JP2010506596A5 - - Google Patents
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- Publication number
- JP2010506596A5 JP2010506596A5 JP2009533527A JP2009533527A JP2010506596A5 JP 2010506596 A5 JP2010506596 A5 JP 2010506596A5 JP 2009533527 A JP2009533527 A JP 2009533527A JP 2009533527 A JP2009533527 A JP 2009533527A JP 2010506596 A5 JP2010506596 A5 JP 2010506596A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- chain region
- specifically binds
- notch3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004965 antibodies Human genes 0.000 claims 30
- 108090001123 antibodies Proteins 0.000 claims 30
- 108010029756 Notch3 Receptor Proteins 0.000 claims 6
- 102000001760 Notch3 Receptor Human genes 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 206010067039 Familial hemiplegic migraine Diseases 0.000 claims 2
- 102100012125 NOTCH3 Human genes 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 201000011374 Alagille syndrome Diseases 0.000 claims 1
- 102000004851 Immunoglobulin G Human genes 0.000 claims 1
- 102100006542 JAG1 Human genes 0.000 claims 1
- 108010047319 Jagged-1 Protein Proteins 0.000 claims 1
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 1
- 208000002425 Type 2 Episodic Ataxia Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Claims (33)
- 配列番号2に記載のものと少なくとも95%の同一性を有するアミノ配列を含む可変重(「VH」)鎖領域。
- 定常領域を更に含む請求項1に記載のVH鎖領域。
- 定常領域がIgG抗体のものである請求項2に記載のVH鎖領域。
- 配列番号3に記載のものと少なくとも95%の同一性を有するアミノ配列を含む可変軽(「VL」)鎖領域。
- 定常領域を更に含む請求項4に記載のVL鎖領域。
- 配列番号4、配列番号5、及び配列番号6を含むVH鎖領域。
- 配列番号7、配列番号8、及び配列番号9を含むVL鎖領域。
- (a)配列番号2に記載のものと少なくとも95%の同一性を有するアミノ配列を含む可変重鎖領域、又は(b)配列番号3に記載のものと少なくとも95%の同一性を有するアミノ配列を含む可変軽鎖領域をコードする核酸。
- (a)配列番号2を含むVH鎖領域、(b)配列番号3を含むVL鎖領域、(c)配列番号4、配列番号5、及び配列番号6を含むVH鎖領域、又は(d)配列番号7、配列番号8、及び配列番号9を含むVL鎖領域をコードする核酸。
- 請求項8又は請求項9に記載の核酸を含むベクター。
- 請求項10に記載のベクターを含む細胞。
- 抗体がノッチ3に特異的に結合する、請求項1に記載のVH鎖領域を含む抗体。
- 配列番号2を含む請求項12に記載の抗体。
- 請求項4に記載のVL鎖領域を更に含む請求項12に記載の抗体。
- VL鎖領域が配列番号3を含み、VH鎖領域が配列番号2を含む請求項14に記載の抗体。
- 抗体がノッチ3に特異的に結合する、請求項4に記載のVL鎖領域を含む抗体。
- 配列番号3を含む請求項16に記載の抗体。
- 配列番号4、配列番号5、及び配列番号6を含む抗体。
- 配列番号7、配列番号8、及び配列番号9を更に含む請求項18に記載の抗体。
- 抗体が抗体断片である請求項12から19の何れか一項に記載の抗体。
- 標識を更に含む請求項12から20の何れか一項に記載の抗体。
- 請求項11に記載の細胞を抗体の生産に適した条件下で培養し、生産された抗体を単離することを含む抗体の生産方法。
- 配列番号10を含むエピトープに特異的に結合する抗体。
- 配列番号11を含むエピトープに特異的に結合する請求項23に記載の抗体。
- 抗体がノッチ3のアゴニストである、請求項23に記載の抗体。
- 抗体がノッチ3のアゴニストである、ノッチ3に特異的に結合する抗体。
- 抗体が抗体断片である請求項23から26の何れか一項に記載の抗体。
- 抗体が10−8から10−10Mの結合親和性(Kd)を有する請求項12から20、及び23から27の何れか一項に記載の抗体。
- 請求項12から20、及び23から28の何れか一項に記載の抗体のヒト化型。
- 医薬の調製における請求項12から20、及び23から29の何れか一項に記載の抗体の使用。
- ノッチ3関連疾病又は疾患の治療のための請求項12から20、及び23から29の何れか一項に記載の抗体の使用。
- 疾病が神経変性疾患である請求項30に記載の使用。
- 疾病がカダシル、家族性片麻痺性片頭痛(FHM)、家族性発作性運動失調、又はアラジール症候群である請求項30に記載の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85286106P | 2006-10-19 | 2006-10-19 | |
US60/852,861 | 2006-10-19 | ||
US87921807P | 2007-01-06 | 2007-01-06 | |
US60/879,218 | 2007-01-06 | ||
PCT/US2007/081797 WO2008051797A2 (en) | 2006-10-19 | 2007-10-18 | Anti-notch3 agonist antibodies and their use in the treatment of notch3-related diseases |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010506596A JP2010506596A (ja) | 2010-03-04 |
JP2010506596A5 true JP2010506596A5 (ja) | 2010-12-09 |
JP5478254B2 JP5478254B2 (ja) | 2014-04-23 |
Family
ID=39325263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009533527A Active JP5478254B2 (ja) | 2006-10-19 | 2007-10-18 | 抗ノッチ3アゴニスト抗体とノッチ3関連疾患の治療におけるその使用 |
Country Status (19)
Country | Link |
---|---|
US (5) | US7994285B2 (ja) |
EP (1) | EP2087006B1 (ja) |
JP (1) | JP5478254B2 (ja) |
KR (2) | KR20150023953A (ja) |
AR (1) | AR063494A1 (ja) |
AU (1) | AU2007309229B8 (ja) |
