JP6395606B2 - 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用 - Google Patents

血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用 Download PDF

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JP6395606B2
JP6395606B2 JP2014535877A JP2014535877A JP6395606B2 JP 6395606 B2 JP6395606 B2 JP 6395606B2 JP 2014535877 A JP2014535877 A JP 2014535877A JP 2014535877 A JP2014535877 A JP 2014535877A JP 6395606 B2 JP6395606 B2 JP 6395606B2
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antibody
sema4d
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アーネスト エス． スミス
アーネスト エス． スミス
モーリス ザウデレル
モーリス ザウデレル
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バクシネックス インコーポレーティッド
バクシネックス インコーポレーティッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014535877A 2011-10-11 2012-10-11 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用 Active JP6395606B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161545809P 2011-10-11 2011-10-11
US61/545,809 2011-10-11
US201161555726P 2011-11-04 2011-11-04
US61/555,726 2011-11-04
US201261593641P 2012-02-01 2012-02-01
US61/593,641 2012-02-01
PCT/US2012/059757 WO2013055922A1 (en) 2011-10-11 2012-10-11 Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability

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JP2014530239A JP2014530239A (ja) 2014-11-17
JP2014530239A5 JP2014530239A5 (https=) 2015-12-03
JP6395606B2 true JP6395606B2 (ja) 2018-09-26

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JP2017129377A Pending JP2017193569A (ja) 2011-10-11 2017-06-30 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用

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US (2) US20130095118A1 (https=)
EP (1) EP2766093B1 (https=)
JP (2) JP6395606B2 (https=)
KR (1) KR101999872B1 (https=)
CN (2) CN104168956A (https=)
AU (1) AU2012322721B2 (https=)
BR (1) BR112014008885B1 (https=)
CA (1) CA2851805C (https=)
DK (1) DK2766093T3 (https=)
EA (1) EA029023B1 (https=)
ES (1) ES2669209T3 (https=)
IL (1) IL232072B (https=)
MX (1) MX353550B (https=)
PT (1) PT2766093T (https=)
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CA2851805A1 (en) 2013-04-18
AU2012322721A1 (en) 2013-05-16
EP2766093B1 (en) 2018-02-21
EP2766093A1 (en) 2014-08-20
US20130095118A1 (en) 2013-04-18
CA2851805C (en) 2021-12-28
MX2014004457A (es) 2014-06-05
KR101999872B1 (ko) 2019-07-12
BR112014008885B1 (pt) 2021-02-17
CN104168956A (zh) 2014-11-26
IL232072A0 (en) 2014-05-28
WO2013055922A1 (en) 2013-04-18
BR112014008885A2 (pt) 2017-04-18
SG11201401458UA (en) 2014-07-30
MX353550B (es) 2018-01-18
CN110105452A (zh) 2019-08-09
EA201490768A1 (ru) 2014-09-30
US20190358321A1 (en) 2019-11-28
ES2669209T3 (es) 2018-05-24
IL232072B (en) 2021-01-31
EA029023B1 (ru) 2018-01-31
JP2017193569A (ja) 2017-10-26
AU2012322721B2 (en) 2016-05-05
DK2766093T3 (en) 2018-06-06
JP2014530239A (ja) 2014-11-17
US11534488B2 (en) 2022-12-27
KR20140076616A (ko) 2014-06-20
PT2766093T (pt) 2018-05-18

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