BRPI0108923B8 - elemento de ligação específico, ácido nucleico isolado, célula hospedeira, métodos para produzir um elemento de ligação específico ou domínio vh ou vl de anticorpo, e, para obter um elemento de ligação específico que liga eotaxina - Google Patents

elemento de ligação específico, ácido nucleico isolado, célula hospedeira, métodos para produzir um elemento de ligação específico ou domínio vh ou vl de anticorpo, e, para obter um elemento de ligação específico que liga eotaxina

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Publication number
BRPI0108923B8
BRPI0108923B8 BR0108923A BR0108923A BRPI0108923B8 BR PI0108923 B8 BRPI0108923 B8 BR PI0108923B8 BR 0108923 A BR0108923 A BR 0108923A BR 0108923 A BR0108923 A BR 0108923A BR PI0108923 B8 BRPI0108923 B8 BR PI0108923B8
Authority
BR
Brazil
Prior art keywords
specific binding
binding member
eotaxin
antibody
methods
Prior art date
Application number
BR0108923A
Other languages
English (en)
Other versions
BR0108923A (pt
BRPI0108923B1 (pt
Inventor
Jane Wilton Alison
Helen Main Sarah
Smith Stephen
John Vaughan Tristan
Original Assignee
Cambridge Antibody Tech Limited
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Antibody Tech Limited, Medimmune Ltd filed Critical Cambridge Antibody Tech Limited
Publication of BR0108923A publication Critical patent/BR0108923A/pt
Publication of BRPI0108923B1 publication Critical patent/BRPI0108923B1/pt
Publication of BRPI0108923B8 publication Critical patent/BRPI0108923B8/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

elemento de ligação específico, ácido nucleico isolado, célula hospedeira, métodos para produzir um elemento de ligação específico ou domínio vh ou vl de anticorpo, e, para obter um elemento de ligação específico que liga eotaxina. elementos de ligação específicos dirigidos para eotaxina-1, particularmente anticorpos humanos e fragmentos de anticorpos contra eotaxina -1 humana e especialmente os que neutralizam atividade de eotaxina-1. os domínios vh e/ou vl de anticorpos de fg scfv, aqui chamado cat- 212 e os de anticorpo igg4, aqui chamados cat 213. uma ou mais regiões de determinação complementares (cdrs) de domínios vh e/ou vl de cat212/213, especialmente vh crd3, em outras regiões de armação de anticorpos. composições contendo elementos de ligação específicos e seu uso em métodos para inibir ou neutralizar eotaxina, incluindo métodos de tratamento do corpo humano ou animal por terapia.
BR0108923A 2000-03-03 2001-03-02 elemento de ligação específico, ácido nucleico isolado, célula hospedeira, métodos para produzir um elemento de ligação específico ou domínio vh ou vl de anticorpo, e, para obter um elemento de ligação específico que liga eotaxina BRPI0108923B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18724600P 2000-03-03 2000-03-03
PCT/GB2001/000927 WO2001066754A1 (en) 2000-03-03 2001-03-02 Human antibodies against eotaxin and their use

Publications (3)

Publication Number Publication Date
BR0108923A BR0108923A (pt) 2003-04-22
BRPI0108923B1 BRPI0108923B1 (pt) 2018-11-13
BRPI0108923B8 true BRPI0108923B8 (pt) 2021-05-25

Family

ID=22688187

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108923A BRPI0108923B8 (pt) 2000-03-03 2001-03-02 elemento de ligação específico, ácido nucleico isolado, célula hospedeira, métodos para produzir um elemento de ligação específico ou domínio vh ou vl de anticorpo, e, para obter um elemento de ligação específico que liga eotaxina

Country Status (14)

Country Link
US (6) US7323311B2 (pt)
EP (1) EP1259615B1 (pt)
JP (1) JP5198704B2 (pt)
AT (1) ATE414151T1 (pt)
AU (1) AU778392B2 (pt)
BR (1) BRPI0108923B8 (pt)
CA (1) CA2401342C (pt)
DE (1) DE60136527D1 (pt)
GB (1) GB2361704C (pt)
IL (2) IL151499A0 (pt)
MX (1) MXPA02008472A (pt)
NO (1) NO20024179L (pt)
NZ (1) NZ521182A (pt)
WO (1) WO2001066754A1 (pt)

