JP6523331B2 - 単鎖trail受容体アゴニストタンパク質 - Google Patents

単鎖trail受容体アゴニストタンパク質 Download PDF

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Publication number
JP6523331B2
JP6523331B2 JP2016564068A JP2016564068A JP6523331B2 JP 6523331 B2 JP6523331 B2 JP 6523331B2 JP 2016564068 A JP2016564068 A JP 2016564068A JP 2016564068 A JP2016564068 A JP 2016564068A JP 6523331 B2 JP6523331 B2 JP 6523331B2
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receptor agonist
trail
trail receptor
agonist protein
cell
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Expired - Fee Related
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Japanese (ja)
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JP2017513503A (ja
JP2017513503A5 (OSRAM
Inventor
ヒル,オリバー
ギーファー,クリスティアン
ティーマン,メイノルフ
ブキャナン,フリッツ・ジー
フィリップス,ダレン・シー
ラッペ,スーザン・イー
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Apogenix AG
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
JP2016564068A 2014-04-23 2015-04-23 単鎖trail受容体アゴニストタンパク質 Expired - Fee Related JP6523331B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23
US61/983,152 2014-04-23
PCT/US2015/027270 WO2015164588A1 (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Related Child Applications (1)

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JP2019082671A Division JP6714751B2 (ja) 2014-04-23 2019-04-24 単鎖trail受容体アゴニストタンパク質

Publications (3)

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JP2017513503A JP2017513503A (ja) 2017-06-01
JP2017513503A5 JP2017513503A5 (OSRAM) 2018-05-31
JP6523331B2 true JP6523331B2 (ja) 2019-05-29

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JP2016564068A Expired - Fee Related JP6523331B2 (ja) 2014-04-23 2015-04-23 単鎖trail受容体アゴニストタンパク質
JP2019082671A Expired - Fee Related JP6714751B2 (ja) 2014-04-23 2019-04-24 単鎖trail受容体アゴニストタンパク質

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US (5) US9908927B2 (OSRAM)
EP (2) EP3134430B1 (OSRAM)
JP (2) JP6523331B2 (OSRAM)
KR (2) KR20190135546A (OSRAM)
CN (2) CN111718424A (OSRAM)
AR (1) AR100168A1 (OSRAM)
AU (3) AU2015249649B2 (OSRAM)
BR (1) BR112016024515B1 (OSRAM)
CA (2) CA3184067A1 (OSRAM)
CL (1) CL2016002683A1 (OSRAM)
CR (1) CR20160516A (OSRAM)
CY (1) CY1120281T1 (OSRAM)
DK (1) DK3134430T3 (OSRAM)
DO (1) DOP2016000284A (OSRAM)
EC (1) ECSP16089579A (OSRAM)
ES (1) ES2672368T3 (OSRAM)
HR (1) HRP20180950T1 (OSRAM)
HU (1) HUE038914T2 (OSRAM)
IL (2) IL248244B (OSRAM)
LT (1) LT3134430T (OSRAM)
MA (2) MA45069A (OSRAM)
MX (2) MX2016013858A (OSRAM)
MY (1) MY181986A (OSRAM)
NO (1) NO2776305T3 (OSRAM)
PE (1) PE20170299A1 (OSRAM)
PH (2) PH12020500377A1 (OSRAM)
PL (1) PL3134430T3 (OSRAM)
PT (1) PT3134430T (OSRAM)
RS (1) RS57153B1 (OSRAM)
RU (1) RU2699285C2 (OSRAM)
SG (3) SG10202111785VA (OSRAM)
SI (1) SI3134430T1 (OSRAM)
SM (1) SMT201800286T1 (OSRAM)
TR (1) TR201806912T4 (OSRAM)
TW (2) TWI747178B (OSRAM)
UA (1) UA118286C2 (OSRAM)
UY (1) UY36095A (OSRAM)
WO (1) WO2015164588A1 (OSRAM)

