|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4675187A
(en)
|
1983-05-16 |
1987-06-23 |
Bristol-Myers Company |
BBM-1675, a new antibiotic complex
|
|
US6054561A
(en)
|
1984-02-08 |
2000-04-25 |
Chiron Corporation |
Antigen-binding sites of antibody molecules specific for cancer antigens
|
|
IL71691A
(en)
|
1984-04-27 |
1991-04-15 |
Yeda Res & Dev |
Production of interferon-ypsilon
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
US5116742A
(en)
|
1986-12-03 |
1992-05-26 |
University Patents, Inc. |
RNA ribozyme restriction endoribonucleases and methods
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
|
US5190929A
(en)
|
1988-05-25 |
1993-03-02 |
Research Corporation Technologies, Inc. |
Cyclophosphamide analogs useful as anti-tumor agents
|
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
EP0394827A1
(en)
|
1989-04-26 |
1990-10-31 |
F. Hoffmann-La Roche Ag |
Chimaeric CD4-immunoglobulin polypeptides
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5552391A
(en)
|
1990-01-16 |
1996-09-03 |
La Jolla Pharmaceutical Company |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
|
|
US6641809B1
(en)
*
|
1990-03-26 |
2003-11-04 |
Bristol-Myers Squibb Company |
Method of regulating cellular processes mediated by B7 and CD28
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
WO1992010591A1
(en)
|
1990-12-14 |
1992-06-25 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US5844095A
(en)
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
|
CA2580812A1
(en)
*
|
1991-06-27 |
1993-01-07 |
Bristol-Myers Squibb Company |
Ctla4 receptor, fusion proteins containing it and uses thereof
|
|
GB9115364D0
(en)
|
1991-07-16 |
1991-08-28 |
Wellcome Found |
Antibody
|
|
AU669124B2
(en)
|
1991-09-18 |
1996-05-30 |
Kyowa Hakko Kirin Co., Ltd. |
Process for producing humanized chimera antibody
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US6162432A
(en)
|
1991-10-07 |
2000-12-19 |
Biogen, Inc. |
Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
|
|
DE4135070C1
(https=)
|
1991-10-24 |
1993-05-19 |
Institut Fuer Rundfunktechnik Gmbh, 8000 Muenchen, De |
|
|
EP0571613B1
(en)
|
1991-12-13 |
2003-09-17 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5824307A
(en)
|
1991-12-23 |
1998-10-20 |
Medimmune, Inc. |
Human-murine chimeric antibodies against respiratory syncytial virus
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
FR2686901A1
(fr)
|
1992-01-31 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
|
|
GB9203459D0
(en)
|
1992-02-19 |
1992-04-08 |
Scotgen Ltd |
Antibodies with germ-line variable regions
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
TW402639B
(en)
|
1992-12-03 |
2000-08-21 |
Transkaryotic Therapies Inc |
Protein production and protein delivery
|
|
US6180377B1
(en)
|
1993-06-16 |
2001-01-30 |
Celltech Therapeutics Limited |
Humanized antibodies
|
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
US5532159A
(en)
|
1994-04-01 |
1996-07-02 |
The Ohio State University |
Monoclonal antibody to canine placental oncofetal protein for detecting cancer
|
|
GB9415379D0
(en)
|
1994-07-29 |
1994-09-21 |
Smithkline Beecham Plc |
Novel compounds
|
|
HUT76369A
(en)
|
1994-07-29 |
1997-08-28 |
Smithkline Beecham Corp |
Novel soluble protein compounds
|
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
EP1658772A3
(en)
|
1995-01-17 |
2007-01-17 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of immunogens
|
|
US6265150B1
(en)
|
1995-06-07 |
2001-07-24 |
Becton Dickinson & Company |
Phage antibodies
|
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US7411051B2
(en)
*
|
1997-03-07 |
2008-08-12 |
Human Genome Sciences, Inc. |
Antibodies to HDPPA04 polypeptide
|
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
ES2312205T3
(es)
|
1998-03-10 |
2009-02-16 |
Genentech, Inc. |
Nuevo polipeptido y acidos nucleicos que lo codifican.
