
・駆動圧力勾配が鼻カニューレNO供給ルーメン内の流れを逆行させて鼻カニューレ101内で周囲空気及び/又は吐き出されるガスとの混合を生じることがあるときの吸息/呼息サイクル中、
・NOと空気/O2が患者の鼻孔内で混合されるときの吸息/呼息サイクル中、
・送達装置への高圧源(例えば、加圧シリンダなど)の接続中(例えば、シリンダ交換時に送達気体中に少量のガスが取り込まれることなどがあるため)、及び
・NOとキャリアガスとの実質的に純粋な混合物が求められることがあるが、容易に達成されない場合がある、高圧NO源のシリンダに充填する製造作業中。
NO通過時間の最小化
本発明の1つ以上の実施形態は、カニューレを通る通過時間を最小にすることでNOのO2との接触時間を最小にすること、カニューレ壁にわたる酸素の通過を最小にすること、及び/又はNOと接触するO2の量を最小にすることによって、NO/O2接触の源(例えば、NO/O2接触の上記の源のうちの1つ以上)に対処し、これにより、意図されるNOドーズの希釈(例えば、NOのO2との混合などによる)に対処する、鼻カニューレに関係する。以下でかなり詳細に説明される、少なくとも意図されるNOドーズの希釈に対処する、図1を参照すると、いくつかの例を挙げると、限定はされないが、トリガルーメン104、NOルーメン106、O2/空気ルーメン108、及び/又はこれらの任意の組み合わせ及び/又はさらなる分離に関連するカニューレ壁などのカニューレ101の任意のルーメン壁にわたる酸素の通過を最小にすることができる。また、少なくとも意図されるNOドーズの希釈への対処は、いくつかの例を挙げると、限定はされないが、カニューレ鼻当て102、キーイング部材110、レジューサ112、接続ピース114、酸素接続ピース116、及び/又はこれらの任意の組み合わせ及び/又はさらなる分離に関連するカニューレ壁などのカニューレ101の任意の壁にわたる酸素の通過を最小にすることができる。
1つ以上の実施形態では、例えば、意図されるNOドーズの希釈を低減するために、NO用のより小さい内径(ID)の送達チューブ/ルーメンを含むカニューレを提供することができる。このより小さいIDのチューブは、カニューレを通るNO分子の通過時間を減少させることができる。これは次に、カニューレの壁にわたって拡散し、内部NOをNO2に酸化することがある酸素との混合に利用可能な時間を減少させることができる。
現在、鼻カニューレを構築するための一般的な材料としてポリ塩化ビニル(PVC)及び/又はシリコーンを用いることが多いが、酸素がこれらの鼻カニューレのルーメン壁を通して拡散することがある。カニューレの壁にわたる酸素の拡散、透過、及び/又は移動に起因して起こる酸素の接触を最小にするために、酸素の拡散速度、透過率、及び/又は酸素移動速度(OTR)を最小にするカニューレ壁材を選択することができる。例示的な実施形態では、カニューレ壁は、低い酸素拡散係数、透過度、及び/又は酸素移動速度(OTR)を有する材料を含むことができる。単なる例として、カニューレ壁は、例えば、以下の単位を用いる約0.001〜約10の酸素移動速度(OTR)を有することができる材料を含むことができる。
「cc」は、材料の四方にわたる酸素の立法センチメートル(ml)を指し、
「ミル」は、材料の四方の1ミル(0.001インチの厚さ)を指し、
「ATM」は、周囲雰囲気圧力の数値を指し、
「24時間」は、酸素が流れることができる持続時間を指し、
「100インチ2」は、材料の二乗の表面積を指す。
・低い酸素透過特徴を有する少なくとも1つの材料を用いることができる同種の及び/又は単一の材料の押出し、
・2つ以上のポリマーの共押出し、この場合、ポリマーのうちの1つ以上は低い酸素透過特徴を有する、
・材料/チュービング上の表面処理/表面コーティング、この場合、こうしたコーティングは低い酸素透過特徴を有することができる、
・ブレンド、及び
・スカベンジャー/ゲッター/ピュリファイア。
逆行性の流れ
