JP2010506596A5 - - Google Patents

Download PDF

Info

Publication number
JP2010506596A5
JP2010506596A5 JP2009533527A JP2009533527A JP2010506596A5 JP 2010506596 A5 JP2010506596 A5 JP 2010506596A5 JP 2009533527 A JP2009533527 A JP 2009533527A JP 2009533527 A JP2009533527 A JP 2009533527A JP 2010506596 A5 JP2010506596 A5 JP 2010506596A5
Authority
JP
Japan
Prior art keywords
antibody
seq
chain region
specifically binds
notch3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009533527A
Other languages
English (en)
Japanese (ja)
Other versions
JP5478254B2 (ja
JP2010506596A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/081797 external-priority patent/WO2008051797A2/en
Publication of JP2010506596A publication Critical patent/JP2010506596A/ja
Publication of JP2010506596A5 publication Critical patent/JP2010506596A5/ja
Application granted granted Critical
Publication of JP5478254B2 publication Critical patent/JP5478254B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009533527A 2006-10-19 2007-10-18 抗ノッチ３アゴニスト抗体とノッチ３関連疾患の治療におけるその使用 Expired - Fee Related JP5478254B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US85286106P 2006-10-19 2006-10-19
US60/852,861 2006-10-19
US87921807P 2007-01-06 2007-01-06
US60/879,218 2007-01-06
PCT/US2007/081797 WO2008051797A2 (en) 2006-10-19 2007-10-18 Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases

Publications (3)

Publication Number Publication Date
JP2010506596A JP2010506596A (ja) 2010-03-04
JP2010506596A5 true JP2010506596A5 (https=) 2010-12-09
JP5478254B2 JP5478254B2 (ja) 2014-04-23

Family

ID=39325263

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009533527A Expired - Fee Related JP5478254B2 (ja) 2006-10-19 2007-10-18 抗ノッチ３アゴニスト抗体とノッチ３関連疾患の治療におけるその使用

Country Status (19)

