JP6437456B2 - ｛［１−シアノ−５−（４−クロロフェノキシ）−４−ヒドロキシ−イソキノリン−３−カルボニル］−アミノ｝−酢酸の結晶形態 - Google Patents

｛［１−シアノ−５−（４−クロロフェノキシ）−４−ヒドロキシ−イソキノリン−３−カルボニル］−アミノ｝−酢酸の結晶形態 Download PDF

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Publication number
JP6437456B2
JP6437456B2 JP2015555276A JP2015555276A JP6437456B2 JP 6437456 B2 JP6437456 B2 JP 6437456B2 JP 2015555276 A JP2015555276 A JP 2015555276A JP 2015555276 A JP2015555276 A JP 2015555276A JP 6437456 B2 JP6437456 B2 JP 6437456B2
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Japan
Prior art keywords
compound
chlorophenoxy
isoquinoline
cyano
hydroxy
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Expired - Fee Related
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JP2015555276A
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Japanese (ja)
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JP2016505071A5 (enExample
JP2016505071A (ja
Inventor
クラウディア ウィッチ，
クラウディア ウィッチ，
マイケル ディー． トンプソン，
マイケル ディー． トンプソン，
ジュン ミン パク，
ジュン ミン パク，
マイケル ピー． アレンド，
マイケル ピー． アレンド，
Original Assignee
フィブロジェン インコーポレイテッド
フィブロジェン インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015555276A 2013-01-24 2014-01-23 ｛［１−シアノ−５−（４−クロロフェノキシ）−４−ヒドロキシ−イソキノリン−３−カルボニル］−アミノ｝−酢酸の結晶形態 Expired - Fee Related JP6437456B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361756361P 2013-01-24 2013-01-24
US61/756,361 2013-01-24
PCT/US2014/012780 WO2014116849A1 (en) 2013-01-24 2014-01-23 Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid

Publications (3)

Publication Number Publication Date
JP2016505071A JP2016505071A (ja) 2016-02-18
JP2016505071A5 JP2016505071A5 (enExample) 2017-02-23
JP6437456B2 true JP6437456B2 (ja) 2018-12-12

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ID=50073508

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JP2015555276A Expired - Fee Related JP6437456B2 (ja) 2013-01-24 2014-01-23 ｛［１−シアノ−５−（４−クロロフェノキシ）−４−ヒドロキシ−イソキノリン−３−カルボニル］−アミノ｝−酢酸の結晶形態

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US (1) US9643928B2 (enExample)
EP (1) EP2951159B1 (enExample)
JP (1) JP6437456B2 (enExample)
KR (1) KR102233081B1 (enExample)
CN (1) CN105452227B (enExample)
AU (1) AU2014209319B2 (enExample)
CA (1) CA2899024C (enExample)
DK (1) DK2951159T3 (enExample)
ES (1) ES2694297T3 (enExample)
IL (1) IL240066B (enExample)
MX (1) MX360048B (enExample)
RU (1) RU2666144C2 (enExample)
SG (2) SG11201505748UA (enExample)
TW (1) TWI685487B (enExample)
WO (1) WO2014116849A1 (enExample)

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EP2370422B1 (en) 2008-11-14 2019-06-05 Fibrogen, Inc. Thiochromene derivatives as hif hydroxylase inhibitors
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
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CA2879238C (en) 2012-07-16 2021-08-10 Fibrogen, Inc. Process for making isoquinoline compounds
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CN110448537A (zh) 2013-06-06 2019-11-15 菲布罗根有限公司 Hif羟化酶抑制剂的药物制剂
WO2016034108A1 (zh) 2014-09-02 2016-03-10 广东东阳光药业有限公司 喹啉酮类化合物及其应用
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Also Published As

Publication number Publication date
MX360048B (es) 2018-10-19
CN105452227B (zh) 2018-05-29
HK1217331A1 (en) 2017-01-06
SG11201505748UA (en) 2015-08-28
IL240066A0 (en) 2015-09-24
IL240066B (en) 2019-08-29
KR20150129679A (ko) 2015-11-20
JP2016505071A (ja) 2016-02-18
AU2014209319A1 (en) 2015-08-27
US9643928B2 (en) 2017-05-09
WO2014116849A1 (en) 2014-07-31
KR102233081B1 (ko) 2021-03-29
AU2014209319B2 (en) 2018-04-19
TWI685487B (zh) 2020-02-21
CA2899024A1 (en) 2014-07-31
EP2951159B1 (en) 2018-08-22
RU2015134420A (ru) 2017-03-03
TW201444800A (zh) 2014-12-01
ES2694297T3 (es) 2018-12-19
SG10202009266PA (en) 2020-10-29
CN105452227A (zh) 2016-03-30
EP2951159A1 (en) 2015-12-09
RU2666144C2 (ru) 2018-09-06
MX2015009617A (es) 2016-04-20
CA2899024C (en) 2022-01-04
DK2951159T3 (en) 2018-11-19
US20160002170A1 (en) 2016-01-07

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