|
|
WO2000068266A1
(en)
|
1999-05-11 |
2000-11-16 |
Eli Lilly And Company |
Amyloid precursor protein protease and related nucleic acid compounds
|
|
EP1514933A1
(en)
|
1999-07-08 |
2005-03-16 |
Research Association for Biotechnology |
Secretory protein or membrane protein
|
|
PL354286A1
(en)
|
1999-08-23 |
2003-12-29 |
Dana-Farber Cancer Institutedana-Farber Cancer Institute |
Pd-1, a receptor for b7-4, and uses therefor
|
|
AU7337400A
(en)
|
1999-09-03 |
2001-04-10 |
Human Genome Sciences, Inc. |
B7-like polynucleotides, polypeptides, and antibodies
|
|
US6429303B1
(en)
|
1999-09-03 |
2002-08-06 |
Curagen Corporation |
Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same
|
|
DK1218504T3
(da)
*
|
1999-09-21 |
2007-11-12 |
Genetics Inst Llc |
GL50 molekyler og anvendelser deraf
|
|
DK1259547T3
(da)
|
2000-03-01 |
2012-10-15 |
Medimmune Inc |
Højpotente, rekombinante antistoffer og fremgangsmåde til fremstilling heraf
|
|
US6569681B1
(en)
|
2000-03-14 |
2003-05-27 |
Transkaryotic Therapies, Inc. |
Methods of improving homologous recombination
|
|
US6416999B1
(en)
|
2000-04-07 |
2002-07-09 |
Raven Biotechnologies, Inc. |
Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof
|
|
US6436704B1
(en)
|
2000-04-10 |
2002-08-20 |
Raven Biotechnologies, Inc. |
Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
|
|
US6987024B1
(en)
|
2000-04-10 |
2006-01-17 |
Raven Biotechnologies, Inc. |
Human ovarian mesothelial cells and methods of isolation and uses thereof
|
|
EP2213743A1
(en)
|
2000-04-12 |
2010-08-04 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US20060154313A1
(en)
|
2000-04-13 |
2006-07-13 |
Immunex Corporation |
Human B7 polypeptide B7-H3A
|
|
JP3597140B2
(ja)
*
|
2000-05-18 |
2004-12-02 |
日本たばこ産業株式会社 |
副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
|
|
WO2001089567A1
(en)
|
2000-05-22 |
2001-11-29 |
Idec Pharmaceuticals Corporation |
Identification of unique binding interactions between certain antibodies and the human b7.1 and b7.2 co-stimulatory antigens
|
|
US20030031675A1
(en)
|
2000-06-06 |
2003-02-13 |
Mikesell Glen E. |
B7-related nucleic acids and polypeptides useful for immunomodulation
|
|
EP1892251A3
(en)
|
2000-06-06 |
2008-12-31 |
Brystol-Myers Squibb Company |
B7-related nucleic acids and polypeptides and their uses for immunomodulation
|
|
US6965018B2
(en)
|
2000-06-06 |
2005-11-15 |
Bristol-Myers Squibb Company |
Antibodies directed to B7-related polypeptide, BSL-2
|
|
AU2001272982B2
(en)
*
|
2000-06-23 |
2006-08-24 |
Biogen Idec Ma Inc. |
GP286 nucleic acids and polypeptides
|
|
EP1301524A1
(en)
*
|
2000-06-30 |
2003-04-16 |
Human Genome Sciences, Inc. |
B7-like polynucleotides, polypeptides, and antibodies
|
|
US6635750B1
(en)
|
2000-07-20 |
2003-10-21 |
Millennium Pharmaceuticals, Inc. |
B7-H2 nucleic acids, members of the B7 family
|
|
US6891030B2
(en)
|
2000-07-27 |
2005-05-10 |
Mayo Foundation For Medical Education And Research |
T-cell immunoregulatory molecule
|
|
WO2002022683A1
(fr)
|
2000-09-12 |
2002-03-21 |
Kirin Beer Kabushiki Kaisha |
Nouvelle membrane a paroi cellulaire dendritique et son utilisation
|
|
US20030134283A1
(en)
|
2000-10-03 |
2003-07-17 |
Peterson David P. |
Genes regulated in dendritic cell differentiation
|
|
EP1399187A4
(en)
|
2000-10-18 |
2005-09-21 |
Sloan Kettering Inst Cancer |
APPLICATIONS OF MONOCLONAL ANTIBODY 8H9
|
|
US6818216B2
(en)
|
2000-11-28 |
2004-11-16 |
Medimmune, Inc. |
Anti-RSV antibodies
|
|
CA2429814C