BR (1) | BRPI0715989A8 (ja) |
CA (1) | CA2666672A1 (ja) |
CL (1) | CL2007002987A1 (ja) |
CO (1) | CO6180445A2 (ja) |
CR (1) | CR10730A (ja) |
MA (1) | MA30900B1 (ja) |
MX (1) | MX2009004106A (ja) |
NO (1) | NO20091926L (ja) |
PE (1) | PE20081264A1 (ja) |
PH (1) | PH12015500576A1 (ja) |
RU (1) | RU2461569C2 (ja) |
TW (1) | TW200824707A (ja) |
WO (1) | WO2008051797A2 (ja) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
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US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
WO2005111072A2 (en) | 2004-04-29 | 2005-11-24 | The Trustees Of Columbia University In The City Of New York | Notch-based fusion proteins and uses thereof |
US20080241150A1 (en) * | 2006-05-15 | 2008-10-02 | The Brigham And Women's Hospital, Inc. | Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1 |
EP2032166B1 (en) * | 2006-06-13 | 2013-04-10 | OncoMed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
BRPI0715989A8 (pt) * | 2006-10-19 | 2018-03-13 | Genentech Inc | "seqüencia variável da cadeia pesada ("vh"), região da cadeia vh, seqüências variável da cadeia leve ("vl"), região da cadeia vl, seqüencias da cadeia vh, ácidos nucléicos, vetor, célula, anticorpos ou fragmentos anticorpos, anticorpos, método para a produção de anticorpo, uso de um anticorpo, epítopos de ligação do notch3, composição e uso da composição" |
CA2666179A1 (en) | 2006-10-19 | 2008-11-13 | Genentech, Inc. | Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease |
AR064388A1 (es) * | 2006-12-18 | 2009-04-01 | Genentech Inc | Anticuerpos antagonistas anti- notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3 |
US8148147B2 (en) | 2007-01-24 | 2012-04-03 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
US8088617B2 (en) * | 2007-01-24 | 2012-01-03 | Oncomed Pharmaceuticals, Inc. | Antibodies that bind the glutamate ligand binding region of Notch1 |
WO2008100563A2 (en) * | 2007-02-14 | 2008-08-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
PE20090321A1 (es) * | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
RU2532830C2 (ru) | 2007-08-23 | 2014-11-10 | Дзе Трастиз Оф Коламбия Юниверсити Ин Дзе Сити Оф Нью Йорк | Композиции гуманизированных слитых белков notch и способы лечения |
EP2899211A1 (en) | 2008-07-08 | 2015-07-29 | OncoMed Pharmaceuticals, Inc. | Notch1 receptor binding agents and methods of use thereof |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
ES2532405T3 (es) | 2008-08-22 | 2015-03-26 | The Trustees Of Columbia University In The City Of New York | Proteínas de fusión basadas en Notch3 humanas como inhibidores señuelo de la señalización de Notch3 |
WO2010039832A1 (en) * | 2008-10-01 | 2010-04-08 | Genentech, Inc. | Anti-notch2 antibodies and methods of use |
WO2010141249A2 (en) * | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-notch3 antibodies |
JP5113812B2 (ja) * | 2009-08-31 | 2013-01-09 | 清 中川 | コロニーピッキング装置、コロニーピッキング方法、及び融合細胞クローン作製方法 |
KR101782180B1 (ko) | 2009-09-30 | 2017-10-23 | 제넨테크, 인크. | Notch3 길항제를 사용한 Notch1―길항제-내성 암(들)의 치료 |
EP2523682B1 (en) | 2010-01-13 | 2015-12-16 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
US20130095493A1 (en) * | 2011-10-03 | 2013-04-18 | The Johns Hopkins University | Identification of the gene notch3 as a novel biomarker for human metastatic melanoma |
TW201329105A (zh) | 2011-10-04 | 2013-07-16 | Thr Trustees Of Columbia University In The City Of New York | 人類notch1引誘物 |
EP2846818A1 (en) * | 2012-05-10 | 2015-03-18 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Immunomodulatory methods using notch agonists |