Country Link
US (5) US7915390B2 (https=)
EP (1) EP2087006B1 (https=)
JP (1) JP5478254B2 (https=)
KR (2) KR101525629B1 (https=)
AR (1) AR063494A1 (https=)
AU (1) AU2007309229B8 (https=)
BR (1) BRPI0715989A8 (https=)
CA (1) CA2666672A1 (https=)
CL (1) CL2007002987A1 (https=)
CO (1) CO6180445A2 (https=)
CR (1) CR10730A (https=)
MA (1) MA30900B1 (https=)
MX (1) MX2009004106A (https=)
NO (1) NO20091926L (https=)
PE (1) PE20081264A1 (https=)
PH (1) PH12015500576A1 (https=)
RU (1) RU2461569C2 (https=)
TW (1) TW200824707A (https=)
WO (1) WO2008051797A2 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
WO2005111072A2 (en) * 2004-04-29 2005-11-24 The Trustees Of Columbia University In The City Of New York Notch-based fusion proteins and uses thereof
US20080241150A1 (en) * 2006-05-15 2008-10-02 The Brigham And Women's Hospital, Inc. Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1
ES2413087T3 (es) 2006-06-13 2013-07-15 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para el diagnóstico y tratamiento del cáncer
PE20080891A1 (es) * 2006-10-19 2008-08-25 Genentech Inc Anticuerpos anti-notch3 y composiciones que los comprenden
RU2461569C2 (ru) * 2006-10-19 2012-09-20 Дженентек, Инк. Агонистические антитела против notch3 и их применение для лечения notch3-ассоциированных заболеваний
AU2007333805B2 (en) 2006-12-18 2013-07-25 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
WO2008092002A2 (en) 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
US20090208491A1 (en) * 2007-02-14 2009-08-20 Austin Gurney Compositions and Methods for Diagnosing and Treating Cancer
PE20090321A1 (es) * 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US9127085B2 (en) 2007-08-23 2015-09-08 The Trustees Of Columbia University In The City Of New York Compositions of humanized notch fusion proteins and methods of treatment
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
WO2010021729A2 (en) 2008-08-22 2010-02-25 The Trustees Of Columbia University In The City Of New York Human notch3 based fusion proteins as decoy inhibitors of notch3 signaling
AR073717A1 (es) * 2008-10-01 2010-11-24 Genentech Inc Anticuerpos anti-notch2 de murino y humano, y metodos de uso
WO2010141249A2 (en) * 2009-06-02 2010-12-09 Merck Sharp & Dohme Corp. Generation, characterization and uses thereof of anti-notch3 antibodies
JP5113812B2 (ja) * 2009-08-31 2013-01-09 清 中川 コロニーピッキング装置、コロニーピッキング方法、及び融合細胞クローン作製方法
MX342250B (es) 2009-09-30 2016-09-22 Genentech Inc Tratamiento de cánceres resistentes a antagonistas notch1, mediante el uso de antagonistas notch3.
MX2012008085A (es) 2010-01-13 2012-09-12 Oncomed Pharm Inc Agentes de union notch1 y metodos de uso de los mismos.
US20130095493A1 (en) * 2011-10-03 2013-04-18 The Johns Hopkins University Identification of the gene notch3 as a novel biomarker for human metastatic melanoma
TW201329105A (zh) 2011-10-04 2013-07-16 Thr Trustees Of Columbia University In The City Of New York 人類ｎｏｔｃｈ１引誘物
US20150140043A1 (en) * 2012-05-10 2015-05-21 Institut National De La Sante De La Recherche Medical (Inserm) Immunomodulatory methods using notch agonists
CA2890571A1 (en) 2012-11-07 2014-05-15 Kenneth G. Geles Anti-notch3 antibodies and antibody-drug conjugates
WO2014100435A1 (en) * 2012-12-19 2014-06-26 Aveo Pharmaceuticals, Inc. Anti-notch3 antibodies
US9683039B2 (en) * 2013-03-14 2017-06-20 New York University Notch agonists for the treatment of cancer
EP3611189A1 (en) 2013-03-14 2020-02-19 Novartis AG Antibodies against notch 3
CN106459919B (zh) * 2014-06-04 2021-03-23 弗莱德哈钦森癌症研究中心 使用notch 1和/或notch 2激动剂扩增和植入干细胞
CN106488775A (zh) 2014-07-11 2017-03-08 基因泰克公司 Notch途径抑制
EP3197494A1 (en) * 2014-09-25 2017-08-02 Inserm Immunological treatment of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
MY194669A (en) 2016-03-31 2022-12-12 Ngm Biopharmaceuticals Inc Binding Proteins and Methods of use Thereof
US11142573B2 (en) * 2016-04-29 2021-10-12 Aveo Pharmaceuticals, Inc. Anti-Notch3 antibody
US11453718B2 (en) 2017-03-27 2022-09-27 The Schepens Eye Research Institute, Inc. NOTCH3 agonist compositions and methods for treating small vessel diseases
US20200103419A1 (en) * 2017-03-27 2020-04-02 The Schepens Eye Research Institute, Inc. Blood biomarkers and diagnostic methods for small vessel diseases
WO2019041024A1 (en) * 2017-08-29 2019-03-07 Gary Levy FGL2 ANTIBODIES AND BINDING FRAGMENTS THEREOF AND USES THEREOF
CA3110089A1 (en) 2018-08-28 2020-03-05 Fred Hutchinson Cancer Research Center Methods and compositions for adoptive t cell therapy incorporating induced notch signaling
JP6892180B2 (ja) * 2018-12-03 2021-06-23 株式会社ｍＡｂＰｒｏｔｅｉｎ 活性型インターロイキン−１８タンパク質のネオエピトープを認識する抗体、及びその応用
TW202216775A (zh) * 2020-06-30 2022-05-01 日商中外製藥股份有限公司 位點特異性Notch活化分子及其用途