(en)
|
2000-12-01 |
2014-02-18 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
PE20020574A1
(es)
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
|
US7083784B2
(en)
|
2000-12-12 |
2006-08-01 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
|
US7651541B2
(en)
|
2001-01-10 |
2010-01-26 |
State Line Holdings, LLC |
Chemical change agent
|
|
US20040096451A1
(en)
|
2002-07-25 |
2004-05-20 |
Young James F. |
Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies
|
|
AU2002250236A1
(en)
|
2001-03-02 |
2002-09-19 |
Medimmune, Inc. |
Cd2 antagonists for treatment of autoimmune or inflammatory disease
|
|
US20070015144A9
(en)
|
2001-05-25 |
2007-01-18 |
Genset, S.A. |
Human cDNAs and proteins and uses thereof
|
|
WO2002097046A2
(en)
|
2001-05-25 |
2002-12-05 |
Amgen, Inc. |
B7 related protein-2 molecules and uses thereof
|
|
EP1390497A2
(en)
|
2001-05-25 |
2004-02-25 |
Genset |
Human cdnas and proteins and uses thereof
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
EP1423402A4
(en)
|
2001-08-02 |
2006-07-05 |
Lilly Co Eli |
NOVEL ANALOGUES OF POLYPEPTIDES AND HYBRID PROTEINS AND METHODS OF USE
|
|
EP1480520A4
(en)
|
2002-02-12 |
2006-02-15 |
Raven Biotechnologies Inc |
EPITHELIAL CELLS FROM THE HUMAN FOLDS BUBBLE
|
|
US20040162236A1
(en)
|
2002-04-01 |
2004-08-19 |
John Alsobrook |
Therapeutic polypeptides, nucleic acids encoding same, and methods of use
|
|
JP4585968B2
(ja)
|
2002-05-10 |
2010-11-24 |
パーデュー・リサーチ・ファウンデーション |
ＥｐｈＡ２アゴニストモノクローナル抗体およびその使用法
|
|
ATE525398T1
(de)
|
2002-05-10 |
2011-10-15 |
Medimmune Inc |
Epha2 monoklonale antikörper und deren anwendungsverfahren
|
|
ATE488530T1
(de)
|
2002-06-19 |
2010-12-15 |
Raven Biotechnologies Inc |
Internalisierende antikörper spezifisch für das raag10 zelloberflächenziel
|
|
EP1539218A4
(en)
|
2002-06-20 |
2007-08-22 |
Univ California |
COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY
|
|
EP2365004B1
(en)
|
2002-06-21 |
2016-01-06 |
Johns Hopkins University School of Medicine |
Membrane associated tumor endothelium markers
|
|
AU2003295600A1
(en)
|
2002-11-14 |
2004-06-15 |
Dharmacon, Inc. |
Functional and hyperfunctional sirna
|
|
US9068234B2
(en)
|
2003-01-21 |
2015-06-30 |
Ptc Therapeutics, Inc. |
Methods and agents for screening for compounds capable of modulating gene expression
|
|
WO2005035575A2
(en)
|
2003-08-22 |
2005-04-21 |
Medimmune, Inc. |
Humanization of antibodies
|
|
WO2006050166A2
(en)
|
2004-10-29 |
2006-05-11 |
Medimmune, Inc. |
Methods of preventing and treating rsv infections and related conditions
|
|
WO2007149067A2
(en)
*
|
2005-05-12 |
2007-12-27 |
Zymogenetics, Inc. |
Methods of using phhla2 to co-stimulate t-cells
|
|
US20070202077A1
(en)
|
2005-12-02 |
2007-08-30 |
Brodsky Robert A |
Use of High-Dose Oxazaphosphorine Drugs for Treating Immune Disorders
|
|
US8021668B2
(en)
|
2005-12-12 |
2011-09-20 |
Immune Disease Institute, Inc. |
Integrin alpha L I domain mutants with increased binding affinity
|
|
EP2124998B8
(en)
*
|
2006-12-27 |
2015-05-06 |
The Johns Hopkins University |
Methods for detecting inflammation and auto-immune diseases
|
|
US20100285039A1
(en)
*
|
2008-01-03 |
2010-11-11 |
The Johns Hopkins University |
B7-H1 (CD274) Antagonists Induce Apoptosis of Tumor Cells
|
|
CA2769822C
(en)
*
|
2009-08-13 |
2019-02-19 |
The Johns Hopkins University |
Methods of modulating immune function
|
|
BR112015014621A2
(pt)
*
|
2012-12-21 |
2017-10-03 |
Amplimmune Inc |
Anticorpos anti-h7cr
|