JP6537532B2 - 補体媒介障害の治療のための化合物 - Google Patents
補体媒介障害の治療のための化合物 Download PDFInfo
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- JP6537532B2 JP6537532B2 JP2016570944A JP2016570944A JP6537532B2 JP 6537532 B2 JP6537532 B2 JP 6537532B2 JP 2016570944 A JP2016570944 A JP 2016570944A JP 2016570944 A JP2016570944 A JP 2016570944A JP 6537532 B2 JP6537532 B2 JP 6537532B2
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- alkyl
- independently selected
- cycloalkyl
- compound
- hydroxyl
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- 0 BC(*)(*)NC(C(C(*)C(C)(*)C1*)N1C(*)=O)=O Chemical compound BC(*)(*)NC(C(C(*)C(C)(*)C1*)N1C(*)=O)=O 0.000 description 27
- PXHHIBMOFPCBJQ-UHFFFAOYSA-N CC1N(C)CCC1 Chemical compound CC1N(C)CCC1 PXHHIBMOFPCBJQ-UHFFFAOYSA-N 0.000 description 3
- JGCIUQCALJBXHI-AYTRYJACSA-N CC(C1)(C2(CC2)NC(c2ncccn2)=O)C=Cc2c1c(C(C)=O)c[n]2CC(N(CC(C1)=C(F)F)[C@@H]1C(NCc1cccc(Cl)c1F)=O)=O Chemical compound CC(C1)(C2(CC2)NC(c2ncccn2)=O)C=Cc2c1c(C(C)=O)c[n]2CC(N(CC(C1)=C(F)F)[C@@H]1C(NCc1cccc(Cl)c1F)=O)=O JGCIUQCALJBXHI-AYTRYJACSA-N 0.000 description 1
- UZWQMHPVOYAYCC-UHFFFAOYSA-N CC(C1)N(C)CC1(F)F Chemical compound CC(C1)N(C)CC1(F)F UZWQMHPVOYAYCC-UHFFFAOYSA-N 0.000 description 1
- UJSSJVAWZDHDTE-UHFFFAOYSA-N CC(C1)N(C)CC1Cl Chemical compound CC(C1)N(C)CC1Cl UJSSJVAWZDHDTE-UHFFFAOYSA-N 0.000 description 1
- XQSHGZLNOUECCL-UHFFFAOYSA-N CC1N(C)CC2C1CCC2 Chemical compound CC1N(C)CC2C1CCC2 XQSHGZLNOUECCL-UHFFFAOYSA-N 0.000 description 1
- SEASAOTYMVFBMC-UHFFFAOYSA-N CC1NC=CC1 Chemical compound CC1NC=CC1 SEASAOTYMVFBMC-UHFFFAOYSA-N 0.000 description 1
- ZKUKXSWKWGHYKJ-UHFFFAOYSA-N CN1CCCCCC1 Chemical compound CN1CCCCCC1 ZKUKXSWKWGHYKJ-UHFFFAOYSA-N 0.000 description 1
- QRTZGWCWMQPPEE-LURJTMIESA-N CNC([C@H](CC1)N(C2=O)N1CCN2I)=O Chemical compound CNC([C@H](CC1)N(C2=O)N1CCN2I)=O QRTZGWCWMQPPEE-LURJTMIESA-N 0.000 description 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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