図2A〜図2Bを参照すると、驚いたことに、希釈の別の源は、周囲空気及び/又は吐き出されるガスが鼻カニューレ(例えば、カニューレ鼻当て200及び/又はこの付近)に流れる現象(例えば、逆行性の流れ、クロスフローなど)によって引き起こされることがあることが分かった。このガスは、鼻カニューレの2つのカニューレ鼻孔部(例えば、カニューレ鼻孔部202/203)に流れ、存在する一酸化窒素ガスを移動させる及び/又は一酸化窒素ガスをカニューレの外に押し出すことがあり、ゆえに、移動された及び/又は押し出された一酸化窒素が患者に送達されない場合がある及び/又はガスの流れ及び/又は他のガスと混ざり、これにより、意図されるNOドーズを希釈する場合がある。さらに、逆行性の流れは、限定はされないが、吸息と呼息との両方の間の鼻孔部間の圧力差などの因子に依拠することがある。鼻孔部間の圧力差は、いくつかの例を挙げると、限定はされないが、人の呼吸パターン、人の鼻孔の閉塞及び/又は部分的閉塞(例えば、図12に示すように)、鼻孔の位置、及び呼吸中の鼻の流れ間のミスバランスの度合いなどの因子に応じて変化することがある。したがって、本発明の1つ以上の実施形態は、逆行性の流れ及び/又は鼻カニューレ内の逆行性の流れから生じる希釈を最小にすることができる鼻カニューレに関係する。
最小ドーズ体積>5[2π(プロング直径/2)2*(プロング長さ)+π(バックプレーン直径/2)2*(バックプレーン長さ)]
一酸化窒素送達システム(例えば、一酸化窒素ガスを患者にパルスする場合がある)が最適な臨床的有効性を有するためには、できるだけ吸息相の早期に及び/又は所望の流れ波形(例えば、パルス形状)で患者に一酸化窒素のパルス又は流れを送達することが必要な場合がある。これに注目すると、例えば、患者からの圧力信号は、患者の吸う力及び/又は患者の吸息の始まりの指標として用いることができるので、気体遅延は最小にされてもよい及び/又はされるべきである。また、例えば、波形形状及び/又はタイミングは臨床的有効性に結び付けられる場合があるので、パルス波形又は流れ波形の歪みは、最小にされてもよい及び/又はされるべきである。したがって、本発明の1つ以上の実施形態は、例えば、患者からカニューレを通過して装置に戻るときの圧力信号の遅延及び/又は歪みを最小にする及び/又は流れ波形の歪みを最小にする鼻カニューレ構成に関係する。
少なくともいくつかの実施形態では、カニューレは、1つのルーメンをNOの送達用及びトリガ用とすることができるように構成することができる(例えば、モノルーメンカニューレ、デュアルルーメンカニューレなど)。こうした構成は、NOの送達とトリガとの両方のためのルーメンを、NOドーズの希釈が最小限であり、かつ、トリガ信号が実質的にヒトの呼吸のスペクトルバンド(例えば、0〜4Hz)にわたる減衰なしに装置に伝搬することを可能にするように最適化することを必要とすることがある。これは、これらが最適化のための競合するメトリクスであり得るので実質的に難しいことがある。例えば、吸息相の早期にNOのパルス及び/又は流れを送達する、気体遅延を低減する、流れ波形の歪みを低減する、圧力信号の遅延及び/又は歪みを低減する、鼻当てでのNO混合体積及び/又はNO酸化を低減する、及び/又は任意の他の所望の特性(例えば、組み合わされたNO/トリガルーメンに関する)に対処するために、ルーメンのIDの幾つかの競合するメトリクスを、限定はされないが以下のように最適化することができる。
a.NO2生成を減少させる→ルーメンのIDを減少させる、
b.NOのドーズ体積の正確度を維持する→ルーメンのIDを減少させる、
c.NO流れの歪みを低減する→ルーメンのIDを増加させる、及び
d.トリガ信号の減衰又は遅延を最小化する→ルーメンのIDを増加させる。
