TWI685487B - ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形 - Google Patents

｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形 Download PDF

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Publication number
TWI685487B
TWI685487B TW103102462A TW103102462A TWI685487B TW I685487 B TWI685487 B TW I685487B TW 103102462 A TW103102462 A TW 103102462A TW 103102462 A TW103102462 A TW 103102462A TW I685487 B TWI685487 B TW I685487B
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Taiwan
Prior art keywords
compound
crystal form
acetic acid
chlorophenoxy
isoquinoline
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TW103102462A
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English (en)
Chinese (zh)
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TW201444800A (zh
Inventor
克勞蒂亞 威其
邁克爾 湯普森
朴貞玟
邁克爾 阿倫德
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美商費比羅根公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW103102462A 2013-01-24 2014-01-23 ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形 TWI685487B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361756361P 2013-01-24 2013-01-24
US61/756,361 2013-01-24

Publications (2)

Publication Number Publication Date
TW201444800A TW201444800A (zh) 2014-12-01
TWI685487B true TWI685487B (zh) 2020-02-21

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TW103102462A TWI685487B (zh) 2013-01-24 2014-01-23 ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形

Country Status (15)

Country Link
US (1) US9643928B2 (enExample)
EP (1) EP2951159B1 (enExample)
JP (1) JP6437456B2 (enExample)
KR (1) KR102233081B1 (enExample)
CN (1) CN105452227B (enExample)
AU (1) AU2014209319B2 (enExample)
CA (1) CA2899024C (enExample)
DK (1) DK2951159T3 (enExample)
ES (1) ES2694297T3 (enExample)
IL (1) IL240066B (enExample)
MX (1) MX360048B (enExample)
RU (1) RU2666144C2 (enExample)
SG (2) SG10202009266PA (enExample)
TW (1) TWI685487B (enExample)
WO (1) WO2014116849A1 (enExample)

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WO2010056767A1 (en) 2008-11-14 2010-05-20 Fibrogen, Inc. Thiochromene derivatives as hip hydroxylase inhibitors
EP3470397B1 (en) 2012-07-16 2021-12-29 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
SG11201500234YA (en) 2012-07-16 2015-02-27 Fibrogen Inc Process for making isoquinoline compounds
SG10202009266PA (en) 2013-01-24 2020-10-29 Fibrogen Inc Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
IL296484B2 (en) 2013-06-06 2025-03-01 Fibrogen Inc Pharmaceutical formulations of HIF hydroxylase inhibitor
CA2959688C (en) 2014-09-02 2024-02-27 Sunshine Lake Pharma Co., Ltd. Quinolone compounds and their use to treat diseases related to hypoxia inducible factor and/or erythropoietin
EP4121009A4 (en) * 2020-03-17 2024-04-17 Zydus Lifesciences Limited Formulation comprising hif prolyl hydroxylase inhibitors
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer

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Publication number Publication date
KR20150129679A (ko) 2015-11-20
CA2899024A1 (en) 2014-07-31
WO2014116849A1 (en) 2014-07-31
JP2016505071A (ja) 2016-02-18
RU2666144C2 (ru) 2018-09-06
EP2951159A1 (en) 2015-12-09
SG11201505748UA (en) 2015-08-28
KR102233081B1 (ko) 2021-03-29
DK2951159T3 (en) 2018-11-19
HK1217331A1 (en) 2017-01-06
ES2694297T3 (es) 2018-12-19
MX360048B (es) 2018-10-19
CA2899024C (en) 2022-01-04
CN105452227A (zh) 2016-03-30
US20160002170A1 (en) 2016-01-07
AU2014209319B2 (en) 2018-04-19
US9643928B2 (en) 2017-05-09
MX2015009617A (es) 2016-04-20
SG10202009266PA (en) 2020-10-29
JP6437456B2 (ja) 2018-12-12
TW201444800A (zh) 2014-12-01
EP2951159B1 (en) 2018-08-22
AU2014209319A1 (en) 2015-08-27
IL240066A0 (en) 2015-09-24
IL240066B (en) 2019-08-29
RU2015134420A (ru) 2017-03-03
CN105452227B (zh) 2018-05-29

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