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JP6738831B2 (ja) * 2015-05-04 2020-08-12 アポジェニックス アーゲー 単鎖cd40受容体アゴニストタンパク質
CN108430492B (zh) 2015-10-23 2022-05-03 阿珀吉科吉尼科斯股份公司 单链cd27受体激动剂蛋白
AU2016342420B2 (en) 2015-10-23 2020-10-01 Apogenix Ag Single-chain LIGHT receptor agonist proteins
WO2017068185A1 (en) * 2015-10-23 2017-04-27 Apogenix Ag Single-chain gitr-receptor agonist proteins
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
CN109153711B (zh) * 2016-03-01 2022-04-26 伊利诺伊大学理事会 具有降低的l-谷氨酰胺酶活性和增强的稳定性的l-天冬酰胺酶变体和融合蛋白
MX2018011219A (es) * 2016-03-16 2019-01-10 Merrimack Pharmaceuticals Inc Trail diseñado por ingenieria para terapia de cancer.
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
KR20190017804A (ko) * 2016-06-13 2019-02-20 메리맥 파마슈티컬즈, 인크. 환자를 선별하고 trail-기반 치료제 또는 사멸 수용체 효능제로 치료하는 방법
EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
CN111050784B (zh) * 2017-08-11 2024-03-19 伊利诺伊大学理事会 截短的豚鼠l-天冬酰胺酶变体及其使用方法
TW202003553A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療癌症之abbv-621與抗癌劑之組合
WO2019178433A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
US20230212260A1 (en) 2020-05-15 2023-07-06 Apogenix Ag Multi-specific immune modulators
AU2022281108A1 (en) 2021-05-28 2023-12-14 Julius-Maximilians-Universität Würzburg Recombinant proteinaceous binding molecules
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

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DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
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HK1207095A1 (en) 2012-07-18 2016-01-22 阿珀吉尼科斯股份公司 Composition comprising a mixture of cd95-fc isoforms

Also Published As

Publication number Publication date
CN106459221B (zh) 2020-09-01
NO2776305T3 (OSRAM) 2018-01-27
CN111718424A (zh) 2020-09-29
AU2015249649A1 (en) 2016-11-10
ES2672368T3 (es) 2018-06-14
MX2019013587A (es) 2020-01-13
RU2016145608A (ru) 2018-05-28
JP6714751B2 (ja) 2020-06-24
IL248244A0 (en) 2016-11-30
TW202024123A (zh) 2020-07-01
DOP2016000284A (es) 2017-02-15
PH12020500377A1 (en) 2022-11-14
IL272612A (en) 2020-03-31
DK3134430T3 (en) 2018-05-22
NZ725476A (en) 2023-09-29
PH12016502079B1 (en) 2016-12-19
AU2020202247A1 (en) 2020-04-23
MY181986A (en) 2021-01-18
KR20190135546A (ko) 2019-12-06
SG10201806465TA (en) 2018-08-30
EP3134430A1 (en) 2017-03-01
MX2016013858A (es) 2017-08-02
RU2699285C2 (ru) 2019-09-04
IL248244B (en) 2020-03-31
UA118286C2 (uk) 2018-12-26
UY36095A (es) 2015-10-30
HRP20180950T1 (hr) 2018-08-10
US20150337027A1 (en) 2015-11-26
PT3134430T (pt) 2018-04-20
TWI683825B (zh) 2020-02-01
KR20170012257A (ko) 2017-02-02
TWI747178B (zh) 2021-11-21
LT3134430T (lt) 2018-05-10
US20210040178A1 (en) 2021-02-11
AU2018271369B2 (en) 2020-01-02
JP2017513503A (ja) 2017-06-01
TR201806912T4 (tr) 2018-06-21
CN106459221A (zh) 2017-02-22
PL3134430T3 (pl) 2018-08-31
ECSP16089579A (es) 2018-05-31
SMT201800286T1 (it) 2018-07-17
US20240174731A1 (en) 2024-05-30
HUE038914T2 (hu) 2018-12-28
EP3134430B1 (en) 2018-03-21
CA2946402C (en) 2023-02-28
CA2946402A1 (en) 2015-10-29
SG11201608767XA (en) 2016-11-29
CA3184067A1 (en) 2015-10-29
CR20160516A (es) 2017-05-10
SG10202111785VA (en) 2021-12-30
MA45069A (fr) 2019-04-03
CY1120281T1 (el) 2019-07-10
US20250145688A1 (en) 2025-05-08
EP3366699A1 (en) 2018-08-29
AU2015249649B2 (en) 2018-10-04
JP2019162114A (ja) 2019-09-26
KR102079919B1 (ko) 2020-02-24
RS57153B1 (sr) 2018-07-31
TW201620928A (zh) 2016-06-16
CL2016002683A1 (es) 2017-07-07
MA39770A (fr) 2015-10-29
SI3134430T1 (en) 2018-05-31
RU2016145608A3 (OSRAM) 2018-12-26
US9908927B2 (en) 2018-03-06
BR112016024515A2 (pt) 2017-10-10
WO2015164588A1 (en) 2015-10-29
AR100168A1 (es) 2016-09-14
US20180222962A1 (en) 2018-08-09
BR112016024515B1 (pt) 2020-03-31
PH12016502079A1 (en) 2016-12-19
AU2018271369A1 (en) 2018-12-20
PE20170299A1 (es) 2017-05-06

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