PE20150892A1 (es) * | 2012-11-07 | 2015-06-11 | Pfizer | Anticuerpos anti-notch y conjugados de anticuerpo-farmaco |
US9879083B2 (en) * | 2012-12-19 | 2018-01-30 | Aveo Pharmaceuticals, Inc. | Anti-Notch3 antibodies |
JP2016514130A (ja) * | 2013-03-14 | 2016-05-19 | ノバルティス アーゲー | Notch3に対する抗体 |
US9683039B2 (en) * | 2013-03-14 | 2017-06-20 | New York University | Notch agonists for the treatment of cancer |
US10208286B2 (en) * | 2014-06-04 | 2019-02-19 | Fred Hutchinson Cancer Research Center | Expansion and engraftment of stem cells using Notch 1 and/or Notch 2 agonists |
CN106488775A (zh) | 2014-07-11 | 2017-03-08 | 基因泰克公司 | Notch途径抑制 |
EP3197494A1 (en) | 2014-09-25 | 2017-08-02 | Inserm | Immunological treatment of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy |
PE20190126A1 (es) | 2016-03-31 | 2019-01-17 | Ngm Biopharmaceuticals Inc | Proteinas de union y metodos de uso de las mismas |
DK3448420T3 (da) * | 2016-04-29 | 2022-12-12 | Aveo Pharmaceuticals Inc | Anti-notch3-antistof |
US20200103419A1 (en) * | 2017-03-27 | 2020-04-02 | The Schepens Eye Research Institute, Inc. | Blood biomarkers and diagnostic methods for small vessel diseases |
WO2018183216A1 (en) | 2017-03-27 | 2018-10-04 | The Schepens Eye Research Institute, Inc. | Notch3 agonist compositions and methods for treating small vessel diseases |
US11325969B2 (en) * | 2017-08-29 | 2022-05-10 | Veritas Therapeutics Inc. | FGL2 antibodies and binding fragments thereof and uses thereof |
AU2019329984A1 (en) | 2018-08-28 | 2021-03-11 | Fred Hutchinson Cancer Center | Methods and compositions for adoptive T cell therapy incorporating induced notch signaling |
WO2020116423A1 (ja) * | 2018-12-03 | 2020-06-11 | 株式会社mAbProtein | 活性型インターロイキン-18タンパク質のネオエピトープを認識する抗体、及びその応用 |
JP2023530797A (ja) * | 2020-06-30 | 2023-07-20 | 中外製薬株式会社 | 部位特異的Notch活性化分子およびその使用 |
Family Cites Families (26)
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IE20030749A1 (en) * | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
US5786158A (en) * | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
AU696293B2 (en) * | 1993-12-08 | 1998-09-03 | Genzyme Corporation | Process for generating specific antibodies |
US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
US20050158859A1 (en) * | 1995-09-29 | 2005-07-21 | Yale University | Manipulation of non-terminally differentiated cells using the Notch pathway |
FR2751986B1 (fr) * | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | Gene implique dans le cadasil, methode de diagnostic et application therapeutique |
US6692919B1 (en) * | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
US6436650B1 (en) * | 1997-07-23 | 2002-08-20 | Yale University | Activated forms of notch and methods based thereon |
FR2777285B1 (fr) | 1998-04-10 | 2000-05-19 | Bio Merieux | Ligand peptidique presentant une affinite specifique vis-a-vis de la proteine p24 du retrovirus hiv-1 |
JP2002526109A (ja) | 1998-10-02 | 2002-08-20 | ザ ガバメント オブ ザ ユナイテッドステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ ザ ナショナル インステ | アポトーシス誘導物質と方法 |
US8084258B2 (en) * | 1999-07-12 | 2011-12-27 | University Of Basel | Manipulation of tissue of organ type using the notch pathway |
US20020151487A1 (en) * | 2000-08-31 | 2002-10-17 | Loyola University Chicago | Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway |
WO2002024221A2 (en) | 2000-09-22 | 2002-03-28 | Genentech, Inc. | Notch receptor agonists and uses |
EP1525221A1 (en) * | 2002-08-03 | 2005-04-27 | Lorantis Limited | Conjugate of notch signalling pathway modulators and their use in medical treatment |