図3Aを参照すると、例示的な実施形態では、鼻カニューレは、酸素を送達する及び/又は送達装置303をトリガするのに用いられるのと同じルーメン内で一酸化窒素を送達することができる少なくとも1つのルーメン(すなわち、モノルーメンカニューレ300)を有することができる。モノルーメンカニューレ300を用いて、シングルルーメン内で、NO307のドーズが流れの中に間欠的にパルスされる状態で酸素及び/又は周囲空気の流れ305を患者に送達することができる。この同じルーメンはトリガに用いられてもよい。この技術を用いると、例えば、O2及び/又は空気は各NOパルス後のカニューレ鼻当てを効果的に一掃することができるので、及び又はシングルルーメンは弁の閉鎖時に装置での閉じたシステムとすることができ、したがって、カニューレルーメンへの流れを防ぐことができるので、逆行性の流れを実質的に減少させることができる。しかしながら、この技術を用いると、酸素及び/又は空気305がカニューレ300のルーメン内でNO307と接触し、反応し(例えば、NO2を生成し)、これにより、意図されるNOドーズを希釈することがある。
図4を参照すると、例示的な実施形態では、鼻カニューレは、酸素を送達することができる(例えば、酸素/空気供給部405から)少なくとも1つのルーメン406とは別のルーメン(例えば、NOルーメン404)内で一酸化窒素を送達することができる、及び/又は送達装置(例えば、送達装置403)をトリガすることができる、少なくとも2つのルーメン(すなわち、デュアルルーメンカニューレ400)を有することができる。NOルーメンは、NOを含む治療ガスをNOの送達装置403から(例えば、カニューレ鼻当て402で)患者に運ぶことができる。2つのルーメンは、各ルーメンに関する別個の流路を有することができる単一のカニューレ鼻当て(例えば、カニューレ鼻当て402)に集まることができる。
図6A〜図7を参照すると、例示的な実施形態では、鼻カニューレは、少なくとも3つのルーメン(すなわち、トリルーメンカニューレ600)を有することができ、1つのルーメンは、例えば、送達装置(例えば、送達装置603)から該ルーメン(例えば、NOルーメン604)内で一酸化窒素を送達することができ、別のルーメンは、例えば送達装置(例えば、送達装置603)のトリガ用とすることができ(例えば、トリガルーメン606)、別のルーメンは、例えば、O2/空気源(例えば、貯蔵器及び/又は濃縮器605)から該ルーメン(例えば、O2ルーメン608)内でO2を送達することができる。3つのルーメンは、各ルーメン及び/又は少なくとも1つのルーメンに関する別個の流路を有することができる単一のカニューレ鼻当て(例えば、カニューレ鼻当て602)に集まることができる。
・短いガス通過時間、
・吸息/呼息相のルーメンへの周囲空気の逆行性の流れの低減(例えば、拡散速度が、より小さいIDと共に減少し得るガス分子の平均自由行程長さに従うことを示す、クヌーセン拡散に従う低減)、
・流れへのガス抵抗の増加(例えば、より小さいIDのチュービングは、ポアズイユの法則によってチュービング半径の4乗に反比例することがあるガスの流動抵抗をもたらす)、及び
・NOの送達ルーメンのT字ループにおける体積の減少。
図8A〜図8Dを参照すると、例示的な実施形態では、鼻カニューレは、少なくとも4つのルーメンを有することができ(すなわち、クワッドルーメンカニューレ800)、2つのルーメンは、例えば、送達装置(例えば、送達装置803)から該ルーメン(例えば、NOルーメン804A及び804B)内で一酸化窒素を送達することができ、別のルーメンは、例えば送達装置(例えば、送達装置803)のトリガ用とすることができ(例えば、トリガルーメン806)、別のルーメンは、例えば、O2/空気源(例えば、貯蔵器及び/又は濃縮器805)から該ルーメン(例えば、O2ルーメン808)内でO2を送達することができる。4つのルーメンは、各ルーメン及び/又は少なくとも1つのルーメンに関する別個の流路を有することができる単一のカニューレ鼻当て(例えば、カニューレ鼻当て802)に集まることができる。
