MX2016013858A - Proteinas agonistas del receptor del ligando que induce la apoptosis relacionada con el factor de necrosis de tumor de cadena individual. - Google Patents

Proteinas agonistas del receptor del ligando que induce la apoptosis relacionada con el factor de necrosis de tumor de cadena individual.

Info

Publication number
MX2016013858A
MX2016013858A MX2016013858A MX2016013858A MX2016013858A MX 2016013858 A MX2016013858 A MX 2016013858A MX 2016013858 A MX2016013858 A MX 2016013858A MX 2016013858 A MX2016013858 A MX 2016013858A MX 2016013858 A MX2016013858 A MX 2016013858A
Authority
MX
Mexico
Prior art keywords
receptor agonist
agonist proteins
trail
chain trail
trail receptor
Prior art date
Application number
MX2016013858A
Other languages
English (en)
Spanish (es)
Inventor
Hill Oliver
Gieffers Christian
Thiemann Meinolf
E Lappe Susan
G Buchanan Fritz
C Phillips Darren
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2016013858A publication Critical patent/MX2016013858A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
MX2016013858A 2014-04-23 2015-04-23 Proteinas agonistas del receptor del ligando que induce la apoptosis relacionada con el factor de necrosis de tumor de cadena individual. MX2016013858A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23
PCT/US2015/027270 WO2015164588A1 (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Publications (1)

Publication Number Publication Date
MX2016013858A true MX2016013858A (es) 2017-08-02

Family

ID=53055121

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016013858A MX2016013858A (es) 2014-04-23 2015-04-23 Proteinas agonistas del receptor del ligando que induce la apoptosis relacionada con el factor de necrosis de tumor de cadena individual.
MX2019013587A MX2019013587A (es) 2014-04-23 2016-10-21 Proteinas agonistas del receptor del ligando que induce la apoptosis relacionada con el factor de necrosis de tumor de cadena individual.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019013587A MX2019013587A (es) 2014-04-23 2016-10-21 Proteinas agonistas del receptor del ligando que induce la apoptosis relacionada con el factor de necrosis de tumor de cadena individual.

Country Status (38)

Country Link
US (5) US9908927B2 (OSRAM)
EP (2) EP3134430B1 (OSRAM)
JP (2) JP6523331B2 (OSRAM)
KR (2) KR20190135546A (OSRAM)
CN (2) CN111718424A (OSRAM)
AR (1) AR100168A1 (OSRAM)
AU (3) AU2015249649B2 (OSRAM)
BR (1) BR112016024515B1 (OSRAM)
CA (2) CA3184067A1 (OSRAM)
CL (1) CL2016002683A1 (OSRAM)
CR (1) CR20160516A (OSRAM)
CY (1) CY1120281T1 (OSRAM)
DK (1) DK3134430T3 (OSRAM)
DO (1) DOP2016000284A (OSRAM)
EC (1) ECSP16089579A (OSRAM)
ES (1) ES2672368T3 (OSRAM)
HR (1) HRP20180950T1 (OSRAM)
HU (1) HUE038914T2 (OSRAM)
IL (2) IL248244B (OSRAM)
LT (1) LT3134430T (OSRAM)
MA (2) MA45069A (OSRAM)
MX (2) MX2016013858A (OSRAM)
MY (1) MY181986A (OSRAM)
NO (1) NO2776305T3 (OSRAM)
PE (1) PE20170299A1 (OSRAM)
PH (2) PH12020500377A1 (OSRAM)
PL (1) PL3134430T3 (OSRAM)
PT (1) PT3134430T (OSRAM)
RS (1) RS57153B1 (OSRAM)
RU (1) RU2699285C2 (OSRAM)
SG (3) SG10202111785VA (OSRAM)
SI (1) SI3134430T1 (OSRAM)
SM (1) SMT201800286T1 (OSRAM)
TR (1) TR201806912T4 (OSRAM)
TW (2) TWI747178B (OSRAM)
UA (1) UA118286C2 (OSRAM)
UY (1) UY36095A (OSRAM)
WO (1) WO2015164588A1 (OSRAM)

