JP2009539841A5 - - Google Patents
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- Publication number
- JP2009539841A5 JP2009539841A5 JP2009514336A JP2009514336A JP2009539841A5 JP 2009539841 A5 JP2009539841 A5 JP 2009539841A5 JP 2009514336 A JP2009514336 A JP 2009514336A JP 2009514336 A JP2009514336 A JP 2009514336A JP 2009539841 A5 JP2009539841 A5 JP 2009539841A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- administered
- amount
- fragment
- intravenously
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 41
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 41
- 239000012634 fragment Substances 0.000 claims 11
- 238000001990 intravenous administration Methods 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 241000288906 Primates Species 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44762806A | 2006-06-06 | 2006-06-06 | |
| US92148506P | 2006-06-06 | 2006-06-06 | |
| PCT/US2007/013232 WO2007145941A2 (en) | 2006-06-06 | 2007-06-05 | Administration of anti-cd3 antibodies in the treatment of autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009539841A JP2009539841A (ja) | 2009-11-19 |
| JP2009539841A5 true JP2009539841A5 (https=) | 2010-07-22 |
Family
ID=38832328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009514336A Pending JP2009539841A (ja) | 2006-06-06 | 2007-06-05 | 自己免疫疾患の治療における抗cd3抗体の投与 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090258001A1 (https=) |
| EP (2) | EP2023955A4 (https=) |
| JP (1) | JP2009539841A (https=) |
| AU (1) | AU2007258694B2 (https=) |
| CA (1) | CA2653387A1 (https=) |
| NZ (1) | NZ573132A (https=) |
| WO (1) | WO2007145941A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5139800B2 (ja) | 2004-06-03 | 2013-02-06 | ノビミューン エスアー | 抗cd3抗体およびその使用方法 |
| AU2006267090B2 (en) | 2005-07-11 | 2013-03-07 | Provention Bio, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| SG10201504662WA (en) | 2006-06-14 | 2015-07-30 | Macrogenics Inc | Methods For The Treatment Of Autoimmune Disorders Using Immunosuppressive Monoclonal Antibodies With Reduced Toxicity |
| AU2009288354A1 (en) * | 2008-08-26 | 2010-03-11 | Macrogenics Inc. | T-cell receptor antibodies and methods of use thereof |
| CN105218673A (zh) * | 2008-10-10 | 2016-01-06 | 新兴产品开发西雅图有限公司 | Tcr复合物免疫治疗剂 |
| JP5816164B2 (ja) * | 2009-05-07 | 2015-11-18 | ビオメリュー・インコーポレイテッド | 抗生物質耐性測定方法 |
| WO2011050104A2 (en) * | 2009-10-20 | 2011-04-28 | Tolerx, Inc. | Methods of using anti-cd3 antibodies to prevent weight gain |
| JP2013508392A (ja) * | 2009-10-20 | 2013-03-07 | グラクソ グループ リミテッド | 自己免疫疾患における抗cd3抗体の投薬 |
| EP2507381A4 (en) | 2009-12-04 | 2016-07-20 | Hoffmann La Roche | MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS AND METHODS |
| RS67768B1 (sr) | 2010-11-30 | 2026-03-31 | Chugai Pharmaceutical Co Ltd | Terapijski agens koji indukuje citotoksičnost |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| CN104011207B (zh) | 2011-10-31 | 2018-09-18 | 中外制药株式会社 | 控制了重链与轻链的缔合的抗原结合分子 |
| SG10201608307WA (en) | 2012-04-20 | 2016-11-29 | Emergent Product Dev Seattle | Cd3 binding polypeptides |
| WO2014022841A1 (en) * | 2012-08-03 | 2014-02-06 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Cyclodextrin for the treatment of lysosomal storage diseases |
| CN118440206A (zh) | 2014-04-07 | 2024-08-06 | 中外制药株式会社 | 免疫活化抗原结合分子 |
| EP3144388B1 (en) | 2014-05-13 | 2020-07-01 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirecting antigen-binding molecule for cells having immunosuppression function |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| BR112017011166A2 (pt) | 2014-11-26 | 2018-02-27 | Xencor, Inc. | anticorpos heterodiméricos que se ligam a cd3 e cd38 |
| EP3352760B1 (en) | 2015-09-21 | 2026-03-11 | Aptevo Research and Development LLC | Cd3 binding polypeptides |
| US11660340B2 (en) | 2015-11-18 | 2023-05-30 | Chugai Seiyaku Kabushiki Kaisha | Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function |
| WO2017086419A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 液性免疫応答の増強方法 |
| CN108368166B (zh) | 2015-12-28 | 2023-03-28 | 中外制药株式会社 | 提高含fc区多肽纯化效率的方法 |
| US11072666B2 (en) | 2016-03-14 | 2021-07-27 | Chugai Seiyaku Kabushiki Kaisha | Cell injury inducing therapeutic drug for use in cancer therapy |
| US12569477B2 (en) * | 2017-06-28 | 2026-03-10 | Mitocholine Ltd | Compositions for synergistically enhancing mitochondrial function |
| WO2019195623A2 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
| TW202546002A (zh) * | 2019-03-29 | 2025-12-01 | 荷蘭商美勒斯公司 | Cd3結合分子 |