US7837993B2 (en) | 2004-03-19 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for regeneration of aged skeletal muscle tissues |
WO2006017173A1 (en) | 2004-07-10 | 2006-02-16 | Alexion Pharmaceuticals, Inc. | Methods for discovering antibodies specific to cancer cells and antibodies discovered thereby |
US20070077245A1 (en) | 2004-08-04 | 2007-04-05 | The Brigham And Women's Hospital, Inc. | NOTCH mutations leading to increased receptor signaling |
WO2006053063A2 (en) | 2004-11-05 | 2006-05-18 | The Regents Of The University Of California | Notch-1 assay to detect neurodegenerative diseases |
WO2006068822A1 (en) | 2004-12-20 | 2006-06-29 | Genentech, Inc. | Notch receptor agonists and uses |
AU2006326417B2 (en) * | 2005-12-16 | 2012-05-24 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with Dll4 antagonists |
US20080241150A1 (en) | 2006-05-15 | 2008-10-02 | The Brigham And Women's Hospital, Inc. | Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1 |
CA2666179A1 (en) | 2006-10-19 | 2008-11-13 | Genentech, Inc. | Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease |
BRPI0715989A8 (pt) * | 2006-10-19 | 2018-03-13 | Genentech Inc | "seqüencia variável da cadeia pesada ("vh"), região da cadeia vh, seqüências variável da cadeia leve ("vl"), região da cadeia vl, seqüencias da cadeia vh, ácidos nucléicos, vetor, célula, anticorpos ou fragmentos anticorpos, anticorpos, método para a produção de anticorpo, uso de um anticorpo, epítopos de ligação do notch3, composição e uso da composição" |
AR064388A1 (es) * | 2006-12-18 | 2009-04-01 | Genentech Inc | Anticuerpos antagonistas anti- notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3 |
PE20090321A1 (es) | 2007-06-04 | 2009-04-20 | Genentech Inc | Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica |
-
2007
- 2007-10-18 BR BRPI0715989A patent/BRPI0715989A8/pt not_active IP Right Cessation
- 2007-10-18 MX MX2009004106A patent/MX2009004106A/es active IP Right Grant
- 2007-10-18 RU RU2009118621/10A patent/RU2461569C2/ru not_active IP Right Cessation
- 2007-10-18 US US11/874,645 patent/US7994285B2/en not_active Expired - Fee Related
- 2007-10-18 CL CL200702987A patent/CL2007002987A1/es unknown
- 2007-10-18 CA CA002666672A patent/CA2666672A1/en not_active Abandoned
- 2007-10-18 US US11/874,682 patent/US7915390B2/en active Active
- 2007-10-18 KR KR1020157004016A patent/KR20150023953A/ko not_active Application Discontinuation
- 2007-10-18 PE PE2007001412A patent/PE20081264A1/es not_active Application Discontinuation
- 2007-10-18 WO PCT/US2007/081797 patent/WO2008051797A2/en active Application Filing
- 2007-10-18 TW TW096139048A patent/TW200824707A/zh unknown
- 2007-10-18 EP EP07844405.6A patent/EP2087006B1/en active Active
- 2007-10-18 AR ARP070104625A patent/AR063494A1/es unknown
- 2007-10-18 JP JP2009533527A patent/JP5478254B2/ja active Active
- 2007-10-18 KR KR1020097010122A patent/KR101525629B1/ko not_active IP Right Cessation
- 2007-10-18 AU AU2007309229A patent/AU2007309229B8/en not_active Ceased
-
2009
- 2009-04-17 CR CR10730A patent/CR10730A/es not_active Application Discontinuation
- 2009-05-14 MA MA31887A patent/MA30900B1/fr unknown
- 2009-05-18 CO CO09050698A patent/CO6180445A2/es active IP Right Grant
- 2009-05-18 NO NO20091926A patent/NO20091926L/no not_active Application Discontinuation
-
2011
- 2011-02-23 US US13/033,500 patent/US8187839B2/en active Active
-
2012
- 2012-04-23 US US13/453,817 patent/US20120213785A1/en not_active Abandoned
-
2013
- 2013-08-21 US US13/972,443 patent/US9518124B2/en active Active
-
2015
- 2015-03-17 PH PH12015500576A patent/PH12015500576A1/en unknown
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