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JP6738831B2 (ja) * 2015-05-04 2020-08-12 アポジェニックス アーゲー 単鎖cd40受容体アゴニストタンパク質
CN108430492B (zh) 2015-10-23 2022-05-03 阿珀吉科吉尼科斯股份公司 单链cd27受体激动剂蛋白
AU2016342420B2 (en) 2015-10-23 2020-10-01 Apogenix Ag Single-chain LIGHT receptor agonist proteins
WO2017068185A1 (en) * 2015-10-23 2017-04-27 Apogenix Ag Single-chain gitr-receptor agonist proteins
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
CN109153711B (zh) * 2016-03-01 2022-04-26 伊利诺伊大学理事会 具有降低的l-谷氨酰胺酶活性和增强的稳定性的l-天冬酰胺酶变体和融合蛋白
MX2018011219A (es) * 2016-03-16 2019-01-10 Merrimack Pharmaceuticals Inc Trail diseñado por ingenieria para terapia de cancer.
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
KR20190017804A (ko) * 2016-06-13 2019-02-20 메리맥 파마슈티컬즈, 인크. 환자를 선별하고 trail-기반 치료제 또는 사멸 수용체 효능제로 치료하는 방법
EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
CN111050784B (zh) * 2017-08-11 2024-03-19 伊利诺伊大学理事会 截短的豚鼠l-天冬酰胺酶变体及其使用方法
TW202003553A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療癌症之abbv-621與抗癌劑之組合
WO2019178433A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
US20230212260A1 (en) 2020-05-15 2023-07-06 Apogenix Ag Multi-specific immune modulators
AU2022281108A1 (en) 2021-05-28 2023-12-14 Julius-Maximilians-Universität Würzburg Recombinant proteinaceous binding molecules
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

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AU7645700A (en) 1999-10-07 2001-05-10 Maxygen Aps Single-chain antagonist polypeptides
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
DK1355942T3 (da) 2000-12-07 2008-11-17 Lilly Co Eli GLP-1-fusionsproteiner
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Also Published As

Publication number Publication date
CN106459221B (zh) 2020-09-01
NO2776305T3 (OSRAM) 2018-01-27
CN111718424A (zh) 2020-09-29
AU2015249649A1 (en) 2016-11-10
ES2672368T3 (es) 2018-06-14
MX2019013587A (es) 2020-01-13
RU2016145608A (ru) 2018-05-28
JP6714751B2 (ja) 2020-06-24
IL248244A0 (en) 2016-11-30
TW202024123A (zh) 2020-07-01
DOP2016000284A (es) 2017-02-15
PH12020500377A1 (en) 2022-11-14
IL272612A (en) 2020-03-31
DK3134430T3 (en) 2018-05-22
NZ725476A (en) 2023-09-29
PH12016502079B1 (en) 2016-12-19
AU2020202247A1 (en) 2020-04-23
MY181986A (en) 2021-01-18
KR20190135546A (ko) 2019-12-06
SG10201806465TA (en) 2018-08-30
EP3134430A1 (en) 2017-03-01
RU2699285C2 (ru) 2019-09-04
IL248244B (en) 2020-03-31
UA118286C2 (uk) 2018-12-26
UY36095A (es) 2015-10-30
HRP20180950T1 (hr) 2018-08-10
US20150337027A1 (en) 2015-11-26
PT3134430T (pt) 2018-04-20
TWI683825B (zh) 2020-02-01
KR20170012257A (ko) 2017-02-02
TWI747178B (zh) 2021-11-21
LT3134430T (lt) 2018-05-10
US20210040178A1 (en) 2021-02-11
AU2018271369B2 (en) 2020-01-02
JP2017513503A (ja) 2017-06-01
TR201806912T4 (tr) 2018-06-21
CN106459221A (zh) 2017-02-22
PL3134430T3 (pl) 2018-08-31
ECSP16089579A (es) 2018-05-31
SMT201800286T1 (it) 2018-07-17
US20240174731A1 (en) 2024-05-30
JP6523331B2 (ja) 2019-05-29
HUE038914T2 (hu) 2018-12-28
EP3134430B1 (en) 2018-03-21
CA2946402C (en) 2023-02-28
CA2946402A1 (en) 2015-10-29
SG11201608767XA (en) 2016-11-29
CA3184067A1 (en) 2015-10-29
CR20160516A (es) 2017-05-10
SG10202111785VA (en) 2021-12-30
MA45069A (fr) 2019-04-03
CY1120281T1 (el) 2019-07-10
US20250145688A1 (en) 2025-05-08
EP3366699A1 (en) 2018-08-29
AU2015249649B2 (en) 2018-10-04
JP2019162114A (ja) 2019-09-26
KR102079919B1 (ko) 2020-02-24
RS57153B1 (sr) 2018-07-31
TW201620928A (zh) 2016-06-16
CL2016002683A1 (es) 2017-07-07
MA39770A (fr) 2015-10-29
SI3134430T1 (en) 2018-05-31
RU2016145608A3 (OSRAM) 2018-12-26
US9908927B2 (en) 2018-03-06
BR112016024515A2 (pt) 2017-10-10
WO2015164588A1 (en) 2015-10-29
AR100168A1 (es) 2016-09-14
US20180222962A1 (en) 2018-08-09
BR112016024515B1 (pt) 2020-03-31
PH12016502079A1 (en) 2016-12-19
AU2018271369A1 (en) 2018-12-20
PE20170299A1 (es) 2017-05-06

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