JP2008507529A5 - - Google Patents
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- JP2008507529A5 JP2008507529A5 JP2007522656A JP2007522656A JP2008507529A5 JP 2008507529 A5 JP2008507529 A5 JP 2008507529A5 JP 2007522656 A JP2007522656 A JP 2007522656A JP 2007522656 A JP2007522656 A JP 2007522656A JP 2008507529 A5 JP2008507529 A5 JP 2008507529A5
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- JP
- Japan
- Prior art keywords
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- receptor
- antibody
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- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 18
- 108010057085 cytokine receptors Proteins 0.000 claims 6
- 102000003675 cytokine receptors Human genes 0.000 claims 6
- 238000003384 imaging method Methods 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102000019223 Interleukin-1 receptor Human genes 0.000 claims 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 claims 1
- 102000004560 Interleukin-12 Receptors Human genes 0.000 claims 1
- 108010017515 Interleukin-12 Receptors Proteins 0.000 claims 1
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 1
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 1
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000036765 blood level Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108010085650 interferon gamma receptor Proteins 0.000 claims 1
- 108040003610 interleukin-12 receptor activity proteins Proteins 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 102000003390 tumor necrosis factor Human genes 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 2
- 206010006895 Cachexia Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 231100000317 environmental toxin Toxicity 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59040004P | 2004-07-22 | 2004-07-22 | |
| PCT/US2005/025588 WO2006014646A2 (en) | 2004-07-22 | 2005-07-20 | Methods for diagnosis using anti-cytokine receptor antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008507529A JP2008507529A (ja) | 2008-03-13 |
| JP2008507529A5 true JP2008507529A5 (https=) | 2008-09-11 |
Family
ID=35787681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522656A Pending JP2008507529A (ja) | 2004-07-22 | 2005-07-20 | 抗サイトカインレセプター抗体を用いる診断のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7727528B2 (https=) |
| EP (1) | EP1781818B1 (https=) |
| JP (1) | JP2008507529A (https=) |
| AU (1) | AU2005269820B2 (https=) |
| CA (1) | CA2574496C (https=) |
| DK (1) | DK1781818T3 (https=) |
| WO (1) | WO2006014646A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0315656D0 (en) * | 2003-07-03 | 2003-08-13 | Oxonica Ltd | Metal oxide formulations |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| KR20170036814A (ko) * | 2007-05-21 | 2017-04-03 | 앨더바이오 홀딩스 엘엘씨 | 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체 |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8058204B2 (en) * | 2008-10-24 | 2011-11-15 | GM Global Technology Operations LLC | Method for generating a shell of noble metal overlaid on a core of non-noble metal, and catalysts made thereby |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US9452227B2 (en) * | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| ES2706403T3 (es) | 2008-12-10 | 2019-03-28 | Joslin Diabetes Center Inc | Métodos para diagnosticar y predecir una enfermedad renal |
| CN102740888B (zh) | 2009-11-24 | 2016-10-12 | 奥尔德生物制药公司 | Il-6抗体及其用途 |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| EP3097420A4 (en) * | 2014-01-24 | 2018-01-17 | Ntercept, LLC | Methods and compositions for immune dis-inhibition |
| EA035898B1 (ru) | 2014-10-03 | 2020-08-28 | НАНОТИКС, ЭлЭлСи | Композиции и способы для ингибирования биологической активности растворимых биомолекул |
| EP3328362A4 (en) | 2015-07-29 | 2019-03-06 | Nanotics, LLC | MODULAR COMPOSITIONS FOR THE DISPOSAL OF SOLUBLE BIOMOLECULES AND RELATED METHODS |
| CA3004830A1 (en) * | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| US10858422B2 (en) | 2016-05-31 | 2020-12-08 | Abcentra, Llc | Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody |
| US10434141B2 (en) | 2016-05-31 | 2019-10-08 | Abcentra, Llc | Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody |
| US11065345B2 (en) | 2017-01-04 | 2021-07-20 | Nanotics, Llc | Methods for assembling scavenging particles |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965132A (en) * | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6096289A (en) * | 1992-05-06 | 2000-08-01 | Immunomedics, Inc. | Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy |
| JPH0630788A (ja) | 1992-07-16 | 1994-02-08 | Otsuka Pharmaceut Co Ltd | ヒトインターロイキン−１に対する組換え抗体 |
| US20030138426A1 (en) * | 1997-10-21 | 2003-07-24 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1, and TR11SV2 |
| US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
| US20020039764A1 (en) | 1999-03-12 | 2002-04-04 | Rosen Craig A. | Nucleic, acids, proteins, and antibodies |
| WO2001074388A1 (en) * | 2000-03-31 | 2001-10-11 | Idec Pharmaceuticals Corporation | Combined use of anti-cytokine antibodies or antagonists and anti-cd20 for the treatment of b cell lymphoma |
| US7358041B2 (en) * | 2001-11-30 | 2008-04-15 | Short Mary K | Antibodies to magmas and uses thereof |
| US20040072237A1 (en) * | 2001-12-26 | 2004-04-15 | Barry Schweitzer | Use of cytokines secreted by dendritic cells |
| JP2008511340A (ja) * | 2004-04-30 | 2008-04-17 | バイオフェレシス テクノロジーズ， インコーポレイテッド | 患者において可溶性ｔｎｆｒ１、可溶性ｔｎｆｒ２、および可溶性ｉｌ２を除去する方法およびシステム |
-
2005
- 2005-07-20 JP JP2007522656A patent/JP2008507529A/ja active Pending
- 2005-07-20 WO PCT/US2005/025588 patent/WO2006014646A2/en not_active Ceased
- 2005-07-20 CA CA2574496A patent/CA2574496C/en not_active Expired - Fee Related
- 2005-07-20 AU AU2005269820A patent/AU2005269820B2/en not_active Ceased
- 2005-07-20 DK DK05775665.2T patent/DK1781818T3/en active
- 2005-07-20 US US11/185,335 patent/US7727528B2/en active Active
- 2005-07-20 EP EP05775665.2A patent/EP1781818B1/en not_active Expired - Lifetime
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