KR101999872B1 - 혈뇌 장벽 투과성의 조정에 있어서의 세마포린-4d 결합 분자의 용도 - Google Patents

혈뇌 장벽 투과성의 조정에 있어서의 세마포린-4d 결합 분자의 용도 Download PDF

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KR101999872B1
KR101999872B1 KR1020147012547A KR20147012547A KR101999872B1 KR 101999872 B1 KR101999872 B1 KR 101999872B1 KR 1020147012547 A KR1020147012547 A KR 1020147012547A KR 20147012547 A KR20147012547 A KR 20147012547A KR 101999872 B1 KR101999872 B1 KR 101999872B1
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antibody
sema4d
bbb
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antigen
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어니스트 에스. 스미스
모리스 자우더러
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백시넥스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147012547A 2011-10-11 2012-10-11 혈뇌 장벽 투과성의 조정에 있어서의 세마포린-4d 결합 분자의 용도 Active KR101999872B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161545809P 2011-10-11 2011-10-11
US61/545,809 2011-10-11
US201161555726P 2011-11-04 2011-11-04
US61/555,726 2011-11-04
US201261593641P 2012-02-01 2012-02-01
US61/593,641 2012-02-01
PCT/US2012/059757 WO2013055922A1 (en) 2011-10-11 2012-10-11 Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability

Publications (2)

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KR20140076616A KR20140076616A (ko) 2014-06-20
KR101999872B1 true KR101999872B1 (ko) 2019-07-12

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US (2) US20130095118A1 (https=)
EP (1) EP2766093B1 (https=)
JP (2) JP6395606B2 (https=)
KR (1) KR101999872B1 (https=)
CN (2) CN110105452A (https=)
AU (1) AU2012322721B2 (https=)
BR (1) BR112014008885B1 (https=)
CA (1) CA2851805C (https=)
DK (1) DK2766093T3 (https=)
EA (1) EA029023B1 (https=)
ES (1) ES2669209T3 (https=)
IL (1) IL232072B (https=)
MX (1) MX353550B (https=)
PT (1) PT2766093T (https=)
SG (1) SG11201401458UA (https=)
WO (1) WO2013055922A1 (https=)

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US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
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US20220220210A1 (en) * 2019-03-29 2022-07-14 Chugai Seiyaku Kabushiki Kaisha Anti-il-6 receptor antibody-containing inhibitor for inhibiting deterioration of bbb function
CN117597360A (zh) * 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
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EP2766093A4 (en) 2015-03-25
IL232072B (en) 2021-01-31
US20130095118A1 (en) 2013-04-18
IL232072A0 (en) 2014-05-28
BR112014008885A2 (pt) 2017-04-18
EP2766093B1 (en) 2018-02-21
KR20140076616A (ko) 2014-06-20
CA2851805C (en) 2021-12-28
JP2017193569A (ja) 2017-10-26
BR112014008885B1 (pt) 2021-02-17
DK2766093T3 (en) 2018-06-06
PT2766093T (pt) 2018-05-18
JP2014530239A (ja) 2014-11-17
CN104168956A (zh) 2014-11-26
EA201490768A1 (ru) 2014-09-30
EA029023B1 (ru) 2018-01-31
JP6395606B2 (ja) 2018-09-26
SG11201401458UA (en) 2014-07-30
MX2014004457A (es) 2014-06-05
AU2012322721A1 (en) 2013-05-16
MX353550B (es) 2018-01-18
CN110105452A (zh) 2019-08-09
EP2766093A1 (en) 2014-08-20
CA2851805A1 (en) 2013-04-18
AU2012322721B2 (en) 2016-05-05
WO2013055922A1 (en) 2013-04-18
US20190358321A1 (en) 2019-11-28
US11534488B2 (en) 2022-12-27
ES2669209T3 (es) 2018-05-24
NZ623856A (en) 2016-04-29

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