1つ以上の実施形態では、鼻カニューレ(例えば、本明細書で開示されるシングルルーメンカニューレ、マルチルーメンカニューレ、鼻カニューレのいずれかなど)は、一酸化窒素送達ラインに存在する及び/又はこれと流体連通することができる1つ以上の逆止め弁を含むことができる。さらに、例示的な実施形態では、一酸化窒素送達ラインに存在する及び/又はこれと流体連通する1つ以上の逆止め弁は、説明されるマルチルーメン構成のいずれかと組み合わせることができる。逆止め弁は、とりわけ、吸息/呼息中のNO供給ルーメンへの逆行性のガス移動を防ぐために用いることができる。逆止め弁は、NOの送達経路内のいくつかの地点に配置する及び/又はNOの送達経路と流体連通することができる任意の低クラッキング圧の逆止め弁とすることができる。こうした逆止め弁は、ダックビル弁、アンブレラ弁、及び/又は任意の他の弁を含むことができるがこれらに限定されない。
本発明の1つ以上の実施形態は、三方弁を用いて送達装置(例えば、酸素/NO接触の上記の源のうちの1つ以上)への高圧源(例えば、加圧シリンダなど)の接続中のNO/O2接触を低減し、これにより、意図されるNOドーズの希釈を低減する、鼻カニューレ及び/又はシステムに関係する。例えば、本発明の鼻カニューレ及び/又はシステムは、酸素を除去する(例えば、吹き払う)べくキャニスタを接続すると三方弁が周囲に開かれるように構成することができる周囲への1つのポートを有する三方弁を含むことができる。
図12〜図13を参照すると、本発明の1つ以上の実施形態は、気体薬剤(例えば、パルスされる一酸化窒素などの形態の)を鼻カニューレを通じて送達するときの少なくとも部分的に閉塞した鼻の通路(例えば、図12に示すように)に起因する薬剤損失(例えば、周囲環境への)の問題に対処する鼻カニューレ及び/又はシステムに関係する。こうした問題の単なる例として、鼻の片側(例えば、鼻1201)が閉塞され(例えば、閉塞1203)、薬剤がどちらの鼻孔(例えば、鼻孔1205)にどれくらい進むかを区別せずに薬剤がカニューレ/送達システム1200を通じて鼻の両側に送達されている場合、閉塞した鼻孔に起因する薬剤損失が存在することがある。加えて、使用されない治療ガスと接触する場合がある他の物質及び/又は化合物との反応などの他の望ましくない結果が存在する場合がある。
本発明の1つ以上の実施形態は、例えば、各鼻孔内の駆動力の量を検出及び/又は判定し、各鼻孔部に送達される薬剤の量を調節することによって、部分的に又は完全に詰まった鼻孔に起因する不適切なドーズの問題に対処する鼻カニューレ及び/又はシステムに関係する。これは、各鼻孔内の比例的及び/又は実質的に比例的なドーズを保証するべく弁、バッフル、フラップ、及び/又は任意の他の装置を用いることによって達成することができる。
上述のように、マルチルーメンカニューレの個々のルーメンを別々に製造し、次いで、互いに取り付けることができ(例えば、パラチューブ配列など)、及び/又は複数のルーメンを、マルチルーメンチューブを製造する単一のダイを通じて押出しすることができる。
図20を参照すると、例示的ないくつかの実施形態によれば、酸素の送達用、NOの送達用、及び呼吸のトリガ用の3つの別個のルーメンを含む鼻カニューレ2001が示される。鼻カニューレは、患者の鼻との間に介在する鼻当て2002を含むことができる。NOルーメン2003はNOを患者に輸送することができ、トリガルーメン2004は圧力信号を伝送することができる。NOルーメン2003とトリガルーメン2004との両方は、それらの組み合わされたチューブが単一のチューブ「パラチューブ」2003/2004に見えるように、チューブ(例えば、D形状のチューブ)とすることができる。パラチューブ2003/2004は、鼻カニューレ接続ピース2014によってNOの送達装置に接続することができる。鼻カニューレ2001は、かなり詳細に後述されるキーイング部材2010、レジューサ2012、及び/又は酸素接続ピース2016をさらに含むことができる。
