JP6482524B2 - 抗ｃｄ５２抗体 - Google Patents

抗ｃｄ５２抗体 Download PDF

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Publication number
JP6482524B2
JP6482524B2 JP2016502067A JP2016502067A JP6482524B2 JP 6482524 B2 JP6482524 B2 JP 6482524B2 JP 2016502067 A JP2016502067 A JP 2016502067A JP 2016502067 A JP2016502067 A JP 2016502067A JP 6482524 B2 JP6482524 B2 JP 6482524B2
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JP
Japan
Prior art keywords
antibody
seq
antibodies
amino acid
acid sequence
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Expired - Fee Related
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JP2016502067A
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English (en)
Japanese (ja)
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JP2016518333A5 (https=
JP2016518333A (ja
Inventor
ホアウエイ・チウ
ロニー・ロン・ウエイ
クラーク・クン・パン
レベッカ・センダック
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Genzyme Corp
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Genzyme Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50391542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6482524(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of JP2016518333A publication Critical patent/JP2016518333A/ja
Publication of JP2016518333A5 publication Critical patent/JP2016518333A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2016502067A 2013-03-15 2014-03-13 抗ｃｄ５２抗体 Expired - Fee Related JP6482524B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794576P 2013-03-15 2013-03-15
US61/794,576 2013-03-15
PCT/US2014/026159 WO2014151644A2 (en) 2013-03-15 2014-03-13 Anti-cd52 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018229547A Division JP2019069960A (ja) 2013-03-15 2018-12-07 抗ｃｄ５２抗体

Publications (3)

Publication Number Publication Date
JP2016518333A JP2016518333A (ja) 2016-06-23
JP2016518333A5 JP2016518333A5 (https=) 2017-04-13
JP6482524B2 true JP6482524B2 (ja) 2019-03-13

Family

ID=50391542

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016502067A Expired - Fee Related JP6482524B2 (ja) 2013-03-15 2014-03-13 抗ｃｄ５２抗体
JP2018229547A Pending JP2019069960A (ja) 2013-03-15 2018-12-07 抗ｃｄ５２抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018229547A Pending JP2019069960A (ja) 2013-03-15 2018-12-07 抗ｃｄ５２抗体

Country Status (35)

Country Link
US (2) US9708407B2 (https=)
EP (1) EP2970467B1 (https=)
JP (2) JP6482524B2 (https=)
KR (1) KR20150131286A (https=)
CN (1) CN105209495B (https=)
AR (1) AR095199A1 (https=)
AU (1) AU2014233685B2 (https=)
BR (1) BR112015022464A2 (https=)
CA (1) CA2906539A1 (https=)
CL (1) CL2015002705A1 (https=)
CR (1) CR20150547A (https=)
CY (1) CY1121795T1 (https=)
DK (1) DK2970467T3 (https=)
DO (1) DOP2015000211A (https=)
EA (1) EA031730B1 (https=)
ES (1) ES2710976T3 (https=)
GT (1) GT201500267A (https=)
HR (1) HRP20190085T1 (https=)
HU (1) HUE041796T2 (https=)
IL (1) IL241410A0 (https=)
LT (1) LT2970467T (https=)
MA (1) MA38485A1 (https=)
MX (1) MX2015012991A (https=)
NZ (1) NZ631473A (https=)
PE (1) PE20151757A1 (https=)
PH (1) PH12015501932A1 (https=)
PL (1) PL2970467T3 (https=)
PT (1) PT2970467T (https=)
SG (1) SG11201506932SA (https=)
SI (1) SI2970467T1 (https=)
TN (1) TN2015000415A1 (https=)
TR (1) TR201900638T4 (https=)
TW (1) TWI644923B (https=)
UY (1) UY35440A (https=)
WO (1) WO2014151644A2 (https=)

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EP2998405B1 (en) 2009-05-13 2019-12-11 Genzyme Corporation Anti-human cd52 immunoglobulins
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US20200299399A1 (en) * 2017-04-21 2020-09-24 Genzyme Corporation Treatment of Multiple Sclerosis with Anti-CD52 Antibodies
EP3752193A4 (en) * 2018-02-13 2022-02-23 Merck Sharp & Dohme Corp. METHODS OF TREATMENT OF CANCER WITH ANTI-PD-1 ANTIBODIES AND ANTI-CTLA4 ANTIBODIES
PE20220568A1 (es) 2019-05-21 2022-04-20 Novartis Ag Moleculas de union a cd19 y usos de las mismas
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WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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EP2970467B1 (en) 2018-10-17
EA031730B1 (ru) 2019-02-28
JP2016518333A (ja) 2016-06-23
PE20151757A1 (es) 2015-12-03
CY1121795T1 (el) 2020-07-31
DK2970467T3 (en) 2019-02-11
HK1219963A1 (en) 2017-04-21
SI2970467T1 (sl) 2019-03-29
HUE041796T2 (hu) 2019-05-28
HRP20190085T1 (hr) 2019-03-08
US20170349665A1 (en) 2017-12-07
JP2019069960A (ja) 2019-05-09
TN2015000415A1 (en) 2017-01-03
MA38485A1 (fr) 2017-06-30
WO2014151644A3 (en) 2015-01-15
PT2970467T (pt) 2019-01-28
TR201900638T4 (tr) 2019-03-21
PL2970467T4 (pl) 2019-07-31
WO2014151644A2 (en) 2014-09-25
TWI644923B (zh) 2018-12-21
EP2970467A2 (en) 2016-01-20
GT201500267A (es) 2017-12-15
AR095199A1 (es) 2015-09-30
KR20150131286A (ko) 2015-11-24
CA2906539A1 (en) 2014-09-25
ES2710976T3 (es) 2019-04-29
IL241410A0 (en) 2015-11-30
DOP2015000211A (es) 2015-11-30
NZ631473A (en) 2017-09-29
CN105209495A (zh) 2015-12-30
US9708407B2 (en) 2017-07-18
MX2015012991A (es) 2015-12-15
BR112015022464A2 (pt) 2017-10-24
US20160024219A1 (en) 2016-01-28
PL2970467T3 (pl) 2019-07-31
TW201522373A (zh) 2015-06-16
CR20150547A (es) 2016-01-08
AU2014233685B2 (en) 2019-02-28
LT2970467T (lt) 2019-02-11
CN105209495B (zh) 2020-06-26
PH12015501932A1 (en) 2016-01-04
UY35440A (es) 2014-10-31
SG11201506932SA (en) 2015-09-29
AU2014233685A1 (en) 2015-10-01
EA201591796A1 (ru) 2016-01-29
CL2015002705A1 (es) 2016-04-22

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