JP2014530239A5 - - Google Patents
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- JP2014530239A5 JP2014530239A5 JP2014535877A JP2014535877A JP2014530239A5 JP 2014530239 A5 JP2014530239 A5 JP 2014530239A5 JP 2014535877 A JP2014535877 A JP 2014535877A JP 2014535877 A JP2014535877 A JP 2014535877A JP 2014530239 A5 JP2014530239 A5 JP 2014530239A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- sema4d
- binding molecule
- subject
- brain barrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545809P | 2011-10-11 | 2011-10-11 | |
| US61/545,809 | 2011-10-11 | ||
| US201161555726P | 2011-11-04 | 2011-11-04 | |
| US61/555,726 | 2011-11-04 | ||
| US201261593641P | 2012-02-01 | 2012-02-01 | |
| US61/593,641 | 2012-02-01 | ||
| PCT/US2012/059757 WO2013055922A1 (en) | 2011-10-11 | 2012-10-11 | Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017129377A Division JP2017193569A (ja) | 2011-10-11 | 2017-06-30 | 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530239A JP2014530239A (ja) | 2014-11-17 |
| JP2014530239A5 true JP2014530239A5 (https=) | 2015-12-03 |
| JP6395606B2 JP6395606B2 (ja) | 2018-09-26 |
Family
ID=48082436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535877A Active JP6395606B2 (ja) | 2011-10-11 | 2012-10-11 | 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用 |
| JP2017129377A Pending JP2017193569A (ja) | 2011-10-11 | 2017-06-30 | 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017129377A Pending JP2017193569A (ja) | 2011-10-11 | 2017-06-30 | 血液脳関門透過性の調節のためのセマフォリン−４ｄ結合分子の使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20130095118A1 (https=) |
| EP (1) | EP2766093B1 (https=) |
| JP (2) | JP6395606B2 (https=) |
| KR (1) | KR101999872B1 (https=) |
| CN (2) | CN110105452A (https=) |
| AU (1) | AU2012322721B2 (https=) |
| BR (1) | BR112014008885B1 (https=) |
| CA (1) | CA2851805C (https=) |
| DK (1) | DK2766093T3 (https=) |
| EA (1) | EA029023B1 (https=) |
| ES (1) | ES2669209T3 (https=) |
| IL (1) | IL232072B (https=) |
| MX (1) | MX353550B (https=) |
| PT (1) | PT2766093T (https=) |
| SG (1) | SG11201401458UA (https=) |
| WO (1) | WO2013055922A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010129917A2 (en) | 2009-05-08 | 2010-11-11 | Vaccinex, Inc. | Anti-cd100 antibodies and methods for using the same |
| US8790652B2 (en) | 2011-12-06 | 2014-07-29 | Vaccinex, Inc. | Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis |
| US9090709B2 (en) | 2012-03-28 | 2015-07-28 | Vaccinex, Inc. | Anti-SEMA4D antibodies and epitopes |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
| BR112015032690B1 (pt) | 2013-06-25 | 2020-03-10 | Vaccinex, Inc. | Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase |
| NZ630881A (en) * | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
| NZ630892A (en) * | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| US10973930B2 (en) | 2016-02-18 | 2021-04-13 | The Penn State Research Foundation | Generating GABAergic neurons in brains |
| US10577427B2 (en) | 2016-04-22 | 2020-03-03 | Vaccinex, Inc. | Integral membrane protein display on poxvirus extracellular enveloped virions |
| BR112019001944A2 (pt) | 2016-08-02 | 2019-05-07 | Vaccinex, Inc. | métodos aperfeiçoados para produção de bibiliotecas de polinucleotídeo em células eucarióticas/vírus de vaccínia |
| RU2753441C2 (ru) * | 2016-09-13 | 2021-08-16 | Ангиокрин Биосайенс, Инк. | Гематоэнцефалический барьер, содержащий сконструированные эндотелиальные клетки |
| EP3585435A4 (en) * | 2017-02-22 | 2020-12-16 | Vaccinex, Inc. | EARLY DETECTION OF GLIAL CELL ACTIVATION IN NEURODEGENERATIVE OR NEURO-INFLAMMATORY DISEASES |