図25A〜図25Qを参照すると、種々の例示的なカニューレ鼻当て2002の種々の図が例示的に示される。図25Aは、酸素ルーメン2008をカニューレ鼻当て2002に接続するカニューレ鼻当て2002の側部を示す。図25Bは、NOルーメン2003及びトリガルーメン2004用の2つのD形状の開口部を示す。図25Cは、NO用の中央ルーメンと酸素及びトリガ用の2つの外側ルーメンとを有する鼻カニューレ接続ピースの各プロングを示す。
例示的な実施形態では、カニューレ鼻当て2002は、鼻中隔への当たりを和らげることができる可撓性支持ブリッジ又は「トランポリン」2517を含むことができる。可撓性支持ブリッジ2517は、例えば、カニューレと鼻中隔との接触表面積の増加によって患者の快適さの増加を提供することができ、及び/又はプロングブリッジを鼻中隔から偏向するように設計することができるので、患者の快適さを高めることができる。
NOの送達の前に鼻カニューレから空気及び他のガスを一掃するのに用いることができるパージ及び/又は洗い流し処置中に、NO含有ガスを鼻カニューレに流すことによって空気/ガスをパージすることができる。しかしながら、NOと空気中の酸素との反応に起因して、この洗い流し処置はNO2を生じることがある。したがって、パージ及び/又は洗い流し処置中は、例えば、NO2を患者に投与することができないように患者が鼻カニューレを装着していないことが重要なことがある。
a.NOの送達装置は、患者にカニューレを除去する及びカニューレ上に含まれるキーイング要素をNOの送達装置のキーホールに挿入するように促すことができる。
b.キーホールは、キーホール内のキーの存在を検出することができる。キーの存在を検出するための例示的な方法は、電子検出(例えば、光ビーム検出器、作動されたスイッチ、IR検出、磁気検出など)又は機械的検出(例えば、マイクロスイッチ)を含むがこれらに限定されない。
c.NOの送達装置は、洗い流し処置を行う前にキーが確実にキーホールにあるようにすることができ、キーがキーホール内にない場合は操作を行わないようにプログラムすることができる。
d.NOの送達装置は、次いで、洗い流し処置を行い、ユーザに処置の完了を知らせることができる。
e.NOの送達装置は、NO療法を開始するためにユーザがキーホールからキーを除去することを可能にすることができる。
図29〜図30を参照すると、パルス送達を伴う吸う呼吸の間の逆行性の流れの例が図29に示され、吸う呼吸と吐く呼吸との両方の間の逆行性の流れの例が図30に示される。
本明細書での本発明は、逆行性の流れを低減し、正確なドーズ送達を保証し、及び/又はNO2生成を最小にし、送達装置と併せて用いることができ、COPDの二次性の肺高血圧症及び/又はPAHとしての肺高血圧症及び/又はIPFの二次性の肺高血圧症及び/又はサルコイドーシスの二次性の肺高血圧症の治療及び又は予防のために用いることができる。
Claims (22)
- 治療ガスを必要とする患者に治療ガスを送達するための鼻カニューレであって、前記鼻カニューレが、
第1の治療ガスを必要とする患者に第1の治療ガスを送達するための第1の治療ガスルーメンである第1のルーメンと、
トリガルーメンである第2のルーメンと、
前記患者に第2の治療ガスを送達するための第2の治療ガスルーメンである第3のルーメンと、
(i)前記第1の治療ガスルーメン、(ii)前記トリガルーメン、及び(iii)前記第2の治療ガスルーメンのうちの少なくとも1つに関する前記患者への別個の流路を可能にするカニューレ鼻当てと、
を備え、
前記第1のルーメンが、前記カニューレ鼻当て内に「U」形状の領域を形成し、前記カニューレ鼻当て内の「U」形状の領域での前記第1のルーメンの内径が、前記「U」形状の領域の外部での前記第1のルーメンの内径よりも小さい、鼻カニューレ。 - 前記鼻カニューレが、(i)前記患者に送達される前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上の希釈を低減するか、又は(ii)前記患者に前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上を送達するために少なくとも1つのシステムと流体連通する状態で配置されるように構成されるか、又はこの両方である、請求項1に記載の鼻カニューレ。
