IL240066B - Crystal forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid - Google Patents

Crystal forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid

Info

Publication number
IL240066B
IL240066B IL240066A IL24006615A IL240066B IL 240066 B IL240066 B IL 240066B IL 240066 A IL240066 A IL 240066A IL 24006615 A IL24006615 A IL 24006615A IL 240066 B IL240066 B IL 240066B
Authority
IL
Israel
Prior art keywords
chlorophenoxy
isoquinoline
cyano
carbonyl
hydroxy
Prior art date
Application number
IL240066A
Other languages
English (en)
Hebrew (he)
Other versions
IL240066A0 (en
Original Assignee
Fibrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50073508&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL240066(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Publication of IL240066A0 publication Critical patent/IL240066A0/en
Publication of IL240066B publication Critical patent/IL240066B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL240066A 2013-01-24 2015-07-21 Crystal forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid IL240066B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361756361P 2013-01-24 2013-01-24
PCT/US2014/012780 WO2014116849A1 (en) 2013-01-24 2014-01-23 Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid

Publications (2)

Publication Number Publication Date
IL240066A0 IL240066A0 (en) 2015-09-24
IL240066B true IL240066B (en) 2019-08-29

Family

ID=50073508

Family Applications (1)

Application Number Title Priority Date Filing Date
IL240066A IL240066B (en) 2013-01-24 2015-07-21 Crystal forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid

Country Status (15)

Country Link
US (1) US9643928B2 (enExample)
EP (1) EP2951159B1 (enExample)
JP (1) JP6437456B2 (enExample)
KR (1) KR102233081B1 (enExample)
CN (1) CN105452227B (enExample)
AU (1) AU2014209319B2 (enExample)
CA (1) CA2899024C (enExample)
DK (1) DK2951159T3 (enExample)
ES (1) ES2694297T3 (enExample)
IL (1) IL240066B (enExample)
MX (1) MX360048B (enExample)
RU (1) RU2666144C2 (enExample)
SG (2) SG11201505748UA (enExample)
TW (1) TWI685487B (enExample)
WO (1) WO2014116849A1 (enExample)

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PL1644336T3 (pl) 2003-06-06 2011-07-29 Fibrogen Inc Związki heteroarylowe zawierające azot i ich zastosowanie w zwiększaniu poziomu endogennej erytropoetyny
EP2370422B1 (en) 2008-11-14 2019-06-05 Fibrogen, Inc. Thiochromene derivatives as hif hydroxylase inhibitors
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
SG10201700873UA (en) 2012-07-16 2017-04-27 Fibrogen Inc Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid
CA2879238C (en) 2012-07-16 2021-08-10 Fibrogen, Inc. Process for making isoquinoline compounds
JP6437456B2 (ja) 2013-01-24 2018-12-12 フィブロジェン インコーポレイテッド ｛［１−シアノ−５−（４−クロロフェノキシ）−４−ヒドロキシ−イソキノリン−３−カルボニル］−アミノ｝−酢酸の結晶形態
CN110448537A (zh) 2013-06-06 2019-11-15 菲布罗根有限公司 Hif羟化酶抑制剂的药物制剂
WO2016034108A1 (zh) 2014-09-02 2016-03-10 广东东阳光药业有限公司 喹啉酮类化合物及其应用
EP4121009A4 (en) * 2020-03-17 2024-04-17 Zydus Lifesciences Limited Formulation comprising hif prolyl hydroxylase inhibitors

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Also Published As

Publication number Publication date
MX360048B (es) 2018-10-19
CN105452227B (zh) 2018-05-29
HK1217331A1 (en) 2017-01-06
SG11201505748UA (en) 2015-08-28
IL240066A0 (en) 2015-09-24
KR20150129679A (ko) 2015-11-20
JP2016505071A (ja) 2016-02-18
AU2014209319A1 (en) 2015-08-27
US9643928B2 (en) 2017-05-09
WO2014116849A1 (en) 2014-07-31
KR102233081B1 (ko) 2021-03-29
AU2014209319B2 (en) 2018-04-19
TWI685487B (zh) 2020-02-21
CA2899024A1 (en) 2014-07-31
EP2951159B1 (en) 2018-08-22
RU2015134420A (ru) 2017-03-03
TW201444800A (zh) 2014-12-01
ES2694297T3 (es) 2018-12-19
SG10202009266PA (en) 2020-10-29
CN105452227A (zh) 2016-03-30
EP2951159A1 (en) 2015-12-09
RU2666144C2 (ru) 2018-09-06
JP6437456B2 (ja) 2018-12-12
MX2015009617A (es) 2016-04-20
CA2899024C (en) 2022-01-04
DK2951159T3 (en) 2018-11-19
US20160002170A1 (en) 2016-01-07

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