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ATE414151T1 (de) 2000-03-03 2008-11-15 Cambridge Antibody Tech Antikörper gegen eotaxin und deren verwendung
JP2005509412A (ja) 2001-08-23 2005-04-14 アールエスアール リミテッド チロトロフィン(tsh)受容体の抗原決定領域、その使用およびその抗体
JP2007525436A (ja) * 2003-03-24 2007-09-06 マーシア・ファーマ・インコーポレイテッド 炎症症状を処置および予防するための方法および組成物
GB0407315D0 (en) 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
CN104151427B (zh) 2005-02-08 2017-09-08 根茨美公司 针对TGFβ的抗体
US20070099239A1 (en) * 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease
SI1942939T2 (sl) 2005-09-30 2021-11-30 Medimmune Limited Sestavek protitelesa proti interlevkinu-13
DK1999152T3 (da) 2006-03-27 2013-01-14 Medimmune Ltd Bindende element til gm-csf-receptor
RU2016142225A (ru) 2009-05-13 2018-12-18 Джензим Корпорейшн Иммуноглобулины к cd52 человека
US8176867B2 (en) 2009-05-28 2012-05-15 Richard J. A. Gayton Watercraft immobilizing system
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
AU2011329647B2 (en) 2010-11-19 2015-10-22 Eisai R&D Management Co., Ltd. Neutralizing anti-CCL20 antibodies
US20130261153A1 (en) * 2012-04-03 2013-10-03 Boehringer Ingelheim International Gmbh Use of ccr3-inhibitors
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US20140271666A1 (en) * 2013-03-14 2014-09-18 Immune Pharmaceuticals Ltd. Use of anti-eotaxin antibodies for treating inflammatory bowel disease
AR095199A1 (es) 2013-03-15 2015-09-30 Genzyme Corp Anticuerpos anti-cd52
DK3050574T3 (da) 2015-01-28 2020-01-20 Univ Bordeaux Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom
KR102261618B1 (ko) 2015-03-31 2021-06-04 메디뮨 리미티드 신규한 il33 형태, il33의 돌연변이된 형태, 항체, 검정 및 이의 이용 방법
MX2018008939A (es) 2016-01-22 2019-08-21 Merck Sharp & Dohme Anticuerpos anti-factor de la coagulacion xi.
EP4000632A1 (en) 2016-06-02 2022-05-25 MedImmune Limited Antibodies to alpha-synuclein and uses thereof
WO2017212488A1 (en) * 2016-06-06 2017-12-14 Hadasit Medical Research Service And Development Ltd. Anti-eotaxin for immunoprotection and hepatoprotection
MY201852A (en) 2016-06-14 2024-03-20 Merck Sharp & Dohme Llc Anti-coagulation factor xi antibodies

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Also Published As

Publication number Publication date
US20080182319A1 (en) 2008-07-31
ATE414151T1 (de) 2008-11-15
IL151499A0 (en) 2003-04-10
US20040014132A1 (en) 2004-01-22
EP1259615B1 (en) 2008-11-12
CA2401342A1 (en) 2001-09-13
DE60136527D1 (de) 2008-12-24
JP5198704B2 (ja) 2013-05-15
JP2003528598A (ja) 2003-09-30
GB2361704C (en) 2006-08-02
US9284589B2 (en) 2016-03-15
MXPA02008472A (es) 2004-03-26
GB2361704B (en) 2002-04-10
GB0105237D0 (en) 2001-04-18
IL151499A (en) 2010-06-30
NO20024179D0 (no) 2002-09-02
NO20024179L (no) 2002-11-01
CA2401342C (en) 2010-08-03
AU778392B2 (en) 2004-12-02
WO2001066754A1 (en) 2001-09-13
US7323311B2 (en) 2008-01-29
US20210277103A1 (en) 2021-09-09
US20140294857A1 (en) 2014-10-02
NZ521182A (en) 2004-11-26
US10577413B2 (en) 2020-03-03
US20160257741A1 (en) 2016-09-08
US20120270265A1 (en) 2012-10-25
AU3585201A (en) 2001-09-17
BR0108923A (pt) 2003-04-22
BRPI0108923B1 (pt) 2018-11-13
EP1259615A1 (en) 2002-11-27
US8715961B2 (en) 2014-05-06
GB2361704A (en) 2001-10-31
US8067564B2 (en) 2011-11-29

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