- 前記鼻カニューレが、一酸化窒素と酸素の混合を抑制する、及び前記患者への二酸化窒素の送達を低減する、のうちの少なくとも1つである、請求項1又は2に記載の鼻カニューレ。
- 前記鼻カニューレが、肺高血圧症の治療のために前記患者に前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上を送達する、請求項1〜3のいずれかに記載の鼻カニューレ。
- 前記鼻カニューレが、慢性閉塞性肺疾患(COPD)の二次性の肺高血圧症、肺動脈性肺高血圧症(PAH)としての肺高血圧症、特発性肺線維症(IPF)の二次性の肺高血圧症、及びサルコイドーシスの二次性の肺高血圧症のうちの少なくとも1つの治療のために前記患者に前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上を送達する、請求項1〜4のいずれかに記載の鼻カニューレ。
- 前記第1の治療ガスが一酸化窒素であり、前記第2の治療ガスが酸素であり、前記一酸化窒素を送達するための第1の治療ガスルーメンが、前記酸素を送達するための第2の治療ガスルーメン及び前記トリガルーメンよりも小さい、請求項1〜5のいずれかに記載の鼻カニューレ。
- 前記第1の治療ガスが一酸化窒素であり、前記一酸化窒素を送達するための第1の治療ガスルーメンが、0.01インチ乃至0.10インチの内径を有する6フィート乃至8フィートの長さである、請求項1〜6のいずれかに記載の鼻カニューレ。
- 前記第1の治療ガスが一酸化窒素であり、前記カニューレ鼻当てが、前記第1の治療ガスルーメンの内径よりも小さい内径を有する一酸化窒素流路を備える、請求項1〜7のいずれかに記載の鼻カニューレ。
- 前記カニューレ鼻当てでの前記第1のルーメンに関する前記流路が、第1のプロング、第2のプロング及びバックプレーンを備え、前記第1のプロングが、前記バックプレーンを介して前記第2のプロングと流体連通しており、前記第1のプロング、前記第2のプロング及び前記バックプレーンの総体積が0.035ml未満である、請求項1〜8のいずれかに記載の鼻カニューレ。
- 前記鼻カニューレが第4のルーメンをさらに備え、
前記第4のルーメンが、前記患者に前記第1の治療ガスを送達するための別の第1の治療ガスルーメンであり、
前記第1のルーメンが前記患者の1つの鼻孔に前記第1の治療ガスを送達し、前記第4のルーメンが前記患者の別の鼻孔に前記第1の治療ガスを送達する、請求項1〜10のいずれかに記載の鼻カニューレ。 - (i)前記第1の治療ガスルーメンと流体連通する少なくとも1つの逆止め弁、(ii)カニューレキー、(iii)掃気材料、及び(iv)可撓性支持ブリッジのうちの1つ以上をさらに備える、請求項1〜11のいずれかに記載の鼻カニューレ。
- 治療ガスを必要とする患者に治療ガスを送達するための鼻カニューレであって、前記鼻カニューレが、
患者に第1の治療ガスを送達するための第1の治療ガスルーメンである第1のルーメンと、
前記第1の治療ガスのパルスの放出をトリガするためのトリガルーメンである第2のルーメンと、
前記患者に第2の治療ガスを送達するための第2の治療ガスルーメンである第3のルーメンと、
を備え、
前記第1の治療ガスルーメン、前記トリガルーメン、及び前記第2の治療ガスルーメンは、カニューレ鼻当てに集まり、前記カニューレ鼻当ては、前記第1の治療ガスルーメン、前記トリガルーメン、及び前記第2の治療ガスルーメンのそれぞれに関する前記患者への別個の流路を可能にし、