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE20030749A1 (en) * 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
US20050112121A1 (en) 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
WO1995015982A2 (en) * 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
FR2751986B1 (fr) * 1996-08-01 1998-12-31 Inst Nat Sante Rech Med Gene implique dans le cadasil, methode de diagnostic et application therapeutique
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
FR2777285B1 (fr) 1998-04-10 2000-05-19 Bio Merieux Ligand peptidique presentant une affinite specifique vis-a-vis de la proteine p24 du retrovirus hiv-1
EP1117778A2 (en) 1998-10-02 2001-07-25 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
US20020151487A1 (en) 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
AU2001292750B2 (en) 2000-09-22 2005-07-14 Genentech, Inc. Notch receptor agonists and uses
WO2004013179A1 (en) * 2002-08-03 2004-02-12 Lorantis Limited Conjugate of notch signalling pathway modulators and their use in medical treatment
US7837993B2 (en) * 2004-03-19 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for regeneration of aged skeletal muscle tissues
CA2573293A1 (en) 2004-07-10 2006-02-16 Alexion Pharmaceuticals, Inc. Methods for discovering antibodies specific to cancer cells and antibodies discovered thereby
US20070077245A1 (en) 2004-08-04 2007-04-05 The Brigham And Women's Hospital, Inc. NOTCH mutations leading to increased receptor signaling
WO2006053063A2 (en) 2004-11-05 2006-05-18 The Regents Of The University Of California Notch-1 assay to detect neurodegenerative diseases
WO2006068822A1 (en) 2004-12-20 2006-06-29 Genentech, Inc. Notch receptor agonists and uses
CA2630839C (en) * 2005-12-16 2017-01-17 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with dll4 antagonists
US20080241150A1 (en) 2006-05-15 2008-10-02 The Brigham And Women's Hospital, Inc. Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1
PE20080891A1 (es) 2006-10-19 2008-08-25 Genentech Inc Anticuerpos anti-notch3 y composiciones que los comprenden
RU2461569C2 (ru) 2006-10-19 2012-09-20 Дженентек, Инк. Агонистические антитела против notch3 и их применение для лечения notch3-ассоциированных заболеваний
AU2007333805B2 (en) * 2006-12-18 2013-07-25 Genentech, Inc. Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica

Similar Documents

Publication Publication Date Title
JP2010506596A5 (https=)
RU2009118621A (ru) Агонистические антитела против notch3 и их применение для лечения ntch3-ассоциированных заболеваний
JP2017507657A5 (https=)
JP2019522490A5 (https=)
JP2017176174A5 (https=)
JP2020023523A5 (https=)
JP2018516554A5 (https=)
JP2009539348A5 (https=)
FI3683235T3 (fi) Anti-IL-33-vasta-aineita ja niiden käyttöjä
FI3487882T3 (fi) Gprc5d-vasta-aineita, bispesifisiä antigeeniä sitovia molekyylejä, jotka sitovat gprc5d:tä ja cd3:a, sekä niiden käyttötapoja
FI4050034T3 (fi) Cd3:een sitoutuvia vasta-aineita
WO2016207304A8 (en) Monoclonal anti-il-1racp antibodies
JP2012526542A5 (https=)
JP2011173884A5 (https=)
JP2018504105A5 (https=)
JP2018524001A5 (https=)
JP2010526028A5 (https=)
JP2018193386A5 (https=)
RU2017137872A (ru) Композиции для ингибирования masp-2-зависимой активации комплемента
JP2013519364A5 (https=)
JP2021501744A5 (https=)
RU2016107814A (ru) Новое антитело к tslp-рецептору человека
JP2014526898A5 (https=)
RU2021124437A (ru) Конструкции, направленные на комплексы пептида afp/mhc, и виды их использования
JP2014516540A5 (https=)