| CA3061963A1 (en) | 2017-05-05 | 2018-11-08 | Vaccinex, Inc. | Human anti-semaphorin 4d antibody |
| WO2019060695A1 (en) * | 2017-09-22 | 2019-03-28 | Kite Pharma, Inc. | CHIMERIC POLYPEPTIDES AND USES THEREOF |
| WO2019152857A1 (en) * | 2018-02-02 | 2019-08-08 | Gong Chen | Methods and materials for treating brain injuries |
| KR20210131335A (ko) * | 2019-01-22 | 2021-11-02 | 메사추세츠 인스티튜트 오브 테크놀로지 | 시험관내 인간 혈액 뇌 장벽 |
| US20220220210A1 (en) * | 2019-03-29 | 2022-07-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function |
| CN117597360A (zh) * | 2020-06-25 | 2024-02-23 | 瓦西尼斯公司 | 脑信号蛋白-4d结合分子在rett综合征治疗中的应用 |
| EP3973979A1 (en) * | 2020-09-25 | 2022-03-30 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | A tight junction (zonulae occludentes) protein for use in treating or preventing epilepsy |
| CN113456813A (zh) * | 2021-07-26 | 2021-10-01 | 苏州大学 | Semaphorin7A单克隆抗体在制备用于治疗血栓及脑血管疾病药物方面的应用 |
| WO2023012314A1 (en) * | 2021-08-05 | 2023-02-09 | Lifearc | Anti-plexin-b1 antibodies |
| US20230101618A1 (en) * | 2021-09-27 | 2023-03-30 | Vaccinex, Inc. | Predictive outcome profiling for use of an anti-semaphorin-4d binding molecule to treat neurodegenerative disorders |
| CN114539204B (zh) * | 2022-03-23 | 2023-08-22 | 福建金兰厚普生物科技有限公司 | 己糖激酶抑制剂及其合成方法和应用 |
| AU2024247601A1 (en) * | 2023-03-28 | 2025-10-23 | Nb Health Laboratory Co., Ltd. | Antibody, nucleic acid, cell and drug |
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| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| US5070192A (en) | 1988-03-23 | 1991-12-03 | The Johns Hopkins University | Cloned human topoisomerase i: cdna expression, and use for autoantibody detection |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US6497872B1 (en) | 1991-07-08 | 2002-12-24 | Neurospheres Holdings Ltd. | Neural transplantation using proliferated multipotent neural stem cells and their progeny |
| FR2686087A1 (fr) | 1992-01-13 | 1993-07-16 | Inst Nat Sante Rech Med | Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications. |
| US5639856A (en) | 1993-09-13 | 1997-06-17 | The Regents Of The University Of California | Semaphorin gene family |
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US6576754B2 (en) | 1995-11-09 | 2003-06-10 | Dana-Farber Cancer Institute | CD100 antigen and uses therefor |
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| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
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| CA2286477A1 (en) | 1997-04-11 | 1998-10-22 | Dendreon Corporation | Composition and method for inducing an immune response against tumour-related antigens |
| EP0892047A3 (de) * | 1997-07-09 | 2000-03-08 | Hoechst Marion Roussel Deutschland GmbH | Humanes und murines Semaphorin L |
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| ATE407206T1 (de) | 1998-11-10 | 2008-09-15 | Univ Rochester | Methoden zu herstellung von genbanken |
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| JP3787473B2 (ja) | 1999-11-30 | 2006-06-21 | 独立行政法人科学技術振興機構 | セマフォリン受容体 |
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| CN1329060A (zh) | 2000-06-19 | 2002-01-02 | 上海博德基因开发有限公司 | 一种新的多肽——人semaphorin蛋白9和编码这种多肽的多核苷酸 |
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| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US20080219974A1 (en) | 2002-03-01 | 2008-09-11 | Bernett Matthew J | Optimized antibodies that target hm1.24 |
| EP1365018A1 (en) | 2002-05-23 | 2003-11-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | CD100 semaphorin in myelination |