前記第1のルーメンが、前記カニューレ鼻当て内に「U」形状の領域を形成し、前記カニューレ鼻当て内の「U」形状の領域での前記第1のルーメンの内径が、前記「U」形状の領域の外部での前記第1のルーメンの内径よりも小さい、鼻カニューレ。 - 前記鼻カニューレが、(i)前記患者に送達される前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上の希釈を低減するか、又は(ii)前記患者に前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上を送達するために少なくとも1つのシステムと流体連通する状態で配置されるように構成されるか、又はこの両方である、請求項13に記載の鼻カニューレ。
- 前記鼻カニューレが、一酸化窒素と酸素の混合を抑制する、及び前記患者への二酸化窒素の送達を低減する、のうちの少なくとも1つである、請求項13又は14に記載の鼻カニューレ。
- 前記鼻カニューレが、肺高血圧症の治療のために前記患者に前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上を送達する、請求項13〜15のいずれかに記載の鼻カニューレ。
- 前記鼻カニューレが、慢性閉塞性肺疾患(COPD)の二次性の肺高血圧症、肺動脈性肺高血圧症(PAH)としての肺高血圧症、特発性肺線維症(IPF)の二次性の肺高血圧症、及びサルコイドーシスの二次性の肺高血圧症のうちの少なくとも1つの治療のために前記患者に前記第1の治療ガス及び前記第2の治療ガスのうちの1つ以上を送達する、請求項13〜16のいずれかに記載の鼻カニューレ。
- 前記第1の治療ガスが一酸化窒素であり、前記一酸化窒素を送達するための前記第1の治療ガスルーメンが、0.01インチ乃至0.10インチの内径を有する6フィート乃至8フィートの長さである、請求項13〜17のいずれかに記載の鼻カニューレ。
- 前記カニューレ鼻当てでの前記第1のルーメンに関する前記流路が、第1のプロング、第2のプロング及びバックプレーンを備え、前記第1のプロングが、前記バックプレーンを介して前記第2のプロングと流体連通しており、前記第1のプロング、前記第2のプロング及び前記バックプレーンの総体積が0.035ml未満である、請求項13〜18のいずれかに記載の鼻カニューレ。
- (i)前記第1の治療ガスルーメンと流体連通する少なくとも1つの逆止め弁、(ii)カニューレキー、(iii)掃気材料、及び(iv)可撓性支持ブリッジのうちの1つ以上をさらに備える、請求項13〜20のいずれかに記載の鼻カニューレ。
- 治療ガスを患者に送達するための鼻カニューレであって、前記鼻カニューレが、
患者に一酸化窒素ガスを送達するための第1の治療ガスルーメンである第1のルーメンと、
トリガルーメンである第2のルーメンと、
前記患者に酸素ガス及び空気ガスのうちの1つ以上を送達するための第2の治療ガスルーメンである第3のルーメンと、
を備え、
前記第1の治療ガスルーメン、前記トリガルーメン、及び前記第2の治療ガスルーメンは、カニューレ鼻当てに集まり、前記カニューレ鼻当ては、前記第1の治療ガスルーメン、前記トリガルーメン、及び前記第2の治療ガスルーメンのそれぞれに関する前記患者への別個の流路を可能にし、
前記患者に前記一酸化窒素ガスを送達するための前記第1の治療ガスルーメンに関する前記流路は、前記カニューレ鼻当てで、第1のプロング、第2のプロング及びバックプレーンを備え、前記第1のプロングが、前記バックプレーンを介して前記第2のプロングと流体連通しており、前記第1のプロング、前記第2のプロング及び前記バックプレーンの総体積が0.035ml未満であり、
前記第1のルーメンが、前記カニューレ鼻当て内に「U」形状の領域を形成し、前記カニューレ鼻当て内の「U」形状の領域での前記第1のルーメンの内径が、前記「U」形状の領域の外部での前記第1のルーメンの内径よりも小さい、鼻カニューレ。
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