| IL322315A (en) | 2019-05-14 | 2025-09-01 | Provention Bio Inc | Methods and preparations for preventing type 1 diabetes |
| KR20220035369A (ko) * | 2019-06-07 | 2022-03-22 | 아디맵 엘엘씨 | 고 친화도 항-cd3 항체, 및 이의 생성 및 사용 방법 |
| EP3984554A4 (en) * | 2019-06-11 | 2023-11-08 | ONO Pharmaceutical Co., Ltd. | IMMUNOSUPPRESSANT |
| CR20220049A (es) | 2019-07-10 | 2022-03-02 | Chugai Pharmaceutical Co Ltd | Moléculas de unión a claudina-6 y usos de las mismas |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| AU2021287998B2 (en) | 2020-06-11 | 2026-03-12 | Benaroya Research Institute At Virginia Mason | Methods and compositions for preventing type 1 diabetes |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Cd3及びcldn6に結合するヘテロ二量体抗体 |
| JP2024509274A (ja) | 2021-03-10 | 2024-02-29 | ゼンコア インコーポレイテッド | Cd3及びgpc3に結合するヘテロ二量体抗体 |
| US12565529B2 (en) | 2021-05-24 | 2026-03-03 | Provention Bio, Inc. | Methods for treating type 1 diabetes |
| WO2023156966A1 (en) | 2022-02-18 | 2023-08-24 | Beren Therapeutics P.B.C. | Compositions of hydroxypropyl-beta-cyclodextrin and methods of purifying the same |
| CN119095873A (zh) | 2022-03-14 | 2024-12-06 | 拉姆卡普生物伽马股份公司 | 用于靶向杀伤GPC3阳性恶性细胞的双特异性GPC3xCD28和GPC3xCD3抗体及其组合 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4658019A (en) | 1979-04-26 | 1987-04-14 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human T cells |
| WO1988007089A1 (en) * | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| AU6642390A (en) * | 1989-10-27 | 1991-05-31 | Arch Development Corporation | Methods and compositions for promoting immunopotentiation |
| US6406696B1 (en) * | 1989-10-27 | 2002-06-18 | Tolerance Therapeutics, Inc. | Methods of stimulating the immune system with anti-CD3 antibodies |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6750325B1 (en) * | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
| US5968509A (en) | 1990-10-05 | 1999-10-19 | Btp International Limited | Antibodies with binding affinity for the CD3 antigen |
| EP1400536A1 (en) * | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| GB9206422D0 (en) | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| US5885573A (en) * | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6491916B1 (en) * | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| JP3111024B2 (ja) * | 1995-07-19 | 2000-11-20 | キヤノン株式会社 | カラーフィルタの製造装置及び製造方法及び表示装置の製造方法及び表示装置を備えた装置の製造方法 |
| US5834597A (en) * | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US7041289B1 (en) | 1997-12-05 | 2006-05-09 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for treating established spontaneous auto-immune diseases in mammals |
| CA2224256C (en) | 1997-12-09 | 2013-04-30 | I.N.S.E.R.M. | Method for treating established spontaneous auto-immune diseases in mammals |
| GB9815909D0 (en) * | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| WO2000046750A1 (en) * | 1999-02-05 | 2000-08-10 | Samsung Electronics Co., Ltd. | Image texture retrieving method and apparatus thereof |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| CA2508264A1 (en) * | 2002-12-05 | 2004-06-24 | Protein Design Labs, Inc. | Methods of treatment of ulcerative colitis with anti-cd3 antibodies |
| DE10336334B3 (de) * | 2003-08-08 | 2005-08-04 | Cnh Baumaschinen Gmbh | Hydraulisches Steuersystem für Baumaschinenen, insbesondere für Bagger |
| DK1687066T3 (da) * | 2003-11-14 | 2012-11-26 | Brigham & Womens Hospital | Fremgangsmåder til immunmodulering |
| US20050249723A1 (en) * | 2003-12-22 | 2005-11-10 | Xencor, Inc. | Fc polypeptides with novel Fc ligand binding sites |
| WO2005076965A2 (en) * | 2004-02-04 | 2005-08-25 | The Trustees Of Columbia University In The City Of New York | Anti-cd3 and antigen-specific immunotherapy to treat autoimmunity |
| JP5139800B2 (ja) * | 2004-06-03 | 2013-02-06 | ノビミューン エスアー | 抗cd3抗体およびその使用方法 |
| AU2006267090B2 (en) * | 2005-07-11 | 2013-03-07 | Provention Bio, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
-
2007
- 2007-06-05 JP JP2009514336A patent/JP2009539841A/ja active Pending
- 2007-06-05 CA CA002653387A patent/CA2653387A1/en not_active Abandoned
- 2007-06-05 EP EP07795754A patent/EP2023955A4/en not_active Withdrawn
- 2007-06-05 US US11/810,235 patent/US20090258001A1/en not_active Abandoned
- 2007-06-05 AU AU2007258694A patent/AU2007258694B2/en not_active Ceased
- 2007-06-05 WO PCT/US2007/013232 patent/WO2007145941A2/en not_active Ceased
- 2007-06-05 EP EP11190677A patent/EP2433650A3/en not_active Withdrawn
- 2007-06-05 NZ NZ573132A patent/NZ573132A/en not_active IP Right Cessation
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