| ATE483472T1 (de) | 2002-05-30 | 2010-10-15 | Macrogenics Inc | Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten |
| US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
| EP1442749A1 (en) | 2003-01-31 | 2004-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of anti-CD100 antibodies for the treatment and the diagnosis of inflammatory disorder affecting the central nervous system |
| CN1788017B (zh) * | 2003-02-10 | 2013-04-24 | to-BBB控股股份有限公司 | 炎症状态下在血脑屏障中差异表达的核酸 |
| UA101945C2 (uk) | 2003-05-30 | 2013-05-27 | Дженентек, Инк. | Лікування злоякісного новоутворення за допомогою бевацизумабу |
| AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
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| US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
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| US8790652B2 (en) | 2011-12-06 | 2014-07-29 | Vaccinex, Inc. | Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis |
| NZ629828A (en) | 2012-03-02 | 2017-05-26 | Vaccinex Inc | Methods for the treatment of b cell-mediated inflammatory diseases |
| US9090709B2 (en) | 2012-03-28 | 2015-07-28 | Vaccinex, Inc. | Anti-SEMA4D antibodies and epitopes |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| US10494440B2 (en) | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
| CN105408355A (zh) | 2013-01-31 | 2016-03-16 | 瓦克纳斯有限公司 | 用于提高免疫球蛋白a水平的方法 |
| US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
| BR112015032690B1 (pt) | 2013-06-25 | 2020-03-10 | Vaccinex, Inc. | Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase |
| NZ630881A (en) | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
| NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| US10577427B2 (en) | 2016-04-22 | 2020-03-03 | Vaccinex, Inc. | Integral membrane protein display on poxvirus extracellular enveloped virions |
| BR112019001944A2 (pt) | 2016-08-02 | 2019-05-07 | Vaccinex, Inc. | métodos aperfeiçoados para produção de bibiliotecas de polinucleotídeo em células eucarióticas/vírus de vaccínia |
| EP3585435A4 (en) | 2017-02-22 | 2020-12-16 | Vaccinex, Inc. | EARLY DETECTION OF GLIAL CELL ACTIVATION IN NEURODEGENERATIVE OR NEURO-INFLAMMATORY DISEASES |
-
2012
- 2012-10-11 AU AU2012322721A patent/AU2012322721B2/en active Active
- 2012-10-11 PT PT128396017T patent/PT2766093T/pt unknown
- 2012-10-11 EP EP12839601.7A patent/EP2766093B1/en active Active
- 2012-10-11 DK DK12839601.7T patent/DK2766093T3/en active
- 2012-10-11 US US13/649,651 patent/US20130095118A1/en not_active Abandoned
- 2012-10-11 EA EA201490768A patent/EA029023B1/ru not_active IP Right Cessation
- 2012-10-11 KR KR1020147012547A patent/KR101999872B1/ko active Active
- 2012-10-11 CN CN201910351743.6A patent/CN110105452A/zh active Pending
- 2012-10-11 ES ES12839601.7T patent/ES2669209T3/es active Active
- 2012-10-11 BR BR112014008885-3A patent/BR112014008885B1/pt active IP Right Grant
- 2012-10-11 JP JP2014535877A patent/JP6395606B2/ja active Active
- 2012-10-11 CA CA2851805A patent/CA2851805C/en active Active
- 2012-10-11 CN CN201280059376.9A patent/CN104168956A/zh active Pending
- 2012-10-11 SG SG11201401458UA patent/SG11201401458UA/en unknown
- 2012-10-11 MX MX2014004457A patent/MX353550B/es active IP Right Grant
- 2012-10-11 WO PCT/US2012/059757 patent/WO2013055922A1/en not_active Ceased
-
2014
- 2014-04-10 IL IL232072A patent/IL232072B/en active IP Right Grant
-
2017
- 2017-06-30 JP JP2017129377A patent/JP2017193569A/ja active Pending
-
2019
- 2019-06-06 US US16/433,496 patent/US11534488B2/en active Active
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